PeptidesSerineAltering nucleotideInhibitorInhibitorsMitochondrialProteasesAntileukoproteinaseCompartmentsNucleic acidsPeptideLipidsMRNASLPICellularCRISPR-CAS SYSTEMSPathwaysViruses and plasmidsSynthesisAggregatesHydrolysisEndoplasmic reticulumTyrosineGeneInhibitsReceptorConformationSerumAntiproteasesAminoMolecularTranslocationTranscriptionalActivationActinMembranePhosphorylationTissueNuclearActivityFoundActivates
Peptides6
- It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. (curehunter.com)
- Intracellular Signaling Peptides and Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
- Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. (jefferson.edu)
- Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. (jefferson.edu)
- Below are the most recent publications written about "Intracellular Signaling Peptides and Proteins" by people in Profiles. (jefferson.edu)
- We show here that the biogenesis of CLEL6 and CLEL9 peptides in Arabidopsis thaliana requires a series of processing events in consecutive compartments of the secretory pathway. (elifesciences.org)
Serine3
- Mechanisms regulating the expression of two pregnancy-associated proteins of the porcine uterus, namely the iron-transport protein uteroferrin (UF) and the lysosomal serine proteinase-inhibitor antileukoproteinase (ALP), were investigated by comparing the effects of estrogen (E), progesterone (P4), and conceptuses on the steady-state levels of their mRNAs. (tamu.edu)
- A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition but differ in their specificity toward proteolytic enzymes. (bvsalud.org)
- The second messenger PIP3 recruits and activates 3-phosphoinositide dependent protein kinase-1 (PDK1) and AKT serine/threonine kinase on the membrane [ 2 ]. (biomedcentral.com)
Altering nucleotide1
- Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism. (harvard.edu)
Inhibitor1
- Antileukoproteinase, also known as secretory leukocyte protease inhibitor (SLPI), is an enzyme that in humans is encoded by the SLPI gene. (wikipedia.org)
Inhibitors2
- They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins. (lookformedical.com)
- MECs were found to express numerous proteinase inhibitors, anti-angiogenic factors, and tumour suppressors proteins. (biomedcentral.com)
Mitochondrial7
- Mitochondrial Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- Proteins encoded by the mitochondrial genome or proteins encoded by the nuclear genome that are imported to and resident in the MITOCHONDRIA. (harvard.edu)
- This graph shows the total number of publications written about "Mitochondrial Proteins" by people in Harvard Catalyst Profiles by year, and whether "Mitochondrial Proteins" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Mitochondrial Proteins" by people in Profiles. (harvard.edu)
- The unfolded protein response of the endoplasmic reticulum supports mitochondrial biogenesis by buffering nonimported proteins. (harvard.edu)
- A defect in mitochondrial protein translation influences mitonuclear communication in the heart. (harvard.edu)
- Genome analysis reveals interplay between 5'UTR introns and nuclear mRNA export for secretory and mitochondrial genes. (umassmed.edu)
Proteases4
- They play a role in INFLAMMATION, tissue repair and innate immunity (IMMUNITY, INNATE) by inhibiting endogenous proteinases such as those produced by LEUKOCYTES and exogenous proteases such as those produced by invading microorganisms. (reference.md)
- These include 37 proteases and antiproteases, which are likely to play a role in the formation of the yolk (vitellogenesis), as regulators of protein metabolism. (biomedcentral.com)
- These results raise the question of the biological significance of egg yolk proteases and antiproteases, and more generally of all minor proteins that have been identified in egg yolk. (biomedcentral.com)
- Screen Quest™ assay kits, a set of HTS-ready tools for high throughput screening of biochemical and cellular targets such as protein kinases, proteases, HDAC, cell apoptosis and cytoxicity, GPCR, ion channels, ADME/metabolism and transporters. (stratech.co.uk)
Antileukoproteinase1
- Regulation of synthesis of uterine secretory proteins: evidence for differential induction of porcine uteroferrin and antileukoproteinase gene expression. (tamu.edu)
Compartments2
- Amino acid sequences found in transported proteins that selectively guide the distribution of the proteins to specific cellular compartments. (umassmed.edu)
- Also difficult the release of the elements from specific MC compartments uses different secretory systems and Laminin (925-933) is managed Laminin (925-933) by an accurate stability of activating and inhibitory signaling pathways. (researchassistantresume.com)
Nucleic acids2
- Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (uams.edu)
- iFluor™ superior fluorescent labelling dyes, optimised for labelling proteins and nucleic acids. (stratech.co.uk)
Peptide2
- Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors. (jefferson.edu)
- The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. (lookformedical.com)
Lipids2
- Egg yolk constitutes a major source of proteins, minerals, vitamins and lipids for the developing embryo. (biomedcentral.com)
- Mucus is a hydrogel composed of water, salts, large mucin polymers, non-mucin proteins, lipids, and cellular debris [ 9 ] [ 10 ] . (encyclopedia.pub)
MRNA4
- For UF, the expression of mRNA with production and secretion of the corresponding protein was also investigated. (tamu.edu)
- and increased levels of secreted UF in uterine luminal fluids 24 h post-E. The presence of conceptuses increased levels of endometrial ALP mRNA and decreased UF protein in uterine luminal fluids, but did not affect levels of endometrial UF mRNA. (tamu.edu)
- Myometrium and endometrium expressed comparable levels of UF and ALP mRNAs within Days 75 or 105, but placenta did not express detectable levels of mRNA for either protein. (tamu.edu)
- Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to evaluate mRNA expression, and immunoblotting (IB) was conducted to evaluate protein expression. (jcancer.org)
SLPI2
- SLPI is a highly cationic single-chain protein with eight intramolecular disulfide bonds. (wikipedia.org)
- SLPI is also one of the dominantly present proteins in nasal epithelial lining fluid and other nasal secretions. (wikipedia.org)
Cellular2
- An unusual cellular factor potentiates protein-DNA complex assembly between Oct-1 and Vmw65. (mcmaster.ca)
- A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. (jefferson.edu)
CRISPR-CAS SYSTEMS2
- Protein components of the CRISPR-CAS SYSTEMS for anti-viral defense in ARCHAEA and BACTERIA. (ucdenver.edu)
- Proteins in RIBONUCLEOPROTEIN assemblies of CRISPR-CAS SYSTEMS that function in targeting DNA of invading viruses and plasmids. (nih.gov)
Pathways1
- One mechanism by which ALS symptoms could spread is by a prion-like propagation of a toxic misfolded protein from cell to cell along anatomic pathways. (docksci.com)
Viruses and plasmids1
- These are proteins that carry out a variety of functions during the creation and expansion of the CRISPR ARRAYS, the capture of new CRISPR SPACERS, biogenesis of SMALL INTERFERING RNA (CRISPR or crRNAs), and the targeting and silencing of invading viruses and plasmids. (ucdenver.edu)
Synthesis4
- Protein synthesis and lipogenesis are highly stimulated in the liver at sexual maturity in hens (15 to 20 fold) to support the incorporation of 0.75 kg proteins and 1.5 kg of triglycerides into the yolk over a year of commercial production. (biomedcentral.com)
- Preferential activation of microsomal diacylglycerol/protein kinase C signaling during glucose treatment (De Novo phospholipid synthesis) of rat adipocytes. (jci.org)
- Glucose has been reported to increase the de novo synthesis of diacylglycerol (DAG) and translocate and activate protein kinase C (PKC) in rat adipocytes. (jci.org)
- Possible prospects for applications of designed proteins with modified activities or other new properties are very high,in the areas of pharmacology, enzyme applications in food industry', waste treatment and chemical synthesis, vaccine design, biosensors etc. (helmholtz-hzi.de)
Aggregates2
- Aggregates of a-syn were hyperphosphorylated and costained for p62 that targets proteins for degradation. (docksci.com)
- PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain). (lookformedical.com)
Hydrolysis2
- An enzyme that catalyzes the hydrolysis of proteins, including elastin. (lookformedical.com)
- this hydrolysis can either activate, inactivate, or modulate the activity of the target protein. (encyclopedia.pub)
Endoplasmic reticulum1
- Mandon EC, Trueman SF, Gilmore R. Protein translocation across the rough endoplasmic reticulum. (umassmed.edu)
Tyrosine4
- Normally, upon the stimulations by growth factors (GFs), the receptor tyrosine kinases (RTKs) are activated, and then recruit PI3K protein complex on the membrane to generate phosphatidylinositol-3,4,5-triphosphate (PIP3) from phosphatidylinositol-4,5-biophosphate (PIP2) [ 2 ]. (biomedcentral.com)
- Tyrosine phosphorylation of RTKs, or adaptor proteins such as IRS-1 facilitate their binding with p85 regulatory subunits of PI3K, and then bring PI3K complex on membrane [ 2 ]. (biomedcentral.com)
- cSH2 domain S690 phosphorylation decreases p85 binding affinity to tyrosine-phosphorylated proteins resulting in less PI3K membrane localization [ 15 ]. (biomedcentral.com)
- SBT6.1-mediated cleavage within the variable domain allows for continued passage of the partially processed precursors through the secretory pathway, and for subsequent post-translational modifications including tyrosine sulfation and proline hydroxylation within, and proteolytic maturation after exit from the Golgi. (elifesciences.org)
Gene2
- Ribbon boosts ribosomal protein gene expression to coordinate organ form and function. (uchicago.edu)
- MC proteinases) in the pathogenesis of joint disease we created book inbred B6 mouse lines when a solitary gene Laminin (925-933) was disrupted. (researchassistantresume.com)
Inhibits1
- It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. (lookformedical.com)
Receptor3
- Jiang Y, Cheng Z, Mandon EC, Gilmore R. An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation. (umassmed.edu)
- One mechanism is the binding of an extracellular ligand to a transmembrane G-protein-coupled receptor (GPCR). (pancreapedia.org)
- The receptor protein has seven transmembrane α-helices connected by alternating cytosolic and extracellular loops. (pancreapedia.org)
Conformation2
- It is of fundamental importance in determining PROTEIN CONFORMATION. (lookformedical.com)
- This cyclic conformation allows cyclic nucleotides to bind to proteins to which other nucleotides cannot. (pancreapedia.org)
Serum2
- The transfer of the major egg yolk proteins such as Very Low Density Lipoproteins (VLDL) containing essentially apovitellenin and apolipoprotein-B, but also vitellogenins and some other plasma proteins from the blood such as serum albumin to the interstitial fluid of the thecae is possible due to the presence of broad discontinuities in the capillary endothelium. (biomedcentral.com)
- Serum proteins that inhibit, antagonize, or inactivate COMPLEMENT C1 or its subunits. (lookformedical.com)
Antiproteases1
- In healthy cells and tissues, both intracellular and extracellular protease activity is well managed by regulation at the transcriptional and translational levels, as well as by inhibitory pro-domains, modulatory factors (such as pH), and antiproteases at the protein level. (encyclopedia.pub)
Amino1
- There are 10°* ways to arrange aminoacids in a medium sized protein chain of 250 amino acids. (helmholtz-hzi.de)
Molecular2
- Activated protein C resistance and low molecular weight lipoprotein (a): dual pathogens for atherothrombosis? (mcmaster.ca)
- This interdisciplinary connection between protein chemists, molecular biologists and stereo-chemists is essential for the protein-design cycle (Fig. 1) consisting of design, cloning, expression andtesting new proteins starting from known ones. (helmholtz-hzi.de)
Translocation1
- Trueman SF, Mandon EC, Gilmore R. Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity. (umassmed.edu)
Transcriptional1
- Deleterious, protein-altering variants in the transcriptional coregulator ZMYM3 in 27 individuals with a neurodevelopmental delay phenotype. (uams.edu)
Activation2
- It has also been proposed that the ability of ALP to downregulate the lipopolysaccharide response in macrophages is most probably related to an inhibitory effect on NF-κB activation [ 6 ]. (biomedcentral.com)
- The downmodulation of stimulation-induced F-actin assembly in neutrophils through the interaction of ALP with the actin-bundling protein l-plastin caused a blockade of the conformational activation of β 2 -integrins [ 5 ]. (biomedcentral.com)
Actin2
- Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1. (umassmed.edu)
- events have receptors stimulated with students( GAGs), unregulated chains docking of a inactive actin, all of an been protein respiration cell a considerable subunits. (evakoch.com)
Membrane2
- A single-pass type I membrane protein. (curehunter.com)
- Depending on which family the G protein is, it goes on to activate (G αs protein subunit) or inhibit (G αi protein subunit) the membrane-bound cyclase. (pancreapedia.org)
Phosphorylation1
- Protein phosphorylation is crucial for signaling transduction of this pathway. (biomedcentral.com)
Tissue1
- Tissue homogenates from paralyzed G93A expressing mice induced MND in 6 of 10 mice expressing low levels of G85R-SOD1 fused to yellow fluorescent protein (G85R-YFP mice) by 3- 11 months, and produced widespread spinal inclusion pathology. (docksci.com)
Nuclear1
- Nuclear Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
Activity2
- the protein is also thought to have broad-spectrum antibiotic activity. (wikipedia.org)
- A family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. (nih.gov)
Found4
- Proteins found in the nucleus of a cell. (uams.edu)
- Proteins found in any species of helminth. (uams.edu)
- We found that "uncharacterized protein LOC419301/similar to porin" (GeneID:419301), an antiprotease and "cathepsin E-A-like/similar to nothepsin" (GeneID:417848), a protease, were the only over-expressed candidates (21-fold and 35-fold difference, respectively) that are present in the egg yolk. (biomedcentral.com)
- A member of the serpin family of proteins that is found in plasma and urine. (lookformedical.com)
Activates1
- After a ligand binds to the GPCR, it activates a heterotrimeric G-protein, which is composed of three subunits: a guanine nucleotide binding α-subunit, and a βγ-heterodimer (98). (pancreapedia.org)