Protein mice mutant strains. Medical search. Frequent questions

this mutation substitutes one protein building block (amino acid) for another amino acid in the HRAS protein. (wikipedia.org)
Figure 1 Homology in domain structures and amino acid sequences between human and mouse NLRP1 and the present knock-in mutation. (frontiersin.org)
The previously reported pathogenic mutation in NLRP1 in humans, and the missense mutation we inserted into the BALB/c mice in this study. (frontiersin.org)
The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)
Our data indicate, for the first time, a requirement for MAPK signaling in the developing XY gonad in order to facilitate normal expression of SRY and the downstream testis-determining genes and also suggest that reduced dosage of MAP3K4 may be the cause of a previously described autosomal sex-reversing mutation in the mouse. (plos.org)
Collectively, our data suggest that huRBCs reconstituted NSG mice infected with attenuated P . falciparum is a valuable tool to explore the role of C9 mutation in the growth and survival of parasite mutants and their response to the host's immune responses. (frontiersin.org)
Back in the 70s, researchers were able to position the luxoid mutation on mouse chromosome 9. (sciencedaily.com)
Using modern methods and the published mouse genome sequence, UW researchers were able to identify the mutation at a gene called ZFP145, which produces the protein PLZF. (sciencedaily.com)
Scientists around the world are working to generate a targeted knockout mutation for every gene in the mouse genome through the Knockout Mouse. (jax.org)
In this study, we hypothesized that histone deacetylase (HDAC) inhibitor, valproic acid (VPA), can improve motor function by enhancing cell survival in PD genetic model mice with LRRK2 R1441G mutation. (en-journal.org)
and virus with this mutation has an increased host range that includes mice ( 5 ). (biorxiv.org)
BNT162b2-immune sera neutralized SARS-CoV-2 (USA/WA-1/2020 background strain) with an introduced N501Y mutation as efficiently as SARS-CoV-2 without the mutation ( 6 ). (biorxiv.org)
Further, 19 pseudoviruses, each bearing a SARS-CoV-2 S with a different mutation found in circulating strains, were also neutralized as efficiently as non-mutant SARS-CoV-2 S bearing pseudoviruses by BNT162b2-immune sera ( 7 ). (biorxiv.org)
A loss-of-function mutation in the mouse delta-like3 (Dll3) gene has been generated following gene targeting, and results in severe axial skeletal defects. (ox.ac.uk)
A homozygous mutation in the murine resulting in a C\terminal truncation from the protein leads to severe mixed immunodeficiency, SCID 17, and a kinase\inactive DNA\PKcs\mutated protein network marketing leads to Ku70/Ku80\ and p53\reliant embryonic lethality in mice 18. (exposed-skin-care.net)

Rs1h mRNA expression was detected in the retina of postnatal day (P)11 and adult CD1 mice, but not homozygous rd/rd mice by Northern blot analysis. (nih.gov)
Homozygous mutant mice show decreased long term poteniation, but normal performance in water maze tests. (jax.org)
Homozygous mutant mice show abnormal cellular responses to either ER- or oxidative- stress. (jax.org)

RNA sequencing revealed the upregulation of inflammasome pathway-related genes, keratinocyte stress marker genes, and keratinocyte differentiation marker genes in the Nlrp1b KI mice after UVB irradiation. (frontiersin.org)
The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including the expression of critical autosomal genes such as SOX9 . (plos.org)
In a new study, McIver's laboratory and researchers at the University of Maryland School of Medicine identified two genes important for invasive group A Streptococcus infections in mice. (scienceblog.com)
Based on patterns in their DNA sequences, these genes likely encode proteins in the bacterial membrane. (scienceblog.com)
AceView: gene:him-8, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView. (nih.gov)
These genes were uncovered on the basis of similarity to the DNA binding domain [ ( PUBMED:9504043 ) ] of Mus musculus (Mouse) Brachyury (T) gene product, which similarity is the defining feature of the family. (embl-heidelberg.de)
Mice contain at least four, and perhaps five, genes with the same TEA DNA binding domain (mTEAD genes). (embl-heidelberg.de)
Mice bearing mutant genes which are phenotypically expressed in the animals. (ucdenver.edu)
Extensive evidence has revealed that the core clock machinery involves "clock genes" and "clock proteins" functioning as molecular cogs. (bioone.org)
VPA reduced iba-1 positive activated microglia and the mRNA levels of pro-inflammatory marker genes in LRRK2 R1441G mice. (en-journal.org)
These regions encoded genes for the synthesis of colibactin toxin, a putative cytotoxin outer membrane protein, secretion systems, nucleases and eukaryotic-like proteins. (pasteur.fr)
AceView: gene:dpy-21, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView. (nih.gov)
Salmonella typhimurium SR-11 strains lacking adenylate cyclase and the cyclic AMP receptor protein (CRP) due to deletion (Δ) mutations in the cya and crp genes, respectively, are avirulent for mice and induce high level protective immunity against subsequent challenge with wild-type virulent S. typhimurium SR-11 cells. (elsevierpure.com)

The phenotype of the L1 mutant mouse indicates that it is a potentially valuable model for the human CRASH syndrome. (jneurosci.org)
The Brachyury gene is named for its phenotype, which was identified 70 years ago as a mutant mouse strain with a short blunted tail. (embl-heidelberg.de)

Glycomics was originally centred on the basic understanding of sugar chemistry and then it evolved to the next level of complexity, when genetic regulation of protein glycosylation was discovered. (bl.uk)
Introduction of several mouse strains with genetic immune deficiencies has greatly benefited the development of a small laboratory animal model ( 7 - 15 ) to study the asexual blood stage infection of P. falciparum . (frontiersin.org)
International database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data. (jax.org)
Mice harboring spontaneous mutations have long been a major source for animal models of human genetic disorders, particularly mendelian diseases. (jax.org)
During the last five years, enormous progress has been made in understanding the molecular basis of circadian systems, mainly by molecular genetic studies using the mouse and fly. (bioone.org)
Genetic analysis revealed that a specific part of the H. pylori gene, called the T-repeat region, varied in length from strain to strain. (news-medical.net)
Slight differences in the genetic sequence of H. pylori can sometimes give certain strains advantages over others that allow it to grow better,' says lead author of the study Ryo Kinoshita-Daitoku. (news-medical.net)
We were interested in the genetic and molecular reasons behind why particular strains are more pathogenic and can live in the stomach for decades, leading to cancer development. (news-medical.net)
The genetic model of DR - the eat-2 mutant - has a decreased pumping rate, thus ingesting less bacteria, and requires the FoxA transcription factor PHA-4 [ 8 ] and the dimethoxy ubiquinone hydroxylase CLK-1 [ 9 ] to extend its lifespan. (biomedcentral.com)
Now a large and ever increasing number of genetic subtypes has been described, and major advances in molecular and cellular biology have clarified the understanding of the role of different proteins in the physiology of peripheral nerve conduction in health and in disease. (medscape.com)

While one\knockout mice are practical, dual\knockout mice are lethal 19 embryonically, 20, 21. (exposed-skin-care.net)

Misidentifi cation of S. iniae infection pathogenic strains were more resistant to oxidative burst is likely to be the main reason for low levels of detection activity in macrophages ( 14 ). (cdc.gov)
Klebsiella pneumoniae strains are pathogenic to animals and humans, in which they are both a frequent cause of nosocomial infections and a re-emerging cause of severe community-acquired infections. (pasteur.fr)
When this RNA was completely absent, the amounts of several bacterial pathogenic factors significantly increased and the strain showed stronger colonization within the rodent stomach. (news-medical.net)
One of the pathogenic factors was the bacterial protein CagA, which is known as an oncoprotein because it can promote cancer development. (news-medical.net)

Additionally, in vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis. (nature.com)
Using this approach, we characterized CoV infection mediated by the SHC014 spike protein in primary human airway cells and in vivo , and tested the efficacy of available immune therapeutics against SHC014-CoV. (nature.com)
Our data show that EZH2i compromise the efficacy of α4-1BB in both CT26 colon carcinoma and in an in vivo protein immunization model. (bvsalud.org)
A human blood chimeric mouse could serve to harmonize in vitro P. falciparum cultivation and in vivo studies carried out in rodent animal models. (frontiersin.org)
persister cells are clinically relevant, and antimicrobial therapy selects for high-persister strains in vivo. (medscape.com)

Each of these mutations changes an amino acid in a critical region of the HRAS protein. (wikipedia.org)
The mutations responsible for Costello syndrome lead to the production of an HRAS protein that is permanently active. (wikipedia.org)
These mutations lead to an HRAS protein that is always active and can direct cells to grow and divide without control. (wikipedia.org)
The hybrid virus allowed us to evaluate the ability of the novel spike protein to cause disease independently of other necessary adaptive mutations in its natural backbone. (nature.com)
This variant has an unusually large number of mutations with 10 amino acid changes in the spike protein, raising concerns that its recognition by neutralizing antibodies may be affected. (biorxiv.org)

Also, C. albicans mutant strains that have defects in glycan assembly at the cell surface are significantly less virulent in mouse infection models. (bl.uk)
The aim of the study was to evaluate the protein similarity degree among 15 C. albicans isolates with different virulence obtained from healthy and infected human and animals. (scialert.net)
The whole-cell protein profile obtained by these techniques could provide additional criteria for the serologic and immunologic studies of C. albicans . (scialert.net)
2005). Different types of electrophoretic techniques have been used for the characterization or typing of C. albicans isolates including separation of chromosomes, DNA fragments, isoenzymes, cell wall glycoproteins and whole cell proteins (Asakura et al . (scialert.net)
In this study, we described the use of SDS-PAGE, along with PAGE techniques, to analyze the similarity of the protein profiles of the cytoplasmic extracts and cell walls of different C. albicans isolates obtained from different host conditions (human against animal isolates and patient against healthy subject isolates) with various virulence degrees. (scialert.net)
7] C albicans prevacuolar protein sorting gene VPS4 is required for extracellular secretion of the secreted aspartyl proteases Sap2p and Saps4-6p. (medscape.com)

both monoclonal antibody and vaccine approaches failed to neutralize and protect from infection with CoVs using the novel spike protein. (nature.com)
Researchers at the Francis Crick Institute in the UK, have shown that a specific area of the SARS-CoV-2 spike protein is a promising target for a pan-coronavirus vaccine that could offer some protection against new virus variants, common colds, and help prepare for future pandemics. (ddw-online.com)
Kevin Ng, co-first author and PhD student in the Retroviral Immunology Laboratory at the Crick said: "The S2 area of the spike protein is a promising target for a potential pan-coronavirus vaccine because this area is much more similar across different coronaviruses than the S1 area. (ddw-online.com)
Drawing on new understanding of the pathogenesis of rabies, including its replication and its expression of the relevant immunity-inducing antigens, these workers designed a highly attenuated - but highly effective - vaccine strain of rabies that shows promise as a significantly improved post-exposure treatment for rabies. (asmblog.org)
Here, we investigated SARS-CoV-2-S pseudoviruses bearing either the Wuhan reference strain or the B.1.1.7 lineage spike protein with sera of 16 participants in a previously reported trial with the mRNA-based COVID-19 vaccine BNT162b2. (biorxiv.org)
50% pseudovirus neutralization titers of 16 sera from BNT162b2 vaccine recipients against VSV-SARS-CoV-2-S pseudovirus bearing the Wuhan or lineage B.1.1.7 spike protein. (biorxiv.org)
Furthermore, these conventional vaccines mainly provide homotypic protection with little cross protective immunity as vaccine strains should closely match to the circulating field strains. (biomedcentral.com)
Avirulent S. typhimurium strains have been endowed with the ability to produce several streptococcal colonization and virulence antigens for the purpose of constructing recombinant bivalent oral vaccine strains. (elsevierpure.com)
The recombinant vaccine strains are stable in vitro and in animals (for a period of at least eight days) where they localize to the gut-associated lymphoid tissue (GALT). (elsevierpure.com)

A more recent NMR pulsed-gradient, spin-echo misfolded proteins (Kelly, 1998), and the nucleation, growth, (PGSE) self-diffusion study concluded that BPTI is pre- and polymorphism of protein crystals (Rosenberger et al. (lu.se)

The late entry into the S/M phase coincides with the timing for the peak expression of PF13_0027, suggesting that the deficiency in the mutant cycle can be correlated with the gene expression pattern ( 26 ). (frontiersin.org)
To understand what was happening at the molecular level, the team compared gene expression in a major muscle of mice. (sciencedaily.com)

mutant HIM-8 fails to suppress mutant egl-13 on a free transgenic array, and also fails to suppress native mutant egl-13 if transgenic excess copies of the egl-13 promoter are present. (nih.gov)
To address this question, we administered VPA in LRRK2 R1441G transgenic mice to determine whether VPA affects 1) histone acetylation and HDAC expression, 2) dopaminergic neuron survival, 3) inflammatory responses, 4) motor or non-motor symptoms. (en-journal.org)

In their study, published in Science Translational Medicine today (Wednesday 27 July), the researchers investigated whether antibodies that target the S2 subunit of SARS-CoV-2's spike protein also neutralise other coronaviruses. (ddw-online.com)
The primary factors contain Ku70, Ku80, X\ray fix cross\complementing proteins 4 (XRCC4), and DNA ligase IV (LIG4), as the accessories factors consist of XRCC4\like aspect (XLF), DNA\reliant proteins kinase catalytic subunit (DNA\PKcs), paralogue of XRCC4 and XLF (PAXX), and modulator of retroviral an infection (MRI). (exposed-skin-care.net)

The efficacy of such htcPep was assessed in C57BL/6 mice injected with syngeneic melanoma B16F10 or lung TC1 tumor cell lines, in combination with metronomic chemotherapy and immune checkpoint inhibitors. (bvsalud.org)

Consistent with these in vitro findings, phage treatment did not reduce bacterial burdens in a neutropenic mouse S. aureus thigh infection model. (bvsalud.org)
The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV. (nature.com)
The 72-amino acid TEA DNA binding domains in mTEAD-2, 3, and 4 are approximately 99% homologous to the same domain in mTEAD-1, and all four proteins bind specifically to the same DNA sequences in vitro with a Kd value of 16-38 nM DNA. (embl-heidelberg.de)

GTPase HRas, from "Harvey Rat sarcoma virus", also known as transforming protein p21 is an enzyme that in humans is encoded by the HRAS gene. (wikipedia.org)
These data demonstrate that MAP3K4-dependent signalling events are required for normal expression of Sry during testis development, and create a novel entry point into the molecular and cellular mechanisms underlying sex determination in mice and disorders of sexual development in humans. (plos.org)
Therefore, to examine the emergence potential (that is, the potential to infect humans) of circulating bat CoVs, we built a chimeric virus encoding a novel, zoonotic CoV spike protein-from the RsSHC014-CoV sequence that was isolated from Chinese horseshoe bats 1 -in the context of the SARS-CoV mouse-adapted backbone. (nature.com)
These defects, which consist of highly disorganised vertebrae and costal defects, are similar to those associated with the Dll3-dependent pudgy mutant in mouse and with spondylocostal dysplasia (MIM 277300) in humans. (ox.ac.uk)
Although a defect in the chemokine receptor CX3CR1 increases susceptibility of mice and humans to systemic candidiasis, it does not in mucosal candidosis. (medscape.com)
Relevant of mutagenicity and clastogenici- angiosarcomas of the liver, which carcinogens discussed in this chap- ty, including the induction of sister are rare tumours, were identified in ter do not include pharmaceutical chromatid exchange (SCE), chro- humans, rats, and mice exposed to drugs classified in Group 1, which mosomal aberrations (CA), and mi- vinyl chloride. (who.int)
or each of these agents, carcinogenicity in rats and/or mice, els, differences in exposure con- there was sufficient evidence of car- for example for the liver (aflatoxins, ditions between studies in animals cinogenicity from studies in rats and/ trichloroethylene [TCE], and vinyl and in humans, or limitations in Part 1 · Chapter 1. (who.int)

In molecular biology, generalized transduction is routinely used as a technique to manipulate and construct bacterial strains. (bvsalud.org)
Bacterial internalization into HeLa cells and macrophages and co-localization with either late endosomes or lysosomes of znuA mutant were not different from those of wild-type strain. (go.jp)

Such results suggest a highly protein similarity degree among the most isolates with low and high virulence as well as from human and animal hosts. (scialert.net)
In order to identify novel putative virulence factors that may account for the severity of K2 infections, the genome sequence of the K2 reference strain Kp52.145 was determined and compared to two K1 and K2 strains of low virulence and to the reference strains MGH 78578 and NTUH-K2044. (pasteur.fr)
In addition to diverse functions related to host colonization and virulence encoded in genomic regions common to the four strains, four genomic islands specific for Kp52.145 were identified. (pasteur.fr)
The avirulence of these Δcya Δcrp mutants has been enhanced by elimination of the 100 kb virulence plasmid pStSR100 without impairing immunogenicity. (elsevierpure.com)

Rs1h mRNA expression was measured from the eyes of wild-type and rd/rd mice by Northern blot analysis and reverse transcription-polymerase chain reaction (RT-PCR). (nih.gov)
Click on any transcript to open the specific mRNA page, to see the exact cDNA clone support and eventual SNPs and to get details on tissues, sequences, mRNA and protein annotations. (nih.gov)
Myelinating Schwann cells form a myelin sheath around a single axon and express high levels of myelin-related proteins and messenger RNA (mRNA). (medscape.com)

The pld1 mutant was avirulent in a pneumonia model in mouse. (pasteur.fr)

(B) Similar and conserved amino acid sequences between human NLRP1 and mouse NLRP1B. (frontiersin.org)

Important antigenic determinants of the Streptococcus sobrinus surface protein antigen A (SpaA), presumed to be a critical colonization antigen of S. sobrinus, are expressed at high level by the Δcya Δcrp S. typhimurium strains. (elsevierpure.com)

The fi rst human infections problems because S. iniae is not listed in commercial or were reported in 1996 ( 1 ), and S. iniae was noted as an clinical databases, and many atypical strains are assigned emerging zoonotic disease transmitted by food animals at low matches ( 1 , 4 ). (cdc.gov)

Since then, several strains-including influenza A strains H5N1, H1N1 and H7N9 and MERS-CoV-have emerged from animal populations, causing considerable disease, mortality and economic hardship for the afflicted regions 5 . (nature.com)

This is a prime location for gene products involved in infection because many dangerous bacteria secrete toxins or proteins through the membrane to attack the host. (scienceblog.com)
MNVs are present in mouse facilities worldwide and persist long after initial infection. (crohnsforum.com)
Substituting MNV CW3 (a nonpersistent norovirus) for CR6 caused mild changes in lysozyme distribution in both wild-type and Atg16L1 HM mice, but neither strain developed the highly abnormal Paneth cells seen with MNV CR6 infection. (crohnsforum.com)
Dextran sodium sulfate (DSS), a toxin that induces intestinal injury, was also tested in the 2 mouse strains, with and without CR6 infection. (crohnsforum.com)
Apparently, viral strain and time of infection are significant in the virus-gene interaction. (crohnsforum.com)
Therefore, humanized mice capable of harboring the human malaria infection are urgently needed to understand the parasite biology. (frontiersin.org)

The present report confirms the avirulence and immunogenicity of these mutant strains, demonstrates that immunization of both four- and eight-week-old mice has no adverse effect on weight gain, and that immunity lasts at least ninety days following initial immunization. (elsevierpure.com)

When Atg16L1 HM mice were inoculated with MNV CR6, within a week their Paneth cells contained granules of abnormal size, distribution, and quantity (this reaction had been attributed to Atg16L1 HM when mice were raised in a 'conventional barrier' facility). (crohnsforum.com)
Wild-type mice inoculated with active virus did not develop abnormal Paneth cells, nor did Atg16L1 HM mice that received ultraviolet-inactivated MNV CR6. (crohnsforum.com)

In a vaccination model using TLR9 ligand as adjuvant, mice immunized at the time of enhanced TLR9 responsiveness presented weeks later with an improved adaptive immune response. (nih.gov)
NLRP1 (NACHT and leucine-rich repeat-containing protein family, pyrin domain-containing protein 1) is an innate immune sensor that is involved in the formation of inflammasome complexes. (frontiersin.org)
Members of the nucleotide-binding domain (NACHT) and leucine-rich repeat-containing protein family (NLR) are known to be innate immune sensors. (frontiersin.org)
Recognition of the inflammatory ligand results in the formation of inflammasomes ( 3 , 6 ), which are multi-protein signaling hubs that initiate immune responses by recruiting and activating proteases, such as caspase-1 (Casp-1) ( 4 - 7 ). (frontiersin.org)
However, the very idea of targeting glycan does not need to be centred on their physiological importance, but basically to use them as targets of glycan binding proteins and later recruitment of immune elements for faster microbial clearance. (bl.uk)
Immune checkpoint inhibitors (ICIs), including programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) and cytotoxic T-lymphocyte-associated protein 4 have shown promising cancer clinical outcomes. (bvsalud.org)
huRBC-reconstituted immunodeficient mice received infectious challenge with attenuated P. falciparum C9 parasite mutants (C9-M), complemented (C9-C), and wild type (NF54) progenitors to study the role of immune effectors in the clearance of the parasite from mouse circulation. (frontiersin.org)
Further, the presence of mutant parasites in deep-seated tissues suggests the escape of parasites from the host's immune responses and thus extended the survival of the parasite. (frontiersin.org)
The reduction in the residual innate immune effectors (mainly cells of monocytes and macrophages lineage) and co-administration of huRBCs supplied with decomplemented human serum through an intravenous route led to the development of a reproducible humanized mouse. (frontiersin.org)
Title : Pulmonary immune responses to Aspergillus fumigatus in an immunocompetent mouse model of repeated exposures Personal Author(s) : Buskirk, Amanda D.;Templeton, Steven P.;Nayak, Ajay P.;Hettick, Justin M.;Law, Brandon F.;Green, Brett J.;Beezhold, Donald H. (cdc.gov)

In the E18 cortex, L1 colocalized with microtubule-associated protein 2, a marker of dendrites and somata. (jneurosci.org)

HRAS acts as a molecular on/off switch, once it is turned on it recruits and activates proteins necessary for the propagation of the receptor's signal, such as c-Raf and PI 3-kinase. (wikipedia.org)
Therefore, specific localization patterns of GEFs and GTPase-activating proteins, and a molecular network of their regulation underlie the spatiotemporal control of Rho GTPases activities in the cells. (life-science-alliance.org)

A study led by scientists at Washington University in St. Louis, Missouri, reports that interaction between a mutant allele of Crohn's disease susceptibility gene Atg16L1 and a specific virus causes abnormalities in Paneth cells of mice. (crohnsforum.com)

Then pJHL65-M2eCD40L or pcDNA-M2eCD40L recombinant plasmid was electroporated into JOL967 strain and the resultant clones were designated as JOL2074 and JOL2076, respectively. (biomedcentral.com)

Our phenotypic analysis of Dll3(neo)/Dll3(neo) mutants shows that the developmental origins of the skeletal defects lie in delayed and irregular somite formation, which results in the perturbation of anteroposterior somite polarity. (ox.ac.uk)

The 3 spliced mRNAs putatively encode good proteins , altogether 3 different isoforms (1 complete, 2 partial ), some containing a coiled coil stretch [Psort2] . (nih.gov)

Paneth cells, located at the base of crypts in the small intestine, secrete proteins that protect and maintain the intestinal epithelium. (crohnsforum.com)

In addition, an insertion within a type VI secretion system locus included sel1 domain containing proteins and a phospholipase D family protein (PLD1). (pasteur.fr)

In the motor, somatosensory, and visual cortex, many pyramidal neurons in layer V exhibited undulating apical dendrites that did not reach layer I. The hippocampus of L1 mutant mice was smaller than normal, with fewer pyramidal and granule cells. (jneurosci.org)

RS1 is expressed and assembled in photoreceptors of the outer retina and bipolar cells of the inner retina as a disulfide-linked oligomeric protein complex. (nih.gov)

The Jackson Laboratory maintains and distributes chromosome-aberration stocks that provide mouse models for Down syndrome, as well as the study of. (jax.org)

We identified a mouse mutant that causes embryonic gonadal sex reversal: the development of ovaries in an XY embryo. (plos.org)
The present study was launched when Atg16L1 HM mice failed to show these changes in protein expression and autophagy after the strain was moved (by embryo transfer) to an 'enhanced barrier facility. (crohnsforum.com)
The researchers went on to show that another protein, OCT4, which functions to maintain the stem cells in the early embryo and in cultured embryonic stem cells, is also present in the adult germ stem cell. (sciencedaily.com)

We demonstrated that UVB irradiation induces IL-1β upregulation and IL-1β-dependent inflammation via caspase-1 activation in these Nlrp1b KI mice. (frontiersin.org)

RS1 antibodies also labeled retinal bipolar cells of photoreceptorless mice and retinal bipolar cells grown in cell culture. (nih.gov)
The secreted complex associates with the surface of these cells, where it may function as a cell adhesion protein to maintain the integrity of the central and peripheral retina. (nih.gov)
Instead of triggering cell growth in response to particular signals from outside the cell, the overactive protein directs cells to grow and divide constantly. (wikipedia.org)
The HRAS protein also may be produced at higher levels (overexpressed) in other types of cancer cells. (wikipedia.org)
When this happens, PrP binds to Mahogunin, a protein believed to be essential to the survival of some brain cells. (nih.gov)
Upon correct folding, proteins are transported to specific locations within cells where they can perform their various functions. (nih.gov)
Mice were treated with cisplatin, and human cancer cells were exposed to inflammatory cytokines, to confirm increased PD-L1 and major histocompatibility complex (MHC) I expression by tumor cells or dendritic cells. (bvsalud.org)
Autophagy is a process by which cells degrade long-lived or insoluble proteins and microorganisms, and it may also regulate inflammation. (crohnsforum.com)
Surprisingly, Paneth cells of Atg16L1 HM mice raised in the enhanced barrier facility looked identical to those of wild-type mice. (crohnsforum.com)
Controlled reactive professional phagocytic leukocytes in immunodeficient mice allowed for sizeable human blood chimerism and injected huRBCs acted as bona fide host cells for P. falciparum . (frontiersin.org)
This NSG mouse, depleted with γ-chain of the IL-2 receptor, has been shown to better tolerate a variety of human transplanted cells ( 17 - 24 ). (frontiersin.org)
Buaas and Braun agreed that it sounded as if the mice were born with germ stem cells, the cells that produce sperm, but then lost their germ line early in puberty. (sciencedaily.com)
Using a fluorescent antibody against the PLZF protein, the researchers were able to show directly that PLZF is expressed in the adult germ stem cells. (sciencedaily.com)
High-affinity zinc uptake system protein mutant ( znuA mutant) showed reduced growth in zinc chelated medium, and failed to replicate in HeLa cells and mouse bone marrow-derived macrophages. (go.jp)
Transformation of znuA mutant with a shuttle vector pBBR1MCS-4 containing znuA gene restored the growth in zinc chelated medium and intracellular replication in HeLa cells and macrophages to a level comparable to that of wild-type strain. (go.jp)
We demonstrate that TRPC6 deficiency in mice not only results in anxious and depressive behavior, but also reduces excitability of hippocampal CA1 pyramidal neurons and dentate gyrus granule cells. (afpm.org.my)
The General Control Nonderepressible 2 (GCN2) kinase is a conserved member of the integrated stress response (ISR) pathway that represses protein translation and helps cells to adapt to conditions of nutrient shortage. (biomedcentral.com)

(C) Differences between the three mouse NLRP1 paralogs. (frontiersin.org)
The study shows the usefulness of proteomics in identifying proteins that may express differences between sensitive and resistant L. tropica isolates. (who.int)

Previous work by the Evans lab into a gene called PPAR delta (PPARD) offered intriguing clues: mice genetically engineered to have permanently activated PPARD became long-distance runners who were resistant to weight gain and highly responsive to insulin -- all qualities associated with physical fitness. (sciencedaily.com)
To address these questions, the researchers infected gerbils and mice with wild type (normal) H. pylori for 8 weeks, then extracted and genetically characterized the mutant strains that appeared. (news-medical.net)

The HRAS protein is a GTPase and is an early player in many signal transduction pathways and is usually associated with cell membranes due to the presence of an isoprenyl group on its C-terminus. (wikipedia.org)
The rate of conversion is usually slow but can be sped up dramatically by an accessory protein of the GTPase activating protein (GAP) class, for example RasGAP. (wikipedia.org)

Cyclic oligonucleotide-based antiphage signalling systems (CBASS) protect prokaryotes from viral (phage) attack through the production of cyclic oligonucleotides, which activate effector proteins that trigger the death of the infected host1,2. (bvsalud.org)

This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)

Gray triangles = other expression annotations only (e.g. absence of expression or data from mutants). (jax.org)

Apparently, Paneth cell abnormalities previously attributed to mutant Atg16L1 only occurred when murine norovirus (MNV) CR6 was present. (crohnsforum.com)
Furthermore, the vps4Δ null mutant has been shown to be markedly hypovirulent in a murine model. (medscape.com)

Yet, the amount of this molecule produced in the bacteria is variable among strains. (news-medical.net)

The major SNTX, CTX and PLA2 toxins were isolated with intravenous median lethal doses determined as 0.13, 1.06 and 0.50μg/g in mice , respectively. (afpm.org.my)
The current study successfully profiled the venom proteome of authenticated N. sputatrix, and showed that the venom is made up of approximately 64% three-finger toxins (including neurotoxins and cytotoxins) and 31% phospholipases A2 by total venom proteins. (afpm.org.my)

Moreover, several studies from Dr. Hegde's group and others showed that when too much of a cell's PrP is exposed to the cytoplasm in laboratory mice, they develop brain deterioration. (nih.gov)
The discovery was made by applying the latest laboratory methods to a strain of mice restored from embryos frozen since the early 70s. (sciencedaily.com)
Green, a well-known mouse geneticist who died several years ago, had several embryos from the 35th generation of the mice frozen at the Jackson Laboratory in Maine, the world's largest mutant mouse resource center. (sciencedaily.com)
The UW researchers contacted The Jackson Laboratory for the embryos, and staff there brought the strain back to life after the 30-year freeze. (sciencedaily.com)

Enlarged ventricles and septal abnormalities were also features of the mutant mouse brain. (jneurosci.org)

In addition to having increased endurance, mice who were given the drug were also resistant to weight gain and more responsive to insulin than the mice who were not on the drug. (sciencedaily.com)
ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)
Our preliminary study using 2D isolates were recovered from liq- new cases throughout the world cu- gel electrophoresis in drug sensitive/ uid nitrogen, and sub-cultured in taneous leishmaniasis (CL) remains resistant strains of L. tropica showed RPMI1640 medium (Gibco/BRL) a serious public health problem in that some proteins were differentially supplemented with 10% fetal bovine numerous countries [1,2]. (who.int)
Sample preparation (protein and drug-resistant L. tropica parasites extraction) niasis, early diagnosis and appropriate [8]. (who.int)

The researchers found that after vaccinating mice with SARS-CoV-2 S2, the mice created antibodies that were able to neutralise a number of other animal and human coronaviruses, including the seasonal 'common cold' coronavirus HCoV-0C43, the original strain of SARS-CoV-2, the D614G mutant that dominated in the first wave, Alpha, Beta, Delta, the original Omicron and two bat coronaviruses. (ddw-online.com)

In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)

The similarity in brain pathology between the Mahogunin mutant mice and that seen in prion diseases suggested to us that there might be a connection," Dr. Hegde said. (nih.gov)

We generated Nlrp1b (the mouse homologue of human NLRP1 ) gain-of-function knock-in ( Nlrp1b KI) mice with UVB irradiation-induced autoinflammatory skin lesions. (frontiersin.org)
(A) Domain structures of human NLRP1 and mouse NLRP1B. (frontiersin.org)
However, Atg16L1 HM mice infected with MNV CR6 a week before DSS administration responded with characteristics resembling human Crohn's disease. (crohnsforum.com)
This resource provides mouse models for facial, dental, eye, ear and skull development research, as well as mouse models of human craniofacial. (jax.org)
Additionally, they were curious how these fluctuations would allow some strains to colonize the human stomach more efficiently than others. (news-medical.net)

This specific area of the spike protein tethers it to the virus membrane and allows the virus to fuse with the membrane of a host cell. (ddw-online.com)
The S2 area of the spike protein has, until recently, been overlooked as providing a basis for vaccination. (ddw-online.com)
The researchers will continue this work studying the potential of a pan-coronavirus that targets the S2 area of the spike protein and how it could be integrated with currently licenced vaccines. (ddw-online.com)
To answer this question, we generated VSV-SARS-CoV-2-S pseudoviruses bearing the Wuhan reference strain or the lineage B.1.1.7 spike protein (Fig S1). (biorxiv.org)

1997) at higher how proteins interact with themselves in solution. (lu.se)

Disruptions of protein functions of one of these factors by small molecule inhibitors were shown to be protective against fungal infections. (bl.uk)

Once activated, receptors stimulate signal transduction events in the cytoplasm, a process by which proteins and second messengers relay signals from outside the cell to the cell nucleus and instructs the cell to grow or divide. (wikipedia.org)

This mutant mouse exhibits plaque and tangle pathology associated with synaptic dysfunction, traits similar to those observed in Alzheimer's disease patients. (mmrrc.org)
The first MNV was identified in the Washington University facility in 2003, so investigators 'considered the possibility' that MNVs might account for the Paneth cell pathology previously seen in Atg16L1 HM mice. (crohnsforum.com)

These mice were studied at the time for their limb deformities, but there was a passing reference in the literature to how the mice were fertile for a little while, but then became infertile. (sciencedaily.com)

The skin inflammation and hyperkeratosis from UVB irradiation in the Nlrp1b KI mice were inhibited by both intraperitoneal and subcutaneous administration of anti-IL-1β antibodies before UVB irradiation. (frontiersin.org)

agar, with some clinical strains isolated from Asia being more mucoid than others ( 6 ). (cdc.gov)

In addition, VPA induced the improvement of PD-like motor and non-motor behavior in LRRK2 R1441G mice. (en-journal.org)

The T-box is defined as the minimal region within the T-box protein that is both necessary and sufficient for sequence-specific DNA binding, all members of the family so far examined bind to the DNA consensus sequence TCACACCT. (embl-heidelberg.de)
During Bretazenil years, almost all the reducing\edge analysis on NHEJ as well as the gathered knowledge over the function of specific NHEJ elements was predicated on typically single reduction\of\function mobile and mouse versions. (exposed-skin-care.net)

Anatomy24

Organisms35

Diseases13

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes90

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Health Care5

Mutation15

Homozygous3

Genes13

Phenotype2

Genetic10

Knockout1

Pathogenic4

Vivo5

Mutations5

Albicans6

Vaccine9

19981

Gene Expression2

Transgenic2

Subunit2

C57BL1

Vitro3

Humans7

Bacterial2

Virulence4

MRNA3

Avirulent1

Amino acid1

Colonization1

Zoonotic1

Influenza1

Infection6

Immunization1

Abnormal2

Immune10

Microtubule-associa1

Molecular2

Allele1

Recombinant1

Defects1

Encode1

Secrete1

Phospholipase1

Hippocampus1

Oligomeric1

Chromosome1

Embryo3

Induces1

Cells17

Differences2

Genetically2

GTPase2

Effector1

Signaling pathway1

Annotations1

Murine2

Bacteria1

Toxins2

Laboratory4

Abnormalities1

Resistant4

D614G1

Transcriptional1

Similarity1

Human5

Spike protein4

19971

Protective1

Cytoplasm1

Pathology2

Limb1

Subcutaneous1

Clinical1

Behavior1

Specific2