The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues. (biolegend.com)
In a search for other costimulatory receptors on T ceils, we have characterized a monoclonal antibody (mAb) that can costimulate T cells in the absence of accessory cells. (nebraska.edu)
Assessment of the ability to produce functional antibodies can be obtained by measuring antibody responses to natural antigens or those antigens to which the population commonly is exposed. (medscape.com)
This assessment can also be done by measuring antibody responses following active immunization with protein or polysaccharide antigens. (medscape.com)
In children who have completed immunizations with diphtheria, pertussis, and tetanus (DPT) or Hib-conjugated vaccines, the antibody response to protein antigens can be tested in adults and older children by measuring IgG antibodies to tetanus or diphtheria toxoid and H influenzae type b (Hib) polysaccharide antigen. (medscape.com)
Therefore, antibody responses should be measured to polysaccharide antigens that are not present in the protein-conjugated pneumococcal vaccine. (medscape.com)
Alternatively antibody response to typhoid-Vi antigen can be measured following typhoid vaccine administration. (medscape.com)
Immunoperoxidase staining of rat lymph node cryosection with Mouse anti Rat CD43 antibody ( MCA54GA ) followed by peroxidase conjugated Goat anti Mouse IgG1 antibody ( STAR132P ) for detection. (bio-rad-antibodies.com)
Independent of antibody secretion B cells secrete proinflammatory cytokines, support the formation of ectopic GCs, and serve as antigen presenting cells. (hindawi.com)
Likewise, antigen/antibody complexes are bound by the FcR of APCs and processed in a unique fashion dependent on the epitope specificity of the bound antibody. (hindawi.com)
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. (thermofisher.com)
Description: This X54-5/7.1 monoclonal antibody recognizes allelic variants a and b of mouse CD64, a high affinity Fc binding receptor also known as Fc-gammaR1 or Fcgr1. (thermofisher.com)
Leukosialin1
Furthermore, the cells did not express cytoplasmic mu-heavy chain (cmu) or surface IgM, but were positive for CD24 (heat stable antigen [HSA]) and CD43 (leukosialin), suggesting that the cells produced were blocked at a late pro-B-cell stage. (ox.ac.uk)
Molecules7
CD161 molecules are C-type lectin-like receptors that can either activate (CD161a) or inhibit (CD161b) effector leucocyte responses, eg, cytotoxicity or cytokine production, against target cells which express C-type lectin-like related (Clr) molecules. (bdbiosciences.com)
Interestingly, both MO-MDSCs and PMN-MDSCs suppressed antigen-specific T-cell responses, albeit using distinct effector molecules and signaling pathways. (ashpublications.org)
Autoantibodies can bind to basic structural molecules and interfere with the synthesis of structural elements and facilitate the uptake of antigen. (hindawi.com)
After processing, antigen is presented on MHC molecules. (hindawi.com)
The venom promoted the differentiation of Bmem and subtypes of ASC that have been characterized by the expression of B220 and CD43 molecules (B220 highCD43high, B220 highCD43low, B220 lowCD43high or B220 negCD43high), indicating a hierarchical course of action of differentiation [13]. (cathepsin-s.com)
A. The linear model describes the activation of naïve T-cells by the presentation of antigen-peptide on major histocompatibility complex (MHC) molecules by the antigen presenting cells (APCs) during the contraction phase of a T-cell response. (flowmetric.com)
The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)
Antibodies5
Similar to CD28 antibodies, this mAb, R2/60, was found to synergize with T cell receptor engagement in inducing proliferation. (nebraska.edu)
Approximately 80% of children have detectable antibodies to these antigens after 3 immunizations during their first year of life. (medscape.com)
c) Effect of antibodies and antigen-specific B cells on antigen uptake. (hindawi.com)
cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)
CD452
Recent findings suggest that one of the key events is the exclusion of the large receptor-type tyrosine phosphatase CD45, from close contacts formed at sites of T-cell/APC interaction. (ox.ac.uk)
If this is true, a full understanding of how close contact formation leads to signaling would require insights into the structures of, and interactions between, large membrane proteins like CD45 and other proteins forming the glycocalyx, such as CD43. (ox.ac.uk)
Ligand5
Expression doning of the R2/60 antigen identified the ligand as murine CD43. (nebraska.edu)
The B cell receptor (BCR) normally providing tonic signals for cell survival and mitogenic responses to antigens, can also contribute to lymphomagenesis upon sustained ligand binding or activating mutations. (oncotarget.com)
Our long-term goals in the lab are to understand how receptor-ligand interactions at the cell surface trigger remodeling of the cytoskeleton, and how the cytoskeleton in turn affects the immune response. (upenn.edu)
The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages . (wikidoc.org)
IFNGR2 , encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor. (wikidoc.org)
CD282
Costimulation mediated by the CD28 receptor has been shown to play an important role in the development of a vigorous T cell immune response. (nebraska.edu)
Together, these data demonstrate that CD43 can serve as a receptor on T cells that can provide CD28-independent costimulation. (nebraska.edu)
CD441
HA binding receptor, CD44 and LYVE-1 expression were also upregulated in the CsA groups, and were localized to the area of fibrosis and the peritubular capillaries of the cortex. (mmp-signal.com)
Cells22
T cells can be distinguished from other lymphocytes by the presence of a T-cell receptor (TCR) on their cell surface. (wikipedia.org)
The earliest cells which arrived in the thymus are commonly termed double-negative, as they express neither the CD4 nor CD8 co-receptor. (wikipedia.org)
Combined signaling through interleukin-7 receptors and flt3 but not c-kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells. (ox.ac.uk)
Larger tumor cells more often expressed CD43 and CD138, which culminated in a plasma cell phenotype in 10% of cases. (oncotarget.com)
The first step of the adaptive immune response involves the interaction of T cells that express T-cell receptors (TCRs) with peptide-loaded major histocompatibility complexes expressed by antigen-presenting cells (APCs). (ox.ac.uk)
Likewise B cells function as crucial antigen presenting cells in autoimmune diseases that are traditionally viewed as T cell mediated. (hindawi.com)
Both secreted autoantibodies and BCR on B cells can modulate the processing and presentation of antigen and thereby affect the nature of presented T-cell determinants. (hindawi.com)
Right panel: antigen binds to the BCR of antigen-specific B cells and is internalized. (hindawi.com)
B cells are highly efficient APCs in situations of low antigen concentrations. (hindawi.com)
In dendritic cells, actin regulatory proteins control the uptake and presentation of antigens, migration of antigen-bearing cells from sites of infection to lymphoid organs, and defining the outcome of T cell stimulation. (upenn.edu)
Topics could include analyzing regulation of T cell actin dynamics at the immunological synapse, analyzing actin function during antigen presentation in dendritic cells, or manipulating cytoskeletal signaling pathways to modify T cell migration during T cell immunotherapy. (upenn.edu)
Chimeric antigen receptor-modified T (CAR T) cells exhibit very effective function in elimination of relapsed/refractory B-cell lymphoid malignancies, we investigated their use in a patient with relapsed MCL. (bmj.com)
Here, we demonstrate that developing self-reactive B cells are not always highly sensitive to the deletion mechanisms imposed by membrane-bound self-antigens. (silverchair.com)
At low amounts, membrane-bound antigens allow survival of B cells bearing a single high affinity self-reactive B cell receptor (BCR). (silverchair.com)
low quantities of self-antigen induce the selection and accumulation of increased numbers of self-reactive B cells with decreased expression of antigen-specific BCRs. (silverchair.com)
By directly measuring antigen binding by intact B cells, we show that the low amounts of self-antigen select self-reactive B cells with a lower association constant. (silverchair.com)
A fraction of these B cells is activated and secretes autoantibodies that form circulating immune complexes with self-antigen. (silverchair.com)
These findings demonstrate that conventional B cells can undergo positive selection and that the fate of a self-reactive B cell depends on the quantity of self-antigen, the number of BCRs engaged, and on its overall antigen-binding avidity, rather than on the affinity of individual BCRs. (silverchair.com)
In transgenic mice expressing hen egg lysozyme (HEL) as a neo self-antigen, B cells transgenic for a high affinity B cell receptor (BCR) specific for HEL undergo different fates ( 2 , 3 ). (silverchair.com)
After antigen stimulation, these cells migrate into tissue areas that are inflamed where they exhibit a strong proliferative response and express and release cytokines that help to eliminate infection. (flowmetric.com)
These are referred to as CD8+ memory T-cells because they 'remember' this previous encounter with the specific antigen, and they are programmed to elicit a faster and stronger immune response to that same antigen. (flowmetric.com)
CD473
Antigens, CD47" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
This graph shows the total number of publications written about "Antigens, CD47" by people in this website by year, and whether "Antigens, CD47" was a major or minor topic of these publications. (rush.edu)
Below are the most recent publications written about "Antigens, CD47" by people in Profiles. (rush.edu)
Protein3
Assessment of responses to polysaccharide antigens is important in patients older than 18-24 months because these responses may be deficient in some patients who can respond normally to protein antigens. (medscape.com)
Rat natural killer cell antigen, NKR-P1, related to C-type animal lectins is a carbohydrate-binding protein. (bdbiosciences.com)
Interferon gamma receptor 1 ( IFNGR1 ) also known as CD119 ( C luster of D ifferentiation 119 ), is a protein that in humans is encoded by the IFNGR1 gene . (wikidoc.org)
High affinity1
CD64 is a high-affinity Fc-gamma receptor and is one of three related gene family members located on chromosome 1. (thermofisher.com)
Binds1
A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN. (wakehealth.edu)
Cytokines1
It has been proposed that long-lasting B cell ediated immunity is sustained by recurrent antigen exposure and within the absence of cognate antigen, inflammatory stimuli related with adaptive immune responses like cytokines, Toll-like receptor (TLR) agonists or T cell aid drive the activation of Bmem in an non-specific manner in vivo [10,11]. (cathepsin-s.com)
Lymphocyte2
Estefanía E, Flores R, Gómez-Lozano N, Aguilar H, López-Botet M, Vilches C: Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets. (exbio.cz)
Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement. (southernbiotech.com)
Differentiation1
Also it is actually not clear whether or not antigen reencounter benefits within the activation of antigenresponding Bmem or if intrinsic changes modulate their differentiation into ASC following appropriate stimulation [9]. (cathepsin-s.com)
Specificity1
van den Berg HA, Wooldridge L, Laugel B, Sewell AK: Coreceptor CD8-driven modulation of T cell antigen receptor specificity. (exbio.cz)
Tumor2
For example, when a cytotoxic T cell recognizes a tumor cell for lysis, specific receptor interactions trigger capping of the cortical actin cytoskeleton, creating a specialized membrane domain that is important for T cell signaling events leading to lysis of the tumor cell. (upenn.edu)
CD8+ T-cell mediated immune responses are important in protection against various pathogens and specific tumor antigens associated with various cancers. (flowmetric.com)
Inhibit1
Secreted autoantibodies specific to receptors or receptor ligands can activate or inhibit receptor functions. (hindawi.com)
Interleukin1
B29), and the -subunit of the E-mail: [email protected] interleukin (IL)-7 receptor [5, 6]. (lu.se)
Cell9
A critical step in T cell maturation is making a functional T cell receptor (TCR). (wikipedia.org)
Glycosylation of classical death receptors fine-tunes cell death programs. (nature.com)
BCR-mediated antigen uptake can influence antigen processing and the nature of MHC-displayed T-cell determinants. (hindawi.com)
B220 + /CD43 + /HSA + ) through fully differentiated B cell stages. (southernbiotech.com)
Based on these results, it was postulated that B cell deletion required BCR cross-linking and could only be induced by membrane bound self-antigens. (silverchair.com)
Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. (thermofisher.com)
The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation, and is expressed in all B cell precursor leukemias. (thermofisher.com)
The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. (thermofisher.com)
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)
Uptake1
This FcR-mediated antigen uptake is more efficient than antigen uptake by pinocytosis. (hindawi.com)
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. (thermofisher.com)
Findings1
These findings suggest that upregulation of HA and its binding receptors are involved in interstitial fibrosis in chronic CsA-induced renal injury. (mmp-signal.com)
LewisY blood antigen or simply BG8, is a blood group antigen that has been identified in studies as a potential marker for differentiating pulmonary adenocarcinoma (PACA) from epithelioid mesothelioma (EM). (neuromics.com)
In 1972 a numerical system for the antigens in this blood group was introduced. (wikidoc.org)
Glycophorin A and glycophorin B carry the blood group MN and Ss antigens respectively. (wikidoc.org)
Response1
The antigen was discovered in 1960 when three women who lacked the antigen made anti-Gea in response to pregnancy. (wikidoc.org)
Year1
[1] The following year a new but related antigen was discovered in a Mrs Yus for whom an antigen in this system is also named. (wikidoc.org)