Mitogen-activaPhosphorylationSubstrateInhibitorAMPKTyrosine kinasesSubunitMAPKCAMP-dependPhosphorylatesEukaryotic proteinPlatelet ActivaHighly conservedCalmodulin-dependentAmino acidsAtypical kinasesGenesSerine or threonine residuesAbstractHistidineCatalytic domainSignal transductionReceptor kinasesSpecificityIntracellularInhibitorsApoptosisPathwayCytoplasmicPathwaysLineageHumanGene encodesCaMKIITumorConformationResiduesAutophagyExpressionMetabolismRegulatorSubstratesCyclicActivation of proteinSequenceActivityPIPKInhibitsCellularDegradationInsulinFamilyMonomericDynamicsMutations
Mitogen-activa10
- Orthologous to human MAPK1 (mitogen-activated protein kinase 1). (nih.gov)
- The mitogen-activated protein kinase homolog, WNK lysine deficient protein kinase 1 (WNK1), is activated downstream of epidermal growth factor receptor during decidualization. (bioone.org)
- PKCζ-Mitogen-Activated Protein Kinase Signaling Mediates Crotalphine-Induced Antinociception. (iasp-pain.org)
- The opioid receptor activation regulates a variety of intracellular signaling, including the mitogen-activated protein kinase (MAPK) pathway. (iasp-pain.org)
- The aim of this study was to evaluate the role of mitogen-activated protein kinase (MAPK) family in serum-induced secretion of LIF and IL-6 by bone marrow stromal cells. (unboundmedicine.com)
- TY - JOUR T1 - Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells. (unboundmedicine.com)
- This study is to investigate the role of p38 mitogen-activated protein kinase (p38MAPK) in tert -butyl hydroperoxide ( t BHP)-induced apoptosis of human trabecular meshwork (iHTM) cells. (molvis.org)
- Here we report a role for the phylogenetically ancient mitogen-activated protein kinase (MAPK) signalling pathway in mouse sex determination. (plos.org)
- The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)
- This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)
Phosphorylation13
- A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules. (wikipedia.org)
- Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. (wikipedia.org)
- While MAP kinases are serine/threonine-specific, they are activated by combined phosphorylation on serine/threonine and tyrosine residues. (wikipedia.org)
- Trans-autophosphorylation (phosphorylation by the other kinase in the dimer) of the kinase. (wikipedia.org)
- We measured this using an improved fluorescent reporter and by phosphorylation of endogenous cAMP-response-element binding protein (CREB). (nature.com)
- Egan, J. J., Greenberg, A. S., Chang, M. K. & Londos, C. Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation. (nature.com)
- Levels of phosphorylation and protein expression were determined using western blotting. (hindawi.com)
- We identify recurrent oncogenic mutations in the PAK5 activation loop predicted to alter substrate binding and phosphorylation and identify common ligand/drug binding residues in PAK family kinases, highlighting the potential application of ProKinO in drug discovery. (biorxiv.org)
- A group of enzymes that are dependent on cyclic GMP and catalyzes the phosphorylation of serine or threonine residues of proteins. (harvard.edu)
- Regulating protein breakdown through proteasome phosphorylation. (harvard.edu)
- Displacement of DVL from the centrosome and its release into the cytoplasm on NEK2 phosphorylation is coupled to the removal of linker proteins, an event necessary for centrosomal separation and proper formation of the mitotic spindle. (muni.cz)
- M2.2 protein interferes with MAVS and inhibits IRF7 phosphorylation. (cdc.gov)
- Downstream of SHP1 and SYK-dependent counterregulation of MyD88 tyrosine phosphorylation , we have demonstrated that the scaffolding function of receptor interacting protein kinase 1 (RIPK1) and tumor growth factor -ß activated kinase 1 (TAK1)- mediating signaling were required to spur inflammatory disease . (bvsalud.org)
Substrate5
- CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD). (proteopedia.org)
- By phosphorylating substrate proteins, kinases modify the activity, location and affinities of up to 30% of all cellular proteins, and direct most cellular processes, particularly in signal transduction and co-ordination of complex pathways. (wormbook.org)
- This peptide is a potential substrate for EGFR protein tyrosine kinases. (eurogentec.com)
- The binding of PKB to PtdIns(3,4,5)P3/PtdIns(3,4)P2 recruits PKB from the cytosol to the plasma membrane and is also thought to induce a conformational change that converts PKB into a substrate that can be activated by the phosphoinositide-dependent kinase 1 (PDK1). (rcsb.org)
- Chloroquine inhibited the membrane bound PTK activity in a dose dependent manner (IC 50 = 45 μ M ). Kinetic studies show that chloroquine is a competitive inhibitor of PTK with respect to peptide substrate and noncompetitive with respect to ATP indicating that chloroquine inhibits PTK activity by binding with protein substrate binding site. (niscair.res.in)
Inhibitor8
- To date, all of the kinase inhibitor drugs on the market are for use in an oncology setting. (soci.org)
- This review explores the two primary kinase classes, the eukaryotic protein kinases (ePKs) and the atypical protein kinases (aPKs), and provides a structure-centered comparison of their sequences, structures, hydrophobic spines, mutation and SNP hotspots, and inhibitor interaction patterns. (ku.dk)
- The distribution of genetic variations in both classes shows multiple ways they can interfere with kinase inhibitor binding. (ku.dk)
- UCN-01, a protein kinase C (PKC) inhibitor, induces growth arrest and apoptosis in cancer cells and was recently introduced in a phase I clinical trial. (karger.com)
- 3: Both PD98059 (MAPK/ERK kinase inhibitor) and SB203580 (p38 MAPK inhibitor) attenuated FCS-induced LIF protein production and gene expression. (unboundmedicine.com)
- The human trabecular meshwork cells were treated with t BHP for 1 or 2 h with or without pretreatment of SB203580, an inhibitor of MAP kinase homologs. (molvis.org)
- The binding site for allosteric inhibitor (amino acid) is highly conserved between human liver pyruvate kinase (hL-PYK) and the rabbit muscle isozyme (rM 1 -PYK). (figshare.com)
- This shape change disrupts the binding of the inhibitor protein FKBP12. (medlineplus.gov)
AMPK6
- The ultimate aim of the AMPKIN project was to achieve an advanced understanding of the dynamic operation of the AMP-activated protein kinase (AMPK) signaling pathway. (europa.eu)
- The data showed that adenine activated AMP-activated protein kinase (AMPK) signaling contributing to autophagic cell death through mTOR in both colon cancer cell lines. (hindawi.com)
- Involvement of AMP-activated protein kinase (AMPK) in anticancer property of adenine was also investigated. (hindawi.com)
- Glutamate excitation induced a rapid alteration in the AMP:ATP ratio that was associated with the activation of the AMP-activated protein kinase (AMPK). (jneurosci.org)
- Notably, inhibition of the CaMKK (calmodulin-dependent protein kinase kinase) had little affect on GLUT translocation, whereas the inhibition or knockdown of AMPK (compound C, siRNA) activity prevented GLUT3 translocation to the cell surface after glutamate excitation. (jneurosci.org)
- AMP-activated protein kinase (AMPK) has become the focus of a great deal of attention as a novel therapeutic target for the treatment of metabolic syndromes, because AMPK has been demonstrated to mediate, at least in part, the effects of a number of physiological and pharmacological factors that exert beneficial effects on these disorders. (aspetjournals.org)
Tyrosine kinases4
- Most of the others are tyrosine kinases, although additional types exist. (wikipedia.org)
- More than 50 receptor tyrosine kinases are known in mammals. (wikipedia.org)
- Many ligands of receptor tyrosine kinases are multivalent. (wikipedia.org)
- Protein tyrosine kinases (PTKs) are believed to be implicated in the parasite growth, maturation and differentiation functions. (niscair.res.in)
Subunit1
MAPK1
- FCS also induced activation of extracellular signal-regulated kinase (ERK), p38 MAPK and c-Jun NH(2)-terminal kinase (JNK). (unboundmedicine.com)
CAMP-depend1
- Previous work shows that activating cAMP-dependent protein kinase (PKA) enhances airway epithelial wound repair while activating protein kinase C (PKC) inhibits wound repair. (cdc.gov)
Phosphorylates3
- This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. (nih.gov)
- Here, we propose a molecular mechanism where the AQP7 mobility in adipocytes is dependent on perilipin 1 and protein kinase A. Biochemical analyses combined with ex vivo studies in human primary adipocytes, demonstrate that perilipin 1 binds to AQP7, and that catecholamine activated protein kinase A phosphorylates the N-terminus of AQP7, thereby reducing complex formation. (lu.se)
- We further identified SYK as a critical kinase that phosphorylates MyD88, promoted MyD88-dependent signaling and mediates dermatosis in Ptpn6spin mice . (bvsalud.org)
Eukaryotic protein2
- Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins that share a conserved catalytic core. (wikipedia.org)
- Most protein kinases share a common ePK (eukaryotic protein kinase) catalytic domain, and can be identified by sequence similarity with Blast or profile hidden Markov models (HMMs). (wormbook.org)
Platelet Activa1
- The expression of protein kinase C (PKC) isoenzymes and the effects of PKC activation on myocardial phospholipase A2 (PLA2) activity, platelet-activating factor (PAF) generation and eicosanoid release were studied in spontaneously beating cultured rat cardiomyocytes. (unige.ch)
Highly conserved2
- The intracellular or cytoplasmic Protein kinase domain is responsible for the (highly conserved) kinase activity, as well as several regulatory functions. (wikipedia.org)
- Many of these pathways are highly conserved, and 53 distinct kinase functions and subfamilies appear to have been conserved between yeasts, nematodes, insects and vertebrates, with a further 91 subfamilies of kinases being seen throughout metazoan genomes. (wormbook.org)
Calmodulin-dependent3
- Ca2+/Calmodulin dependent protein kinase (CaMK) are mammalian calmodulin-dependent calcium-dependent protein kinases activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr. (proteopedia.org)
- A multifunctional calcium-calmodulin-dependent protein kinase subtype that occurs as an oligomeric protein comprised of twelve subunits. (curehunter.com)
- It differs from other enzyme subtypes in that it lacks a phosphorylatable activation domain that can respond to CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE. (curehunter.com)
Amino acids2
- The chemical activity of a protein kinase involves removing a phosphate group from ATP and covalently attaching it to one of three amino acids that have a free hydroxyl group. (wikipedia.org)
- There are also protein kinases that phosphorylate other amino acids, including histidine kinases that phosphorylate histidine residues. (wikipedia.org)
Atypical kinases2
- We identified 438 protein kinase genes, including 20 atypical kinases, and an additional 25 kinase fragments or pseudogenes. (wormbook.org)
- Despite the limited sequence similarity between these two classes, atypical kinases commonly share the archetypical kinase fold but lack conserved eukaryotic kinase motifs and possess altered hydrophobic spines. (ku.dk)
Genes5
- The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes. (wikipedia.org)
- Such radiations include genes involved in spermatogenesis, chemosensation, Wnt signaling and FGF receptor-like kinases. (wormbook.org)
- Protein kinases constitute one of the largest and most important of protein families, accounting for ~2% of genes in a variety of eukaryotic genomes. (wormbook.org)
- This abrogated expression of the decidual marker genes, insulin like growth factor binding protein 1 ( IGFBP1 ) and prolactin ( PRL ), and prevented adoption of decidual cell morphology. (bioone.org)
- The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including the expression of critical autosomal genes such as SOX9 . (plos.org)
Serine or threonine residues1
- Activity of MAP kinases is restricted by a number of protein phosphatases, which remove the phosphate groups that are added to specific serine or threonine residues of the kinase and are required to maintain the kinase in an active conformation. (wikipedia.org)
Abstract1
- ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)
Histidine1
- The most common variant, which occurs in all individuals with the classic features of the condition, substitutes the protein building block (amino acid) histidine for the amino acid arginine at position 206 of the ACVR1 protein (written as Arg206His or R206H). (medlineplus.gov)
Catalytic domain2
- There are a number of conserved regions in the catalytic domain of protein kinases. (wikipedia.org)
- Although the role of modular protein-protein interaction domains in kinase and phosphatase signaling has been well characterized, it is becoming clear that many kinases and phosphatases utilize docking interactions - recognition of a short peptide motif in target partners by a groove on the catalytic domain that is separate from the active site. (nih.gov)
Signal transduction4
- Up to 30% of all human proteins may be modified by kinase activity, and kinases are known to regulate the majority of cellular pathways, especially those involved in signal transduction. (wikipedia.org)
- Tyrosine-specific protein kinases (EC 2.7.10.1 and EC 2.7.10.2) phosphorylate tyrosine amino acid residues, and like serine/threonine-specific kinases are used in signal transduction. (wikipedia.org)
- A further 91 subfamilies were found in all three metazoan kinomes, including the tyrosine kinase (TK) group and the TKL group, which mediate much of the complexity of intercellular signal transduction. (wormbook.org)
- Mathematical modeling of signal transduction networks has previously been used to map out thermodynamical using rate equations is increasingly attracting attention as a properties of protein-folding models (6,7). (lu.se)
Receptor kinases2
- Ligand binding causes two reactions: Dimerization of two monomeric receptor kinases or stabilization of a loose dimer. (wikipedia.org)
- Some tyrosine receptor kinases (e.g., the platelet-derived growth factor receptor) can form heterodimers with other similar but not identical kinases of the same subfamily, allowing a highly varied response to the extracellular signal. (wikipedia.org)
Specificity3
- Most kinases act on both serine and threonine, others act on tyrosine, and a number (dual-specificity kinases) act on all three. (wikipedia.org)
- Hormones mobilize intracellular second messengers and initiate signalling cascades involving protein kinases and phosphatases, which are often spatially compartmentalized by anchoring proteins to increase signalling specificity 1 . (nature.com)
- To achieve high biological specificity, protein kinases and phosphatases often recognize their targets through interactions that occur outside of the active site. (nih.gov)
Intracellular2
- These kinases consist of extracellular domains, a transmembrane spanning alpha helix, and an intracellular tyrosine kinase domain protruding into the cytoplasm. (wikipedia.org)
- Given the critical role of PKC isozymes and G proteins in modulating intracellular cross-talk between neurotransmitter systems and thereby the integrative functions of the CNS, future studies using other inhibitors of inositol monophosphatases are warranted, and offer the hope for the development of more potent and more rapidly acting mood-stabilizing drugs. (unboundmedicine.com)
Inhibitors3
- In a keynote lecture, Professor Malcolm Ranson (University of Manchester / Christie Hospital) provided an insight into the clinical aspects of developing kinase inhibitors as effective medicines. (soci.org)
- Additional presentations detailed kinase inhibitors, which have potential for the treatment of diseases in therapeutic areas other than cancer. (soci.org)
- Furthermore, atypical kinase inhibitors explore only a limited number of binding modes both inside and outside the orthosteric binding site. (ku.dk)
Apoptosis3
- This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. (nih.gov)
- This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. (antibodies-online.com)
- Here, we report that during intestinal inflammation, multiple inflammatory cytokines promote the activity of a master regulator of cell proliferation and apoptosis, serine/threonine kinase CK2. (diva-portal.org)
Pathway1
- In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)
Cytoplasmic1
- Essential for recruitment of Atg proteins to the pre-autophagosomal structure, the putative site for autophagosome formation, under starvation condition, resulting in the sequestration of cytoplasmic proteins and organelles for bulk degradation. (yeastgenome.org)
Pathways4
- Protein kinases are one of the largest and most influential of gene families: constituting some 2% of the proteome, they regulate almost all biochemical pathways and may phosphorylate up to 30% of the proteome. (wormbook.org)
- Vascular smooth muscle cell contractile protein expression is increased through protein kinase G-dependent and -independent pathways by glucose-6-phosphate dehydrogenase inhibition and deficiency. (harvard.edu)
- Dishevelled (DVL) is a key scaffolding protein and a branching point in Wnt signaling pathways. (muni.cz)
- This finding is inconsistent with the idea that allosteric pathways are conserved between homologues of a protein family. (figshare.com)
Lineage1
- The gain and loss of kinase functions and subfamilies in each evolutionary lineage is also seen. (wormbook.org)
Human9
- The structures of over 280 human protein kinases have been determined. (wikipedia.org)
- There are over 500 protein kinases in the human kinome. (soci.org)
- Find TAO Kinase 2 Proteins for a variety of species such as anti-Human TAO Kinase 2, anti-Mouse TAO Kinase 2. (antibodies-online.com)
- The Protein Kinase Ontology (ProKinO) is an integrated knowledge graph that conceptualizes the complex relationships connecting protein kinase sequence, structure, function, and disease in a human and machine-readable format. (biorxiv.org)
- Specifically, through graph mining and aggregate SPARQL queries, we identify the p21-activated protein kinase 5 (PAK5) as one of the most frequently mutated dark kinase in human cancers with abnormal expression in multiple cancers, including an unappreciated role in acute myeloid leukemia. (biorxiv.org)
- Kinases are deeply conserved in evolution, and the worm has family homologs for over 80% of the human kinome. (wormbook.org)
- To put worm kinases into an evolutionary and functional context, we compared them with the distant kinomes of human, fly, and yeast. (wormbook.org)
- Distribution of 212 kinase subfamilies throughout four kinomes: the yeast Saccharomyces cerevisiae , the nematode worm Caenorhabditis elegans , the fruit fly Drosophila melanogaster and human. (wormbook.org)
- Nematodes share 153 subfamilies with human, providing close homologs for 81% (419/518) of all human kinases. (wormbook.org)
Gene encodes1
- This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. (nih.gov)
CaMKII2
- CaMKII is multifunctional kinase. (proteopedia.org)
- Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S. Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. (proteopedia.org)
Tumor2
Conformation1
- Autophosphorylation stabilizes the active conformation of the kinase domain. (wikipedia.org)
Residues1
- DVL accumulates during the cell cycle and associates with NIMA-related kinase 2 (NEK2), which is able to phosphorylate DVL at amultitude of residues, as detected by a set of novel phospho-specific antibodies. (muni.cz)
Autophagy2
- The Atg1-kinase complex tethers Atg9-vesicles to initiate autophagy. (yeastgenome.org)
- Noda NN and Fujioka Y (2015) Atg1 family kinases in autophagy initiation. (yeastgenome.org)
Expression5
- Feliciello, A., Rubin, C. S., Avvedimento, E. V. & Gottesman, M. E. Expression of a kinase anchor protein 121 is regulated by hormones in thyroid and testicular germ cells. (nature.com)
- Here we extend the scope of ProKinO as a discovery tool by including new classes and relationships capturing information on kinase ligand binding sites, expression patterns, and functional features, and demonstrate its application in uncovering new knowledge regarding understudied members of the protein kinase family. (biorxiv.org)
- Enhanced mucosal CK2 protein expression and activity were observed in animal models of chronic colitis, particularly within intestinal epithelial cells (IECs). (diva-portal.org)
- 4: Expression of a dominant-negative mutant form of JNK1 that blocked FCS-induced JNK activity had no effect on protein production and gene expression of these cytokines. (unboundmedicine.com)
- Expression analysis of mutant XY gonads at the same stage also reveals a dramatic reduction in Sox9 and, crucially, Sry at the transcript and protein levels. (plos.org)
Metabolism1
- Protein kinase B (PKB/Akt) is a key regulator of cell growth, proliferation and metabolism. (rcsb.org)
Regulator1
- Cyclin-dependent kinase 4 is a key regulator of G1 PHASE of the CELL CYCLE. (bvsalud.org)
Substrates1
- TY - JOUR T1 - Modulation of protein kinase C isozymes and substrates by lithium: the role of myo-inositol. (unboundmedicine.com)
Cyclic3
- Cyclic GMP-Dependent Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- This graph shows the total number of publications written about "Cyclic GMP-Dependent Protein Kinases" by people in Harvard Catalyst Profiles by year, and whether "Cyclic GMP-Dependent Protein Kinases" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Cyclic GMP-Dependent Protein Kinases" by people in Profiles. (harvard.edu)
Activation of protein1
- Using primary cultures of sensory neurons, it was demonstrated that crotalphine increases the level of activated ERK1/2 and JNK-MAPKs and this increase is dependent on the activation of protein kinase Cζ (PKCζ). (iasp-pain.org)
Sequence3
- The updated ontology browser and a web component, ProtVista, which allows interactive mining of kinase sequence annotations in 3D structures and Alphafold models, provide a valuable resource for the signaling community. (biorxiv.org)
- The remaining atypical protein kinases (aPK) belong to several families, some of which have structural, but not sequence similarity to ePKs. (wormbook.org)
- The classification is based on sequence similarity within the kinase domain, the presence of additional domains, known biological functions, and conservation across divergent genomes. (wormbook.org)
Activity8
- Activity of these protein kinases can be regulated by specific events (e.g. (wikipedia.org)
- and protein kinase activity. (nih.gov)
- Find TAO Kinase 2 Proteins with a specific Biological Activity. (antibodies-online.com)
- This makes kinase signaling particularly amenable to comparative studies, and kinase activity a particularly good readout of the physiological state of any cell. (wormbook.org)
- The increase in immunodetectable PKC protein correlated with a 40% elevation in the activity of PKC at the membrane. (jci.org)
- Normalization of circulating glucose in the rat model by either insulin or phlorizin treatment did not result in a reduction in membrane PKC isozyme protein or kinase activity. (jci.org)
- This study investigated the effects of insulin therapy, inhibition of advanced glycation end-product formation with aminoguanidine and angiotensin-converting enzyme inhibition with ramipril on diabetes-related increases in protein kinase C (PKC) activity in the streptozotocin-diabetic rat. (portlandpress.com)
- Protein tyrosine kinase activity was found to be distributed in all the stages of P. falciparum parasite maturation. (niscair.res.in)
PIPK1
Inhibits1
- IFN signaling: 3C protease inhibits activation of antiviral protein complexes. (cdc.gov)
Cellular4
- These proteins have an effect on cellular replication and cellular death in inflammatory, ischemic, and malignant diseases. (lupusresearch.org)
- Adenine forms several biological compounds involved in a variety of cellular physiological processes such as adenosine triphosphate (ATP) in cellular respiration and deoxyribonucleic acid (DNA) in protein synthesis. (hindawi.com)
- Since kinases perform such a variety of distinct basic cellular functions, it is not surprising to see that 53 subfamilies and functions are present in all four kinomes ( Figure 1 ). (wormbook.org)
- Pathogenesis and sporulation are complex processes that are governed by cellular signalling networks including G-protein and phospholipid signalling. (wur.nl)
Degradation3
- Mechanisms That Activate 26S Proteasomes and Enhance Protein Degradation. (harvard.edu)
- cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases. (harvard.edu)
- PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy. (harvard.edu)
Insulin3
- It possesses an N-terminal pleckstrin homology (PH) domain that interacts with equal affinity with the second messengers PtdIns(3,4,5)P3 and PtdIns(3,4)P2, generated through insulin and growth factor-mediated activation of phosphoinositide 3-kinase (PI3K). (rcsb.org)
- Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia. (jci.org)
- We tested the hypothesis that liver protein kinase C (PKC) is increased in non-insulin-dependent diabetes mellitus (NIDDM). (jci.org)
Family2
- Mitogen-activated protein kinases (MAPKs) comprise a large family of proteins activated by a wide range of proinflammatory cytokines and environmental stress. (molvis.org)
- The ACVR1 gene provides instructions for making the activin receptor type-1 (ACVR1) protein, which is a member of a protein family called bone morphogenetic protein (BMP) type I receptors. (medlineplus.gov)
Monomeric1
- PiGK1 and PiGK4 were fused to monomeric red fluorescent protein (mRFP) and ectopically expressed in P.¿infestans. (wur.nl)
Dynamics1
- PKA: a portrait of protein kinase dynamics. (nature.com)
Mutations2
- NEMO consists of 10 exons, and most mutations cause deletions of exons 4-10, resulting in a truncated protein. (medscape.com)
- Hypomorphic mutations may impair but not abolish NEMO protein function. (medscape.com)