Protein genes fibroblast growth factor 4. Medical search. Frequent questions

and 3) task performance in aged rats only (soluble fibroblast growth factor receptor IIIb, osteoregulin, and osteocalcin). (cdc.gov)
Loss-of-function mutations of the gene encoding fibroblast growth factor receptor 1 (FGFR1) have been described in patients with autosomal dominant Kallmann syndrome. (medscape.com)
[ 4 ] Of note, anosmin may enhance fibroblast growth factor signaling through the fibroblast growth factor receptor 1. (medscape.com)
[3] [5] FGF2 binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins which themselves constitute a family of closely related molecules. (wikidoc.org)
It was also shown to act on preosteoblasts - in the form of an increased proliferation - after binding to fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase . (wikidoc.org)
FGF R2 is a transmembrane tyrosine kinase that functions as a receptor for several FGF family proteins. (rndsystems.com)
The apelin‑apelin receptor (APJ) system has been implicated in suppressing fibroblast‑to‑myofibroblast transition in non‑neoplastic organ fibrosis. (spandidos-publications.com)
Encodes the fibroblast growth factor receptor 1, a cell surface receptor of the tyrosine kinase family. (chuv.ch)
2006). "Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. (chuv.ch)
10] Mutations of genes encoding either leptin or the leptin receptor underlie isolated cases of autosomally transmitted idiopathic hypogonadotropic hypogonadism associated with early-onset obesity. (medscape.com)
11] Several loss-of-function mutations of the GnRH receptor gene leading to GnRH resistance and autosomally transmitted hypogonadotropic hypogonadism have been described. (medscape.com)
In one patient, isolated bioinactive luteinizing hormone (LH) was present as a result of a homozygous mutation in the LH beta subunit gene, which prevented binding of LH to its receptor. (medscape.com)
Homozygous mutations in GPR54, a gene encoding a G protein-coupled receptor, which binds kisspeptin 1, have been reported as a cause of hypogonadotropic hypogonadism. (medscape.com)
CXCL12 is a constitutively expressed chemokine which binds primarily to the CXCR4 receptor and regulates cell growth, chemotaxis, myelopoiesis, lymphopoiesis, and development of the nervous and cardiovascular systems. (haematologica.org)
Here, we demonstrate more than this happens in the ways of concentration and the dependent period in the astrocytes of the grown rat spinal cord and is suppressed by FGF receptor inhibitors as well as mitogen activated proteins (MAPKS). (fgf-4.com)
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have been emerged as the standard selection in non-small cell lung cancer (NSCLC) patients with EGFR sensitive mutations. (biomedcentral.com)
Owing to the well-established beneficial outcomes of clinical trials, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), have been approved as the standard regimens in patients with non-small cell lung cancer (NSCLC) harboring EGFR sensitive mutations [ 1 ]. (biomedcentral.com)
This gene provides instructions for making a protein called fibroblast growth factor receptor 2. (medlineplus.gov)
Identification of novel fibroblast growth factor receptor 3 gene mutations in actinic cheilitis and squamous cell carcinoma of the lip. (cdc.gov)
Kim and Morshead, 2003), and the fibroblast that SSEA4 associated with CD133 can be used for growth factor (FGF) receptor 4 (Cai et al. (lu.se)

This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)
This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. (nih.gov)

Biotinylated Recombinant Human FGFR2 alpha (IIIb) Fc Chimera Avi-tag (Catalog # AVI663) binds Recombinant Human FGF acidic/FGF1 (aa 16-155) Protein (Catalog # 232-FA ) with an ED 50 of 0.0500-0.500 μg/mL. (rndsystems.com)
2 μg/lane of Biotinylated Recombinant Human FGFR2 alpha (IIIb) Fc Chimera Avi-tag Protein (Catalog # AVI663) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 100-112 kDa and 200-220 kDa, respectively. (rndsystems.com)
Mutations in the FGFR2 gene cause Jackson-Weiss syndrome. (medlineplus.gov)
A mutation in a specific part of the FGFR2 gene overstimulates signaling by the FGFR2 protein, which promotes the premature fusion of skull bones and affects the development of bones in the feet. (medlineplus.gov)

Acidic fibroblast growth factor intracellular-binding protein is a protein that in humans is encoded by the FIBP gene. (wikipedia.org)

Retrogenes arise from molecules called messenger RNA (mRNA), which are copies of a gene's DNA code that the cell needs in order to make proteins. (nih.gov)
mRNA was extracted using TRizol, Affymetrix oligonucleotide 230A genechip analysis performed and analyzed statistically (3-4/group). (cdc.gov)
Also, CD4 antigen, IL-4 and IL-10 mRNA decreased in young 3 week HRLF rats, but not in aged HRLF rats. (cdc.gov)
FGFR1 comprises 18 exons and the corresponding mRNA (NM_023110.2) encodes an 820 amino acid protein, FGFR1. (chuv.ch)
Recent evidence suggests that a physiological function of TTP is to inhibit tumor necrosis factor alpha secretion from macrophages by binding to and destabilizing its mRNA (Carballo, E., Lai, W.S., Blackshear, P.J., 1998. (embl.de)
We first confirmed the presence of Vdr mRNA and protein expression in livers of mice. (nih.gov)
Changes in hepatic Cyp7a1 messenger RNA (mRNA) correlated with those of Cyp24a1 (a Vdr target gene) and inversely with Shp mRNA, but not ileal Fgf15 mRNA. (nih.gov)
The expression levels of the MIR-188-3P growth factor and fibroblast 1 (FGF1) the mRNA has been detected using the quantitative reverse-polymerase transcription chain reaction (QRT-PCR). (fgf-4.com)
Rattus norvegicus insulin-like growth factor binding protein 5 (Igfbp5), mRNA. (genscript.com)

Additional screens for MMTV provirus entry sites in tumors revealed several other upregulated genes that are associated with other gene development pathways such as INT2, INT3, and INT4 [4,5,6]. (chemdiv.com)
What pathways are this gene/protein implicaed in? (cancerindex.org)
In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. (mdpi.com)

Our purpose was to examine expression patterns of genes related to bone mineralization and inflammation in flexor forelimb muscles from young adult and aged (16 months) rats performing a repetitive reaching and grasping task. (cdc.gov)
In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)
Expression analysis of mutant XY gonads at the same stage also reveals a dramatic reduction in Sox9 and, crucially, Sry at the transcript and protein levels. (plos.org)
The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including the expression of critical autosomal genes such as SOX9 . (plos.org)
Analysis of embryonic XY gonads suggests that sex reversal is caused by delayed and reduced expression of the sex-determining gene SRY . (plos.org)
Our data indicate, for the first time, a requirement for MAPK signaling in the developing XY gonad in order to facilitate normal expression of SRY and the downstream testis-determining genes and also suggest that reduced dosage of MAP3K4 may be the cause of a previously described autosomal sex-reversing mutation in the mouse. (plos.org)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
These defects are mediated by increased expression of a protein called Xrp1, which is involved in gene expression regulation. (europa.eu)
We show that dysregulation of appropriate expression of components of the fibroblast growth factor (FGF) pathway contributes to muscle developmental defects in cabeza mutant Drosophila. (europa.eu)
Xrp1 is a DNA-binding protein that is involved in gene expression regulation. (europa.eu)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
The results were validated both by gene expression analysis and immunohistochemistry study in an independent 55 clinical samples from Fudan University Shanghai Cancer Center. (cancerindex.org)
It has been demonstrated to induce gremlin expression which in turn is known to inhibit the induction of differentiation by bone morphogenetic proteins . (wikidoc.org)
Two-thirds of these are regulatory genes-genes that govern the expression of other genes. (answersingenesis.org)
However, rosiglitazone significantly increased adiponectin protein expression in WAT, suggesting that WAT contributes to hyperadiponectinemia in this context. (frontiersin.org)
The role of exosomes collected by ultracentrifugation were also analyzed as mediators of p53 expression in cancer cells and APJ expression in fibroblasts. (spandidos-publications.com)
APJ expression in fibroblasts co‑cultured with p53‑suppressed colon cancer cells (HCT116 sh p53 cells) was significantly lower than in control colon cancer cells (HCT116 sh control cells). (spandidos-publications.com)
MicroRNA 5703 enriched in exosomes derived from HCT116 sh p53 cells inhibited APJ expression, and inhibition of miR‑5703 diminished APJ suppression in fibroblasts caused by cancer cells. (spandidos-publications.com)
CAFs and normal fibroblasts differ with respect to the expression of various markers, such as fibrotic markers, growth factors, chemokines and cytokines ( 9 ). (spandidos-publications.com)
Identification of four CCCH zinc finger proteins in Xenopus, including a novel vertebrate protein with four zinc fingers and severely restricted expression. (embl.de)
A novel technology, Brainbow, creates hundreds of hues by combinatorial expression of multiple fluorescent proteins (FPs). (bvsalud.org)
Plasma and tissue samples were collected and levels of Vdr, Shp, Cyp7a1, Cyp24a1, and rodent fibroblast growth factor (Fgf) 15 expression, as well as levels of cholesterol, were measured. (nih.gov)
At the molecular level, knockdown of PQBP1 in Xenopus animal cap explants inhibits target gene induction by FGF but not by BMP, Nodal or Wnt ligands, and knockdown of either PQBP1 or WBP11 in embryos inhibits expression of fgf4 and FGF4 -responsive cdx4 genes. (xenbase.org)
While the mechanisms responsible for aberrant plasma cell expression of CXCL12 remain to be determined, studies in other systems suggest a role for hypoxia and hypoxia-inducible transcription factors. (haematologica.org)
Design and Methods The expression of hypoxia-inducible factor protein was examined in patients' bone marrow biopsy specimens using immunohistochemistry. (haematologica.org)
The role of hypoxia-inducible factors-1 and -2 in the regulation of CXCL12 expression was examined using over-expression and short hairpin RNA knockdown constructs, electrophoretic mobility shift assays and chromatin immunoprecipitation. (haematologica.org)
Results Strong hypoxia-inducible factor-2 protein expression was detected in CD138 + multiple myeloma plasma cells in patients' biopsy specimens. (haematologica.org)
Prolonged exposure to hypoxia strongly up-regulated CXCL12 expression in multiple myeloma plasma cells and hypoxia-inducible factor-2 was found to play a key role in this response. (haematologica.org)
Over-expression of hypoxia-inducible factor in multiple myeloma plasma cells strongly induced in vivo angiogenesis, and administration of a CXCL12 antagonist decreased hypoxia-inducible factor-induced angiogenesis. (haematologica.org)
Conclusions Hypoxia-inducible factor-2 is a newly identified regulator of CXCL12 expression in multiple myeloma plasma cells and a major contributor to multiple myeloma plasma cell-induced angiogenesis. (haematologica.org)
12 It is well established that hypoxia is an important selective force in the evolution of tumor cells, 13 and elevated expression of the hypoxia-inducible transcription factors HIF-1 and HIF-2 has been documented in several human cancers. (haematologica.org)
Western blot was used to evaluate FGF1 protein expression. (fgf-4.com)
We previously shown that the fibroblast growth factor 2 (FGF2) regularly increases the expression and activity of ecto-5′-nucleotidase (CD73) enzymes and adenosine deaminase (ADA). (fgf-4.com)
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues. (atlasantibodies.com)
LOC426217 , also named claw keratin-like, was the most up-regulated gene in the deformed beaks from a previous digital gene expression (DGE) analysis and was selected as an important candidate gene for further analysis. (biomedcentral.com)
In the present study, quantitative real-time PCR (qRT-PCR) was firstly performed to determine the expression pattern of LOC426217 gene in deformed and normal beaks to verify the DGE results. (biomedcentral.com)
Tissue-specific expression profile of this gene in 14 tissues was also determined using qRT-PCR. (biomedcentral.com)
Sets of differently expressed genes in the deformed and normal beaks have been detected using digital gene expression (DGE) profile analysis based on high-sequencing technology. (biomedcentral.com)
Title: Differential gene expression and immunolocalization of insulin-like growth factors and insulin-like growth factor binding proteins between experimental nonunions and standard healing fractures. (genscript.com)
states'' or gene expression patterns. (lu.se)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)

[ 2 , 3 ] Heterozygous loss-of-function mutations of the gene encoding FGFR1 have also been described in individuals with idiopathic hypogonadotropic hypogonadism, normal smell sense, and normal MRI of the olfactory system. (medscape.com)
The defining cytogenetic abnormality, a translocation at the 8p11 locus, was found to involve the FGFR1 gene [ 14 ]. (nature.com)

Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. (wikipedia.org)
Like other FGF family members, basic fibroblast growth factor possess broad mitogenic and cell survival activities, and is involved in a variety of biological processes, including embryonic development , cell growth , morphogenesis , tissue repair , tumor growth and invasion. (wikidoc.org)
FGF-4 is mitogenic for fibroblasts and endothelial cells in vitro and has autocrine transforming potential. (biofargo.com)

Proteins containing CCCH Znf domains include Znf proteins from eukaryotes involved in cell cycle or growth phase-related regulation, e.g. human TIS11B (butyrate response factor 1), a probable regulatory protein involved in regulating the response to growth factors, and the mouse TTP growth factor-inducible nuclear protein, which has the same function. (embl.de)
The reason for its use is the higher number of platelets, which is an important source of growth factors, such TGF- β1, that hypothetically possess a stimulating effect on regulation and differentiation in mesenchymal tissue repair 10 . (bvsalud.org)

This results in overproduction of the FGF4 protein, which the researchers hypothesize may turn on key growth receptors at the wrong times during fetal development. (nih.gov)
Four distinct genes encoding closely related FGF receptors, FGFR-1to -4 are known. (prospecbio.com)
Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. (rndsystems.com)

Only the alpha isoform has been identified for FGFR-3 and FGFR-4. (prospecbio.com)
A IIIa isoform which is a secreted FGF binding protein containing only the N-terminal half of the IgIII domain plus some intron sequences has also been reported for FGFR-1. (prospecbio.com)
The fibroblast growth factor receiver (FGFR) tyrosine kinases, which are expressed on the cell membrane, are involved in a wide range of biological functions such as cell proliferation, survival, migration and differentiation. (fgf-4.com)
It signals through FGFR 1c, 2c, and 4. (peprotech.com)

It's caused by calcification of growth plates, which curtails long bone development and results in short legs with a curved appearance. (nih.gov)
Bone mineralization and inflammation genes increase in muscles as a consequence of age and performance of a high repetition task. (cdc.gov)
A significant upregulation of Osteoactivin, a gene related to bone mineralization, was found in aged rats (both control and task), while alpha-2-HS-glycoprotein was significantly down-regulated in young adult 3 week HRLF task rats only. (cdc.gov)
These results show that a high repetition-low force reaching and grasping task induces genes related to both inflammation and bone mineralization in muscle tissues, suggesting that these molecules play a role in either inflammation or injury healing. (cdc.gov)
Extreme differences in limb length define many of the dog breeds around the world, and the association between specific "short-legged" breeds and premature intervertebral disc degeneration has been documented since the early twentieth century [referenced in ( 4 , 5 )] Skeletal dysplasia is a general term describing abnormalities of growth and development of cartilage and/or bone and associated alterations in stature ( 6 , 7 ). (frontiersin.org)
Matrix extracellular phosphoglycoprotein (MEPE) [ 12 ] and frizzled related protein-4 (FRP-4) have emerged as candidate mediators of the bone-renal pathophysiology as well but are rarely described in literature, so far [ 11 , 12 ]. (hindawi.com)
We recently reported that bone-conditioned medium from autogenous bone chips contains a number of factors that might affect cell activity. (unibe.ch)
The effects of bone-conditioned medium on the expressions of transforming growth factor-beta (TGF-β) target genes in oral fibroblasts were assessed. (unibe.ch)
Bone-conditioned medium from bone chips exposed to a total radiation dose up to 120 Gy did not affect expressions of TGF-β target genes, including adrenomedullin, BTB/POZ domain-containing protein 11, proteoglycan 4, NADPH oxidase 4, and interleukin 11, in oral fibroblasts. (unibe.ch)
Among its multiple functions, this protein signals immature cells to become bone cells during embryonic development. (medlineplus.gov)
Introduction and Objective: Because L-PRP constitutes an important source of growth factor that is associated with osteogenesis and fibrogenesis, the aim of this study was to evaluate the effect of L-PRP on the presence of collagen III and MMP-2 and MMP-9, while comparing these results by means of a histomorphometric analysis of bone matrix and fibrous deposition on bone repair. (bvsalud.org)

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. (cancerindex.org)
This gene encodes a protein that regulates skeletal and cardiovascular development in humans. (answersingenesis.org)
The splicing factor PQBP1 regulates mesodermal and neural development through FGF signaling. (xenbase.org)
selectively regulates the fibroblast 3 growth factor receiver (FGFR3) and its FGF9 ligand to promote the activation of fibroblast and tissue fibrosis, Cassing an important FGFR3 signature in the SSC skin. (fgf-4.com)

The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). (wikipedia.org)

2001 May 15;100(4):325-9. (medlineplus.gov)
2001 May 15;100(4):315-24. (medlineplus.gov)

All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. (rndsystems.com)

Fibroblast growth factor homologous factors are intracellular signaling proteins. (nih.gov)

Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorgenesis. (rndsystems.com)
Both genes are expressed in the nascent mesoderm and neurectoderm , and morpholino knockdown of either causes defects in differentiation and morphogenesis of the mesoderm and neural plate . (xenbase.org)
Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. (peprotech.com)
Fibroblast growth factor-21 (FGF-21) and growth differentiation factor-15 (GDF-15) are additional biomarkers that may suggest mitochondrial dysfunction. (msdmanuals.com)

The dogs have an extra copy of the gene that codes for a growth-promoting protein called fibroblast growth factor 4 (FGF4). (nih.gov)
While preliminary data from studies investigating FGF4 retrogenes in IVDD implicate FGF4 overexpression as a major disease factor, they have also highlighted knowledge gaps in our understanding of intervertebral disc herniation which is a complex and multifactorial disease process. (frontiersin.org)
However, overexpression of FGF4 associated with insertion of FGF4 retrogenes on CFA12 and CFA18 appear to have broader influences on limb length across many breeds and are the only genes to have been implicated in body size in across-breed association studies ( 3 , 13 - 16 ). (frontiersin.org)
Generx is a viral vector - a virus that has been modified to deliver a specific gene to a target cell type - that delivers a gene for fibroblast growth factor 4 (FGF4) to cardiac tissue damaged due to lack of oxygen during a heart attack. (biotechprimer.com)
The damaged tissue then produces the FGF4 protein, which promotes the formation of new blood vessels in damaged regions, increasing the heart's ability to deliver oxygen-rich blood. (biotechprimer.com)
The FGF4 gene delivered by Generx does not incorporate into the cardiac cell's genome. (biotechprimer.com)

Despite the requirement for a number of transcription factors and secreted signalling molecules in sex determination, intracellular signalling components functioning in this process have not been defined. (plos.org)
During nephrogenesis, multiple genes, transcription factors, and growth factors control the essential interaction between the ureteric bud and the metanephric mesenchyme. (medscape.com)
The T-box family genes are evolutionarily conserved transcription factors. (keio.ac.jp)
TBX4 is an essential transcription factor for the development of the hindlimbs and lungs [3]. (keio.ac.jp)
Mutations of the DAX1 gene, which encodes a nuclear transcription factor, lead to X-linked idiopathic hypogonadotropic hypogonadism associated with adrenal hypoplasia congenita (AHC). (medscape.com)
14 , 15 HIF-1 and HIF-2 mediate adaptive responses to hypoxia by inducing the transcription of genes associated with erythropoiesis, glycolytic metabolism, cell survival and angiogenesis. (haematologica.org)
2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)

In the recent fifth edition of the World Health Organization classification, similar to the recent update to the International Consensus Classification, the category was renamed to "myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions" and both classifications added novel subtypes with new JAK2 rearrangements (e.g. (nature.com)
Here we propose comprehensive response criteria based on the heterogenous clinical presentations of patients with MLN with eosinophilia and tyrosine kinase gene fusions. (nature.com)

These proteins were firstly discovered in 1989. (chemdiv.com)
310 "A high efficiency method for site-directed mutagen -esis with any plasmid":Gene;1989 (Dec 7);84(1);p153-7.Average yield of mutants was 60% with simple and rapid techniques. (globalchange.com)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. (antibodies-online.com)
Fibulin-4 is a member of the fibulin family, a group of extracellular matrix proteins prominently expressed in medial layers of large veins and arteries. (uzh.ch)
Immunoblotting analysis showed a decreased amount of fibulin-4 protein in the fibroblast culture media of two patients, a finding sustained by diminished fibulin-4 in the extracellular matrix of the aortic wall on immunohistochemistry. (uzh.ch)

FGF2 , also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene . (wikidoc.org)
Gene sequencing revealed that this group was in fact the same FGF2 protein and that it was a member of a family of FGF proteins. (wikidoc.org)

For intermediate-risk patients whose first surveillance cystoscopy is negative for tumor, perform subsequent cystoscopy with cytology every 3-6 months for 2 years, then 6-12 months for years 3 and 4, and then annually thereafter. (medscape.com)
Cancer‑associated fibroblasts (CAFs) are pivotal in tumor progression. (spandidos-publications.com)
The present study aimed to elucidate the oncogenic role of the apelin‑APJ system in tumor fibroblasts. (spandidos-publications.com)
In addition, xenografts of HCT116 cells with APJ‑suppressed fibroblasts showed accelerated tumor growth. (spandidos-publications.com)
Thus, the APJ system in fibroblasts in the tumor microenvironment may be a promising therapeutic target. (spandidos-publications.com)
The tumor microenvironment consists of various cell types and fibroblasts in the tumor tissue, called cancer-associated fibroblasts (CAFs), which play pivotal role in tumor progression ( 7 , 8 ). (spandidos-publications.com)
TP53 is a significant tumor suppressor gene, and its somatic mutations are one of the most frequent alterations in ~50% of all human cancers, including colorectal cancer ( 10 ). (spandidos-publications.com)
The mutational inactivation of the TP53 gene in tumor cells has been reported to affect not only tumor cells but also the surrounding cells in the tumor microenvironment and to promote tumor-stromal activation and subsequent tumor growth ( 11 , 12 ). (spandidos-publications.com)
It is a slowly growing tumor, usually benign, but displays a marked propensity for invasive growth. (curehunter.com)
Se- IL-9, IL-13, IL-15, GM-CSF, interferon-, tumor necrosis rum samples showed elevated concentrations in the acute factor- (TNF-), RANTES, basic fibroblast growth factor phase of the illness and, more pronounced, in the long-last- ing convalescent phase. (cdc.gov)

2023 April 4 Epub 04/04/2023. (rochester.edu)
2023 January 4 Epub 01/04/2023. (rochester.edu)
2022 June 4 Epub 06/04/2022. (rochester.edu)

The link site between MIR-188-3P and 3 'a non-translated (3'-UTR) region of FGF1 has been identified and FGF1 has been verified as MIR-188-3P target gene. (fgf-4.com)

Basic fibroblast growth factor has been shown to interact with casein kinase 2, alpha 1 , [13] RPL6 [14] and ribosomal protein S19 . (wikidoc.org)

Insulin growth factor binding protein 5 (IGFBP-5), insulin growth factor (IGF-1) and transforming growth factor (TGF-beta1) in the type II alveolar epithelial cells (AECs) play a key role in lung injury caused by bleomycin and pioglitazone attenuates the lung injury/fibrosis by restoring IGFBP-5 and IGF-1 and decreasing TGF-beta1 expressions in the type II AECs. (genscript.com)

explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)

This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. (nih.gov)

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
Finally, rosiglitazone upregulated uncoupling protein 1 in brown adipose tissue (BAT), but this protein was undetectable in tibiae, suggesting that MAT is unlikely to share thermogenic properties of BAT. (frontiersin.org)
and colon fibroblasts, CCD‑18Co), resected human tissue samples of colorectal cancers, and immune‑deficient nude mouse xenograft models. (spandidos-publications.com)
Various genetic abnormalities such as wingless and int-1 (Wnt) signaling, tissue growth factor beta (TGFβ) signaling, or TP53 signaling have been known in the carcinogenesis of colorectal cancer ( 2 , 3 ). (spandidos-publications.com)
pSmad2 and CTGF immunostaining of aortic and lung tissue revealed an increase in transforming growth factor (TGF)beta signaling. (uzh.ch)
Subsequent drive gene analysis with the method of amplification refractory mutation system (ARMS) using a collected tissue sample suggested a deletion of EGFR exon 19 without T790 M mutation. (biomedcentral.com)

Some of the genes involved in the pathogenesis of Kallmann syndrome and idiopathic hypogonadotropic hypogonadism have been identified. (medscape.com)

While about two-thirds of cases of human hypochondroplasia have been linked to a different gene, the cause of the other third remains a mystery. (nih.gov)
This study points to a new gene that should be investigated for its possible role in human hypochondroplasia," Ostrander says. (nih.gov)
This paper reports that loss of function of the Drosophila gene cabeza (the Drosophila equivalent of the human FUS gene, mutations in which can cause a familial form of the motor neurodegenerative disease amyotrophic lateral sclerosis or ALS) induces muscle developmental defects. (europa.eu)
A human genetic disorder called Marfan syndrome is caused by a mutation in one gene, yet it affects many aspects of growth and development, including height, vision, and heart function. (khanacademy.org)
Genes affected in human genetic disorders are often pleiotropic. (khanacademy.org)
2011). "Role of fibroblast growth factor (FGF) signaling in the neuroendocrine control of human reproduction. (chuv.ch)
Another protein containing this domain is the human splicing factor U2AF 35kDa subunit, which plays a critical role in both constitutive and enhancer-dependent splicing by mediating essential protein-protein interactions and protein-RNA interactions required for 3' splice site selection. (embl.de)
Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human FGF12 (NP_004104.3). (prosci-inc.com)
Recombinant Human FGF-6 is an 18.7 kDa protein consisting of 168 amino acid residues. (peprotech.com)
A potentially pre-clinical aspect of this thesis is detailed in paper №4 where I describe a robust protocol for the generation of functional mesDA neurons from human embryonic stem cells that are functional in a rat model of PD. (lu.se)

Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism. (nih.gov)
Some of the distinctive giraffe genes regulate metabolism, skeletal growth, and cardiovascular function. (answersingenesis.org)

When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. (prosci-inc.com)

Polyglutamine-binding protein 1 ( PQBP1 ) is an RNA-splicing factor that, when mutated, in humans causes Renpenning syndrome, an X-linked intellectual disability disease characterized by severe cognitive impairment, but also by physical defects that suggest PQBP1 has broader functions in embryonic development. (xenbase.org)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
The stage-specific embryonic antigen 4 (SSEA4) is brain. (lu.se)

and 3) task performance in aged rats only (corticotropin releasing hormone, interleukin 4, interferon regulatory factor 1, inhibin alpha, and interleukin 6). (cdc.gov)

bFGF), macrophage inflammatory protein 1 (MIP1), and VEGF in comparison to healthy controls. (cdc.gov)

Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated basic FGF, Heparin-binding growth factor-2, and Endothelial cell growth factor-2. (wikidoc.org)
and vascular endothelial growth factor (VEGF). (cdc.gov)

Mutations of the gene encoding fibroblast growth factor 8 have been found in a small minority of patients with autosomal dominant Kallmann syndrome. (medscape.com)
[ 3 ] In addition, mutations of the gene encoding chromodomain-helicase DNA-binding protein 7 ( CHD7 ) have been found in some patients with Kallmann syndrome or idiopathic hypogonadotropic hypogonadism, some of whom have features of the CHARGE syndrome (characterized by delayed growth and development, congenital cardiac defects, dysmorphic ears, hearing loss, coloboma of the eyes). (medscape.com)
3] In addition, mutations of the gene encoding chromodomain-helicase DNA-binding protein 7 (CHD7) have been found in some patients with Kallmann syndrome or idiopathic hypogonadotropic hypogonadism. (medscape.com)
13] Inactivating mutations of the gene encoding kisspeptin 1 may also underlie hypogonadotropic hypogonadism. (medscape.com)

In TIO most tumors overexpress the protein fibroblast growth factor-23 (FGF-23) inhibiting renal phosphate reabsorption in the proximal tubules and acting as a phosphaturic factor [ 1 , 3 , 11 ]. (hindawi.com)

APJ‑suppressed fibroblasts treated with an antagonist or small interfering RNA showed myofibroblast‑like properties, including increased proliferation and migratory abilities, via accelerated phosphorylation of Sma‑ and Mad‑related protein 2/3 (Smad2/3). (spandidos-publications.com)

In another patient, a mutation in the prohormone convertase gene (PC1) led to hypogonadotropic hypogonadism, in addition to extreme obesity, hypocortisolemia, and deficient conversion of proinsulin to insulin. (medscape.com)
Role of insulin like growth factor axis in the bleomycin induced lung injury in rats. (genscript.com)
Critical role of insulin?like growth factor binding protein?5 in methamphetamine?induced apoptosis in cardiomyocytes. (genscript.com)
Insulin-like growth factor binding protein 5 (IGFBP5) mediates methamphetamine-induced dopaminergic neuron apoptosis. (genscript.com)

By contrast, apelin suppressed the upregulation of phosphorylated Smad2/3 in fibroblasts. (spandidos-publications.com)

In samples from patients in the arthralgic conva- analyzed serum cytokine, chemokine, and growth factor lescent phase, we noted increases in IL-1, IL-4, IL-6, IL-8, levels in travelers returning to Germany from Australia. (cdc.gov)

The molecular weight of proteins were 102, 88 and 80 kDa, so they were named α, β and γ-catenin. (chemdiv.com)

Using a transgenic mouse model in which an ALS-like mutation was introduced in the mouse Fus gene, we could show that ALS pathology starts at the neuromuscular juction (the transition between motor nerves and skeletal muscle cells), long before motor neuron cell bodies in the spinal cord degenerate. (europa.eu)
A very important finding reported in this paper is that ALS-mutant FUS protein is toxic to both skeletal muscle cells and motor neurons. (europa.eu)

Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. (cancerindex.org)
12]. In addition, autosomal recessive mutations of the GnRH gene may underlie hypogonadotropic hypogonadism. (medscape.com)

IGFBP5 mediates high glucose-induced cardiac fibroblast activation. (genscript.com)

Environmental factors that can detect specific IgE antibodies against most low-molecular- affect the initiation of occupational asthma include the intrinsic weight agents has resulted in a search for alternative or characteristics of causative agents as well as the influence of the complementary physiopathologic mechanisms leading to airway level and route of exposure at the workplace. (cdc.gov)

Mutations of the KAL1 gene, which encodes a putative neural cell adhesion molecule (anosmin), have been described in several patients with X-linked Kallmann syndrome. (medscape.com)
Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl.de)
To address these challenges, this study presents a subzero-temperature-enabled molecule stacking strategy for the on-demand tailoring of aptamer glues for the precision recognition and efficient degradation of membrane protein. (bvsalud.org)

For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). (prospecbio.com)
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1% BSA, 10%FBS, 5%HSA or 5% trehalose solution), protein aliquots should be stored at -20 degrees Celsius or -80 degrees Celsius for 3-6 months. (biofargo.com)

[1] [2] It is synthesized primarily as a 155 amino acid polypeptide, resulting in an 18 kDa protein. (wikidoc.org)
However, there are four alternate start codons which provide N-terminal extensions of 41, 46, 55, or 133 amino acids, resulting in proteins of 22 kDa (196 aa total), 22.5 kDa (201 aa total), 24 kDa (210 aa total) and 34 kDa (288 aa total), respectively. (wikidoc.org)
Based on 49% overall amino acid identity and 84% amino acid identity within the double zinc finger domain, one of the Xenopus proteins (XC3H-1) appears to be the homologue of TTP. (embl.de)

The following Igfbp5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)

After discovery of the involvement of several key toolkit genes-FGF10, BMP4, and Shh, huge amount of molecular information on lung development is now available. (elsevierpure.com)

Anatomy38

Organisms11

Diseases12

Chemicals and Drugs121

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes50

Disciplines and Occupations1

Information Science3

Receptor20

Signaling pathway2

FGFR24

Intracellular binding1

MRNA9

Pathways3

Expression43

FGFR12

Mitogenic3

Regulation2

Receptors3

FGFR4

Bone11

Regulates4

Binds1

20012

Acidic1

Homologous1

Differentiation4

FGF46

Transcription7

Tyrosine2

19892

Extracellular matrix3

FGF22

Tumor10

Epub3

Target gene1

Ribosomal1

Epithelial1

20021

Kinases1

Tissue6

Involved in the pathogenesis1

Human10

Metabolism2

Mammalian cells1

Embryonic3

Interleukin1

BFGF1

Endothelial2

Mutations of the gene4

Tumors1

Proliferation1

Insulin4

Upregulation1

Cytokine1

Molecular weight1

Skeletal muscle2

Autosomal2

Cardiac1

Antibodies1

Molecule3

Carrier protein4

Amino3

RefSeq1

BMP41