DeficiencyCholinesteraseAcetylcholinesterase and pseudocholinesteraseButyrylcholinesteraseMetabolized by serum pseudocholinesteraseSerumAChEDeficientLiverPlasmaSuccinylcholineActivityBloodLevelsDeficiency and electroconvulsive therapyPCHESerumEnzymeAcetylcholinesteraseSuxamethoniumBiomarkerBCHEOrganophosphateAnesthesiaPrognosticSevereLocal anestheticsSensitivityCase reportSpecificDrugsTreatmentPeoplePatient
Deficiency22
- A case of pseudocholinesterase deficiency in the PACU. (medscape.com)
- Pseudocholinesterase deficiency and electroconvulsive therapy. (medscape.com)
- Maiorana A, Roach RB Jr. Heterozygous pseudocholinesterase deficiency: a case report and review of the literature. (medscape.com)
- What Is Pseudocholinesterase Deficiency? (usa-good.com)
- Pseudocholinesterase deficiency could be a condition that leads to hyperbolic sensitivity to sure relaxant medication used throughout general anesthesia, known as B-complex vitamin esters. (usa-good.com)
- However, folks with pseudocholinesterase deficiency might not be able to move or breathe on their own for some hours when the medication is administered. (usa-good.com)
- The condition causes no other signs or symptoms and is sometimes not discovered until an abnormal drug reaction occurs.Pseudocholinesterase deficiency could be a condition that causes increased sensitivity to certain relaxant drugs used throughout general anesthesia (choline esters). (usa-good.com)
- folks with Pseudocholinesterase deficiency might not be able to move or breathe on their own for a few hours after these drugs are given. (usa-good.com)
- Pseudocholinesterase deficiency may be inheritable (genetic) or acquired. (usa-good.com)
- Pseudocholinesterase (soo-doe-koh-lin-ES-tur-ays) deficiency is a rare disorder that makes you sensitive to certain muscle relaxants ― muscle relaxant or mivacurium ― used throughout general anesthesia. (usa-good.com)
- With pseudocholinesterase deficiency, the body muscles keep relaxed for a longer time than expected. (usa-good.com)
- Pseudocholinesterase deficiency will be caused by a sequence modification (mutation) that's inherited. (usa-good.com)
- There's no cure for pseudocholinesterase deficiency. (usa-good.com)
- Pseudocholinesterase deficiency is a genetic disorder that can cause slow development seizures and diminished muscle control It occurs when the body does not produce enough pseudocholinesterase -- a protein that breaks down certain chemicals in the brain and nervous system.Pseudocholinesterase deficiency are often non inheritable ANd/or be transmissible. (usa-good.com)
- The patient demonstrated no return of twitches fifteen minutes after succinylcholine administration, and a pseudocholinesterase deficiency was suspected. (ispub.com)
- The primary role of Cholinesterase in Clinical Diagnostics is to detect or monitor an acquired or inherited pseudocholinesterase deficiency. (elitechgroup.com)
- Pseudocholinesterase deficiency is a condition that causes increased sensitivity to certain muscle relaxant drugs used during general anesthesia (choline esters). (elitechgroup.com)
- 1) If pseudocholinesterase deficiency stays undetected it may lead to prolonged muscular paralysis after clinical anesthesia. (elitechgroup.com)
- Dr. Michael Kaback and Dr. David Rimoin, who developed the West Coast study, included HIBIM as well as three diseases common to the Persian community, which are relatively easy to treat: pseudocholinesterase deficiency (anesthesia sensitivity) congenital hypoaldosteronism (salt losing disorder), and polyglandular deficiency (multiple hormone deficiency). (jta.org)
- Pseudocholinesterase deficiency: Some individuals have a genetic disorder that causes the lack of pseudocholinesterase. (apollo247.com)
- Family studies may be done when an individual with a genetically abnormal type is documented by serum pseudocholinesterase deficiency and, ideally, confirmed by phenotyping. (evexiadiagnostics.com)
- Wow, you've connected some dots, but its too technical for my wee brain at the moment, however the association between the diseases you list (POTS, ME, CFS, MS, Autoimmune Myasthenia Gravis, Rheumatoid Arthritis and Pseudocholinesterase Deficiency, and Alzheimer's) makes me wonder if one day all these 'different' illnesses will be discovered to be on the same spectrum under acetylcholine dysfunction. (healthrising.org)
Cholinesterase17
- Human cholinesterase (pseudocholinesterase): genetic variants and their recognition. (medscape.com)
- What is the Cholinesterase (Pseudocholinesterase) test? (orangehealth.in)
- When is the Cholinesterase (Pseudocholinesterase) test recommended? (orangehealth.in)
- The Cholinesterase (Pseudocholinesterase) test: Analyzes the total activity of cholinesterase in the patient's blood. (orangehealth.in)
- What is the cost of the Cholinesterase (Pseudocholinesterase) test in Delhi? (orangehealth.in)
- The cost of the Cholinesterase (Pseudocholinesterase) test in Noida is Rs. (orangehealth.in)
- How often should I get the Cholinesterase (Pseudocholinesterase) test? (orangehealth.in)
- The Cholinesterase (Pseudocholinesterase) test is prescribed by your doctor after completing the assessment of your condition. (orangehealth.in)
- What are the normal values for the Cholinesterase (Pseudocholinesterase) test? (orangehealth.in)
- Is fasting required for a Cholinesterase (Pseudocholinesterase) test? (orangehealth.in)
- Any other precautions to be taken before getting myself tested for a Cholinesterase (Pseudocholinesterase) test? (orangehealth.in)
- How can I book a Cholinesterase (Pseudocholinesterase) test in Delhi? (orangehealth.in)
- Why should I book a Cholinesterase (Pseudocholinesterase) test with Orange Health Labs in Delhi? (orangehealth.in)
- Cholinesterase hydrolyses choline esters and there are two types: Acetylcholinesterase and Pseudocholinesterase. (elitechgroup.com)
- Organophosphate pesticide exposure: Most insecticides and pesticides contain organophosphates that inhibit the activity of cholinesterase and pseudocholinesterase. (apollo247.com)
- There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. (medchemexpress.com)
- Two types of cholinesterase are found in blood: "true" cholinesterase (acetylcholinesterase) in red cells and "pseudocholinesterase" (acylcholine acylhydrolase) in serum (plasma). (evexiadiagnostics.com)
Acetylcholinesterase and pseudocholinesterase2
- These substances are acetylcholinesterase and pseudocholinesterase. (orangehealth.in)
- An optimized micromethod for the determination of soluble acetylcholinesterase and pseudocholinesterase in gastrointestinal biopsy tissue is introduced. (archive.org)
Butyrylcholinesterase2
- Pseudocholinesterase may refer to: Butyrylcholinesterase, an enzyme Aryl-acylamidase, an enzyme This article includes a list of related items that share the same name (or similar names). (wikipedia.org)
- butyrylcholinesterase (pseudocholinesterase) found in the blood plasma and acetylcholinesterase found in red blood cells. (labtestsonline.org.uk)
Metabolized by serum pseudocholinesterase1
- Neuromuscular blockade has the potential to be prolonged when using medications metabolized by serum pseudocholinesterase (i.e., succinylcholine or mivacurium). (ispub.com)
Serum6
- The aim of this study was to investigate the effect of intravenous lipid emulsion (20% lipid solution) on serum pseudocholinesterase in an toxication model of diazinon. (ejgm.org)
- At the end of the experimental period, blood samples were taken from animals, and serum pseudocholinesterase levels were measured. (ejgm.org)
- In our study, there was no positive effect of lipid treatment detected on serum pseudocholinesterase. (ejgm.org)
- Patients who demonstrate an abnormal genetic variant, a decrease in concentration by seventy-five percent, or who are exposed to chemicals or medications that block or reduce the serum concentration of pseudocholinesterase will potentially experience prolonged duration of action. (ispub.com)
- Pseudocholinesterase is found predominantly in the liver but also in the pancreas, intestine, heart, and brain, and it's present in serum/plasma. (elitechgroup.com)
- Serum glutamic oxalacetic transaminase, serum pseudocholinesterase, serum alkaline phosphatase, serum cholesterol and the EEG were not significantly changed by either of the 3 drugs. (erowid.org)
AChE1
- acetylcholinesterase (AChE) and pseudocholinesterase (PChE). (orangehealth.in)
Deficient1
- Pseudocholinesterase may be deficient in the critically ill (eg. (derangedphysiology.com)
Liver4
- Acetylcholinesterase is found in nerve tissue and red blood cells and pseudocholinesterase is found primarily in the liver. (orangehealth.in)
- Pseudocholinesterase, found in plasma and connective tissue, is a tetrahedral molecule with a MW of 320,000, is formed in the liver, and has a half-life of approximately 8-16 hours. (ispub.com)
- Most pseudocholinesterase activity is found in plasma and liver. (pharmacology2000.com)
- Pseudocholinesterase is low also in some instances of liver disease, including decompensated cirrhosis, hepatitis, metastatic carcinoma, CHF, and in malnutrition, but not sufficiently consistently enough to be a useful clinical test for such disorders. (evexiadiagnostics.com)
Plasma4
- For example, amino amides undergo hepatic metabolism, whereas amino esters are metabolized in the plasma via pseudocholinesterases. (medscape.com)
- Medikamentet ble hydrolysert i plasma av enzymet pseudocholinesterase til para-amino benzosyre (PABA) som var potensielt allergifremkallende. (tannlegetidende.no)
- A low level of activity of pseudocholinesterase has been demonstrated in cerebrospinal fluid, at about 1/20 to 1/100 the activity present in the corresponding plasma. (evexiadiagnostics.com)
- With clinical conditions characterized by bleeding into the CSF, pseudocholinesterase activity increases to one-fourth to one-half that of plasma. (evexiadiagnostics.com)
Succinylcholine1
- About 1 of 1,500 people have low levels of pseudocholinesterase, a blood enzyme that inactivates drugs such as succinylcholine , which is sometimes given to temporarily relax muscles during surgical procedures. (msdmanuals.com)
Activity3
- Prognostic significance of estimation of pseudocholinesterase activity and role of pralidoxime therapy in organophosphorous poisoning. (medscape.com)
- Of six medically monitored employees, two had evidence of greater than 30% decreases in pseudocholinesterase (P-ChE) activity and one had a decrease in P- ChE activity approaching 30% indicating possible overexposure to organophosphate or carbamate pesticides. (cdc.gov)
- Enzyme activities were obtained from measurements of total activity and activity in the presence of an inhibitor of pseudocholinesterase. (archive.org)
Blood1
- Perioperative blood transfusion may conceal atypical pseudocholinesterase. (medscape.com)
Levels3
- When the pseudocholinesterase levels were analyzed, no significant difference was found between diazinon and diazinon + lipid emulsion treatment groups. (ejgm.org)
- Pseudocholinesterase Levels in OP Poisoning. (drrameshkumar.com)
- Carbamate-poisoned persons can appear to have near normal or normal levels of pseudocholinesterase. (evexiadiagnostics.com)
Deficiency and electroconvulsive therapy1
- Pseudocholinesterase deficiency and electroconvulsive therapy. (medscape.com)
PCHE2
- This issue describes an interesting case of an unusual presentation of pseudocholinesterase (PChE) deficiency in a parturient undergoing emergent cesarean section by Upadaya and Garg. (jicajournal.in)
- An elevated pseudocholinesterase (PChE) activity has no pathological significance. (human.de)
Serum2
- The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. (thermofisher.com)
- Serum pseudocholinesterase activity decreased with dose in females. (nih.gov)
Enzyme6
- The pseudocholinesterase enzyme is involved in the breakdown of choline ester drugs. (medlineplus.gov)
- Some BCHE gene mutations that cause pseudocholinesterase deficiency result in an abnormal pseudocholinesterase enzyme that does not function properly. (medlineplus.gov)
- Other mutations prevent the production of the pseudocholinesterase enzyme. (medlineplus.gov)
- A lack of functional pseudocholinesterase enzyme impairs the body's ability to break down choline ester drugs efficiently, leading to abnormally prolonged drug effects. (medlineplus.gov)
- Activity of the pseudocholinesterase enzyme can be impaired by kidney or liver disease, malnutrition, major burns, cancer, or certain drugs. (medlineplus.gov)
- Pseudocholinesterase deficiency happens when people don't have enough of an enzyme called pseudocholinesterase. (jewishgenetics.org)
Acetylcholinesterase1
- Demecarium inactivates both pseudocholinesterase and acetylcholinesterase. (aksci.com)
Suxamethonium1
- Brozović G, Mazul Sunko B, Hafner T, Bekavac I. Allergic reaction to suxamethonium during emergency caesarean section and pseudocholinesterase deficiency in the same patient. (medscape.com)
Biomarker1
- Pseudocholinesterase as a Biomarker for Untreated Wilson's Disease. (nih.gov)
BCHE2
- Pseudocholinesterase deficiency can be caused by mutations in the BCHE gene. (medlineplus.gov)
- Pseudocholinesterase deficiency is caused by pathogenic (disease-causing) variants in the BCHE gene and exhibits autosomal recessive inheritance . (jewishgenetics.org)
Organophosphate3
- Organophosphate exposure with pseudocholinesterase deficiency. (medscape.com)
- Of six medically monitored employees, two had evidence of greater than 30% decreases in pseudocholinesterase (P-ChE) activity and one had a decrease in P- ChE activity approaching 30% indicating possible overexposure to organophosphate or carbamate pesticides. (cdc.gov)
- Treatment the treatment of brain stem rabies diphtheria eaton-lambert syndrome pseudocholinesterase deficiency organophosphate intoxication other drugs are necessary. (albionfoundation.org)
Anesthesia3
- Pseudocholinesterase deficiency is a condition that results in increased sensitivity to certain muscle relaxant drugs used during general anesthesia, called choline esters. (medlineplus.gov)
- In the Operating Room, a 23-year-old female patient with an undiagnosed pseudocholinesterase deficiency is undergoing general anesthesia for a D&E. As the surgical case is completed, the Student Registered Nurse Anesthetist (SRNA) turns the anesthesia off. (simxvr.com)
- In the Operating Room, a 23-year-old female patient with an undiagnosed pseudocholinesterase deficiency is undergoing general anesthesia for a D&E. As the surgical case is. (simxvr.com)
Prognostic1
- Prognostic significance of estimation of pseudocholinesterase activity and role of pralidoxime therapy in organophosphorous poisoning. (medscape.com)
Severe2
- Investigated post-ECT, she was found to have severe pseudocholinesterase deficiency. (nih.gov)
- Patients with severe hepatic disease or pseudocholinesterase deficiency, because of their inability to metabolize local anesthetics normally, are at a greater risk of developing toxic plasma concentrations of lidocaine and tetracaine. (druglib.com)
Local anesthetics1
- Ester local anesthetics are metabolized predominantly by pseudocholinesterase. (mhmedical.com)
Sensitivity1
- People with pseudocholinesterase deficiency may also have increased sensitivity to certain other drugs, including the local anesthetic procaine, and to specific agricultural pesticides. (medlineplus.gov)
Case report1
- Maiorana A, Roach RB Jr. Heterozygous pseudocholinesterase deficiency: a case report and review of the literature. (medscape.com)
Specific2
- There's no specific treatment for this, but those with pseudocholinesterase deficiency can carry a medical ID to let doctors and nurses know about it. (jewishgenetics.org)
- A specific inhibitor of pseudocholinesterases. (lookformedical.com)
Drugs2
- However, people with pseudocholinesterase deficiency may not be able to move or breathe on their own for a few hours after the drugs are administered. (medlineplus.gov)
- If someone has pseudocholinesterase deficiency, these drugs don't work well for them. (jewishgenetics.org)
Treatment1
- Implications of pseudocholinesterase deficiency for ECT treatment and anaesthetic strategies are discussed. (nih.gov)
People1
- Pseudocholinesterase deficiency occurs in 1 in 3,200 to 1 in 5,000 people. (medlineplus.gov)
Patient1
- Zoller M, Walther S. [Residual relaxant block due to pseudocholinesterase deficiency - First manifestation in an elderly patient]. (medscape.com)