• Mitotic checkpoint serine/threonine-protein kinase BUB1 also known as BUB1 (budding uninhibited by benzimidazoles 1) is an enzyme that in humans is encoded by the BUB1 gene. (wikipedia.org)
  • Bub1 is a serine/threonine protein kinase first identified in genetic screens of Saccharomyces cerevisiae. (wikipedia.org)
  • The protein kinase Bub1 possesses versatile and distinct functions during the cell cycle, mainly in the SAC and chromosome alignment during metaphase. (wikipedia.org)
  • Aurora A is involved with centrosome readiness, spindle assembly, and uneven protein localization throughout mitosis. (others-signal.com)
  • Immune system Nevertheless, nuclear launch of Bora isn't the only system by which its service of Aurora A is controlled since the bora mutant phenotype can be rescued by Bora fused to a signal, which keeps the protein in the cytoplasm, or fused to a localization signal, which maintains the protein in the nucleus until nuclear envelope breakdown. (others-signal.com)
  • Bae KM, Wang H, Jiang G, Chen MG, Lu L, Xiao L. Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. (famri.org)
  • Our data demonstrate that RalA and RalB are phosphorylated by different kinases, and RalB phosphorylation is necessary for in vitro cellular functions and in vivo tumor growth and metastasis. (iahrgrenoble2016.org)
  • Metformin (MTF) has been reported to target NLK (Nemo-like kinase) to inhibit non-small lung cancer cells. (cancerindex.org)
  • Kinase selectivity studiesshowed that AP24534 does not inhibit Aurora kinases, clearly distinguishing it from other T315I inhibitors in development. (others-signal.com)
  • Some kinases are essential scientific objectives of imatinib, nilotinib, and/or dasatinib, although only dasatinib has been reported to inhibit all SRC family kinases. (others-signal.com)
  • Despite improvements in the efficacy of therapeutics, the overall five-year survival rate for lung cancer still hovers around 15% [ 1 ]. (oncotarget.com)
  • Delivery of small interfering RNA (siRNA) to tumours remains a major obstacle for the development of RNA interference (RNAi)-based therapeutics. (biomedcentral.com)
  • Taken together, our findings suggest that Bora is just a important activator of Aurora A that is functionally conserved between Drosophila and vertebrates. (others-signal.com)
  • In this regard, restoration of p53 in tumor cells with loss or mutation of p53 will reinforce the cytotoxicity of combined Polo-like kinase 1 therapy and provide a proficient strategy for combating relapse and metastasis of cancer. (oncotarget.com)
  • For example, AHR is activated by the metabolite kynurenine, which is secreted into the tumor microenvironment by cancer cells leading to broad immunosuppression. (bvsalud.org)
  • Cytochrome P450-based suicide gene therapy for cancer using prodrugs such as cyclophosphamide (CPA) increases anti-tumor activity, both directly and via a bystander killing mechanism. (biomedcentral.com)
  • In human lung tumors, combined activation of K-RAS and inactivation of RASSF1A is closely associated with the development of the most aggressive and worst prognosis tumors. (cancerindex.org)
  • More over, TPX2 is only necessary for a part of Aurora A dependent processes: TPX2 inactivation by RNAi causes spindle problems and reduction of Aurora A from the mitotic spindle, but centrosome maturation is normal, and the centrosome pool of the kinase is unchanged. (others-signal.com)
  • Since the discovery of Polo kinase in Drosophila in 1988 [ 1 ], the Polo-like kinase (Plk) family has been attracting enormous attention, both in academia and in pharmaceutical industry. (oncotarget.com)
  • We show here that the conserved binding partner Bora is essential for Aurora A to perform these functions in Drosophila. (others-signal.com)
  • Although in Drosophila, Bora so far may be the only known activator of Aurora A, many in vitro activators of Aurora A have now been discovered in other creatures. (others-signal.com)
  • Therefore, unlike Bora, TPX2 appears to be specifically in charge of the spindle assembly purpose of Aurora A. To date, no TPX2 homolog has been discovered in Drosophila. (others-signal.com)
  • Dr. Curtis has been the recipient of numerous awards, including the National Institutes of Health (NIH) Director's Pioneer Award (2018) and the American Association for Cancer Research (AACR) Award for Outstanding Achievement in Basic Science (2022). (stanford.edu)
  • NSCLC is divided into adeno-, squamous- and large cell lung carcinomas, accounting for about 40%, 30% and 10-15% of all lung cancer cases, respectively. (oncotarget.com)
  • We showed that high level expression of FBXL20 in cancer cells reduces therapeutic drug-induced apoptosis and promotes chemoresistance. (iahrgrenoble2016.org)
  • TAS-103 Overall, this TAS-103 study highlights the importance of targeting FBXL20 in cancers in conjunction with chemotherapy and may represent a promising anticancer strategy to overcome chemoresistance. (iahrgrenoble2016.org)
  • Polo-like kinase 1, a pivotal regulator of mitosis and cytokinesis, is highly expressed in a broad spectrum of tumors and its expression correlates often with poor prognosis, suggesting its potential as a therapeutic target. (oncotarget.com)
  • Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. (famri.org)
  • As a monotherapy and combined with an anti-PD-1 antibody, IK-175 demonstrates antitumor activity in syngeneic mouse models of colorectal cancer and melanoma. (bvsalud.org)
  • Anderson C, Ellenhorn J, Hellan M, Pigazzi A. Pilot series of robot-assisted laparoscopic subtotal gastrectomy with extended lymphadenectomy for gastric cancer. (famri.org)
  • Frameshift mutation of MAPRE3, a microtubule-related gene, in gastric and colorectal cancers with microsatellite instability. (nih.gov)
  • Bacterial kynureninases (KYNases), which preferentially degrade kynurenine, can relieve immunosuppression in multiple cancer models, but immunogenicity concerns preclude their clinical use, while the human enzyme (HsKYNase) has very low activity for kynurenine and shows no therapeutic effect. (bvsalud.org)
  • A comprehensive kinase interaction map for dasatinib was recently described, though assay differences preclude direct comparison of the kinase users of AP24534 and dasatinib. (others-signal.com)
  • Figure1 In humans Bub1 accumulates gradually during G1 and S phase of the cell cycle, peaks at G2/M, and drops dramatically after mitosis. (wikipedia.org)
  • Contrary to cells treated with a siRNA, cells treated with siRNAs against Bora often displayed multipolar spindles in mitosis, a phenotype that is also seen upon TPX2 RNAi Geneticin distributor and after injection of antibodies blocking Aurora A function. (others-signal.com)
  • Transcription factors and nuclear receptors constitute a link between exposure to heterocyclic amines and polycyclic aromatic hydrocarbons from meat and tobacco smoke and colorectal cancer (CRC) risk. (biomedcentral.com)
  • In addition, compared to the mono-treatment, combination of Polo-like kinase 1 inhibition with anti-mitotic or DNA damaging agents boosts more severe mitotic defects, effectually triggers apoptosis and strongly inhibits proliferation of cancer cells with functional p53. (oncotarget.com)
  • Thus, we present the novel TSN-S100A11-PLA 2 axis regulating superoxide-dependent apoptosis, triggered by platinum-based chemotherapeutic agents in NSCLC that may be targeted by innovative cancer therapies. (oncotarget.com)
  • The crystal structure of human Bub1 revealed the presence of a N-terminal tetratricopeptide repeat (TPR) domain and a C-terminal kinase domain (residues 784-1085), adopting a canonical kinase fold with two lobes. (wikipedia.org)
  • RNAi-mediated ablation of FBXL20 results in increased levels of PUMA as well as BAX, which further enhances the sensitivity of cancer cells to chemotherapeutic drugs. (iahrgrenoble2016.org)
  • Downregulation of S100A11 by RNAi resulted in enhanced sensitivity of NSCLC cells to cisplatin, oxaliplatin and 5-fluouracil. (oncotarget.com)
  • In human primary immune cells, IK-175 decreased AHR target gene expression and anti-inflammatory cytokine release and increased proinflammatory cytokine release. (bvsalud.org)
  • Non-small cell lung cancer (NSCLC), the major lung cancer subtype, is characterized by high resistance to chemotherapy. (oncotarget.com)
  • Studies in Xenopus extracts using RNAi or antibody depletion have indicated a crucial function of Bub1 in the organization of the inner centromere. (wikipedia.org)
  • Five members of the Plk family have been discovered in humans and these serine/threonine kinases have emerged as key players by performing crucial functions in the cell cycle, DNA damage response and neuron biology [ 2 - 6 ]. (oncotarget.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Thus, a switch between two signaling kinases AKT1 and GSK3/ modulates the functional activity of these proapoptotic regulators, thereby determining cell survival or death. (iahrgrenoble2016.org)
  • Cancer Cell. (elsevierpure.com)
  • Downregulation of TSN by RNAi in NSCLC cells led to strong potentiation of cell death in response to cisplatin. (oncotarget.com)
  • Lung cancer is classified as small cell lung carcinomas (SCLCs) and non-small cell lung carcinomas (NSCLCs). (oncotarget.com)
  • An increase in cancer cell invasion and microvascular density is associated with a poorer prognosis for patients with endometrial cancer. (biomedcentral.com)
  • box accepts queries based upon compound , cancer gene or cell line identify. (sirna-library.com)
  • The search result web page lists matching compounds, cancer genes or cell lines with back links towards the thorough drug gene web page of your site. (sirna-library.com)
  • p53 represses the promoter of Polo-like kinase 1, whereas Polo-like kinase 1 inhibits p53 and its family members p63 and p73 in cancer cells lacking functional p53. (oncotarget.com)
  • Thus, inactive p53 is not associated with a susceptible cytotoxicity of Polo-like kinase 1 inhibition and could rather foster the induction of polyploidy/aneuploidy in surviving cells. (oncotarget.com)
  • UMUC3 human being bladder malignancy cells. (iahrgrenoble2016.org)
  • The PKC was purified by sequential chromatography as multiple PKC isoforms from human red blood cells (23). (iahrgrenoble2016.org)
  • We now report that DU145 human prostate cancer cells with reduced levels of PAK4 expression are unable to successfully migrate in response to HGF, have prominent actin stress fibres, and an increase in the size and number of focal adhesions. (silverchair.com)
  • In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)
  • Intrahepatic cholangiocarcinoma (ICC) is the second most common type of primary liver cancer. (biomedcentral.com)
  • The drebrin/EB3 pathway drives invasive activity in prostate cancer. (nih.gov)
  • IK-175 inhibits AHR activity in experimental systems derived from multiple species including mouse, rat, monkey, and humans. (bvsalud.org)
  • Dr. Curtis's laboratory leverages computational modeling, high-throughput molecular profiling and experimentation to develop new ways to prevent, diagnose and treat cancer. (stanford.edu)
  • Her research has redefined the molecular map of breast cancer and led to new paradigms in understanding the origins of human cancers, as well as how they evolve and metastasize. (stanford.edu)
  • Her research has redefined the molecular map of breast cancer and led to new paradigms in understanding how human tumors evolve and metastasize. (stanford.edu)
  • Role of tau N-terminal motif in the secretion of human tau by End Binding proteins. (nih.gov)
  • This feature probably contributes to the relatively wide kinase specificity profile of AP24534, including VEGFR and FGFR family kinases, receptors perhaps not restricted by the three currently authorized BCR ABL drugs. (others-signal.com)
  • Increased mammographic breast density is a moderate risk factor for breast cancer. (biomedcentral.com)
  • Christina Curtis, PhD, MSc is the RZ Cao Professor of Medicine, Genetics and Biomedical Data Science at Stanford University where she also serves as the Director of Artificial Intelligence and Cancer Genomics and of Breast Cancer Translational Research. (stanford.edu)
  • These studies provide rationale for targeting AHR in patients with cancer. (bvsalud.org)
  • Data table showing topics related to specific cancers and associated disorders. (cancerindex.org)
  • p21-activated kinase 4 (PAK4), a specific effector of the Rho GTPase Cdc42, is activated by HGF, and we have previously shown that activated PAK4 induces a loss of both actin stress fibres and focal adhesions. (silverchair.com)
  • RNAi mediated depletion of human Bub1 has indicated function in correct metaphase congression. (wikipedia.org)
  • The service of Aurora A by Cdc2 is PP1 independent, and, for that reason, TPX2 is impossible to participate in this particular function. (others-signal.com)
  • Disturbed mitotic checkpoints are a common feature of many human cancers. (wikipedia.org)
  • Lack of association of alcohol and tobacco with HPV16-associated head and neck cancer. (famri.org)
  • Obesity-related diseases including heart disease, stroke, type 2 diabetes, and cancer are a leading cause of preventable death. (cshlpress.org)