• Individual non-coding RNAs dwarf the number of protein-coding genes, and include classes that are well understood as well as classes for which the nature, extent and functional roles are obscure. (inra.fr)
  • Members of an extensive class of both small RNAs and CAGE tags were distributed across internal exons of annotated protein coding and non-coding genes, sometimes crossing exon-exon junctions. (inra.fr)
  • We further identify genes and processes in which splicing changes are observed in both human and mouse. (nih.gov)
  • Synthetic antisense RNAs are used to effect the functioning of specific genes for investigative or therapeutic purposes. (genomicglossaries.com)
  • 1 It turns out that the bacterial genome has a few high-level instructions that control a few middle-level processes, that in turn control a massive number of protein-coding genes. (creation.com)
  • In the majority of cases, Rf genes produce proteins that act directly on the CMS conferring mitochondrial transcripts by binding them specifically and promoting processing events. (frontiersin.org)
  • In the majority of cases, Rf genes produce proteins that bind specifically to the CMS conferring transcripts in the mitochondria and promote processing events leading to a strong reduction in the production of mitochondrial CMS-inducing proteins (reviewed in Chen and Liu, 2014 ). (frontiersin.org)
  • We have also identified a group of genes either up- or down-regulated at translational levels that participate in pre-mRNA splicing, 3´-processing of the pre-RNA, RNA-mediated post-transcriptional gene silencing, miRNA-mediated repression and mRNA turnover, as well as genes involved in epigenetic and transcriptional regulation. (conicet.gov.ar)
  • 20,000 lncRNAs genes, and an increasing portion of them has been implicated as important in a myriad of biological processes, including dosage compensation, transcriptional regulation, and establishment of cell identity. (weizmann.ac.il)
  • In exploring the basis for this unexpected outcome, Rich and his wife Carolyn Napoli discovered the process of co-suppression, through which introduction of an additional copy of a host gene resulted in the loss of transcripts, from both the endogenous and introduced genes. (aspb.org)
  • Importantly, such co-suppression events occurred without affecting the process of transcription, revealing that co-suppression of homologous genes, in plants, occurred by a process of posttranscriptional gene silencing (PTGS), later termed RNA interference (RNAi). (aspb.org)
  • We successfully employed deep sequencing RNA-Seq data in combination with an elaborate bioinformatics strategy in order to identify novel genes, incorrect gene models and mechanisms of transcript processing in the corn anthracnose fungus C. graminicola . (biomedcentral.com)
  • ADARs have been shown to contribute to disease pathologies by editing of glutamate receptors, editing of serotonin receptors, mutations in ADAR genes, and by other mechanisms, including recently identified regulatory roles in microRNA processing. (biomedcentral.com)
  • Post-transcriptional regulation of human genes by TE-derived sequences has been observed in specific contexts, but has yet to be systematically and comprehensively investigated. (biomedcentral.com)
  • Of the 31 genes, the 21 upregulated genes were primarily associated with cell paracrine and intracellular signaling, transcription regulation and cell adhesion and migration, and their transcriptional products included transforming growth factor-β2 (TGF-β2), insulin-like growth factor-binding protein 2 and transcriptional factor AP-2α/γ ( 11 ). (spandidos-publications.com)
  • The project will identify key genes, pathways, and biological processes that are differentially regulated in response to hypoxia. (lu.se)
  • It will extend to the identification and characterization of HIF-2α target genes, with a specific emphasis on their role in modulating the fundamental processes associated with intestinal stemness and tissue renewal. (lu.se)
  • eling require a broad range of signal processing approaches, Two salient goals of functional genomics are to screen for including signal representation relevant to transcription and key genes and gene combinations that explain specific cel- system modeling using nonlinear dynamical systems. (lu.se)
  • In addition, mitochondrial DNA (mtDNA) encodes 2 ribosomal RNA genes and 22 transfer RNA (tRNA) genes necessary for the intramitochondrial synthesis of these 13 polypeptides. (medscape.com)
  • RNA-seq experiments generate reads derived not only from mature RNA transcripts but also from pre-mRNA. (nature.com)
  • Overall, small RNAs tended to align with CAGE (cap-analysis of gene expression) tags, which mark the 5' ends of capped, long RNA transcripts. (inra.fr)
  • Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. (nature.com)
  • The structure also shows a PIN domain at the C-terminal tip of Chp1 that controls subtelomeric transcripts through a post-transcriptional mechanism. (rcsb.org)
  • A-to-I RNA editing is a post-transcriptional modification that converts adenosines to inosines in both coding and noncoding RNA transcripts. (biomedcentral.com)
  • Eukaryotic RNA transcripts can undergo a range of post-transcriptional modifications, which increase the diversity of the transcriptome without requiring increases in genome size. (biomedcentral.com)
  • Importantly, the alternative splicing of the LMNA gene was highly sensitive to the levels of specific Serine-Arginine rich (SR) proteins (5) , and produced several splicing isoforms that affect adipose tissue metabolism and aging in opposite manners, with Lamin A and Progerin promoting energy expenditure and aging, while Lamin C favors slower metabolism and moderately slows the aging process in mice (4) . (unil.ch)
  • Our research focuses on the roles of two particular RNA binding proteins of the SR protein family, SRSF1 and SRSF2, in metabolism and adipose tissue biology. (unil.ch)
  • PPR proteins represent the most frequent protein class among identified Rfs and they exhibit ideal characteristics to evolve into restorer of fertility when the mechanism of restoration implies a post-transcriptional action. (frontiersin.org)
  • His fields of research comprise RNA-mediated gene silencing processes with a focus on epigenetic phenomena, including studies on RNA-directed DNA methylation, the characterization of virus silencing suppressor proteins, the development of plant bioreactor platforms and viroid research. (degruyter.com)
  • Viroids are non-encapsidated, single-stranded (ss), 250-400 nucleotide (nt)-long circular RNA molecules that do not encode proteins (1, 2). (degruyter.com)
  • By transporting "cargos" such as proteins, RNAs, DNAs, and lipids [ 26 ], exosomes regulate the eventual fate of recipient cells. (hindawi.com)
  • Here, we study a collection of 75 CLIP-Seq experiments mapping the RNA binding sites for a diverse set of 51 human proteins to explore the role of TEs in post-transcriptional regulation of human mRNAs and lncRNAs via RNA-protein interactions. (biomedcentral.com)
  • We detect widespread interactions between RNA binding proteins (RBPs) and many families of TE-derived sequence in the CLIP-Seq data. (biomedcentral.com)
  • Transposable elements (TEs) have significantly influenced the evolution of transcriptional regulatory networks in the human genome. (biomedcentral.com)
  • PCFGs have application in areas as diverse as natural language processing to the study the structure of RNA molecules and design of programming languages. (wikipedia.org)
  • Because alternative RNA splicing allows different types of mRNA molecules to be created from a single gene, it generates the diversity of protein function and structure that is essential to complex organisms. (genomicglossaries.com)
  • RNA molecules which hybridize to complementary sequences in either RNA or DNA altering the function of the latter. (genomicglossaries.com)
  • More specifically, antisense oligonucleotides that are useful as reagents for target validation , or as drugs, are engineered molecules that differ from natural RNA but that have a base sequence that is recognized as being complementary to a very specific mRNA sequence. (genomicglossaries.com)
  • At least in plants, DNA regions that become de novo methylated can be defined by homologous RNA molecules in a process termed RNA-directed DNA methylation (RdDM). (degruyter.com)
  • Viroids are pathogenic circular, non-coding, single-stranded RNA molecules. (degruyter.com)
  • Upon inoculation, mature Pospiviroidae RNA molecules enter the plant cell nucleus. (degruyter.com)
  • Many of these "noncoding" regions are transcribed into long RNA molecules that remain poorly understood. (weizmann.ac.il)
  • We are also studying other noncoding RNA fragments such as UTRs, and are generally interested in both the process of transcription and in the post-transcriptional fate of RNA molecules. (weizmann.ac.il)
  • In the case of RNA molecules that bind target RNA segments, such as microRNAs (miRNAs), the altered base pairing can change binding specificities. (biomedcentral.com)
  • MicroRNAs (miRNAs or miRs) are small non-coding RNAs that participate in diverse cellular processes and negatively regulate gene expression at the post-transcriptional level by binding with 3′-untranslated regions (3′-UTRs) ( 2 - 4 ). (spandidos-publications.com)
  • MicroRNAs (miRNAs) are small non-coding RNAs responsible for posttranscriptional regulation of gene expression. (lu.se)
  • ADAR3 contains an arginine-rich domain, shown in pink, which binds single-stranded RNA. (biomedcentral.com)
  • MiRNAs are approximately 19- to 25-nucleotide estimated about 250,000 and mortality does not appear single-stranded, noncoding RNAs that exist in both to correlate well with prevalence. (cdc.gov)
  • Comparative analysis of RNA-Seq data and the genome sequence did not provide evidence for RNA editing in C. graminicola . (biomedcentral.com)
  • Along with the reorganization of epigenetic and transcriptional networks, somatic cell reprogramming brings about numerous changes at the level of RNA processing. (nih.gov)
  • Cellular RNAs are regulated at multiple stages, including transcription, RNA maturation and degradation. (nature.com)
  • mRNA half-lives have been determined, for example, by blockage of transcription followed by transcriptional profiling 5 . (nature.com)
  • In two of these, the read coverage along introns was related to nascent transcription in combination with co-transcriptional splicing events 24 and later was used to fit a detailed transcriptional model within a single sample 25 . (nature.com)
  • Previous Cold Spring Harbor Symposia have addressed many different aspects of RNA biology such as Mechanisms of Transcription (1998), The Ribosome (2001), Epigenetics (2004) and Regulatory RNAs (2006). (cshlpress.com)
  • These strategies involve rearrangements at the molecular level starting from transcription, regulation of mRNA processing, translation, and protein modification or its turnover. (intechopen.com)
  • The project aims to investigate the transcriptional differences between intestinal organoids cultured under normoxic (21% O 2 ) and hypoxic (1-5% O 2 ) conditions, with a particular focus on the involvement of the transcription factor HIF-2α. (lu.se)
  • Utilizing the upstream regulator (i.e. transcription factors, cytokines, growth factors) analysis, the lung had 285, blood cells 30, aorta 39, and heart 32 significantly altered mediators 4 h post-exposure. (cdc.gov)
  • We found that the regulation of TE transcription during brain development is essential for the establishment of long-term transcriptional repression carried to adulthood (Paper I and IV). (lu.se)
  • Here we analyze 17 published RNA-seq data sets covering a wide range of cell types and perturbations. (nature.com)
  • Long noncoding RNAs (lncRNAs) contain at least 200 bases, and are molecularly identical to mRNAs. (weizmann.ac.il)
  • Through the centre, we have access to human islets from which we have investigated the miRNA-profile and together we perform large-scale RNA-sequencing studies in human islets that has given us the opportunity to investigate other non-coding RNAs such as the lncRNAs and their role in beta cell function. (lu.se)
  • Strand-specific, massively parallel cDNA sequencing (RNA-seq) is a powerful tool for transcript discovery, genome annotation and expression profiling. (nature.com)
  • Our meta-analysis suggests a widespread role for TEs in shaping RNA-protein regulatory networks in the human genome. (biomedcentral.com)
  • Signals generated by the genome must be processed to the genome, regulatory models require the kind of nonlinear characterize their regulatory effects and their relationship to dynamics studied in signal processing and control. (lu.se)
  • New systems processing of numerous and different kinds of signals, math- must capture the specific biological mechanisms of opera- ematical and computational methods are required to model tion and distributed regulation at work within the genome. (lu.se)
  • The mitochondrial genome encodes the genetic information for the 13 polypeptide subunits essential for the process of oxidative phosphorylation. (medscape.com)
  • Increasingly applied to identify mutations conferring antimicrobial resistance (AMR), disease outbreaks, and pathways of disease spread, whole genome sequencing (WGS)the process of determining the complete DNA sequence of an organisms genome at a single timehas emerged as a powerful tool for public health. (cdc.gov)
  • The results of these analyses revealed that the differentially expressed exosomal miRNAs participate in multiple biological processes, such as gene expression, synthesis of biomolecules, cell development, differentiation, and signal transduction, among others. (hindawi.com)
  • Moreover, we found that these differentially expressed exosomal miRNAs connect osteogenic differentiation to processes such as axon guidance, MAPK signaling, and Wnt signaling. (hindawi.com)
  • miRNAs are a large family of non-coding RNAs which play important roles in translational and post-transcriptional regulation of gene expression and biological processes. (unboundmedicine.com)
  • Mainly, it focuses on newly emerged enhanced SPR biosensors towards high-throughput and ultrasensitive screening of miRNAs using labeling processes with focusing on the future application in biomedical research and clinical diagnosis. (unboundmedicine.com)
  • Brian Larkins - Rich's discovery of "co-suppression", the first evidence of gene silencing via small RNAs, created the foundation for a whole new area of research in gene regulation. (aspb.org)
  • Upstream of the metabolic pathways, transcriptomic profiles of the kidney reveal gene activity focused on gene regulation mechanisms, cell signaling, cell structure, developmental processes, and cell proliferation. (bvsalud.org)
  • Regulation of gene expression occurs at multiple levels within eukaryotic cells, including chromatin-based, transcriptional and post-transcriptional events. (conicet.gov.ar)
  • Central to this process is the RNA-induced initiation of transcriptional gene silencing (RITS) complex, which physically anchors small noncoding RNAs to chromatin. (rcsb.org)
  • Chromatin target of Prmt1 (Chtop) is a vertebrate-specific chromatin-bound protein that plays an important role in transcriptional regulation. (embl.de)
  • The recruitment of this machinery results in the production of viroid-derived small RNAs (vd-sRNAs) that mediate RNA degradation and DNA methylation of cognate sequences. (degruyter.com)
  • Here we review recent observations that now reveal that many of the factors involved are shared with processing, translation and degradation of poly(A) mRNA. (elsevierpure.com)
  • It can be inferred from these findings that RID2 contributes to the nucleolar activity for pre-rRNA processing, probably through some methylation reaction. (nih.gov)
  • Since then, he has been working as a postodoc in Dr. Wassenegger's lab (RLP AgroScience GmbH, AlPlanta) and his main field of interest is RNA-interference (RNAi) and RNA-directed DNA methylation (RdDM) in plants. (degruyter.com)
  • In addition, using invitro methylation assay we identified 4 new substrates for PRMT6, extending the involvement of this enzyme to other cellular processes beyond its well-established role in gene expression regulation. (embl.de)
  • A total of 7 possible genetic alterations and epigenetic changes in CAFs are discussed, including gene differential expression, karyotype analysis, gene copy number variation, loss of heterozygosis, allelic imbalance, microsatellite instability, post‑transcriptional control and DNA methylation. (spandidos-publications.com)
  • Epigenetic alterations, represented by post-transcriptional control and DNA methylation, have been the focus of recent studies. (spandidos-publications.com)
  • Supplying synthetic promoter-associated small RNAs corresponding to the c-MYC transcriptional start site reduced MYC messenger RNA abundance. (inra.fr)
  • More recently, another group of researchers reported that they had developed a process for optimizing low- abundance RNA, by combining aRNA amplification with template- switching. (genomicglossaries.com)
  • We show that human and chimpanzee cells differentiate in a similar man¬ner and that the difference in interspecies protein abundance is higher than transcript-level differences, suggesting that post-transcriptional mechanisms play a role in the difference between human and chim¬panzee brain development. (lu.se)
  • In general, these protocols aim to enrich for mature mRNA by selection of polyadenylated RNA or by depletion of ribosomal RNA. (nature.com)
  • Post-transcriptional biological modification of messenger, transfer, or ribosomal RNAs or their precursors. (bvsalud.org)
  • Endogenous antisense RNAs function as regulators of gene expression by a variety of mechanisms. (genomicglossaries.com)
  • Taken together, our results suggest that post-transcriptional mechanisms play an important role in the brain both during development and in the adult brain. (lu.se)
  • RNA editing refers to post-transcriptional processes that alter the nucleotide sequence of an RNA transcript by insertion, deletion or nucleotide conversion. (biomedcentral.com)
  • Here we show that processing of mature mRNAs through an as yet unknown mechanism may generate complex populations of both long and short RNAs whose apparently capped 5' ends coincide. (inra.fr)
  • This approach has excluded levels of post-transcriptional regulation, associated with a rapid response through the activation of pre-existing mRNAs. (conicet.gov.ar)
  • It involves mRNA 30 end formation by histone-specific nuclear RNA processing, which produces mRNAs lacking a poly(A) tail, translation and mRNA stability control. (elsevierpure.com)
  • Although RNA editing has long been considered a relatively rare processing event, more recent research suggests that the vast majority of pre-mRNAs are edited [ 6 ]. (biomedcentral.com)
  • Researchers at Stanford University used such a method to produce amplified heterogeneous populations of RNA from limited quantities of cDNA. (genomicglossaries.com)
  • Amplified RNA synthesized from limited quantities of heterogeneous cDNA. (genomicglossaries.com)
  • After second- strand cDNA synthesis, T7 RNA polymerase was used to generate aRNA. (genomicglossaries.com)
  • It involves crosslinking cells to lock RNA-protein interactions, immunoprecipitating the complexes using an antibody specifically targeted to the RBP, sequencing cDNA reverse transcribed from the captured RNA, and statistically analyzing the aligned sequencing reads [ 26 ]. (biomedcentral.com)
  • Since then, she has been working as a postodoc in Dr. Wassenegger's lab (RLP AgroScience GmbH, AlPlanta) and her main field of interest is RNA-interference (RNAi) and viroid biology in plants. (degruyter.com)
  • RNA interference (RNAi) is critical for the assembly of heterochromatin at Schizosaccharomyces pombe centromeres. (rcsb.org)
  • As Rich pointed out, this property of PD to mediate in non-cell-autonomous trafficking of RNA could well underlie the unusual irregular PTGS/RNAi patterning that they observed in the petals of the transgenic petunia. (aspb.org)
  • Furthermore, they support the concept that splicing factors with evolutionarily conserved, cell type-specific expression can modulate the efficiency of the process by reinforcing intermediate states resembling the cell types in which these factors are normally expressed. (nih.gov)
  • RNA splicing is a key phase in gene expression in eukaryotic cells. (unil.ch)
  • Despite the wealth of data concerning adipose tissue metabolic alterations in conditions of obesity and insulin resistance, the involvement of RNA splicing and other post-transcriptional RNA processing events in these processes remains poorly studied. (unil.ch)
  • RNA-Seq offers the potential for substantially improved gene annotations and for the identification of posttranscriptional RNA modifications, such as alternative splicing and RNA editing. (biomedcentral.com)
  • These include alternative splicing and RNA editing. (biomedcentral.com)
  • Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex. (uchicago.edu)
  • Recent insights into the structure, function, and regulation of the eukaryotic transfer RNA splicing endonuclease complex. (uchicago.edu)
  • This change characterizes the movement into the era signal processing community in relation to attacking the fun- of functional genomics. (lu.se)
  • Many small RNAs, including the previously described promoter-associated small RNAs, appeared to possess cap structures. (inra.fr)
  • Probabilistic context free grammars (PCFGs) have been applied in probabilistic modeling of RNA structures almost 40 years after they were introduced in computational linguistics. (wikipedia.org)
  • 87(5): 1663-1667] Specifically, the investigators started by priming whole cerebellar RNA with a synthetic oligonucleotide containing a T7 RNA polymerase promoter sequence. (genomicglossaries.com)
  • Here we present a computational approach called exon-intron split analysis (EISA) that measures changes in mature RNA and pre-mRNA reads across different experimental conditions to quantify transcriptional and post-transcriptional regulation of gene expression. (nature.com)
  • RNA-like oligonucleotides that are complementary to a portion of a target mRNA molecule. (genomicglossaries.com)
  • A complementary RNA sequence that binds to a naturally occurring (sense) mRNA molecule, thus blocking its translation. (genomicglossaries.com)
  • Here, we used Translating Ribosome Affinity Purification (TRAP) combined with RNA-seq to allow the characterization of mRNA and sRNA populations associated to polysomes (referred as the translatome). (conicet.gov.ar)
  • Secondary, mRNA-seq analysis identified Gadd45 as a potential transcriptional target of dGLYAT, as depletion of dGLYAT decreased Gadd45 mRNA level. (sdbonline.org)
  • We use modern molecular biology, cellular biology and RNA sequencing approaches, in addition of metabolically phenotyping our conditional knockout models. (unil.ch)
  • Little information is available about how post-transcriptional RNA processing regulates metabolic adaptation in adipose tissue depots. (unil.ch)
  • Although RNA-seq mostly generates reads that map to exons, it also captures less abundant intronic sequences 6 . (nature.com)
  • The Inside-Outside algorithm is used in model parametrization to estimate prior frequencies observed from training sequences in the case of RNAs. (wikipedia.org)
  • RACK1 was expressed transiently in the skeletal muscle of post-natal mice, being abundant in the early phase of muscle growth and almost disappearing in adult mature fibers. (sdbonline.org)
  • The 84th Cold Spring Harbor Symposium focused on RNA Control & Regulation and provided a current synthesis of the enormous progress in our understanding of RNA's influence on cells and organisms and how, when aberrant, its effects may contribute to the progression of disease. (cshlpress.com)
  • The rid2-1 mutation was shown to cause nucleolar vacuolation and excessive accumulation of various intermediates of pre-rRNA processing. (nih.gov)
  • But what this really boils down to is recognition that, in addition to selection, drift, mutation and other established evolutionary processes, other factors, particularly developmental influences, shape the evolutionary process in important ways. (uncommondescent.com)
  • RNA which contains an intron sequence that has an enzyme- like catalytic activity. (genomicglossaries.com)
  • Presumably, this process involves the interaction between the host's bromodomain-containing viroid RNA-binding protein 1 (VIRP1) and the viroid's TR domain (6). (degruyter.com)
  • In mammals, the most prevalent form of RNA editing involves the conversion of adenosine to inosine (A-to-I) by hydrolytic deamination at the C6 position of adenine (Figure 1 a) [ 1 ]. (biomedcentral.com)
  • Since requires its own model systems, not simply straightforward transcriptional (and posttranscriptional) control involves the adaptations of currently formulated models. (lu.se)
  • However, a comprehensive evaluation of the involvement of RNA processing factors in the reprogramming of somatic mammalian cells is lacking. (nih.gov)
  • Post-transcriptional processing generates a diversity of 5'-modified long and short RNAs. (inra.fr)
  • Three recent studies based on RNA-seq provided evidence that intronic reads might correlate with transcriptional activity. (nature.com)
  • After acute injury in muscle of both mouse and the fruit fly Drosophila melanogaster (used as alternative in vivo model) this study found that RACK1 accumulated in regenerating fibers while it declined with the progression of repair process. (sdbonline.org)
  • Arginine, a semiessential amino acid implicated in diverse cellular processes, is a substrate for two arginases-Arg1 and Arg2-having different expression patterns and functions. (unige.ch)
  • It spurred a number of studies that ultimately led to great advances in our understanding of the small RNAs' role in gene epigenetic regulation. (aspb.org)
  • Several analytic methods have been developed to measure these processes on a transcriptome-wide scale. (nature.com)
  • For mechanistic insight, we investigated global transcriptional alterations in the target organ (lung) as well as several extrapulmonary tissues (heart, aorta, whole blood cells) following inhalation (40 mg/m3 for 3 h/d for 5 d a week for 10 d) to stainless steel welding fume. (cdc.gov)
  • Improved wound healing due to cardiac overexpression RNA m5C modification's emerging role in Cardiovascular Diseases. (alliedacademies.org)
  • Here, we review recent studies investigating connections between ADAR-mediated RNA editing and human diseases. (biomedcentral.com)
  • Here we developed a comprehensive computational pipeline to compare library quality metrics from any RNA-seq method. (nature.com)
  • The studies presented here expand the catalogue of cellular small RNAs and demonstrate a biological impact for at least one class of non-canonical small RNAs. (inra.fr)
  • The detection assays need to be extremely sensitive and selective in small value of intricate RNA samples. (unboundmedicine.com)
  • However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)
  • A number of studies have uncovered RNA processing factors that modulate the efficiency of the reprogramming process. (nih.gov)
  • Furthermore, changes in post-transcriptional regulation can be predicted from differences between exonic and intronic changes. (nature.com)
  • In line with our previous results, we found that there are marked differences between HD patients and controls at the protein level but not at the transcriptional level. (lu.se)
  • EISA reveals both transcriptional and post-transcriptional contributions to expression changes, increasing the amount of information that can be gained from RNA-seq data sets. (nature.com)
  • Figure 6: Digital expression profiling using strand-specific RNA-seq. (nature.com)
  • A biological process that is crucial for gene expression in most animal life, including humans. (genomicglossaries.com)
  • Noda Y, Okada S , Suzuki T. Regulation of A-to-I RNA editing and stop codon recoding to control selenoprotein expression during skeletal myogenesis. (yoshiyama-lab.org)
  • Using available RNA sequencing data from previously published studies on intestinal organoids, the project will compare the gene expression profiles with newly generated RNA sequencing data from our lab's organoid cultures at hypoxia. (lu.se)