Peptide receptor radionuclide therapyNaturally occurring radSeparation of radionuclidesRadiopharmaceuticalImagingNuclidesTracersRadioactiveTherapyRadiopharmaceuticalsNorthStar Medical RadioisotopesGeneratorsConcentrationsIsotopeQuantifyExposureIodineDecayTechnetiumTherapeuticNuclear medicineRadiationConsistsProcessesGammaWasteAtmosphereDetectionConventionalStudiesTreatmentLaboratoryPeopleEarthPresentHalf-lifeSamplesBetaProducePatientsCancerMedicalGlobal
Peptide receptor radionuclide therapy7
- peptide receptor radionuclide therapy (PRRT), which uses a small amount of a radioactive substance that has been combined with a cell-targeting protein (peptide). (cancercouncil.com.au)
- The first patient has been treated using NorthStar Medical Radioisotopes' electron accelerator-generated copper-67 (Cu-67) radioisotope in Clarity Pharmaceutical's U.S.-based SARTATE peptide receptor radionuclide therapy trial. (auntminnie.com)
- Lu-177 dotatate , a peptide receptor radionuclide therapy, consists of the somatostatin analog octreotate connected with the beta- and gamma-emitting radiopharmaceutical lutetium-177. (ascopost.com)
- The study randomized 229 patients with well-differentiated metastatic or locally advanced inoperable midgut neuroendocrine tumors to receive 4 intravenous administrations (every 8 weeks) of the peptide receptor radionuclide therapy (plus best supportive care, including standard-dose octreotide long-acting repeatable [LAR]) or high-dose octreotide LAR alone. (ascopost.com)
- Perhaps one of the most striking findings for this peptide receptor radionuclide therapy is the long median duration of progression-free survival. (ascopost.com)
- Dr. Loaiza-Bonilla posed the question of whether Lu-177 dotatate is more effective than a similar peptide receptor radionuclide therapy containing the radioisotope yttrium-90. (ascopost.com)
- As both speakers indicated, peptide receptor radionuclide therapy (90-Y dotatate or Lu-177 dotatate ) is recommended for patients with somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors that are progressing despite standard-dose long-acting somatostatin analog therapy and for pancreatic neuroendocrine tumors progressing after somatostatin analog therapy or everolimus (Afinitor). (ascopost.com)
Naturally occurring rad2
- On Earth, naturally occurring radionuclides fall into three categories: primordial radionuclides, secondary radionuclides, and cosmogenic radionuclides. (wikipedia.org)
- The cat litters were measured with gamma-ray spectroscopy to identify and quantify the naturally occurring radionuclides in the samples. (aarst.org)
Separation of radionuclides1
- However, the UNEX process is designed for large-scale separation of radionuclides and thereby requires considerable dilution of the radionuclide and requires large quantities of organic solvents. (aiche.org)
Radiopharmaceutical5
- A pharmaceutical drug made with radionuclides is called a radiopharmaceutical. (wikipedia.org)
- We are proud to be a leader in expanding the horizons of patient health by providing innovative solutions to ensure robust, reliable access to radioisotopes and radiopharmaceutical products that can make a positive difference in healthcare for people around the world. (businesswire.com)
- 1 The basic principle of radionuclide MPI is to administer a radiopharmaceutical intravenously and image blood flow to the heart muscle (myocardial perfusion), both at rest and under stress. (cadth.ca)
- Radiopharmaceuticals are classified into four different categories, which are radiopharmaceutical preparation, radionuclide generator, radiopharmaceutical precursor, and radiopharmaceutical preparation kit. (transparencymarketresearch.com)
- The Research Department for Nuclear Medicine and Theranostics together with Radiopharmaceutical Production Department, Radiopharmaceutical Quality Control Department and Radioisotope Imaging/PET Department are comprised in the Nuclear Medicine Research Unit. (almazovcentre.ru)
Imaging6
- An imaging tracer made with radionuclides is called a radioactive tracer. (wikipedia.org)
- A radionuclide cystogram is a special imaging nuclear scan test. (mountsinai.org)
- BUSINESS WIRE )-- NorthStar Medical Radioisotopes , LLC, a global innovator in the development, production and commercialization of radiopharmaceuticals used for therapeutic and medical imaging applications, today announced a corporate update highlighting progress across its key programs during the past twelve months, and indicating important upcoming milestones. (businesswire.com)
- As with nuclear imaging for other cardiac indications, the relative distribution of the radionuclide allows for visualization of blood flow through the heart and gives information regarding the functional capacity of the heart. (cadth.ca)
- Studying the diagnostic effectiveness of radionuclide imaging methods in patients with internal diseases. (almazovcentre.ru)
- Imaging studies such as ultrasonography and radionuclide studies help in confirming the diagnosis of chronic kidney disease and may also provide clues to its etiology. (medscape.com)
Nuclides5
- There are about 730 radionuclides with half-lives longer than 60 minutes (see list of nuclides). (wikipedia.org)
- Radionuclides are produced in stellar nucleosynthesis and supernova explosions along with stable nuclides. (wikipedia.org)
- It is possible decay may be observed in other nuclides, adding to this list of primordial radionuclides. (wikipedia.org)
- Many of these radionuclides exist only in trace amounts in nature, including all cosmogenic nuclides. (wikipedia.org)
- In the presence of background, the algorithm is able to identify the nuclides present in unknown radionuclide mixtures of three nuclides, when at least 1000 counts from the sources are detected. (hw.ac.uk)
Tracers4
- Long-lived radioisotopes (Sr, Nd and U-Th) as tracers for exogene geochemical processes: The importance of particles, colloids and dissolved components for element transport in fresh and brackish water. (dtu.dk)
- radioactive i. the i. radioisotopes 131I, 125I, or 123I used as tracers in biology and medicine. (theodora.com)
- The comparative advantages and drawbacks of some reactor-produced arsenic radioisotopes having favourable characteristics for their use as tracers are discussed. (springer.com)
- SHANGHAI , Nov. 15, 2023 /PRNewswire/ - Radioisotope assays a microanalytical method that uses radionuclides as tracers to label research objects. (diwou.com)
Radioactive8
- A radionuclide (radioactive nuclide, radioisotope or radioactive isotope) is a nuclide that has excess nuclear energy, making it unstable. (wikipedia.org)
- During those processes, the radionuclide is said to undergo radioactive decay. (wikipedia.org)
- The radioactive decay can produce a stable nuclide or will sometimes produce a new unstable radionuclide which may undergo further decay. (wikipedia.org)
- Exotic radionuclides such as for instance 44 Ti, 60 Fe, 26 Al, 10 Be and many others are of great interest in several research domains like astrophysics, nuclear medicine, geophysics, fundamental nuclear physics or radioactive beam facilities. (psi.ch)
- Introduction Radioisotopes of the three naturally occurring radioactive-decay series, headed by 232Th, 235 U, and 238U, are ubiquitous in soils. (aarst.org)
- Also known as radioisotope therapy, this involves radioactive material being taken by mouth as a capsule or liquid, or given by injection. (cancercouncil.com.au)
- The most common radionuclide therapy is radioactive iodine, which is taken as a capsule and used to treat certain types of thyroid cancer. (cancercouncil.com.au)
- Radioactive waste is defined as the material that contains or is contaminated with radionuclides at concentrations or activities greater than clearance levels as established by regulatory authorities. (intechopen.com)
Therapy6
- In the field of radioisotope therapy, much discussion and debate have focused on what radioisotope might be "ideal" for treatment of malignant tumors. (nih.gov)
- New approaches in systemic radioisotope therapy require radionuclides that have different nuclear properties in comparison to those used for diagnostics. (psi.ch)
- The β − -particle-emitting erbium-169 is a potential radionuclide toward therapy of metastasized cancer diseases. (frontiersin.org)
- This path, however, is not suitable for receptor-targeted radionuclide therapy, where high specific molar activities are required. (frontiersin.org)
- Currently, the β − -emitting 177 Lu is used on a routine basis in clinics for targeted radionuclide therapy. (frontiersin.org)
- 100 keV 1 ) and 165 Er ( t 1/2 = 10.36 h) have promising decay properties toward radionuclide therapy of metastasized cancer diseases ( Table 1 ). (frontiersin.org)
Radiopharmaceuticals2
- Radiopharmaceuticals are basically unique therapeutic compositions that incorporate radioisotopes. (transparencymarketresearch.com)
- Developing and implementing the modern radioisotope techniques, new radiopharmaceuticals and software applications for the processing of diagnostic and research data. (almazovcentre.ru)
NorthStar Medical Radioisotopes1
- NorthStar's industry-leading reputation is grounded in technological innovation, successful execution and proven expertise, and we have made tremendous strides in advancing our portfolio over the past year," said Stephen Merrick, Chief Executive Officer of NorthStar Medical Radioisotopes. (businesswire.com)
Generators2
- Radionuclides occur naturally or are artificially produced in nuclear reactors, cyclotrons, particle accelerators or radionuclide generators. (wikipedia.org)
- Finally, was signed a deal for the supply of radionuclide heat units (UHR) used as parts of radioisotope thermoelectric generators to power equipment in China's space programme, for use in lunar exploration in particular. (rosatom.ru)
Concentrations3
- Because of its possibility to determine the radioisotopes at the faintest level, in some cases isotopic concentrations down to the range of 10-16, extremely wide applications in different fields are evolved. (psi.ch)
- He has been awarded a rapid-response grant from the National Science Foundation's (NSF) Division of Ocean Sciences to establish baseline concentrations of several radionuclides in the Atlantic and Pacific Oceans. (nsf.gov)
- She is monitoring ocean waters to establish baseline concentrations of radionuclides, and to determine the spreading of released radionuclides. (nsf.gov)
Isotope3
- The extraction of radioisotopes produced from the cyclotron involves dissolution of the target material (containing impurities) in an aqueous acid followed by separation of the isotope of interest from the bulk solution using liquid-liquid extraction (LLE). (aiche.org)
- 7 Viable myocardial cells take up the radionuclide tracer (either thallium isotope [ 201 TI] or isotope 99m Tc-labelled radiotracer) in proportion to blood flow. (cadth.ca)
- Our radioisotope laboratory in Jiangsu, China is BioDuro-Sundia's third isotope laboratory with this qualification, building on the extensive experience of the two established isotope laboratories. (diwou.com)
Quantify1
- A universal method to screen for and quantify individual radionuclides as well as both levels of alpha and beta emitters would address these concerns. (cdc.gov)
Exposure5
- Unplanned exposure to radionuclides generally has a harmful effect on living organisms including humans, although low levels of exposure occur naturally without harm. (wikipedia.org)
- Occupational exposure to radionuclides (Possibly safe. (e-lactancia.org)
- There is a small amount of radiation exposure with any nuclear scan (it comes from the radioisotope, not the scanner). (mountsinai.org)
- Developing and improving the protocols for radionuclide studies and computed tomography to reduce the exposure of patients and medical staff to ionizing radiation. (almazovcentre.ru)
- As part of the Centers for Disease Control and Preventions post-radiological/nuclear incident response mission, we developed rapid bioassay analytical methods to assess possible human exposure to radionuclides and internal contamination. (cdc.gov)
Iodine3
- A radioisotope of iodine with a 159 keV gamma emission and a physical half-life of 13.2 h, used for studies of thyroid disease and of renal function. (theodora.com)
- A result of the loss of electricity, overheating at the power plant led to significant releases of iodine, cesium and other radioisotopes to the environment. (nsf.gov)
- Dulaiova is also planning to look at other radionuclides such as iodine, strontium and some actinides that were released. (nsf.gov)
Decay2
- Some radionuclides have half-lives so long (many times the age of the universe) that decay has only recently been detected, and for most practical purposes they can be considered stable, most notably bismuth-209: detection of this decay meant that bismuth was no longer considered stable. (wikipedia.org)
- Secondary radionuclides are radiogenic isotopes derived from the decay of primordial radionuclides. (wikipedia.org)
Technetium2
- Elements heavier than lead, and the elements technetium and promethium, exist only as radionuclides. (wikipedia.org)
- In the last 25 years, diagnostic nuclear medicine has come to depend on the versatile chemistry of a single radioisotope, technetium-99m (Tc-99m). (nih.gov)
Therapeutic2
- No single radioisotope similarly dominates therapeutic applications. (nih.gov)
- NorthStar is poised to be the first commercial-scale producer of therapeutic radioisotopes Cu-67 and non-carrier added (n.c.a. (businesswire.com)
Nuclear medicine2
- However, radionuclides with suitable properties are used in nuclear medicine for both diagnosis and treatment. (wikipedia.org)
- Increased presence in the environment, ease of entry into the food chain, nuclear medicine applications, and the possibility of radiological terrorism incidents can lead to human intake of these radionuclides (Radionuclides/Radiation Protection/US EPA (2020). (cdc.gov)
Radiation1
- At least another 60 radionuclides are detectable in nature, either as daughters of primordial radionuclides or as radionuclides produced through natural production on Earth by cosmic radiation. (wikipedia.org)
Consists1
- The package consists of 4 deals and envisages the construction of 4 Gen 3+ VVER-1200 units (at the Xudabao and Tianwan sites), cooperation in the CFR-600 fast reactor pilot project, and supply of the RITEG (Radioisotope Thermoelectric Generator) parts for China's lunar exploration programme. (rosatom.ru)
Processes1
- The information is needed,' she says, 'so that any subsequent efforts to understand the severity of the releases, the bioaccumulation of radionuclides in the ocean food web, and ocean processes and spreading patterns of the released radioisotopes, all have good baseline data. (nsf.gov)
Gamma1
- Gamma-ray emitters Activities of radioisotopes were determined in the cat litters using gamma-ray spectroscopic measurements. (aarst.org)
Waste3
- Conventionally, the UNEX process has been developed to isolate radionuclides from an acidic waste [1-3]. (aiche.org)
- 5.1 Strontium-90 is a major component of nuclear waste and is also a potential radioisotope for use as a weapon of mass destruction in a radiological dispersal device. (astm.org)
- The higher the concentration of radionuclides above the established levels, the greater the hazard the waste possesses. (intechopen.com)
Atmosphere1
- Because the atmosphere and oceans are linked, scientists would expect radionuclides present in the atmosphere also to appear in the ocean, albeit at very low levels, says chemical oceanographer Henrieta Dulaiova of the University of Hawaii. (nsf.gov)
Detection4
- Compared with conventional biological sample detection techniques, Radioisotope assay has distinct advantages such as high specificity, high sensitivity at the nanomolar level, short detection time, accurate positioning, and quantification, etc. (diwou.com)
- Rapid detection and quantification of gross alpha/beta-emitting radionuclides by liquid scintillation counting (LSC) is vital in guiding response to a nuclear or radiological incidents. (cdc.gov)
- Liquid scintillation counting (LSC) is a valuable analytical tool for the rapid detection and quantification of gross alpha/beta-emitting radionuclides in urine samples. (cdc.gov)
- A key characteristic of this type of bioassay method is its detection sensitivity for the priority threat radionuclides. (cdc.gov)
Conventional1
- Conventional techniques in commercial radioisotope production - restricted mainly on reactor-based or accelerator-driven production routes - are approaching their limitations. (psi.ch)
Studies1
- Providing rare radionuclide samples in sufficient amount for such facilities would open new possibilities for studies in the field of fundamental nuclear physics. (psi.ch)
Treatment1
- The alpha-emitter radium-223 ((223)Ra) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone-refractory prostate cancer. (researchgate.net)
Laboratory1
- BioDuro-Sundia's radioisotope laboratory in Jiangsu, China is part of the in vitro biology department of our drug discovery business unit, which mainly provides in vitro pharmacological assays and metabolic assays based on cellular or biochemical reactions. (diwou.com)
People1
- Responding to a radiological or nuclear incident may require assessing tens to hundreds of thousands of people for possible radionuclide contamination. (cdc.gov)
Earth1
- Thirty-two of those are primordial radionuclides that were created before the earth was formed. (wikipedia.org)
Present2
- Primordial radionuclides, such as uranium and thorium, exist in the present time because their half-lives are so long (>100 million years) that they have not yet completely decayed. (wikipedia.org)
- Strontium-89 is also a beta emitting radionuclide, but with a half-life of only ~50 days it is not usually present in significant quantities. (astm.org)
Samples3
- He and colleagues will establish a baseline radionuclide data set for the Atlantic and Pacific Oceans, using an east-to-west network of sampling stations where the ability to retrieve ocean water samples already exists. (nsf.gov)
- The samples are then analyzed for cesium isotopes, whose signature allows scientists to identify radionuclides released from Fukushima. (nsf.gov)
- Nuclear industry advancements and growing concerns about environmental contamination and terrorist activity have increased interest in quantifying radioisotopes in environmental and human samples. (cdc.gov)
Beta1
- In the public health response to the incident, valuable information could be obtained in a timely and accurate manner by using liquid scintillation counting techniques to determine who has been contaminated above background for alpha and beta emitting radionuclides. (cdc.gov)
Produce1
- Technological solutions we have developed may be used to produce both radionuclides at an industrial scale. (medgadget.com)
Patients2
- Prescribe radionuclides and dosages to be administered to individual patients. (gulftalent.com)
- Review procedure requests and patients' medical histories to determine the applicability of procedures and radioisotopes to be used. (gulftalent.com)
Cancer1
- TerraPower Isotopes and PanTera signed a strategic collaboration that they say will increase the global availability of actinium-225 (Ac-225), a radioisotope that may prove able to treat a large variety of cancer indications. (auntminnie.com)
Medical3
- Radioisotopes for medical use are perennially in short supply and their variety is certainly lacking, limiting their practical use in a variety of cancers. (medgadget.com)
- About 80% of the worldwide produced radioisotopes are being used for medical purposes. (psi.ch)
- For example, in health care, radioisotopes are used to treat medical conditions, while in space exploration, radioisotopes power missions, rovers and probes. (nnl.co.uk)
Global1
- The researchers hope to develop an understanding of marine radionuclides on a global scale. (nsf.gov)