• 2017). Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity . (up.pt)
  • This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). (origene.com)
  • The synthesis of acceptor-functionalised oligothiophene derivatives (t3, t6, t7, t8) is described, where the pteridine-2,4-dione acceptor units are arranged symmetrically in derivatives t6-t8. (gla.ac.uk)
  • A direct role for IDO in pteridine synthesis has not been shown, and this parallel induction may reflect coordinate regulation of genes induced by IFN-gamma. (nih.gov)
  • Emphasis is placed on the properties of 2-thioalkyl pyrimidines as intermediates because they provide the basis for a traceless solid-state synthesis of purines, pteridines, and their analogues. (strath.ac.uk)
  • Pteridine is an aromatic organic compound composed of fused pyrimidine and pyrazine rings. (wikipedia.org)
  • The New Medicine for Trypanosomatid Infections (NMTrypI) consortium uses a highly interdisciplinary approach to optimize pteridine, benzothiazole and miltefosine derivatives, as well as natural products against Trypanosomatids. (europa.eu)
  • Derivatives of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton. (bvsalud.org)
  • Pteridines also constitute a group of heterocyclic compounds containing a wide variety of substituents on this parent structure. (wikipedia.org)
  • Pterins and flavins are classes of substituted pteridines that have diverse biological roles. (wikipedia.org)
  • Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine. (planteome.org)
  • IDO induction has been correlated with induction of GTP-cyclohydrolase, the key enzyme in pteridine biosynthesis. (nih.gov)
  • Pyrazines are components of many important compounds, including pteridines, some vitamins and antibiotics, and numerous dyes called phenazines. (dictionary.com)
  • Link to all direct and indirect annotations to regulation of pteridine metabolic process. (planteome.org)
  • If Phe is elevated, a test of erythrocyte DHPR activity and a urine pteridine profile are recommended. (nih.gov)
  • Its chemical structure is relatively simple, consisting of a pteridine ring, para-aminobenzoic acid, and glutamic acid. (pc-mobile.net)
  • In contrast to EC 1.5.1.3 and EC 1.5.1.34 , pteridine reductase will not catalyze the reduction of the quinonoid form of dihydrobiopterin. (expasy.org)
  • Pteridine reductase (PTR1) is essential for salvage of pterins by parasitic trypanosomatids and is a target for the development of improved therapies. (rcsb.org)
  • The detection limits of these pteridines are under 1 x 10 -10 M. The levels of neopterin, pterine, xanthopterin, and pterin-6-carboxylic acid were found to be significantly elevated in urine excreted by cancer patents, while the level of isoxanthopterin dropped in these patients. (mst.edu)
  • Neopterin is a pteridine derivative that can be used as an early biomarker in various disorders such as tissue rejection, human immunodeficiency virus, multi-organ failure, sepsis, and cancer. (hacettepe.edu.tr)
  • Pteridines' urinary concentrations seem to vary independently from each other and from normal values to yield a pattern of excreted pteridines that is diagnostic for different species, tissues, and tumor types. (hmdb.ca)
  • 6. Altered urinary excretion of pteridines in neoplastic disease. (nih.gov)
  • Confirmatory laboratories should have the capability to perform ion exchange chromatography (or another accepted method for measuring plasma Phe and tyrosine), erythrocyte DHPR analysis, and urinary pteridine testing (California Department of Health Services, 1997). (nih.gov)
  • Pteridines also constitute a group of heterocyclic compounds containing a wide variety of substituents on this parent structure. (wikipedia.org)
  • Pteridines are a class of compounds excreted in urine, the levels of which are found to elevate significantly in tumor-related diseases. (mst.edu)
  • These are polycyclic aromatic compounds containing a pterin moiety, which consist of a pteridine ring bearing a ketone and an amine group to form 2-aminopteridin-4(3H)-one. (hmdb.ca)
  • Pteridines metabolism and its regulation in normal and pathological conditions have not been extensively investigated due to the difficulty of their quantification. (hmdb.ca)
  • Nare, B., Hardy, L. and Beverley, S.M. The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major . (enzyme-database.org)
  • Pteridine Analysis in Urine by Capillary Electrophoresis using Laser- " by Futian Han, Bryan H. Huynh et al. (mst.edu)
  • For the first time, we have developed a method, based on high-performance capillary electrophoresis (HPCE) and laser-induced fluorescence (LIF) detection, to monitor the pteridine levels in urine. (mst.edu)
  • Pteridine Analysis in Urine by Capillary Electrophoresis using Laser- Induced Fluorescence Detection," Analytical Chemistry , vol. 71, no. 7, pp. 1265 - 1269, American Chemical Society (ACS), Apr 1999. (mst.edu)
  • Isoxanthopterin is a pteridine normally present in plasma, urine, and other bodily fluids also vary from normal concentrations in some disease states and also have diagnostic value. (hmdb.ca)
  • If Phe is elevated, a test of erythrocyte DHPR activity and a urine pteridine profile are recommended. (nih.gov)
  • In embryos mutant for edison, yobo, yocca and brie, differences in pteridine synthesis can be observed under UV light and by thin-layer chromatography. (zfin.org)
  • Because the fluorescence is associated with a pigment (pteridine) produced by the organism, hairs that fluorescence only at the tips is a common finding in cured cats. (tica.org)
  • Pteridine is an aromatic organic compound composed of fused pyrimidine and pyrazine rings. (wikipedia.org)
  • Within the scope of the thesis, it was determined that exposure to heavy metals, especially lead, in the recycling sector affects the pteridine and kynurenine pathways. (hacettepe.edu.tr)
  • Ziegler, I. The pteridine pathway in zebrafish: regulation and specification during the determination of neural crest cell-fate. (nature.com)
  • Hence, the amount of unconjugated pteridines in biological fluids has been found to be modified as a result of several disorders. (deepdyve.com)
  • 5,6,7,8-Tetrahydrobiopterin (H4biopterin) is a compound related to the vitamins folic acid and riboflavin which are all characterised by the common pteridine heterocycle. (i-med.ac.at)