• This was studied in SK-N-SH neuroblastoma cells, which possess a muscarinic receptor-regulated PLCβ 1 -signaling pathway. (jneurosci.org)
  • Transfected muscarinic acetylcholine receptors selectively couple to Gi-type G proteins and Gq/11. (aspetjournals.org)
  • Effect of phospholipid hydrolysis by phospholipase A2 on the kinetics of antagonist binding to cardiac muscarinic receptors. (mpg.de)
  • In comparison the contractions to carbachol and U46619-credited to activation of muscarinic and thromboxane A2 receptors respectively both probably G-protein combined to IP3 (Thierauch et al . (biongenex.com)
  • Thus, these data are consistent with the possibility that the EGF receptor tyrosine kinase regulates PLC-γ1 activity in native meningioma tissue. (elsevierpure.com)
  • Platelet-derived growth factors (PDGFs) acting via their tyrosine kinase receptors are major mitogens for many cell types of mesenchymal origin, including fibroblasts and vascular smooth muscle cells (VSMCs)[ 1 - 4 ]. (biomedcentral.com)
  • Each PDGF receptor has five extracellular immunoglobulin-like domains and two intracellular tyrosine kinase domains. (biomedcentral.com)
  • Reinforcement effect of histamine on the differentiation of murine myeloblasts and promyelocytes: externalization of granulocyte colony-stimulating factor receptors induced by histamine. (aspetjournals.org)
  • H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. (smpdb.ca)
  • Recent advances in our understanding of the role of histamine and its four receptors suggest new approaches which target the histamine receptors alone or as combination therapies to more efficiently combat pruritus and inflammation in atopic dermatitis. (springeropen.com)
  • With this review, we provide an overview on histamine and the expression of its four receptors on skin resident and nonresident cells. (springeropen.com)
  • The microtubule protein tubulin regulates adenylyl cyclase and phospholipase Cβ 1 (PLCβ 1 ) signaling via transactivation of the G-protein subunits Gαs, Gαi1, and Gαq. (jneurosci.org)
  • These observations presented a spatial and temporal resolution of the sequence of events underlying receptor-evoked involvement of tubulin in G-protein-mediated signaling. (jneurosci.org)
  • It is suggested that G-protein-coupled receptors might modulate cytoskeletal dynamics, intracellular traffic, and cellular architecture. (jneurosci.org)
  • The interaction of tubulin with these polypeptides involves a GTP transfer from the exchangeable GTP-binding site (E site) of tubulin to Gα, which activates the G-protein (transactivation) ( Roychowdhury and Rasenick, 1994 ). (jneurosci.org)
  • 5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms. (aspetjournals.org)
  • Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family. (embl.de)
  • P2Y receptors) are G protein-coupled to phospholipase C Gq/G11 (Burnstock 1995 Brass a Ca2+-induced Ca2+ launch system (Boittin et al . (biongenex.com)
  • Targeting Receptor-Type Protein Tyrosine Phosphatases with Biotherapeutics: Is Outside-in Better than Inside-Out? (westminster.ac.uk)
  • The TSH-receptor is the only G-protein-coupled receptor known able to activate all G protein families, an activity directly mimicked by fluoride. (poisonfluoride.com)
  • The physiological activator of protein kinase C (PKC), diacylglycerol, is formed by hydrolysis of phosphoinositides (PI) by phospholipase C (PLC) or phosphatidylcholine by phospholipase D (PLD). (reading.ac.uk)
  • We established that corticotropin-releasing hormone (CRH), CRH-binding protein (CRH-BP) and CRH-receptor 1 (CRH-R1) are expressed in the gills and skin of common carp Cyprinus carpio , an early vertebrate. (silverchair.com)
  • The aggregative enzyme (ACA) is activated following cAMP-binding to the G-protein coupled cell surface cAMP receptor (cAR1). (biomedcentral.com)
  • Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1. (eu.org)
  • TCDD for every step of the mechanism described for 2,3,7,8-TCDD carcinogenesis in humans including receptor binding, gene expression, protein activity changes, cellular replication, oxidative stress, promotion in initiation-promotion studies and complete carcinogenesis in laboratory animals. (who.int)
  • Secreted phospholipases A 2 (sPLA 2 s) (EC 3.1.1.4) are a structurally related group of low-molecular-mass enzymes (14-18 kDa) that catalyse the hydrolysis of glycerophospholipids (phospholipids hereafter) at their sn -2 position, to produce lysophospholipids and free fatty acids. (ijbs.com)
  • Furthermore, ET-1 and BK heterologously desensitized the stimulation of PI hydrolysis by PE, ET-1 or BK homologously uncoupled their own receptors from [3H]InsP3 formation, but there was no evidence of heterologous desensitization with these two agonists. (reading.ac.uk)
  • Anomalously, chronic exposure to TPA increased the stimulation of PI hydrolysis by BK, but this probably resulted from an increase in BK receptor density. (reading.ac.uk)
  • In this study we evaluated phospholipase C-γ1 (PLC-γ1) expression, activity, and association with the epidermal growth factor (EGF) receptor in a series of human meningiomas as well as cultured meningioma cells. (elsevierpure.com)
  • Epidermal growth factor receptors were detected by immunoblot in six of nine meningiomas (67%) and by immunohistochemistry in 13 of 19 meningiomas (68%) but not in normal leptomeningeal cells. (elsevierpure.com)
  • Although metabotropic glutamate receptor (mGluR) modulation has been studied extensively in neurons, it has not been investigated in astrocytes. (jneurosci.org)
  • These data suggest that glutamate, acting at several metabotropic receptors expressed by astrocytes, could modulate glial activity evoked by neurotransmitters and thereby influence the ongoing modulation of neurons by astrocytes. (jneurosci.org)
  • Postsynaptic membranes contain several types of glutamate receptors, notably NMDA & AMPA receptors, which allow calcium ion entry. (benbest.com)
  • The inhibition of the proton pump by W-7 causes a leakage of Ca 2+ that indirectly stimulates adenylyl cyclase activity via phospholipase C. (biomedcentral.com)
  • Impact of beta and gamma variants on ligand-binding properties of gamma-aminobutyric acid type A receptors. (aspetjournals.org)
  • A carboxyl-terminally truncated mutant and nonglycosylated A2a adenosine receptors retain ligand binding. (aspetjournals.org)
  • Mignery GA, Sudhof TC: The ligand binding site and transduction mechanism in the inositol-1,4,5-triphosphate receptor. (smpdb.ca)
  • Although this remains unclear, the presence of a receptor on glial cells for a ligand on the organism has been suggested to enhance its invasion. (wikidoc.org)
  • As there is redundancy in signalling between the five PDGF ligand isoforms and three PDGF receptor isoforms, and deletion of either of the receptors in vivo produces an embryonic lethal phenotype, it is not know which ligand and receptor combinations mediate specific cellular functions. (biomedcentral.com)
  • Arrows show proven in vitro ligand-receptor interactions. (biomedcentral.com)
  • Disclaimer: As per 'Pre-Natal Diagnostic Techniques (Regulation and prevention of Misuse) Act, 1994', our labs strictly does not determine the sex of the fetus. (redcliffelabs.com)
  • Regulation of phospholipases C and D in rat ventricular myocytes: stimulation by endothelin-1, bradykinin and phenylephrine. (reading.ac.uk)
  • The anti-phospholipase-a2-receptor-pla2r measures anti-phospholipase A2 receptor levels in the blood for detecting membranous glomerulonephritis and nephrotic syndrome. (redcliffelabs.com)
  • In 2009, we had a seminal moment when you published a manuscript in The New England Journal of Medicine describing PLA2R, phospholipase A2 receptor, as the antigen that was responsible for a majority of the cases of MN. (medscape.com)
  • The selectin adhesion molecules and chemoattractant receptors synergistically regulate leukocyte migration into lymphoid tissues and sites of inflammation, but little is known about how these families of receptors modulate each other's function. (upenn.edu)
  • The D2S and D2L dopamine receptor isoforms are differentially regulated in Chinese hamster ovary cells. (aspetjournals.org)
  • Mammalian phosphatidylinositol-specific phospholipase C (PI-PLC) (see IPR000909 ) isoforms gamma and delta. (embl.de)
  • polysaccharide capsule which makes the organism withstand phagocytosis and host immune system, melanin production, ability to thrive at mammalian body temperatures, urease production and phospholipase production. (wikidoc.org)
  • Although stimulation of PDGFRα and PDGFRβ evokes similar signal transduction cascades, in vitro studies suggest distinct requirements for specific pathways to initiate particular receptor-mediated functions. (biomedcentral.com)
  • This 20:4-NAPE-induced inhibition was blocked by anandamide-synthesizing enzyme N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor LEI-401. (frontiersin.org)
  • In addition, the inhibition was prevented by the CB 1 receptor antagonist PF 514273 (0.2 μM) but not by the TRPV1 receptor antagonist SB 366791 (10 μM). (frontiersin.org)
  • Interestingly, DAG to which PKD1 is recruited in this pathway is formed downstream of phospholipase D1 (PLD1) and a lipase-inactive PLD1 or inhibition of PLD1 by pharmacological inhibitors blocked PKD1 activation under oxidative stress. (biologists.com)
  • Reducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression of pro-inflammatory cytokines, cell adhesion molecules, and chemotactic factors. (smpdb.ca)
  • Transient receptor potential ion channel, vanilloid subfamily, type 1 (TRPV1) cation channel, and cannabinoid receptor 1 (CB 1 ) are essential in the modulation of nociceptive signaling in the spinal cord dorsal horn that underlies different pathological pain states. (frontiersin.org)
  • THC and CBD act on specific cannabinoid receptors called CB1 and CB2. (biomedcentral.com)
  • Ras signaling can be thought of in simple terms as occuring downstream of receptor tyrosine kinases, triggered by association of adaptor proteins with the phosphorylated cytoplasmic tails of these receptors. (sdbonline.org)
  • Secreted phospholipases A 2 (sPLA 2 s) participate in a very broad spectrum of biological processes through their enzymatic activity and as ligands for membrane and soluble receptors. (ijbs.com)
  • Neutralising antibodies against PDGFRs were shown to block signalling through PDGFRα and PDGFRβ receptors, reduce human PDGF-AA and PDGF-BB-induced collagen gel remodelling in dermal fibroblasts, and reduce migration stimulated by all PDGF ligands in human dermal and lung fibroblasts. (biomedcentral.com)
  • TRPV1 and CB 1 receptors share the endogenous agonist anandamide (AEA), produced from N-arachidonoylphosphatidylethanolamine (20:4-NAPE). (frontiersin.org)
  • Under inflammatory conditions, 20:4-NAPE (20 μM) also exhibited a significant inhibitory effect (74.5 ± 8.9%) on the mEPSCs frequency that was prevented by the TRPV1 receptor antagonist SB 366791 but not by PF 514273 application. (frontiersin.org)
  • One striking feature of these enzymes is their close homology to venom phospholipases of snakes. (wikipedia.org)
  • Bothropstoxin-I (BthTx-I) is a Lys49-phospholipase A 2 (Lys49-PLA 2 ) from the venom of Bothrops jararacussu, which despite of the lack of catalytic activity induces myotoxicity, inflammation and pain. (biomedcentral.com)
  • Furthermore, a strong positive genetic interaction occurs between Gap1 and phospholipase Cgamma (PLCgamma), an enzyme that generates inositol-1,4,5-trisphosphate, a precursor for IP4 and a second messenger for intracellular Ca2+ release. (sdbonline.org)
  • Cell surface receptors that bind signalling molecules released by neurons and convert these signals into intracellular changes influencing the behavior of cells. (bvsalud.org)
  • In this study, we used PDGFR-specific neutralising antibodies to dissect out receptor-specific signalling events in fibroblasts in vitro , to further understand key cellular processes involved in wound healing and tissue repair. (biomedcentral.com)
  • Phospholipase A2, group 1B is an enzyme that in humans is encoded by the PLA2G1B gene. (wikipedia.org)
  • 3-[3-Amino-4-(indan-2-yloxy)-5-(1-methyl-1 H -indazol-5-yl)-phenyl]-propionic acid (AK106-001616) is a novel, potent, and selective inhibitor of the cytosolic phospholipase A 2 (cPLA 2 ) enzyme. (aspetjournals.org)
  • Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC: Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1). (smpdb.ca)
  • Adler GM - "The effect of sialic acid on adenylate cyclase activity and thyrotropin-receptor binding in human thyroid membranes" Acta Biochim Pol. (poisonfluoride.com)
  • Interactions between L-selectin and chemoattractant receptors were therefore examined using transfected rat basophilic leukemia cell lines (RBL-2H3) that expressed human L-selectin along with human leukocyte chemoattractant receptors. (upenn.edu)
  • Our results show that 20:4-NAPE application has a significant modulatory effect on spinal cord nociceptive signaling that is mediated by both TRPV1 and CB 1 presynaptic receptors, whereas peripheral inflammation changes the underlying mechanism. (frontiersin.org)
  • Second-generation antihistamines are more selective for H1-receptors of the peripheral nervous system (PNS) and do not cross the blood-brain barrier. (smpdb.ca)
  • The switch between TRPV1 and CB 1 receptor activation by the AEA precursor 20:4-NAPE during inflammation may play an important role in nociceptive processing, hence the development of pathological pain. (frontiersin.org)
  • Accordingly, CB 1 receptor activation has been reported to suppress nociceptive behavior both in pathological pain states and in healthy organisms ( Pertwee, 2009 ). (frontiersin.org)
  • Expression of mRNAs encoding subunits of the N-methyl-D-aspartate receptor in cultured cortical neurons. (aspetjournals.org)
  • We demonstrate the presence in the human fetal testis of two key endocannabinoids, 2-arachidonylglycerol (2-AG) and to a lower level anandamide (AEA), as well as a range of enzymes and receptors for the ECS. (biomedcentral.com)
  • Both of these receptors also respond to naturally synthesized cannabinoids, namely anandamide (AEA) and 2-arachidonyl-glycerol (2-AG), so-called endocannabinoids. (biomedcentral.com)
  • Both PLC-γ1 and EGF receptors also exhibited the same pattern of immunostaining on meningioma tissue sections. (elsevierpure.com)
  • In two of three meningiomas EGF receptors and/or a 170-kd phosphotyrosine band precipitated with a PLC-γ1 antiserum. (elsevierpure.com)
  • In accord with our hypothesis that the link from Ca 2+ to cAMP synthesis is mediated by a Ca 2+ -dependent phospholipase C we found that W-7 was not active in the phospholipase C knockout mutant. (biomedcentral.com)
  • In addition to the endocannabinoids and their receptors, this endocannabinoid system (thereafter called ECS) comprises synthesis and degradation enzymes and transporters [ 14 ]. (biomedcentral.com)
  • We conclude that LDL receptors are largely responsible for the resistance of wild type mice to atherosclerosis. (jci.org)
  • The human 180-kDa receptor for secretory phospholipases A2. (wikipedia.org)
  • Peruzzi D, Calabrese G, Faenza I, Manzoli L, Matteucci A, Gianfrancesco F, Billi AM, Stuppia L, Palka G, Cocco L: Identification and chromosomal localisation by fluorescence in situ hybridisation of human gene of phosphoinositide-specific phospholipase C beta(1). (smpdb.ca)
  • We have measured activation of these phospholipases by endothelin-1 (ET-1), bradykinin (BK), or phenylephrine (PE) in ventricular myocytes cultured from neonatal rat. (reading.ac.uk)
  • Receptors in the posterior pharynx are then activated to initiate the involuntary phase of deglutition, which involves carefully sequenced contraction of numerous head and neck muscles. (nature.com)