Receptor adenoviruses human. Medical search. Frequent questions

Coxsackievirus and adenovirus receptor (CAR) is a protein that in humans is encoded by the CXADR gene. (wikipedia.org)
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Coxsackievirus and adenovirus receptor in samples from serum, plasma, tissue homogenates and other biological fluids. (mugen-noe.org)
The coxsackievirus and adenovirus receptor (CAR) is a cell adhesion molecule used as a docking molecule by some adenoviruses (AdVs) and group B coxsackieviruses. (cnrs.fr)
Adv infects the host cells through binding to different cellular receptors such as coxsackievirus and adenovirus receptor (CAR) [ 12 ]. (hindawi.com)
Tunicamycin has also been used to study the functional effects of coxsackievirus and adenovirus receptor (CAR) glycosylation in COS-7 cells. (sigmaaldrich.com)
On the other hand, Ad vectors also have a number of disadvantages, including their low transduction efficiency in cells lacking coxsackievirus-adenovirus receptor (CAR) and their induction of innate immune responses. (hindawi.com)

Acute respiratory disease associated with adenovirus serotype 14-four states, 2006-2007. (cdc.gov)
Louie JK , Kajon AE , Holodniy M , Guardia-LaBar L , Lee B , Petru AM , Severe pneumonia due to adenovirus serotype 14: a new respiratory threat? (cdc.gov)
Esposito DH , Gardner TJ , Schneider E , Stockman LJ , Tate JE , Panozzo CA , Outbreak of pneumonia associated with emergent human adenovirus serotype 14-southeast Alaska, 2008. (cdc.gov)
Most vectors are derived from human adenovirus (Ad) serotype 5 despite limited applicability caused by pre-existing immunity and unfavorable liver tropism, whereas the other more than 100 known human serotypes remain largely unused. (bvsalud.org)

The protein encoded by this gene is a type I membrane receptor for group B coxsackie viruses and subgroup C adenoviruses. (wikipedia.org)
Human CAR protein has a theoretical molecular weight of 40.0 kDa and is composed of 365 amino acids. (wikipedia.org)
Here we report that adenovirus 14.7K protein inhibits ligand-induced TNFR1 internalization. (jci.org)
In contrast, 14.7K did not affect TNF-induced NF-κB activation via recruitment of receptor-interacting protein 1 (RIP-1) and TNF receptor-associated factor 2 (TRAF-2). (jci.org)
2021. The fiber knob protein of human adenovirus type 49 mediates highly efficient and promiscuous infection of cancer cell lines using a novel cell entry mechanism . (cardiff.ac.uk)
2019. Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions . (cardiff.ac.uk)
Regulation of recombinant gamma-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C. (nih.gov)
By state-of-the-art sequencing ESR6&7 showed that Bartonella henselae adhesin A (BadA) is nearly 4000 residues long (not ≈3000), and with ESR12 determined which parts of this very long protein bound human fibronectin as a promising basis for novel antimicrobial therapies. (europa.eu)
ESR11 studied the complex between the human adenovirus type 5 penton base capsid protein and its integrin receptor by cryo-electron microscopy, leading to a preliminary structure of the interaction of the complex, as well as a 4 Å structure of the penton base. (europa.eu)
BNIP3 (Bcl-2/ adenovirus E1B 19-kDa-interacting protein 3) is a receptor accounting for priming damaged mitochondria for autophagic removal. (chinaphar.com)
Using mass spectrometric analysis insulin receptor substrate 4 (IRS-4) has been identified as a novel adenovirus 5 early region 1A (Ad5E1A)-binding protein. (ox.ac.uk)
Prolonged expression of Ad5E1A13S is required for the observed dramatic increase in the levels of IRS-4 mRNA and protein in Ad5E1-transformed human cell lines. (ox.ac.uk)

It also exhaustively introduces the concrete mechanism of invading GC cells and the viral genome composition of adenovirus and herpes simplex virus type 1 (HSV-1). (frontiersin.org)
Adenovirus (Ad) vectors are among the most commonly used viral vectors in gene therapy clinical trials because they have the following advantages. (hindawi.com)
Here we show that for several of the 135 known viral miRNAs in human viruses, the human genes targeted by the viral miRNA are enriched for specific host pathways whose targeting is likely beneficial to the virus. (biomedcentral.com)
Given that viral miRNAs continue to be discovered as technologies evolve, we extended the investigation to 6809 putative miRNAs encoded by 23 human viruses. (biomedcentral.com)
We conclude that the association and altered regulation of IRS proteins by Ad5E1A contribute to the adenovirus-transformed phenotype and modulates viral infection in an Akt-dependent manner. (ox.ac.uk)

We previously proposed that the preferential transduction of neurons by canine adenovirus type 2 (CAV-2) is due to CAR-mediated internalization. (cnrs.fr)
He and his colleagues demonstrated that transduction of mice with an adenovirus expressing the human receptor for MERS-CoV, DPP4, rendered them sensitive to infection, providing the first rodent model useful for studying MERS. (hstalks.com)
Cell-Surface Integrins and CAR Are Both Essential for Adenovirus Type 5 Transduction of Canine Cells of Lymphocytic Origin. (auburn.edu)

Antiviral immune responses present a major hurdle to the efficacious use of oncolytic adenoviruses as cancer treatments. (aacrjournals.org)
In this study, we tested the hypothesis that tumor-infiltrating T cells could be more effectively activated and redirected by oncolytic adenoviruses that were armed with bispecific T-cell-engager (BiTE) antibodies. (aacrjournals.org)

This was examined using human umbilical vein endothelial cells infected with recombinant adenovirus encoding the human A2AAR. (gla.ac.uk)

Mesothelin-redirected chimeric antigen receptor T cell (meso-CAR T cell) therapy has shown some efficacy in clinical trials but antitumor efficacy remains modest. (jci.org)

Our study highlights the mechanistic differences that a receptor can have for two viruses from the same family. (cnrs.fr)
The Company plans to first screen its novel nanoviricides that have been effective against different viruses, including adenoviruses, against hAd41-F once the antiviral assay is established. (biospace.com)
Human Advs are nonenveloped double-stranded DNA viruses and belong to the Adenoviridae family [ 7 , 8 ]. (hindawi.com)
Our analysis further suggests that human viruses have evolved their miRNA repertoire to target specific human pathways, such as cell growth, axon guidance, and cell differentiation. (biomedcentral.com)
In this review article, we outline key characteristics of major gene therapy viruses-adenovirus, adeno-associated virus (AAV), and lentivirus-and summarize the mechanisms regulating important steps in the virus journey from binding at peripheral nerve terminals to nuclear delivery. (frontiersin.org)
Similarly, direct injection of viruses into the cerebrospinal fluid (e.g., via lumbar puncture in humans) also permits targeting of the peripheral (PNS) and central nervous systems (CNS). (frontiersin.org)
METHODS: Reporter-gene-expressing viruses representative of the natural human Ad diversity were used to transduce an array of muscle cell lines and two- or three-dimensional tumor cultures. (bvsalud.org)

2022. Development of a low seroprevalence, αvβ6 integrin selective virotherapy based on human adenovirus type 10 . (cardiff.ac.uk)
2018. Ad5NULL-A20 - a tropism-modified, αvβ6 integrin-selective oncolytic adenovirus for epithelial ovarian cancer therapies . (cardiff.ac.uk)
A number of human congenital disorders have been associated with defective integrin-mediated adhesion, including the blistering disorder junctional epidermolysis bullosa, the bleeding disorder Glanzmann's thrombastenia , leukocyte adhesion deficiency-I (β2 integrins in leukocytes) and leukocyte adhesion deficiency-III, nephrotic syndrome and interstitial lung disease and muscular dystrophy. (transcriptionfactor.org)
Integrin alpha-V/beta-5 is a receptor for fibronectin and it recognizes the sequence R-G-D in its ligand. (transcriptionfactor.org)
To eliminate this, biotin-coated ultrasound contrast agents, or microbubbles (MBs), were streptavidin-coupled with biotinylated antibodies to three distinct tumor vasculature-associated receptors (α V Β 3 integrin, P-selectin and vascular endothelial growth factor receptor-2) for systemic targeting of a previously generated vector Ad5/3-Id1-SEAP-Id1-mCherry. (elsevierpure.com)

Adenovirus infection did not change the adherence of cells of poorly adhering strains of S. pneumoniae or H. influenzae. (lu.se)
The increase in adherence of S. pneumoniae could be inhibited by the DNA synthesis inhibitor cytosine arabinofuranoside, which is known to block the late phase of the adenovirus infection. (lu.se)
This suggested that adenovirus infection upregulated receptors for S. pneumoniae. (lu.se)
Adenovirus infection activates akt1 and induces cell proliferation in pancreatic islets1. (nih.gov)
Human adenovirus (Adv) infection is responsible for most community-acquired pneumonia in infants and children, which results in significant morbidity and mortality in children every year. (hindawi.com)
Knowing the miRNA expression profile will help understand the role of miRNAs in modulating the host response to adenovirus infection and possibly improve the diagnosis of adenovirus-infected pneumonia. (hindawi.com)
Human adenovirus (Adv) infection is responsible for most community-acquired pneumonia in infants and children [ 1 , 2 ]. (hindawi.com)
Here, we report the discovery of human monoclonal antibodies (mAbs) from the circulating memory B cells of the only known human case and survivor of SOSV infection. (cdc.gov)
Human infection with Sosuga virus (SOSV), a recently discovered pathogenic paramyxovirus, has been reported in one individual to date. (cdc.gov)

One of the aims of this study was to characterise phosphorylation of the human A2AAR and to determine whether this could provide a means for regulating the binding of C-terminal interacting proteins. (gla.ac.uk)
Integrins are a family of cell surface transmembrane receptors, each consisting of an α and a β subunit that bind to extracellular matrix (ECM) proteins and cellular counter receptors and associate with the cytoskeleton. (transcriptionfactor.org)
These findings provide insight into the molecular basis for human antibody recognition of paramyxovirus surface proteins and the mechanisms of SOSV neutralization. (cdc.gov)

OAd-TNFa-IL2 enhanced the antitumor efficacy of meso-CAR T cells in human-PDA-xenograft immunodeficient mice and efficacy was associated with robustly increased tumor-infiltrating lymphocytes (TILs), enhanced and prolonged T cell function. (jci.org)
We also evaluated this approach in a syngeneic mouse tumor model by combining adenovirus expressing murine TNF-α and IL-2 (Ad-mTNFa-mIL2) and mouse CAR T cells. (jci.org)
Despite the existence of a highly immunosuppressive tumor environment, adenovirus-infected cells can nonetheless be efficiently cleared by infiltrating cytotoxic T lymphocytes (CTL) without compromising tumor burden. (aacrjournals.org)
Notably, intratumoral injection of this cBiTE-expressing adenovirus increased the persistence and accumulation of tumor-infiltrating T cells in vivo , compared with the parental virus lacking such effects. (aacrjournals.org)

Analysis of purified magnetically labeled TNFR1 complexes from murine and human cells stably transduced with 14.7K revealed that prevention of TNFR1 internalization resulted in inhibition of DISC formation. (jci.org)
Furthermore, we found that the same TNF defense mechanisms were instrumental in protecting wild-type adenovirus-infected human cells expressing 14.7K. This study describes a new molecular mechanism implemented by a virus to escape immunosurveillance by selectively targeting TNFR1 endocytosis to prevent TNF-induced DISC formation. (jci.org)
The present study analyzed the effect of adenovirus on bacterial adherence to human respiratory tract epithelial cells. (lu.se)
Adenovirus (types 1, 2, 3, and 5) commonly causing respiratory tract infections increased the binding of adherent S. pneumoniae strains to the cells. (lu.se)
Our proposed pathway of CAV-2 entry is in contrast to that of human AdV type 5 (HAdV-C5) in non-neuronal cells, where internalization is mediated by auxiliary receptors such as integrins. (cnrs.fr)
Adv replicates efficiently in human cells and triggers an innate immune response such as inflammatory response in the host cells. (hindawi.com)
Although miRNAs have been examined in Adv type 3-infected human laryngeal epithelial cells and Adv type 2-infected human lung fibroblast cells [ 19 , 20 ], there is no research about small RNA profiling in whole blood of Adv-infected pneumonia children. (hindawi.com)
Tunicamycin has been used to study the effect of N-linked glycosylation of human proton-coupled folate transporter (HsPCFT) in HeLa cells. (sigmaaldrich.com)
We hypothesized that combined meso-CAR T cells with an oncolytic adenovirus expressing TNF-α and IL-2 (Ad5/3-E2F-D24-TNFa-IRES-IL2, or OAd-TNFa-IL2) would improve efficacy. (jci.org)
We showed that TMZ dosage-dependently inhibited the viability of human U87, U251, T98G, LN18 and rat C6 glioma cells with IC 50 values of 135.75, 128.26, 142.65, 155.73 and 111.60 μM, respectively. (chinaphar.com)
These results demonstrate that FOXO3a attenuates temozolomide-induced DNA double strand breaks in human glioma cells via promoting BNIP3-mediated mitophagy. (chinaphar.com)
Cell-specific delivery of a transforming growth factor-beta type I receptor kinase inhibitor to proximal tubular cells for the treatment of renal fibrosis. (rug.nl)
van de Bovenkamp M, Groothuis GMM, Meijer DKF, Olinga P. Liver slices as a model to study fibrogenesis and test the effects of anti-fibrotic drugs on fibrogenic cells in human liver. (rug.nl)
PDGF-receptor b -targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells. (rug.nl)
the effect was inhibited by the H1 receptor antagonist diphenhyramine, suggesting that BEAS cells retain functioning histamine receptors. (epa.gov)
To avoid elimination by this mechanism, human papillomaviruses (HPV) have developed several mechanisms that enable the cells they infect to elude both extrinsic and intrinsic apoptosis. (mdpi.com)
In a side-by-side in vitro analysis, we evaluated the effect of 40 AdV types covering human AdV (HAdV) species A through G on the expression of 11 activation markers and the secretion of 12 cytokines by AdV-transduced dendritic cells, and the effect on CD8+ T cell proliferation capacity. (bvsalud.org)
Univariate and multivariate regression analyses suggested an important role of type I interferons in mediating this suppression of CD8+ T cells, which we confirmed experimentally in a proliferation assay using a type I interferon receptor blocking antibody. (bvsalud.org)

Here, we compare the role of a cell adhesion molecule (CAR), in the internalization of adenoviruses that naturally infect humans and Canidae. (cnrs.fr)

Aguila A, Goldsmith ME, Gollapalli SJ, Alley MC, Waud WW, Bates S and Fojo T. Coxsackie-adenovirus receptor (CAR) levels can be increased in human xenografts followed by treatment with FK228, a histone deacetylase inhibitor. (mhs.net)

Immunolocalization of CAR to intercalated discs in human and murine cardiac muscle. (biomedcentral.com)

2018. Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses . (cardiff.ac.uk)
Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR. (expasy.org)
Type F adenoviruses and the EKC-causing adenoviruses are substantially different in their cellular receptor homing, and thus tissue tropism, as well as their structure. (biospace.com)

Houng HS , Gong H , Kajon AE , Jones MS , Kuschner RA , Lyons A , Genome sequences of human adenovirus 14 isolates from mild respiratory cases and a fatal pneumonia, isolated during 2006-2007 epidemics in North America. (cdc.gov)

It was found that phosphorylation of the human A2AAR could be induced in HUVECs by treatment with PMA or by stimulation of endogenous histamine H1 receptors. (gla.ac.uk)
Response of a Human Bronchial Epithelial Cell Line to Histamine: Intracellular Calcium Changes and Extracellular Release of Inflammatory Mediators. (epa.gov)
The authors therefore investigated the response of an SV-40/adenovirus-transformed human bronchial epithelial cell line (BEAS-2B) to histamine, a mediator with relevance for airway diseases. (epa.gov)
no recommendations were made about the use of sucralfate, histamine-2 receptor antagonists, or antacids for stress-bleeding prophylaxis. (cdc.gov)

The human CAR gene (CXADR) is found on chromosome 21. (wikipedia.org)
Studies from human hearts have shown that lower expression of CXADR mRNA is associated with a risk allele at chromosome 21q21, which may in fact predispose hearts to arrhythmias. (wikipedia.org)

tetanus immune globulin (TIG) decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. (medscape.com)
efgartigimod alfa will decrease the level or effect of tetanus immune globulin (TIG) by receptor binding competition. (medscape.com)
rozanolixizumab will decrease the level or effect of tetanus immune globulin (TIG) by receptor binding competition. (medscape.com)

Wang H , Tuve S , Erdman DD , Lieber A . Receptor usage of a newly emergent adenovirus type 14. (cdc.gov)
Specifically, the Company has initiated a program to screen its library of broad-spectrum antiviral nanoviricides against human Adenovirus 41 Type F (hAd41-F), believed to be strongly associated with the occurrence of severe hepatitis syndrome in some children, causing liver transplants as well as fatalities in large percentages of cases. (biospace.com)
Adenovirus-41, Type F (hAd41-F) is widely believed to be the cause of the growing number of hepatitis cases in children worldwide that have required liver transplants and have reported fatalities. (biospace.com)
In addition, his laboratory is characterizing a liver specific knockout mouse model of human Niemann Pick disease type C. (auburn.edu)
Angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and calcium channel blockers, rather than beta-adrenergic blockers, should be considered as first-line therapy for hypertension in patients with type 2 diabetes mellitus who are obese. (medscape.com)

These highly upregulated microRNAs may have crucial roles in Adv pathogenesis and are potential biomarkers for adenovirus-infected pneumonia. (hindawi.com)

Phylogenetic analysis was performed by using reference sequences from GenBank for the adenovirus B2 subgenera, including prototype reference strains. (cdc.gov)
Hierholzer JC , Pumarola A . Antigenic characterization of intermediate adenovirus 14-11 strains associated with upper respiratory illness in a military camp. (cdc.gov)
Furthermore, Human Cytomegalovirus (CMV) miRNAs that target specific human pathways exhibit increased conservation across CMV strains. (biomedcentral.com)

El receptor 2 del complemento humano (CR2) sirve como receptor tanto para el C3dg como para la glicoproteína gp350/220 del HERPESVIRUS 4 HUMANO, y se une al anticuerpo monoclonal OKB7, el que bloquea la unión de ambos ligandos al receptor. (bvsalud.org)
Human complement receptor 2 (CR2) serves as a receptor for both C3dg and the gp350/220 glycoprotein of HERPESVIRUS 4, HUMAN, and binds the monoclonal antibody OKB7, which blocks binding of both ligands to the receptor. (bvsalud.org)

Goldsmith ME, Aguila A, Alley MC, Waud WR, Bates S and Fojo T. The histone deacetylase inhibitor FK228 can increase adenovirus transgene expression in human LOX IMVI melanoma xenografts. (mhs.net)

Human Advs are divided into seven subgroups including 53 serotypes based on immunologic and biological characteristics. (hindawi.com)

For the development of new adenovirus (AdV)-based vectors, it is important to understand differences in immunogenicity. (bvsalud.org)

In our study, total RNA extracted from whole blood of adenovirus-infected pneumonia children and healthy controls were analyzed by small RNA deep sequencing. (hindawi.com)

Adult β 2 AR -/- mice featured glucose intolerance, and pancreatic islets isolated from these animals displayed impaired glucose-induced insulin release, accompanied by reduced expression of peroxisome proliferator-activated receptor (PPAR)γ, pancreatic duodenal homeobox-1 (PDX-1), and GLUT2. (elsevierpure.com)

Her seminal early papers on GPCR signaling demonstrated that dopamine receptors are the target of antipsychotic drugs, that muscarinic receptors inhibit adenylate cyclase and that phospholipase C and CaM kinase II activation mediate cardiac hypertrophy. (aspet.org)

Adenovirus-mediated gene transfer of human β 2 AR rescued these defects. (elsevierpure.com)

The oncolytic adenovirus ICOVIR-15K was engineered to express an EGFR-targeting BiTE (cBiTE) antibody under the control of the major late promoter, leading to generation of ICOVIR-15K-cBiTE, which retained its oncolytic properties in vitro . (aacrjournals.org)
Induction of metabolism and transport in human intestine: Validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro. (rug.nl)
We conducted an in vitro time course experiment with the human airway epithelial cell line Calu-3 and the human colorectal adenocarcinoma cell line Caco-2. (bvsalud.org)

Adenovirus (types 1, 2, 3, and 5) commonly causing respiratory tract infections increased the binding of. (lu.se)
[ 5 ] Ideally, SCID can be detected in a newborn before the onset of infections, with one well-documented example by screening of T-cell-receptor excision circles. (medscape.com)

Description: A competitive ELISA for quantitative measurement of Human True insulin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (mugen-noe.org)
In this study, we investigated the significance of β 2 - adrenergic receptor (β 2 AR) in age-related impaired insulin secretion and glucose homeostasis. (elsevierpure.com)
Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase/Akt signalling pathway. (ox.ac.uk)
Once expressed, as well as binding to E1A and the insulin receptor, IRS-4 remains tyrosine phosphorylated and constitutively associates with the regulatory p85 subunit of phosphoinositide 3 kinase, resulting in the phosphorylation of Akt (causing activation) and GSK-3beta (causing inhibition). (ox.ac.uk)

2019. Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions . (cardiff.ac.uk)

Here, we screened a library of human Ad types and identified Ad4 as a promising candidate vector. (bvsalud.org)

Immunoplates for Exosome capture and quantification from human biofluids (plasma, serum, urine, saliva) and from human or mouse cell media. (transcriptionfactor.org)

Characterization and sequencing of the HCA1 and HCA2 Receptors in Cats. (auburn.edu)

One of the major limitations of cancer gene therapy using recombinant human adenovirus (Ad) is rapid Ad inactivation from systemic delivery. (elsevierpure.com)
Coadministration of efgartigimod with medications that bind to the human neonatal Fc receptor may lower systemic exposures and effectiveness of such medications. (medscape.com)

SwissProt sequences and OMIM curated human diseases associated with missense mutations within the IG domain. (embl.de)

2020. Identification of folate receptor α (FRα) binding oligopeptides and their evaluation for targeted virotherapy applications . (cardiff.ac.uk)

Non-loaded (free) Ad particles were effectively inactivated by treatment with human complement. (elsevierpure.com)

In human cell lines, tunicamycin enhances cytotoxicity stimulated by cisplatin. (sigmaaldrich.com)

Maximum-likelihood trees of the full-length fiber (A), E1A (B), and hexon (C) open reading frames of adenovirus B2 subgenera. (cdc.gov)

The Company's top priority remains initiating human clinical trials of its SARS-CoV-2 drug candidate NV-CoV-2 to combat COVID-19. (biospace.com)
This production capacity is anticipated to be sufficient for the Phase I and Phase II human clinical trials for our anti-coronavirus drug candidate NV-CoV-2, as well as for the anticipated clinical trials of NV-HHV-101 skin cream for the treatment of shingles. (biospace.com)
The Company plans on further developing the shingles drug candidate into human clinical trials after clinical trials of our COVID-19 drug candidate. (biospace.com)
The award is intended to extend funding for preclinical or clinical research directed towards improving human health. (aspet.org)

Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture. (cdc.gov)

Abrupt emergence of diverse species B adenoviruses at US military recruit training centers. (cdc.gov)
Chmielewicz B , Benzler J , Pauli G , Krause G , Bergmann F , Schweiger B . Respiratory disease caused by a species B2 adenovirus in a military camp in Turkey. (cdc.gov)

Detta steg är nödvändigt för att virus ska kunna föröka sig i en infekterad cell och sprida sig vidare till intilliggande celler och vidare till andra människor. (umu.se)
The Bsa For Elisa reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (mugen-noe.org)
Cell surface receptors containing an immunoglobin domain. (embl.de)
Killer cell inhibitory receptors. (embl.de)
These findings indicate that combining cytokine-armed oncolytic adenovirus to enhance the efficacy of CAR T cell therapy is a promising approach to overcome the immunosuppressive TME for the treatment of PDA. (jci.org)
Comparison of the data with published reports for human airway epithelia in primary culture suggests that the BEAS cell line is, in a number of respects, a relevant model for the study of airway epithelial responses to a variety of stimuli. (epa.gov)

Van Der Veen J , Kok G . Isolation and typing of adenoviruses recovered from military recruits with acute respiratory disease in the Netherlands. (cdc.gov)

Kajon AE , Lu X , Erdman DD , Louie J , Schnurr D , George KS , Molecular epidemiology and brief history of emerging adenovirus 14-associated respiratory disease in the United States. (cdc.gov)

The top 3 upregulated miRNA (hsa-miR-127-3p, hsa-miR-493-5p, and hsa-miR-409-3p) were identified in adenovirus-infected children and provided a clear distinction between infected and healthy individuals. (hindawi.com)

Anatomy25

Organisms33

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Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Phenomena and Processes56

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Coxsackievirus6

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Protein12

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Oncolytic adenoviruses2

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Viruses7

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Infection9

Proteins3

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