Rab5. Medical search. Frequent questions

rab5 GTP-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
This graph shows the total number of publications written about "rab5 GTP-Binding Proteins" by people in this website by year, and whether "rab5 GTP-Binding Proteins" was a major or minor topic of these publications. (wakehealth.edu)
Below are the most recent publications written about "rab5 GTP-Binding Proteins" by people in Profiles. (wakehealth.edu)
It is the first motor using two components, two differently sized proteins, Rab5 and EEA1, and is driven by GTP instead of ATP. (innovations-report.com)
One example is a molecular motor composed of two proteins, EEA1 and Rab5. (innovations-report.com)
These string-shaped tether proteins can recognize the Rab5 protein present in a vesicle membrane and bind to it. (innovations-report.com)

Retrograde transport of Akt by a neuronal Rab5-APPL1 endosome. (mpg.de)
This taken together, the data shows that IGF-1 signaling in breast cancer cells relies on IGF-1R phosphorylation, caveolae internalization and sequestration to the early endosome RIN1 function and Rab5 activation. (fiu.edu)
Using the endosome marker Rab5, we observed localization into endosomes. (mdpi.com)

Here, we characterized the motility of Rab5 endosomes in primary cultures of mouse hippocampal pyramidal cells by live-cell imaging and showed that they exhibit bi-directional long-range motility in axons, with a strong bias toward retrograde transport. (mpg.de)
Further analysis of APPL1-positive endosomes showed that, similar to Rab5-endosomes, they display more frequent long-range retrograde than anterograde movement, with the endosomal levels of APPL1 correlated with faster retrograde movement. (mpg.de)
We conclude that Rab5-APPL1 endosomes exhibit the hallmarks of axonal signaling endosomes to transport Akt1 in hippocampal pyramidal cells. (mpg.de)
The Rab5 effector FERRY links early endosomes with mRNA localization. (mpg.de)

Various lines of evidence suggest that the small GTPase Rab5 plays a role in neuronal signaling via early endosomal transport. (mpg.de)
In 2016, an interdisciplinary team of cell biologists and biophysicists in the groups of MPI-CBG directors Marino Zerial and Stephan Grill and their colleagues, including PoL and BIOTEC research group leader Marcus Jahnel, discovered that the small GTPase protein Rab5 could trigger a contraction in EEA1. (innovations-report.com)
Strikingly, they discovered that the EEA1 protein could undergo multiple flexibility transition cycles, from rigid to flexible and back again, driven solely by the chemical energy released by its interaction with the GTPase Rab5. (innovations-report.com)
In this regard, we have recently shown that efficient activation of Ypk1 by TORC2 requires stimulation of TORC2 by the GTP-bound state of a Rab5 GTPase (Vps21/Ypt51) and that, in turn, Rab5-dependent endocytosis may be a mechanism to down-regulate TORC2 signaling after it has been activated. (berkeley.edu)
ALS2CL acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. (novusbio.com)

Here, the results thus far, have shown that while activation of Rab5 may mediate increased cell proliferation, migration and invasion in breast cancer cells, the Rab5 GEF, RIN1 interacts with the IGFR thereby facilitating migration and invasion activities in breast cells. (fiu.edu)

The GDP/GTP cycle of Rab5 in the regulation of endocytotic membrane traffic. (nih.gov)
GAPVD1 and ANKFY1 Mutations Implicate RAB5 Regulation in Nephrotic Syndrome. (bvsalud.org)

This modification would make it easier to characterize the protein structure and the changes that can occur when it interacts with Rab5," explains Joan Antoni. (innovations-report.com)

Structural and Functional Specificity of Rab5 Activating Protein-6 (RA" by Ivan Jozic, Silva M. Rodriguez et al. (nova.edu)
I was delighted to learn that the approach to characterize the EEA1 protein could answer whether EEA1 and Rab5 form a two-component motor, as previously suspected. (innovations-report.com)

The article, titled " Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's ," is the result of research by lead author Dr. Anna Pensalfini and other collaborators from the CDR and NKI. (rfmh.org)

This research involves the role of Rab GTPases, specifically Rab5 and its guanine exchange factors (GEFs), in the promotion of cancer cell migration and invasion. (fiu.edu)
What role does Rab5 play in cell migration and invasion of cancer cells? (fiu.edu)
The hypothesis is that growth factor signaling is dependent on Rab5 activity in mediating the aggressiveness of cancer cells. (fiu.edu)
The goal is to demonstrate that IGF-1 signaling is dependent on Rab5 function in breast cancer progression. (fiu.edu)

Role of RAB5 GEF in maintaining potassium levels under sodium chloride stress. (ncbs.res.in)

Confocal immunofluorescent analysis of HeLa cells using Rab5 (C8B1) Rabbit mAb (green). (cellsignal.com)
Analysis of DENND1-Rab35, Rabex-Rab5, TRAPP-Rab1 and DrrA-Rab1 suggests Rabs have the potential for activation by distinct GDP-release pathways. (elifesciences.org)

Structural basis of mRNA binding by the human FERRY Rab5 effector complex. (mpg.de)
The Rab5 effector FERRY links early endosomes with mRNA localization. (mpg.de)
To investigate the mechanism of Legionella endocytic avoidance, we screened an expression library of 147 L. pneumophila translocated effector proteins for Rab5 interaction and discovered that VipD specifically interacted with Rab5. (nih.gov)

VipD is a Rab5-activated phospholipase A1 that protects Legionella pneumophila from endosomal fusion. (nih.gov)
We demonstrate that VipD targets active Rab5 and binding triggers phospholipase A1 activity in VipD. (nih.gov)
A crystallographic analysis of the complex reveals that a loop obstructing the active site in VipD is repositioned upon Rab5 binding, thereby exposing the catalytic pocket of the phospholipase domain. (nih.gov)

The recruitment of Rab5 leads to recruitment of Vps34 and is essential for early SCV biogenesis. (medscape.com)

Recognition and stabilization of geranylgeranylated human Rab5 by the GDP Dissociation Inhibitor (GDI). (mpg.de)