• 3 H]Pirenzepine and (-)-[ 3 H]quinuclidinyl benzilate binding to rat cerebral cortical and cardiac muscarinic cholinergic sites. (arizona.edu)
  • The chemical warfare agent 3-quinuclidinyl benzilate (QNB, BZ) is an anticholinergic agent that affects both the peripheral and central nervous systems (CNS). (medscape.com)
  • Quinuclidinyl benzilate is a anticholinergic glycolate that acts as a competitive, non-selective antagonist of muscarinic receptors in cardiac muscle, smooth muscle, exocrine glands and at postsynaptic receptors in neurons. (guidetomalariapharmacology.org)
  • One anticholinergic chemical-warfare agent is 3-quinuclidinyl benzilate, North Atlantic Treaty Organization (NATO) code BZ. (msdmanuals.com)
  • The binding of [3H] quinuclidinyl benzilate ( [3H] QNB) to muscarinic cholinergic receptors in dentate gyrus of rat hippocampal formation was analyzed by membrane binding assay and in vitro autoradiography. (duke.edu)
  • Binding of the potent muscarinic antagonist [ 3 H]quinuclidinyl benzilate ( 3 H-QNB) showed that the cochlea has sites with the pharmacological specificity of muscarinic cholinergic receptors. (northwestern.edu)
  • The deliriant drugs atropine , scopolamine (both found in Datura) and diphenhydramine all act as antagonists upon muscarinic acetylcholine receptors, as does the chemical incapacitating agent 3-Quinuclidinyl benzilate, better known as BZ. (psychonautwiki.org)
  • In the absence of PZ, treatment of cerebral cortical membranes with 20 nM PBCM at 4 degrees C for 50 min resulted in a 69% reduction in the density of M1 binding sites and a 55% reduction in the density of M2 binding sites with no change in the equilibrium dissociation constants of the radioligands [3H]quinuclidinyl benzilate or [3H]PZ. (aspetjournals.org)
  • In radioligand binding experiments using cerebral cortical membranes, PZ inhibited the binding of [3H]quinuclidinyl benzilate in a biphasic manner. (aspetjournals.org)
  • In addition, intraperitoneally administered Colivelin suppresses memory impairment caused by a muscarinic acetylcholine receptor antagonist, 3-quinuclidinyl benzilate, indicating that a substantial portion of intraperitoneally administered Colivelin passes through the blood-brain barrier and suppresses functional memory deficit. (jneurosci.org)
  • Neither compound was effective in displacing [3H]quinuclidinyl benzilate (QNB) used to label the entire muscarinic receptor population. (cdc.gov)
  • The 16 metal boxes with special markings that suggest they contained BZ (3-Quinuclidinyl benzilate) incapacitating agent as well as CS (chlorobenzylidenemalononitrile) and CR (dibenzoxazepine) harassing 'riot-control' agents, were accompanied by the "citizens of foreign nations," he also alleged. (rt.com)
  • Chemical calmative weapons such as BZ (3-quinuclidinyl benzilate, a compound related to scopolamine) were developed during the Cold War. (globalresearch.ca)
  • Neither compound was effective in displacing [3H]quinuclidinyl benzilate (QNB) used to label the entire muscarinic receptor population. (cdc.gov)
  • The data demonstrate that perinatal choline supplementation causes (a) long-term facilitative effects on working and reference memory components of a 12-arm radial maze task, and (b) alternations of muscarinic receptor density as indexed by [3H]quinuclidinyl benzilate (QNB) binding and choline acetyltransferase (ChAT) levels in the hippocampus and frontal cortex of adult rats. (nih.gov)
  • Using N-(2-[18F]fluoroethyl)-4-piperidyl benzilate ([18F]FEPB), a moderate affinity (Ki = 1.7 nmol/L) nonsubtype-selective muscarinic receptor antagonist, the authors examined the sensitivity of equilibrium in vivo radioligand binding in rat brain with changes in endogenous acetylcholine levels produced by treatments with acetylcholinesterase inhibitors. (lookformedical.com)
  • A binding assay employing tritiated quinuclidinyl benzilate permits us to investigate properties of receptor binding sites and to measure receptor levels in cultured neuroblastoma and hybrid cells under systematically varied conditions. (nih.gov)
  • Determination of 3-quinuclidinyl benzilate (QNB) and its major metabolites in urine by isotope dilution gas chromatography/mass spectrometry. (medscape.com)
  • 3 H]Quinuclidinyl benzilate specific binding analysis showed that the equilibrium dissociation constant (K D ) did not differ between control and MSG, indicating that affinity is not affected by obesity induced by MSG. (bvsalud.org)
  • In vitro and in vivo metabolism of 3-quinuclidinyl benzilate by high-resolution mass spectrometry. (medscape.com)
  • Acetylcholinesterase inhibition increases in vivo N-(2-[18F]fluoroethyl)-4-piperidyl benzilate binding to muscarinic acetylcholine receptors. (lookformedical.com)
  • One anticholinergic chemical-warfare agent is 3-quinuclidinyl benzilate, North Atlantic Treaty Organization (NATO) code BZ. (msdmanuals.com)
  • 125I] 3-quinuclidinyl 4-iodobenzilate: a high affinity, high specific activity radioligand for the M1 and M2-acetylcholine receptors. (medscape.com)
  • Fusek J, Dlabkova A, Misik J. Psychotomimetic Agent BZ (3-Quinuclidinyl Benzilate). (medscape.com)
  • Psychodelic Agent 3 - Quinuclidinyl Benzilate (BZ). (medscape.com)