• The salt-inducible kinases (SIKs) are a family of related serine-threonine kinases. (axonmedchem.com)
  • Pim-1, 2 and 3 (EC 2.7.11.1) make up a distinct and highly homologous family of serine/threonine kinases belonging to the Ca2+/ calmodulin -dependent protein kinase-related (CAMK) family. (axonmedchem.com)
  • Protein-Serine-Threonine Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • This graph shows the total number of publications written about "Protein-Serine-Threonine Kinases" by people in this website by year, and whether "Protein-Serine-Threonine Kinases" was a major or minor topic of these publications. (uchicago.edu)
  • Below are the most recent publications written about "Protein-Serine-Threonine Kinases" by people in Profiles. (uchicago.edu)
  • The great majority are serine/threonine kinases, which phosphorylate the hydroxyl groups of serines and threonines in their targets. (inamericawithgrace.com)
  • Regarded as constitutively active enzymes, known to participate in many, diverse biological processes, the intracellular regulation bestowed on the CK1 family of serine/threonine protein kinases is critically important, yet poorly understood. (inamericawithgrace.com)
  • The specificity of serine/threonine kinases is partly determined by interactions with a few residues near the phospho-acceptor residue, forming the so-called kinase-substrate motif. (inamericawithgrace.com)
  • Serine/threonine (S/T) protein kinases are crucial components of diverse signaling pathways in eukaryotes, including the model filamentous fungus Neurospora crassa. (inamericawithgrace.com)
  • The kinases of this family that have been suggested to play a role in apoptosis are the mitogen-activated protein kinase (MAPK) family, specifically p42/44 ERK, p38 MAPK and c-Jun N-terminal kinase (JNK), cyclic AMP-dependent protein kinase (PKA), protein kinase B (PKB), or Akt and protein kinase C (PKC). (inamericawithgrace.com)
  • Analyses of the data in GenBank demonstrated a high degree of homology between the product of the 1,218-bp open reading frame, referred to as the adr-1 gene, and Ser (Thr) protein kinases. (psu.edu)
  • A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfiler TM service. (guidetomalariapharmacology.org)
  • A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase Hotspot SM platform. (guidetomalariapharmacology.org)
  • Serine/threonine kinases (STK3) is a core component of the Hippo pathway and modulates oxidative stress and inflammatory responses in cardiovascular diseases. (ijbs.com)
  • We characterized the ATM protein expression in immortalized cells from AT and AT-variant patients, and heterozygotes and correlated it with two ATM-dependent radiation responses, G1 checkpoint arrest and p53-Ser 15 phosphorylation. (nih.gov)
  • The radiation-induced phosphorylation of p53 protein at serine 15, largely mediated by ATM kinase, was defective in AT, A(-T) and in 2/4 heterozygous carriers, while the G1 cell cycle checkpoint was disrupted in all AT and A(-T) cases, and in 3/10 AT heterozygotes. (nih.gov)
  • However, this limited expression of ATM protein provides no benefit regarding the ATM-dependent responses related to G1 arrest and p53-ser15 phosphorylation. (nih.gov)
  • In the current study we found that trypsin and the selective PAR-2 activating peptide, 2f-LIGKV-OH, stimulated large and sustained increases in the serine 536 phosphorylation of p65/RelA in a transfected skin epithelial cell line and primary keratinocytes. (strath.ac.uk)
  • Overall these novel data demonstrate an IKK2-dependent, predominantly G-protein-independent pathway involved in PAR-2 regulation of NFκB phosphorylation in keratinocytes. (strath.ac.uk)
  • A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors. (uchicago.edu)
  • Zhu H, Dai Z, Liu X, Zhou H, Wang Y. Serine/threonine kinase 3 promotes oxidative stress and mitochondrial damage in septic cardiomyopathy through inducing Kelch-like ECH-associated protein 1 phosphorylation and nuclear factor erythroid 2-related factor 2 degradation. (ijbs.com)
  • STK3-mediated phosphorylation of Kelch-like ECH-associated protein 1 (KEAP1) was shown to suppress antioxidant gene transcription controlled by nuclear factor erythroid 2-related factor 2 (Nrf2) in macrophages. (ijbs.com)
  • Exposure of BEAS-2B cells to SWCNT resulted in the phosphorylation of protein p42/44 (p42/44) and protein p38 (p38). (cdc.gov)
  • SWCNT did not induce protein serine-threonine kinase (AKT) phosphorylation. (cdc.gov)
  • Serpins function in the regulation of proteolytic cascades by entrapping and destroying proteases through a conformational switch of the protein. (umaryland.edu)
  • Together, the structure of VP4 provides insights into the mechanism of a recently characterized clan of serine proteases that utilize a lysine general base and reveals the structure of potential targets for antiviral therapy, especially for other related and economically important viruses, such as infectious bursal disease virus in poultry and infectious pancreatic necrosis virus in aquaculture. (rcsb.org)
  • Involved or implicated in a wide spectrum of diseases, trypsin-like serine proteases comprise well studied drug targets and anti-targets that can be subdivided into two major classes. (rcsb.org)
  • Mannan-binding lectin associated serine protease (MASP-2) is homologous to MASP-1 and the two C1q-associated serine proteases C1r and C1s. (lu.se)
  • Serum serine proteases which participate in COMPLEMENT ACTIVATION. (bvsalud.org)
  • They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). (bvsalud.org)
  • A topological analysis predicted PknB, the serine/threonine protein kinase of S. The serine/threonine-specific protein kinase Akt (protein kinase B), when phosphorylated by phosphotidylinositol-3-kinase, is a key mediator of tolerance. (inamericawithgrace.com)
  • Akt is a serine/threonine-specific protein kinase that plays a critical role in controlling the balance between survival and death pathways in cells. (inamericawithgrace.com)
  • Protein of unknown function UPF0025:Metallo-phosphoesterase:Serine/threonine-specific protein. (systemsbiology.net)
  • A competitive ELISA for quantitative measurement of Monkey Serine/threonine protein phosphatase PP1 β catalytic subunit(PPP1CB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (pp1b.com)
  • Comparison of proteomic changes in the hippocampus and spinal cord of these animals revealed several members of the serine protease inhibitor (serpin) protein family are more highly expressed in P497S animals compared to either WT356 or Non-Tg controls. (umaryland.edu)
  • This Human Plasma serine protease inhibitor (SERPINA5) ELISA Kit employs a two-site sandwich ELISA to quantitate SERPINA5 in samples. (abbkine.com)
  • Human Plasma serine protease inhibitor (SERPINA5) ELISA Kit has high sensitivity and excellent specificity for detection of Human SERPINA5. (abbkine.com)
  • Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor (serpin) which limits the expression of protein C.Suzuki et al. (abbkine.com)
  • Altogether, our study shows that AT and A(-T) cases bearing truncation mutations of the ATM gene can produce modest amounts of full-length (and only rarely truncated) ATM protein. (nih.gov)
  • Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) - Serine/threonine-protein kinase A-Raf is an enzyme that in humans is encoded by the ARAF gene. (researchandmarkets.com)
  • The nucleotide sequences of Serine-Rich Entamoeba histolytica Protein (SREHP) gene have already exhibited stable and significant polymorphism in the gene studies. (scialert.net)
  • The polymorphism of the Serine-Rich Entamoeba dispar Protein (SREDP) gene among 8 isolates obtained from Iranian cyst carriers were analyzed by a nested PCR-RFLP followed by sequencing of the PCR products. (scialert.net)
  • The first nucleotide sequences have been shown the stable and significant polymorphism in the Strain Specific Gene (SSG) and the Serine-Rich E. histolytica Protein (SREHP) gene. (scialert.net)
  • We have determined the effect of seven serine- and arginine-rich (SR) proteins and 15 heterogenous nuclear ribonucleoproteins (hnRNPs) on human papillomavirus type 16 (HPV16) late gene expression. (lu.se)
  • Of the seven SR proteins analyzed here, SRSF1, SRSF3, and SRSF9 induced HPV16 late gene expression, and five of the SR proteins affected HPV16 L1 mRNA splicing. (lu.se)
  • Of the 15 hnRNP proteins analyzed here, hnRNP A2, hnRNP F, and hnRNP H efficiently induced HPV16 late gene expression, and all of the hnRNPs affected HPV16 L1 mRNA levels or mRNA splicing. (lu.se)
  • V-Raf murine sarcoma viral oncogene homolog B1 ( B-RAF) is a gene that codes a protein B-Raf, which is a serine/ threonine-protein kinase. (inamericawithgrace.com)
  • STRAP (Serine/Threonine Kinase Receptor Associated Protein) is a Protein Coding gene. (inamericawithgrace.com)
  • The ATM gene provides instructions for making a protein that is located primarily in the nucleus of cells, where it helps control the rate at which cells grow and divide. (medlineplus.gov)
  • The CASK gene provides instructions for making a protein called calcium/calmodulin-dependent serine protein kinase (CASK). (medlineplus.gov)
  • Research suggests that the CASK protein may also interact with the protein produced from another gene, FRMD7 , to promote development of the nerves that control eye movement (the oculomotor neural network). (medlineplus.gov)
  • Affected individuals with nystagmus may have CASK gene mutations that disrupt the interaction between the CASK protein and the protein produced from the FRMD7 gene, leading to problems with the development of the oculomotor neural network and resulting in abnormal eye movements. (medlineplus.gov)
  • The mutated gene produces a hyperphosphorylated protein that binds excessively to pyrin, thus restricting pyrin's anti-inflammatory activity, which possibly involves inhibiting neutrophil activation and chemotaxis by blocking activation of inflammasomes. (msdmanuals.com)
  • Orthologous to human MAPK1 (mitogen-activated protein kinase 1). (nih.gov)
  • SWCNT induced a significant activation of activator protein-1 (AP-1) and nuclear factor kappa B (NF-kB), and the effect was inhibited by mitogen-activated protein kinase (MAPK) inhibitors. (cdc.gov)
  • SIK2 is found in adipocytes and phosphorylates a specific serine residue in insulin receptor substrate-1. (axonmedchem.com)
  • The ATM protein coordinates DNA repair by activating enzymes that fix the broken strands. (medlineplus.gov)
  • ALLWHEY is formulated with enzymes that enhance digestion and result in higher levels of absorption and ultimately help you better utilize the protein you consume. (vitacost.com)
  • Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis (PubMed:15528381, PubMed:1825810, PubMed:31548394). (inamericawithgrace.com)
  • and protein kinase activity. (nih.gov)
  • Phosphorylates the microtubule-associated protein MAPT/TAU. (cusabio.com)
  • Ser-9 in GSK3) catalyzed by either MAPKAP kinase-1/or p70S6K [11,12], whereas proteins kinase C phosphorylates and partly inhibits GSK3, however, not GSK3 [13]. (techblessing.com)
  • Purification: This antibody is purified through a protein A column, followed by peptide affinity purification. (hatinhibitor.com)
  • In this study, we expressed and characterized a new serine protease inhibitory protein (PI-QT) from the metagenome of sponge-associated microorganisms in Escherichia coli . (bmrat.org)
  • Conservation and variation of the parapoxvirus GM-CSF inhibitory factor (GIF) proteins. (cdc.gov)
  • Serine protease, D- or L-serine arginine rich enzyme of serine threonine kinase with serine that is encoded by the codons UCU, UCC, UCA, UCG, AGU and AGC is an ɑ-amino acid that is used in the biosynthesis of proteins. (pp1b.com)
  • Monkeys are generally considered to be intelligent, particularly Old World monkeys.Serine protease, D- or L-serine arginine rich enzyme of serine threonine kinase with serine that is encoded by the codons UCU, UCC, UCA, UCG, AGU and AGC is an ɑ-amino acid that is used in the biosynthesis of proteins. (pp1b.com)
  • The systematic name of this enzyme class is [protein]-serine epimerase. (wikipedia.org)
  • This enzyme is also called protein-serine racemase. (wikipedia.org)
  • The tests used for protein C testing can include enzyme-linked immunosorbent assay (ELISA), chromogenic assays, and the activated partial thromboplastin time (aPTT)-based functional protein C assay. (medscape.com)
  • The protein pVP2 is further processed by VP4 to give rise to the capsid protein VP2 and four structural peptides. (rcsb.org)
  • Rhesus Monkeys proteins are often measured by ELISA on serum or plasma since consensus epitopes with the human ELISA are used for producing the antibodies of these ELISA test kits. (pp1b.com)
  • The complement system as understood today is a multimolecular system composed of more than 32 proteins and consisting of serum proteins, serosal proteins, and cell membrane receptors that bind to complement fragments. (medscape.com)
  • The complement system consists of 7 serum and 9 membrane regulatory proteins, 1 serosal regulatory protein, and 8 cell membrane receptors that bind complement fragments. (medscape.com)
  • On Western blots, the full-length ATM protein was detected in eight of 18 AT cases, albeit at 1-32% of the normal levels, whereas a truncated ATM protein was detected in a single case, despite the prevalence among cases of truncation mutations. (nih.gov)
  • Mutations in the protein UBQLN2, which functions in protein quality control, cause amyotrophic lateral sclerosis with frontotemporal dementia (ALS/FTD). (umaryland.edu)
  • Thus, we tested the hypothesis that ALS/FTD mutations in UBQLN2 perturb proteostasis, causing aberrant accumulation of misfolded serpin proteins. (umaryland.edu)
  • Taken together, this study identifies a novel role for UBQLN2 in the proper regulation of serpin expression and suggests that misaggregation of serpin proteins may be a pathologic consequence of UBQLN2 mutations. (umaryland.edu)
  • The mutations that cause CASK -related intellectual disability affect the role of the CASK protein in brain development and function. (medlineplus.gov)
  • MICPCH is caused by mutations that eliminate CASK function, while mutations that impair the function of this protein cause XL-ID with or without nystagmus. (medlineplus.gov)
  • To further investigate the aberrant accumulation and mislocalization of serpins, we performed aggregation assays on cortical tissue from 8- and 32-week-old P497S, WT356, and Non-Tg animals, which revealed that serpin proteins have an increased tendency to aggregate in P497S animals compared to control mice. (umaryland.edu)
  • We also studied the effects of altered UBQLN2 expression on serpin protein levels and aggregation and found that UBQLN2 knockout induces serpin aggregation while overexpression of WT or mutant UBQLN2 oppositely affected serpin protein levels. (umaryland.edu)
  • In the present study, the role of cell-envelop associated eukaryotic serine/threonine protein kinase (STPK) in S. mutans during interspecies competition has been investigated. (elsevierpure.com)
  • Zhu, L & Kreth, J 2010, ' Role of Streptococcus mutans eukaryotic-type serine/threonine protein kinase in interspecies interactions with Streptococcus sanguinis ', Archives of Oral Biology , vol. 55, no. 5, pp. 385-390. (elsevierpure.com)
  • The matching is com- plicated by the fact that there are protein modifications and the sequence databases store the unmodified sequences. (lu.se)
  • Thus, the majority of SR proteins and hnRNPs have the potential to regulate HPV16 L1 mRNA splicing. (lu.se)
  • Myelinating Schwann cells form a myelin sheath around a single axon and express high levels of myelin-related proteins and messenger RNA (mRNA). (medscape.com)
  • Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) pipeline Target constitutes close to 7 molecules. (researchandmarkets.com)
  • The latest report SerineThreonine Protein Kinase A Raf - Pipeline Review, H1 2020, outlays comprehensive information on the Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (researchandmarkets.com)
  • Furthermore, this report also reviews key players involved in Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) targeted therapeutics development with respective active and dormant or discontinued projects. (researchandmarkets.com)
  • Each of these pathways uses different proteins. (medscape.com)
  • Now a large and ever increasing number of genetic subtypes has been described, and major advances in molecular and cellular biology have clarified the understanding of the role of different proteins in the physiology of peripheral nerve conduction in health and in disease. (medscape.com)
  • Serine hydroxymethyltransferase (Streptococcus equi subsp. (nih.gov)
  • When the serine residue present in the wild-type nonresponsive beta1 subunit is replaced by an asparagine found in the same position in the beta3 subunit, the resulting point-mutated beta1S265N forms receptors responsive to intravenous general anesthetics, like the wild-type beta3 subunits. (nih.gov)
  • The success of proteomics experiments, such as studies of protein function and cell signaling pathways, ultimately de- pends on how well the protein content in samples is identified and annotated. (lu.se)
  • We describe a statistical measure, Mass Distance Fingerprint, for automatic de novo detection of predominant peptide mass distances, i.e., putative protein mod- ifications. (lu.se)
  • The need to keep track of protein modifications is readily recognized by the proteomics community, and few repositories of known peptide modifications have been created. (lu.se)
  • These proteins are considered to be constitutively active and, therefore, regulated by expression and proteosomal degradation. (axonmedchem.com)
  • We report here the crystal structure of a VP4 protease from BSNV, which displays a catalytic serine/lysine dyad in its active site. (rcsb.org)
  • Strict control of the expression of the immunogenic L1 and L2 capsid proteins may contribute to the. (lu.se)
  • This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag. (cusabio.com)
  • Genetic diversity of Iranian E. dispar isolates based on the SREDP was more polymorphic in comparison of Serine-Rich Entamoeba histolytica Protein (SREHP) of the E. histolytica isolates as well as were different from a few known SREDP genes. (scialert.net)
  • Instead of activating DNA repair, the altered ATM protein allows variants to accumulate in other genes, which may cause cells to grow and divide in an uncontrolled way. (medlineplus.gov)
  • The CASK protein is primarily found in nerve cells (neurons) in the brain, where it helps control the activity (expression) of other genes that are involved in brain development. (medlineplus.gov)
  • Pim proteins are widely expressed with high levels in hematopoietic tissue and are aberrantly expressed in a variety of human malignancies . (axonmedchem.com)
  • 1987) determined the sequence of cDNA for human protein C inhibitor (PCI). (abbkine.com)
  • Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
  • If the activity and concentrations of protein C and protein S antigens are normal, this usually indicates clotting regulation is adequate. (medscape.com)
  • If the protein is not functioning properly (ie, normal protein levels but improper function), insufficient regulation of the coagulation process ensues, which can result in an increased risk of clot development and vein blockage. (medscape.com)
  • If an acquired deficiency is identified, protein C or protein S concentrations may be monitored occasionally as the underlying condition progresses or resolves. (medscape.com)
  • Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. (inamericawithgrace.com)
  • The biosynthesis of GAG chains is initiated by xylosylation of a serine residue of the core protein, followed by galactosylation by beta 4GalT7. (lu.se)