Protein cell survival. Medical search. Frequent questions

Plasma tumor necrosis factor-α and C-reactive protein as biomarker for survival in head and neck squamous cell carcinoma. (diva-portal.org)
Tumor TNM staging is the main basis for prognosis and treatment decision for head and neck squamous cell carcinoma (HNSCC) despite significant heterogeneity in terms of outcome among patients with the same clinical stage. (diva-portal.org)
Purpose: We evaluated X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1) protein in head and neck squamous cell carcinoma (HNSCC) patients in association with outcome. (psu.edu)
Esophageal squamous cell carcinoma affects the squamous cells and usually develops within the middle third of the esophagus. (medicinenet.com)
Oral squamous cell carcinoma, or OSCC, makes up over 90% of all head and neck cancers that involve the upper layer of the epithelium. (asbmb.org)
Zdenka is investigating the role of WNT5A signaling in Oral Squamous cell Carcinoma. (lu.se)

Apoptosis signal-regulating kinase 1 (ASK1) is a ubiquitously expressed mitogen-activated protein kinase kinase kinase that activates the c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase signaling cascades. (nih.gov)
Fig. 2: Fructose metabolism enhances hypoxic cell survival and decreases pyruvate kinase activity. (nature.com)
After Fas stimulation, Daxx is activated and plays its role of pro-apoptotic protein in activating the c-JUN-N-Terminal Kinase (JNK) pathway. (wikipedia.org)
When the cell is treated with TGF-β, HIPK2, a nuclear kinase, phosphorylates Daxx and the activated Daxx in turn activates the JNK pathway (see "The Daxx Pathway" figure). (wikipedia.org)
The liberated HSP60 associates with and activates the IκB kinase (IKK) complex in the cytosol, which consequently induces the NF-κB-dependent expression of survival genes in nucleus. (ewha.ac.kr)
In a screen for protein phosphatase homologs that functionally interact with the autophagy-dedicated protein kinase Atg1p in yeast, we have identified Aup1p, encoded by Saccharomyces cerevisiae reading frame YCR079w. (huji.ac.il)
Lipopolysaccharide induced MAP kinase activation in RAW 264.7cells attenuated by cerium oxide nanoparticle s. (cdc.gov)
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. (cancerindex.org)
Knockdown of MAGEA6 Activates AMP-Activated Protein Kinase (AMPK) Signaling to Inhibit Human Renal Cell Carcinoma Cells. (nih.gov)
The mammalian target of rapamycin complex 2 (mTORC2) has been implicated in the regulation of cell survival by phosphorylating the protein kinase Akt. (bl.uk)
RAF genes encode serine and threonine kinase proteins downstream of Ras in the pathway. (news-medical.net)
Mutant B-Raf proteins that have been implicated in tumorigenesis often have elevated kinase activity, known as a gain of function mutaion. (news-medical.net)
Conserved region 3 (CR3) is a catalytic protein kinase domain. (news-medical.net)
Inhibition of the kinase domain is halted through binding of the Ras-binding domain, or residues 155-227 of the protein, to the Ras-GTP effector domain. (news-medical.net)

Complement C11 binding protein (C1QBP, also named p32 and HABP1) is a multifunctional protein which plays a pivotal role in diverse cellular processes such autophagy and cell apoptosis [ 7 , 8 ]. (jcancer.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
In addition, BMP-2 overexpression induced p21 WAF1/CIP1 and p27 KIP1 expression, and cellular apoptosis in RCC cells. (oncotarget.com)
The researchers found that the cellular survival mechanism provided by Hsp12 functioned under several different kinds of assault, including heat shock, oxidative stress, and osmotic stress -- a sudden change in the solution surrounding a cell that challenges its ability to regulate the flow of water through the membrane. (mytum.de)
Together with previous reports indicating that ASK1 functions as a pro-apoptotic signaling intermediate, these results suggest that ASK1 has a broad range of biological activities depending on cell types and/or cellular context. (nih.gov)
These are as follows: sustained proliferative signalling, cell death resistance, replicative immortality, genome instability and increased mutations, tumour-promoted inflammation, insensibility to growth repressors, deregulation of cellular energetics, evasion of immune destruction, induction of metastasis, and promotion of angiogenesis. (hindawi.com)
TGF-β regulates a variety of different cellular developmental processes including growth, differentiation, proliferation, and cell death. (wikipedia.org)
Mitochondria communicate with other cellular compartments via the secretion of protein factors. (ewha.ac.kr)
These proteins provide a selective conduction of ions across cellular membranes, which is crucial for cell survival. (surrey.ac.uk)
This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. (cancerindex.org)
Seo YJ, Jothikumar P, Suthar MS, Zhu C , Grakoui A (2016) Local Cellular and Cytokine Cues in the Spleen Regulate In Situ T Cell Receptor Affinity, Function, and Fate of CD8+ T Cells. (meduniwien.ac.at)
MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
B-Raf is a protein encoded by the BRAF gene and is involved in the RAS/MAPK pathway, which regulates cellular growth and division. (news-medical.net)
A new study in the journal Molecular & Cellular Proteomics characterizes the functions of CD151, a protein that researchers have found to be significant in TNBC. (asbmb.org)
One important discovery was that the N-terminal portion of the protein could block a cellular stress response called the unfolded protein response that normally is activated by the virus during infection. (asbmb.org)
However, some prefibrillar oligomers of amyloidogenic proteins have direct cellular toxicity, an important component of disease pathogenesis. (msdmanuals.com)

The B-Raf protein has 766 amino acids in three conserved domains. (news-medical.net)

RBM47 expression in renal cancer cell lines was reduced significantly when compared to normal renal tubular epithelial cells . (bvsalud.org)
Multimeric alpha-lactalbumin killed all transformed, embryonic, and lymphoid cells tested but spared mature epithelial elements. (lu.se)
Finally, analysis of the mechanism by which multimeric alpha-lactalbumin induces apoptosis in transformed epithelial cells could lead to the design of antitumor agents. (lu.se)
A study comparing survival times among 341 epithelial ovarian cancer patients of whom 297 were non-diabetic, 28 were type II diabetics who did not use metformin, and 16 were type II diabetics who used metformin to find out if metformin use is associated with significantly longer progression free survival and overall survival in ovarian cancer patients. (naturalmedicinejournal.com)
The study compared survival times among 341 epithelial ovarian cancer patients, of whom 297 were non-diabetic, 28 were type II diabetics who did not use metformin, and 16 were type II diabetics who used metformin. (naturalmedicinejournal.com)
Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer (ie, an epithelial tumor) that arises from basal cells (ie, small, round cells found in the lower layer of the epidermis). (medscape.com)

Molecular Cell paper provides evidence that FOXO3a triggers transcription of HIF1 target gene, which in turn inhibits HIF-1 induced apoptosis. (genengnews.com)
HIF-1 induced apoptosis in normal and breast cancer cells was inhibited due to FOXO3a stimulating the transcription of the HIF1 target gene, CITED2, according to Dr. Mak. (genengnews.com)
The idea is to disrupt every gene and screen to see if it's required for cell viability in culture. (blogspot.com)
One of the annoying things about all three papers is that they use the words "gene" and "protein-coding gene" as synonyms. (blogspot.com)
The HSP70 gene family encodes the major heat shock protein of molecular weight 70,000. (blogspot.com)
This is an example of the kind of gene that will be missed in the screen because the cells were not stressed during the screening. (blogspot.com)
Expression and CpG methylation of the BMP-2 gene were analyzed using RCC cell lines, and 96 matched RCC and normal renal tissues. (oncotarget.com)
Survival of motor neuron-related-splicing factor 30 is a protein that in humans is encoded by the SMNDC1 gene. (wikipedia.org)
Death-associated protein 6 also known as Daxx is a protein that in humans is encoded by the DAXX gene. (wikipedia.org)
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and the cytoplasm. (wikipedia.org)
Other studies showed that lack of Daxx gene caused a higher apoptotic rate in embryonic stem cells. (wikipedia.org)
When Treacher Collins syndrome results from variants in the TCOF1 or POLR1D gene, it is considered an autosomal dominant condition, which means one copy of the altered gene in each cell is sufficient to cause the disorder. (medlineplus.gov)
Autosomal recessive inheritance means both copies of the gene in each cell have variants. (medlineplus.gov)
What does this gene/protein do? (cancerindex.org)
Kat - What exactly is the protein, the gene that you're looking at that's faulty in these flies? (thenakedscientists.com)
In humans the protein is encoded by a single gene found near the inversion telomere of a large inverted region of CHROMOSOME 5. (harvard.edu)
Mutations in the gene coding for survival of motor neuron 1 protein may result in SPINAL MUSCULAR ATROPHIES OF CHILDHOOD. (harvard.edu)
Survival Motor Neuron Gene Copy Number Analysis by Exome Sequencing: Assisting Spinal Muscular Atrophy Diagnosis and Carrier Screening. (harvard.edu)
The requirement of Sin1 in cell survival, and in particular in neuronal survival, has not been established due to the early embryonic lethality of mice with a targeted deletion of the Sin1 gene. (bl.uk)
Gene-expression analysis of Sin1 knockout cortical neurons demonstrated an important down-regulation of transcription factors, cytoskeletal proteins and components of signalling pathways involved in neuronal survival, aiding to uncover the mechanism by which Sin1 promotes neuronal survival. (bl.uk)
With a minimalist model of metabolism, cell growth and transcriptional regulation in a microorganism, we explore how the interaction between environmental conditions and gene regulation set the growth rate of cells in the phase of exponential growth. (lu.se)
A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)
Clonal plasma cell proliferative diseases in which the Vl 6 gene is expressed are always associated with amyloid deposition. (medscape.com)
A highly expressed protein in tumor cells, encoded by Tpt1 gene. (bvsalud.org)

Scientists report that an evolutionarily conserved transcription factor may have both positive and negative effects on tumor growth depending on whether or not the tumor cells have enough oxygen. (genengnews.com)
In this study, a possible role of plasma interleukin-2 (IL-2), interleukin-6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) as biomarkers for survival of HNSCC patients was investigated. (diva-portal.org)
Our findings indicate that CRP and TNF-α might be suitable as biomarkers in combination with tumor TNM staging for predicting survival and individualized treatment of HNSCC patients. (diva-portal.org)
Higher levels of C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-α) were detected in plasma of the patients compared with the levels in the controls. (diva-portal.org)
Although a variety of studies have shown that Complement C11 binding protein (C1QBP) may play a tumor-promoting or tumor-suppressive role in cancer, the functions and mechanisms of C1QBP in HCC progression are under-investigating. (jcancer.org)
A significant association of BMP-2 mRNA expression was also found with advanced tumor stage and lymph node involvement, while lower BMP-2 mRNA expression was significantly associated with poor overall survival after radical nephrectomy. (oncotarget.com)
RNA binding motif protein 47 (RBM47) has been proven to have anti- tumor effects on many cancers , but its effect is not yet clear in renal cancer . (bvsalud.org)
A solitary extra copy of Dscr1 enhances survival of mice developing spontaneous lung tumors through suppression of tumor angiogenesis. (biomedigs.org)
Depletion of DKK3 in a mouse model of pancreatic cancer reduces proliferating tumor cells and prolongs survival by more than double. (medicalxpress.com)
The tumor-associated stroma is comprised mostly of pancreatic stellate cells (PSCs) and its density and possibly the cells themselves are thought to prevent current treatments from effectively killing the tumor. (medicalxpress.com)
Hwang's lab found DKK3 to be highly expressed in pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer , and specifically by PSCs rather than cancer cells, and her team discovered different ways to silence DKK3 from acting on cancer cells as well as immune cells in the tumor microenvironment. (medicalxpress.com)
Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma," Science Translational Medicine (2018). (medicalxpress.com)
Clear cell renal cell carcinoma (ccRCC) is the seventh most frequently diagnosed tumor in adults in Europe and represents approximately 2.5% of cancer deaths. (cancerindex.org)
The molecular biology underlying renal cell carcinoma (RCC) development and progression has been a key milestone in the management of this type of tumor. (cancerindex.org)
Calebin-A induced death of malignant peripheral nerve sheath tumor cells by activation of histone acetyltransferase. (cancerindex.org)
One mechanism behind chemo-resistance involves the upregulation of multidrug resistance (MDR) genes (ABC transporters) that effectively transport (efflux) drugs out of the tumor cells. (muni.cz)
To demonstrate relevance of our findings to ovarian cancer patients, we studied relative efflux in human ovarian cancer cells obtained from either patient ascites or from primary tumor. (muni.cz)
Efflux in ascites-derived human ovarian cancer cells is associated with increased expression of ABC transporters compared to that in primary tumor-derived human ovarian cancer cells. (muni.cz)
These cells grow out of control and form a mass or tumor. (medicinenet.com)
OSCC has paired human primary tumor cells and lymph node metastasis cells, making it a prime target for extracellular vesicle, or EV, analysis and for the search for molecular targets for the disease. (asbmb.org)
WNT5A act as both tumor promoter as well as tumor suppressor, depending on cell type. (lu.se)

MTT analysis, PI/Annexin V staining, transwell and metabolic flux assays were performed to examine the effects of C1QBP on proliferation, apoptosis, migration, invasion, and oxidative phosphorylation of HCC cells. (jcancer.org)
We also observed that ASK1DeltaN induced expression of several neuron-specific proteins and phosphorylation of neurofilament proteins, confirming that PC12 cells differentiated into mature neuronal cells by ASK1. (nih.gov)
The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. (wikipedia.org)
Immunoblotting was performed on the cell lysates to evaluate the effect of cerium oxide nanoparticle treatment on LPS induced changes in Mitogen Activated Protein Kinases (MAPK) p-38, ERK 1/2, and SAPK/JNK phosphorylation. (cdc.gov)
The loss of Sin1 significantly affected the phosphorylation and activity of Akt in fibroblasts and caused a reduction in cell survival by potentially inducing premature senescence. (bl.uk)
It catalyzes phosphorylation of serine and threonine on target proteins, converting adenosine triphosphate (ATP) to adenosine diphosphate (ADP). (news-medical.net)

Although multiple myeloma patients younger than 66 years of age have an aggressive presentation, this did not translate into an inferior overall survival, particularly in those undergoing autologous hematopoietic stem cell transplantation. (scielo.br)
The extremely low 5-year overall survival of patients is, in part, due to pancreatic cancer cells having several mechanisms of resistance to different chemotherapeutic treatments, one of which is their capacity to efficiently repair alkylating agent-induced DNA damage. (frontiersin.org)
Type II diabetes diagnosis and metformin usage were compared with progression-free survival (PFS), overall survival (OS), and chemotherapy resistance rate. (naturalmedicinejournal.com)
In this study Romero et al report that metformin use was associated with significantly longer progression-free survival and overall survival in ovarian cancer patients receiving standard treatments. (naturalmedicinejournal.com)
This is based on final overall survival results from the phase 3 randomized KEYNOTE-826 study , which showed that adding immunotherapy resulted in a 40% reduction in risk of death compared with chemotherapy alone for women with advanced cervical cancers expressing programmed cell death-ligand-1 (PD-L1). (medscape.com)
Patients in the report had a 5-year overall survival rate of 93.1%, although survival rates were lower in children who experienced symptoms, local recurrence, or metastasis or who did not undergo treatment with surgery or surgery plus radiotherapy. (medscape.com)
Kaplan-Meier analysis and the log rank test were applied to evaluate ovarian cancer-specific survival (OCSS) and overall survival (OS) in strata, according to SOX11 expression. (lu.se)

In paper I, a possible role of plasma cytokines or proteins associated with immune response or inflammation, as biomarkers for the survival of HNC patients was investigated. (diva-portal.org)
Consequently, the recruitment of immune cells during chronic inflammation increases oxidative stress (OS) in the microenvironment [ 2 ]. (hindawi.com)
However, if the linings of the sinuses have been breached by infection or irritants in the environment, then the IL-25 can access the underlying tissue, resulting in recruitment of additional immune cells and local inflammation. (sciencedaily.com)
GM-CSF, a protein that modifies the immune response to the flu, may also help reduce lung inflammation and improve survival during influenza, according to Penn State researchers. (news-medical.net)
When acid backwashes from the stomach into the lower esophagus, inflammation and cell damage may occur. (medicinenet.com)
Over a period of time, abnormal cells begin to form (metaplasia) and if the GERD is not treated and inflammation continues, the lining of the esophagus begins to change the way it looks and functions (dysplasia). (medicinenet.com)
NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)
The fibers irritate mesothelial cells, causing inflammation. (mesothelioma.com)

Loss-of-function assays showed that proliferation, migration and invasion of HCC cells were mitigated while cell apoptosis was augmented upon the loos of C1QBP. (jcancer.org)
Cancer cells demand high energy production to sustain their pathological increase in proliferation rate. (hindawi.com)
RBM47 overexpression could repress the migration, invasion activity, and proliferation capacity of renal cancer cells , while RBM47 inhibition could promote the development of the malignant features through EMT signaling by RNA stability modification. (bvsalud.org)
Recent evidence, however, supports a dual role for macrophages in the regulation of tumour proliferation and immune control 10 , 16 , and indicates that the local tissue microenvironment plays a critical role in determining cell phenotypes. (ersjournals.com)
Recent studies have revealed that AXL contributes to leukaemic phenotypes through activation of oncogenic signalling pathways that lead to increased cell migration and proliferation. (cancerindex.org)

We investigated whether impaired regulation of bone morphogenetic protein-2 (BMP-2) via epigenetic pathways is associated with renal cell carcinoma (RCC) pathogenesis. (oncotarget.com)
These data suggest that various nuclear mRNA export pathways, which may be indicated by different adaptor RNA binding proteins, exist in higher eukaryotes. (biomedcentral.com)
Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
AMPK pathways inhibit biosynthetic pathways with energy consumption, such as protein, fatty acid and glycogen synthesis. (springer.com)
NF-kB or similar pathways increase the survival and growth of mesothelial cells. (mesothelioma.com)
Our laboratory focusses on how WNT5A expression is regulated in these cancers and deciphering the WNT5A signaling pathways governing cancer cell migration and invasion. (lu.se)

ASK1 thus appears to mediate signals leading to both differentiation and survival of PC12 cells. (nih.gov)

The study also establishes the importance of studying proteins that leave cancerous cells for noncancerous targets within the body as possible therapeutic targets. (asbmb.org)

The members of this family encode proteins with 50 to 80% sequence identity to each other. (nih.gov)
The polycomb group of genes encode proteins that enhance cell survival. (aicr.org)

Demethylation was successfully performed using 5'-Aza-2'deoxycytidine (5-Aza-dC) resulting in SOX11 mRNA and protein expression in a previously negative EOC cell line. (lu.se)

It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1 (ETS1). (wikipedia.org)
Monocytes activated by tumour-derived microvesicles from pancreatic, colon and lung cancer cell lines have been found to show increased expression of human leukocyte antigen (HLA)-DR and a resulting increase in production of reactive oxygen intermediates and TNF-α 11 . (ersjournals.com)
These cells are reported to express the CD163 antigen 7 , 8 . (ersjournals.com)

Patients with monoclonal gammopathy of unknown significance, smoldering MM, plasma cell leukemia and amyloidosis were excluded. (scielo.br)
Amyloidosis is any of a group of disparate conditions characterized by extracellular deposition of insoluble fibrils composed of misaggregated proteins. (msdmanuals.com)
A number of normal (wild-type) and mutant proteins are susceptible to such misfolding and aggregation (amyloidogenic proteins), thus accounting for the wide variety of causes and types of amyloidosis. (msdmanuals.com)
For amyloidosis to develop, in addition to production of amyloidogenic proteins, there is probably also a failure of the normal clearance mechanisms for such misfolded proteins. (msdmanuals.com)
In systemic amyloidosis, circulating amyloidogenic proteins form deposits in a variety of organs. (msdmanuals.com)
Localized forms of amyloidosis appear to be caused by local production and deposition of an amyloidogenic protein (most often immunoglobulin light chains) within the affected organ rather than by deposition of circulating proteins. (msdmanuals.com)
Immunoglobulin-related amyloidosis is a monoclonal plasma cell disorder in which the secreted monoclonal immunoglobulin protein forms insoluble fibrillar deposits in one or more organs. (medscape.com)
Before the discovery that the major fibril component in these patients was an immunoglobulin fragment, patients with light chain-type amyloidosis were described as having primary (in the sense of idiopathic) amyloidosis or, when the burden of monoclonal plasma cells was large, myeloma-associated amyloidosis. (medscape.com)
Immunoglobulin L and H chains are two of 20 different fibril proteins that have been described in human amyloidosis. (medscape.com)
The relationship among light chain-type amyloidosis (AL), the other monoclonal plasma cell disorders, and the other amyloidoses. (medscape.com)
The most common light chain-type amyloidosis precursor proteins are L chains of the lambda (l) class. (medscape.com)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
Barrett's esophagus describes abnormal dysplasia and is thought to perhaps be a precursor to the development of further cell mutations and adenocarcinoma. (medicinenet.com)

Some of them are the protein-coding genes for RNA polymerase subunits, ribosomal proteins, enzymes of lipid metabolism, and many other enzymes. (blogspot.com)
Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)

Oxidative stress produces DNA damage and also induces responses, which could help the cell to restore the initial equilibrium. (hindawi.com)
But if this is not possible, oxidative stress finally activates signals that will lead to cell death. (hindawi.com)
The protein HMGB1 behaves as a redox sensor and its structural changes, which are conditioned by the oxidative environment, are associated with different functions of the protein. (hindawi.com)
This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. (hindawi.com)
The maintenance of the steady-state equilibrium between ROS generation and elimination is crucial for cell survival, while its loss causes cell death by different mechanisms triggered by oxidative damage. (hindawi.com)
Indeed, inhibition of the HSP60 release or HSP60-IKK interaction sensitizes the cancer cells to mild oxidative stress and regresses the tumorigenic growth of cancer cells in the mouse xenograft model. (ewha.ac.kr)
Thus, this study reveals a novel mitonuclear survival axis responding to oxidative stress. (ewha.ac.kr)

Daxx, a Death domain-associated protein, was first discovered through its cytoplasmic interaction with the classical death receptor Fas. (wikipedia.org)
At the level of the cell, Daxx is found in the cytoplasm, interacting with Fas-receptor or other cytoplasmic molecules, as well as in the nucleus, where it interacts with some subnuclear structures. (wikipedia.org)
Daxx interacts with the TGF-β type II receptor by binding of C-terminal domain of the protein. (wikipedia.org)
It tests negative for the three main targets of hormonal and protein receptor therapies: estrogen receptors, progesterone receptors and an upregulation of HER2 protein. (asbmb.org)
19 normal healthy in- receptor protein (CD117) that is structurally dividuals were recruited as a control group. (who.int)

Combination of upregulated CRP and TNF-α in the patient plasma was significantly related to shorter patient survival, independent of clinical stage. (diva-portal.org)
BMP-2 mRNA expression was significantly enhanced in RCC cells by 5-aza-2'-deoxycitidine treatment. (oncotarget.com)
In the extended survival group, M1 islet density was significantly increased compared with M2 density, 70% of islet macrophages were positive for M1 markers versus 38% for M2, and the islet:stromal ratio of M1 macrophages was markedly increased compared with M2. (ersjournals.com)
In particular, the loss of ALKBH6 in human pancreatic cancer cells increases alkylating agent-induced DNA damage and significantly decreases cell survival. (frontiersin.org)
AXL significantly promotes tumour cell migration, invasion and metastasis, as well as angiogenesis. (cancerindex.org)
Cell culture techniques were advanced significantly in the 1940s and 1950s to support research in virology . (wikipedia.org)
Survival significantly improved with this approach, regardless of PD-L1 expression, further supporting its use for all patients in this population," commented ASCO Expert Merry Jennifer Markham, MD, from the University of Florida in Gainseville. (medscape.com)

ASK1DeltaN-induced neurite outgrowth was strongly inhibited by treatment with the p38 inhibitor SB203580 but not with the MEK inhibitors, suggesting that activation of p38, rather than of ERK, is required for the neurite-inducing activity of ASK1 in PC12 cells. (nih.gov)
Immortalized cell lines developed from human ascites show increased susceptibility to efflux inhibitors (MRP1, BCRP) compared to a cell line derived from a primary ovarian cancer, suggesting an association between ascites and efflux function in human ovarian cancer. (muni.cz)
Some pharmaceutical companies are developing inhibitors of B-Raf protein as anticancer therapies. (news-medical.net)
Immunotherapy with programmed cell death protein-1 (PD-1) inhibitors had previously shown efficacy as monotherapy in second- or later-line therapy for women with cervical cancer, but KEYNOTE 826 was the first study to show a benefit to promoting immunotherapy to the front ranks. (medscape.com)

Adenocarcinoma is more common than squamous cell cancer in western countries, including the U.S. The reason for this change has yet to be determined. (medicinenet.com)

Metabolically active cells, neutrophils, and macrophages from the immune system produce high levels of ROS. (hindawi.com)
Targeting DKK3 in a pancreatic cancer mouse model boosted immune cell infiltration and more than doubled survival. (medicalxpress.com)
Researchers from the Perelman School of Medicine at the University of Pennsylvania have identified the source of the inflammatory cytokine Interleukin-25 (IL-25), an immune molecule that recruits a subset of inflammatory cells. (sciencedaily.com)
The more of these cells are present, the more likely the body will mount an inappropriate, exaggerated immune response due to elevated levels of IL-25. (sciencedaily.com)
At this protocol-specified final analysis of KEYNOTE-826, the addition of immune therapy to chemotherapy with or without the antiangiogenic bevacizumab showed substantial and clinically meaningful improvement in survival," said lead author Bradley J. Monk, MD, from HonorHealth Research Institute in Phoenix, Arizona. (medscape.com)
This project will grow brain immune cells call microglia from blood cells of people with ALS. (cdc.gov)

The researchers did find that the DNA sequences of other fungi code for proteins that could be considered Hsp12 "family members," and they identified one protein in human neurons that may have similar features. (mytum.de)
Cancer and neurodegeneration are detrimental conditions associated with an inappropriate regulation of cell survival and cell death, causing compromised cells to evade death or excessive death of healthy neurons. (bl.uk)
The role of Sin1 in regulating cell survival was evaluated in fibroblasts and cortical neurons. (bl.uk)
In contrast, the loss of Sin1 caused an increase in caspase-independent cell death in cortical neurons. (bl.uk)

Survival of Motor Neuron 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Survival of Motor Neuron 1 Protein" by people in Harvard Catalyst Profiles by year, and whether "Survival of Motor Neuron 1 Protein" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Survival of Motor Neuron 1 Protein" by people in Profiles. (harvard.edu)
Whole blood survival motor neuron protein levels correlate with severity of denervation in spinal muscular atrophy. (harvard.edu)

Combined, these changes may cause normal mesothelial cells to become cancerous. (mesothelioma.com)

41.0 months vs. OS not reached, P = 0.009) and poorer progression-free survival (28.0 months vs. 73.0 months, P = 0.031). (psu.edu)

Here, we report an unexpected messenger role for heat shock protein 60 (HSP60) as a mitochondrial-releasing protein factor that couples stress-sensing signaling and cell survival machineries. (ewha.ac.kr)

In the cytoplasm, the encoded protein may function to regulate apoptosis. (wikipedia.org)

The survival of HNC patients has only improved marginally during the last decade. (diva-portal.org)
The aim for this thesis was to investigate rapid and low cost blood based biomarkers which could indicate the risk of HNC, recurrence of the disease or the survival of HNC patients. (diva-portal.org)
Bioinformatic approaches were employed for checking the expression of C1QBP in HCC patient samples and the association between C1QBP mRNA expression and survival rates of patients with HCC or the promoter methylation of C1QBP . (jcancer.org)
Finally, we suggested that C1QBP is correlated with genes encoding ribosome RPL-related proteins and mitochondrial MRPL-related proteins in HCC patients. (jcancer.org)
C1QBP is correlated with a poor prognosis of HCC patients and promotes the survival, migration and invasion of HCC cells. (jcancer.org)
Although patients with HCC have been benefiting from the development of various effective therapeutic approaches, the five-year survival rate is still rather low (around 12% as reported in China) [ 2 ]. (jcancer.org)
Downregulation of RNA binding protein 47 predicts low survival in patients and promotes the development of renal cell malignancies through RNA stability modification. (bvsalud.org)
We retrospectively analyzed clinical characteristics, response to treatment and survival of 282 patients with active newly-diagnosed multiple myeloma, comparing results between patients younger and older than 65 years. (scielo.br)
Outcome and survival of myeloma patients diagnosed 2008-2015. (scielo.br)
The aims of the present study were to describe clinical features at diagnosis, response to treatment and survival in 282 patients with active newly-diagnosed MM (NDMM) and compare outcomes between patients younger and older than 65 years. (scielo.br)
There is a marked survival advantage for patients with nonsmall cell lung cancer (NSCLC) expressing high numbers of macrophages in their tumour islets. (ersjournals.com)
CD68 + macrophages expressing markers of a cytotoxic M1 phenotype or a noncytotoxic M2 phenotype were identified in the islets and stroma of surgically resected tumours from 20 patients with extended survival (median 92.7 months) and 20 with poor survival (median 7.7 months), using immunohistochemistry. (ersjournals.com)
The islet density of both M1 and M2 macrophages was markedly increased in extended compared with poor survival patients. (ersjournals.com)
Macrophages infiltrating the tumour islets in nonsmall cell lung cancer were predominantly of the M1 phenotype in patients with extended survival. (ersjournals.com)
Currently, even in patients with stage IA disease, the 5-yr survival after putatively curative surgical resection is only 67% 1 . (ersjournals.com)
The association between prognosis and islet macrophage count has been confirmed recently by others in an independent cohort of patients 5 but the stromal macrophage counts in that study were not associated with survival. (ersjournals.com)
Experimental Design: XRCC1 protein expression was assessed by immunohistochemical (IHC) staining of pretreatment tissue samples in 138 consecutive HNSCC patients treated with surgery (n = 31), radiation (15), surgery and radiation (23), surgery and adjuvant chemoradiation (17), primary chemoradiation (51), and palliative measures (1). (psu.edu)
In patients treated with nonchemoradiation modalities, there was no survival difference by XRCC1 expression. (psu.edu)
Conclusions: In HNSCC, high XRCC1 protein expression is associated with poorer survival, particularly in patients receiving chemoradiation. (psu.edu)
Furthermore, in silico analysis from The Cancer Genome Atlas (TCGA) database suggests that overexpression of ALKBH6 provides better survival outcomes in patients with pancreatic cancer. (frontiersin.org)
Here, we demonstrate that when cultured with ascites derived from ovarian cancer-bearing mice, a murine ovarian cancer cell line became less sensitive to paclitaxel, a first line chemotherapeutic agent for ovarian cancer patients. (muni.cz)
Trial patients had a median survival of about two years. (mesothelioma.com)
There's a tail to this [survival] curve, and I can't believe that in my lifetime we as a group, as a team, have sort of figured out ― and it's not enough ― that we can actually cure some patients, and if not maybe cure, have them at least live a long time, so it's exciting. (medscape.com)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)
Results: SOX11 expression was associated with an improved survival of patients with high grade EOC, although not independent of stage. (lu.se)
AL is caused by overproduction of an amyloidogenic immunoglobulin light chain in patients with a monoclonal plasma cell or other B cell lymphoproliferative disorder. (msdmanuals.com)
In most patients with a monoclonal plasma cell disorder, whether multiple myeloma or MGUS, the monoclonal L chain secreted by the clone remains soluble in the bloodstream. (medscape.com)
In contrast, WNT5A expression is associated with increased metastasis and reduced survival in melanoma patients. (lu.se)

Although drugs, for example a MEK inhibitor Refametinib [ 5 ], targeting key driver genes involved in HCC progression are being utilized for the clinical intervene, chemotherapy-resistance and the following cancer recurrence or metastasis still hinder the improvement of patient survival rates. (jcancer.org)
Dickkopf-3 (DKK3), is produced by the stromal cells but acts on the neighboring cancer cells to increase their growth, metastasis and resistance to therapy. (medicalxpress.com)

Using the adhesion frequency assay, the force-clamp lifetime assay, the thermal fluctuation assay, and the molecular stiffness assays the Zhu lab has applied these 2D assays to the studies of interactions of the T cell receptors, CD4/8 coreceptors, and co-stimulatory/co-inhibitory receptors with their respective ligands. (meduniwien.ac.at)
CD151 is a scaffolding protein that interacts with integrin receptors. (asbmb.org)

Base editing rescue of spinal muscular atrophy in cells and in mice. (harvard.edu)

Pathology can also provide researchers with insights into the details of mesothelioma cells. (mesothelioma.com)

This is the most abundant protein in the yeast S. cerevisiae under stress -- not only heat, but different kinds of stress -- and we found that it does not protect other proteins from unfolding or aggregation as other HSPs do. (mytum.de)

High mobility group B (HMGB) proteins have been previously related to the onset and progressions of cancers of different origins. (hindawi.com)
Nuclear factor-kappaB (NF-B) has a vital part in cell survival and inhibition of NF-B had proven to be an efficient restorative pathway for numerous cancers though little is usually known about the underlying mechanism. (biomedigs.org)

p = 0.001) and higher in those who received autologous hematopoietic stem cell transplantation. (scielo.br)
Multivariable analysis revealed that creatinine ≥2 mg/dl, extramedullary disease, ≤very good partial remission and non-autologous hematopoietic stem cell transplantation are independent risk factors for shorter survival. (scielo.br)
Thus we considered the hematopoietic system and found that seven days after poly injection, the number of blood cells in peripheral blood decreased drastically. (biomedcentral.com)
Second-line chemotherapy regimens vary, depending on whether hematopoietic stem cell transplantation (HSCT) is being considered. (medscape.com)

These proteins may accumulate locally, causing relatively few symptoms, or widely, involving multiple organs and causing severe multiorgan failure. (msdmanuals.com)
In addition to cases of monoclonal gammopathy in which the secreted clonal immunoglobulin remains in solution and those in which secreted clonal immunoglobulin forms amyloid deposits, a third group consists of cases in which the monoclonal proteins accumulate in various organs, but the deposits do not form fibrils. (medscape.com)

In contrast, the typical median survival time after completion of first-line chemotherapy is just 15 months. (naturalmedicinejournal.com)

RNA binding proteins (RBPs) are crucial for cell function, tissue growth , and disease development in disease or normal physiological processes . (bvsalud.org)
Thrombin-induced autoinhibitory element, Down syndrome crucial region-1, attenuates NFAT-dependent vascular cell adhesion molecule-1 manifestation and swelling in the endothelium. (biomedigs.org)

Here, we tested whether ALKBH6 plays a significant role in preventing alkylating DNA damage and decreasing genomic instability in pancreatic cancer cells. (frontiersin.org)
Overall, our data suggest that ALKBH6 is required to maintain the integrity of the genome and promote cell survival of pancreatic cancer cells. (frontiersin.org)

It has been associated with heterochromatin and PML-NBs (Promyelocytic Leukaemia nuclear bodies) and has been implicated in many nuclear processes including transcription and cell cycle regulation. (wikipedia.org)
Furthermore, mechanistically depletion of THOC5/Fms interacting protein causes the down-regulation of its direct interacting partner, THOC1 which may contribute to altered THO complex function and cell death. (biomedcentral.com)
Here, the function of regulation is quite clear: expressing energy and carbon, that a number around 0.2% would be the right genes at the right time will enable the cell to make the expected, and that the difference is more or less specific to the lac most of the resources within its reach, by maximizing the uptake operon [7]. (lu.se)

The surprising answer is revealed in the Aug. 27 issue of Molecular Cell, where German researchers explain how they discovered the function of Hsp12, a protective mechanism unlike any previously observed. (mytum.de)
Yet an exhaustive investigation led by Munich-based researchers has revealed that Hsp12 is structurally and functionally different from every other stress protein that has been studied before. (mytum.de)
Surprisingly, the researchers also found that IL-25 is secreted into mucus, not tissue, meaning an extra step is apparently required before the cells can go to work. (sciencedaily.com)
The researchers studied the survival and lung function of mice with influenza in the lab. (news-medical.net)
The researchers found that the mice with GM-CSF had a better chance of survival than the other mice. (news-medical.net)
Now researchers at MIT have discovered the vital role a protein, calprotectin, plays in this process, known as "nutritional immunity. (mit.edu)
This calcium effect was in line with previous work by the researchers, which had shown that the protein "morphs" into a far more effective scavenger of zinc and manganese ions when calcium is present. (mit.edu)
For example, researchers found a protein on the outside of several types of cancer cells in the 1990s. (mesothelioma.com)
Researchers previously have demonstrated that CD151 can activate extracellular signal-related proteins as well as the intercellular signaling cascade Akt/PKB, which promotes nontumor mammary cell replication. (asbmb.org)
The Vanderbilt researchers divided the protein into three fragments based on known domains: the N-terminal, middle and C-terminal fragments. (asbmb.org)

Aup1p is highly similar to a family of protein phosphatase homologs in animal cells that are predicted to localize to mitochondria based on sequence analysis. (huji.ac.il)
How similar are nonstructural proteins between coronavirus homologs? (asbmb.org)

However, the mechanisms behind their selectivity - e.g. how these proteins can perfectly discriminate between ions - is not entirely understood. (surrey.ac.uk)
The mechanisms by which cell death occurs are genetically encoded and carefully controlled. (cshlpress.com)
Chapters are additionally devoted to cell death signaling mechanisms in plants and lower organisms, as well as the evolution of those mechanisms and the influence of pathogens that seek to evade them. (cshlpress.com)

The ability to knock out human genes using CRISPR technology has opened to door to testing for essential genes in tissue culture cells. (blogspot.com)
The answer may lie in treating a protein found in the scar-type tissue called stroma which often surrounds the tumors. (medicalxpress.com)
In non-inflamed tissue, SCCs make up about one percent of human cells lining the sinuses. (sciencedaily.com)
Cell culture or tissue culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment. (wikipedia.org)
After the cells of interest have been isolated from living tissue , they can subsequently be maintained under carefully controlled conditions. (wikipedia.org)
Tissue culture commonly refers to the culture of animal cells and tissues, with the more specific term plant tissue culture being used for plants. (wikipedia.org)
In practice, the term "cell culture" now refers to the culturing of cells derived from multicellular eukaryotes , especially animal cells, in contrast with other types of culture that also grow cells, such as plant tissue culture , fungal culture, and microbiological culture (of microbes ). (wikipedia.org)
The historical development and methods of cell culture are closely interrelated to those of tissue culture and organ culture . (wikipedia.org)
The laboratory technique of maintaining live cell lines (a population of cells descended from a single cell and containing the same genetic makeup) separated from their original tissue source became more robust in the middle 20th century. (wikipedia.org)
[12] He suggested that the potentialities of individual cells via tissue culture as well as that the reciprocal influences of tissues on one another could be determined by this method. (wikipedia.org)
Since Haberlandt's original assertions, methods for tissue and cell culture have been realized, leading to significant discoveries in biology and medicine. (wikipedia.org)
Biodistribution of onasemnogene abeparvovec DNA, mRNA and SMN protein in human tissue. (harvard.edu)
Within the V region families, certain amino acid residues occurring at particular positions in the L-chain sequence render those chains are more amyloidogenic, with a combination of such residues increasing the chances of a particular L-chain protein being associated with tissue amyloid deposition. (medscape.com)

The proteins produced from the TCOF1 , POLR1C , and POLR1D genes all appear to play important roles in the early development of bones and other tissues of the face. (medlineplus.gov)
of certain cells involved in the development of facial bones and tissues. (medlineplus.gov)
When cancer cells develop in the tissues of this muscular tube, it is defined as esophageal cancer . (medicinenet.com)

Hou G, Lu Z, Wang Z, Yang X. The Mitochondrial Protein C1QBP Promotes Hepatocellular Carcinoma Progression by Enhancing Cell Survival, Migration and Invasion. (jcancer.org)
It actually promotes the survival of cells which is great in one sense, but also, you don't want to. (thenakedscientists.com)

However, whether ascites drives multidrug resistance in ovarian cancer cells awaits elucidation. (muni.cz)
Moreover, incubation of murine ovarian cancer cells in vitro with ascites drives efflux function in these cells. (muni.cz)
Preclinical data indicate that metformin may chemosensitize ovarian cancer cells to platinum therapy. (naturalmedicinejournal.com)

The diagnosis of diffuse large cell lymphoma is usually confirmed after positive findings are obtained from a lymph node biopsy specimen. (medscape.com)
There are more rare forms of cancer that affect the esophagus, including lymphoma , malignant melanoma , sarcoma, choriocarcinoma, and small cell cancer. (medicinenet.com)

We report here that expression of constitutively active ASK1 (ASK1DeltaN) induces neurite outgrowth in the rat pheochromocytoma cell line PC12. (nih.gov)
We found that p38 and to a lesser extent JNK, but not ERK, were activated by the expression of ASK1DeltaN in PC12 cells. (nih.gov)
Here, we demonstrated the expression and the prognostic role of RBM47 in public databases and clinical samples of clear cell renal carcinoma (ccRCC) with bioinformatics analysis . (bvsalud.org)
Daxx is uniformly expressed throughout the body, except in the testes and thymus, which have especially high expression of the protein. (wikipedia.org)
No expression of Daxx leads to malfunction of S phase and cells with two nuclei are formed. (wikipedia.org)
Myeloid related protein (MRP) 8/14 expression by macrophages is associated with the release of TNF-α 12 . (ersjournals.com)
During expression of protein-coding genes, pre-mRNAs are transcribed in the nucleus and undergo several RNA-processing steps. (biomedcentral.com)
They found increased expression levels of ITGB1, a known prognostic marker for cancer, and the protein CD151 in TNBC serum samples. (asbmb.org)

These proteins are involved in the production of a molecule called ribosomal RNA (rRNA), a chemical cousin of DNA. (medlineplus.gov)

The ability of fructose to promote cell survival through an allosteric metabolite thus provides additional insights into the excess adiposity generated by a Western diet, and a compelling explanation for the promotion of tumour growth by high-fructose corn syrup. (nature.com)
Thus, increasing numbers of macrophages within the tumour islets conferred a marked survival advantage, while increased numbers of macrophages in the tumour stroma were associated with worse prognosis. (ersjournals.com)
The M1 phenotype (classically activated) macrophages are thought to be induced by interferon-γ, with or without lipopolysaccharide and tumour necrosis factor (TNF)-α, and exert a cytotoxic effect against cancer cells. (ersjournals.com)
A novel human anti-AXL monoclonal antibody attenuates tumour cell migration. (cancerindex.org)
Furthermore, methylation-dependent silencing of SOX11 has been reported for B cell lymphomas and indicates that epigenetic drugs may be used to re-express this tumour suppressor, but information on SOX11 promoter methylation in EOC is still lacking. (lu.se)
Njainday's research focuses on WNT5A, and its role in tumour cell progression and plasticity. (lu.se)
In particular, the interchangeable modes of migration tumour cells utilise during invasion and the factors involved. (lu.se)

The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. (cancerindex.org)
It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). (cancerindex.org)
Sipeng Li and Xinya Li of Peking University and a research team in China reviewed literature establishing extracellular vesicles from TNBC as key players in cancer progression before focusing on the proteins transferred within those vesicles. (asbmb.org)
They determined that CD151 regulates the intracellular trafficking of proteins as well as regulating when the cell secretes these proteins using extracellular vesicles. (asbmb.org)

Our results reveal a pro-survival role for FOXO3a in normal cells and cancer cells that are adapting to hypoxic stress," explains Dr. Mak. (genengnews.com)
Several recent reports suggest that mitophagy is a selective process that targets damaged mitochondria, whereas other studies imply a role for mitophagy in cell death processes. (huji.ac.il)
Viability studies demonstrate that Aup1p is required for efficient survival of cells in prolonged stationary phase cultures, implying a pro-survival role for mitophagy under our working conditions. (huji.ac.il)
To study the role of THOC5/Fms interacting protein in vivo , we generated THOC5/Fms interacting protein knockout mice. (biomedcentral.com)
Ion channels in living cells are examples of where quantum effects can play a role in biology. (surrey.ac.uk)
Taken together, the results presented in this study show a key role of the scaffold protein Sin1 in regulating neuronal survival. (bl.uk)
What role does the protein CD151 play in triple-negative breast cancer? (asbmb.org)
Pemphigus vulgaris (PV) is a life-threate- disorders and to shed a light on the role of ning blistering skin disease in which pa- mast cells in autoimmune diseases [ 7 ]. (who.int)
CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)
Furthermore, overexpression of SOX11 in EOC cell lines confirmed the growth regulatory role of SOX11. (lu.se)
Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodelling processes in endothelial cells. (lu.se)

These monoclonal plasma cell disorders can be categorized according to the total body burden of monoclonal plasma cells. (medscape.com)

Kupffer cells, hepatic stellate cells and sinusoidal endothelium) and infiltrating leukocytes (e.g., monocytes, monocyte-derived macrophages, neutrophils and lymphocytes). (mdpi.com)

Tak W. Mak, Ph.D., from the Campbell Family Institute for Breast Cancer Research at Princess Margaret Hospital in Toronto, and colleagues found that hypoxia stimulates an HIF1-dependent increase in a protein called FOXO3a. (genengnews.com)
Cancer cells try to avoid the overproduction of reactive oxygen species by metabolic rearrangements. (hindawi.com)
In cancer cells, ROS production is mainly due to overexpression of the NADPH oxidase [ 3 ]. (hindawi.com)
While a balance between enhanced ROS production and detoxification can be maintained, cancer cells will proliferate and survive. (hindawi.com)
Commonly used radio- and chemotherapies are prooxidant strategies that alter cancer cells through ROS modulation and induce cell death [ 5 , 6 ]. (hindawi.com)
The biological functions of HMGB1 are diverse in normal cells and during the start and progression of cancer. (hindawi.com)
Consequently, several human diseases, including cancer and neurodegenerative disorders, are caused by defects in this highly regulated form of cell death. (nature.com)
Nonsmall cell lung cancer (NSCLC) is the most common cause of cancer-related death worldwide. (ersjournals.com)
The present authors have previously shown that the anatomical microlocalisation of macrophages in NSCLC strongly predicts patient survival, regardless of cancer stage 4 . (ersjournals.com)
Several alkylating agents are commonly used in chemotherapy but may induce DNA damage to cancer cells as well as normal cells. (frontiersin.org)
Obviously, there's a danger that you don't want to have cells living so long that they're actually replicating uncontrollably and you get into territories of cancer which is not good. (thenakedscientists.com)
Knockdown of MAGE-A6 enhanced the irradiation sensitivity of non-small cell lung cancer cells by activating the AMPK pathway. (nih.gov)
Esophageal cancer describes the disease where cells that line the esophagus change or mutate and become malignant . (medicinenet.com)
Squamous cells describe thin, flat cells that line the inner surface of the entire esophagus and this type of cancer may occur anywhere in the esophagus, though most are found in the upper half. (medicinenet.com)
This type of cancer arises from the glandular cells found in that area of the esophagus. (medicinenet.com)
Esophageal cancer occurs because changes occur in the DNA of cells that line the esophagus. (medicinenet.com)
Squamous cell cancer of the esophagus is related to the use of alcohol and tobacco products, both smoke and smokeless. (medicinenet.com)
In the past, squamous cell cancer was the most common worldwide, but that has changed. (medicinenet.com)
Bmi-1 is a protein that is over expressed in skin cancer cells. (aicr.org)
We champion the latest and most authoritative scientific research from around the world on cancer prevention and survival through diet, weight and physical activity, so that we can help people make informed lifestyle choices to reduce their cancer risk. (aicr.org)
Perturbations that enhance or suppress cell death may lead to cancer, neurodegeneration, and inflammatory diseases. (cshlpress.com)
This volume is therefore an essential reference for cell and developmental biologists, cancer biologists, and all who wish to explore recent progress in our understanding of cell death programs. (cshlpress.com)
While investigating the effect of human milk on bacterial adherence to a human lung cancer cell line, we were surprised to discover that the milk killed the cells. (lu.se)
That mutation has been found in papillary thyroid carcinoma, colorectal cancer, melanoma, and non-small cell lung cancer. (news-medical.net)
The possibility that a common, inexpensive, and relatively safe drug might have a profound impact on cancer survival has taken root in recent months. (naturalmedicinejournal.com)
The association of metformin usage with improved cancer survival may be surprising at first, given that diabetics have additional comorbidities and a higher overall risk of cancer mortality. (naturalmedicinejournal.com)
What group of proteins are candidates for targeting oral cancer? (asbmb.org)
Briefing co-moderater Julie R. Gralow, MD, chief medical officer and executive vice-president of ASCO, agreed that the survival benefit "is exciting to see, and in my long career as a breast medical oncologist, I'm pretty sure we cure some metastatic breast cancer. (medscape.com)
For example, in breast cancer loss of WNT5A protein is associated with poor survival. (lu.se)
Despite methodological differences, findings evidence that although IBC presents particular features (lower survival rate and worse prognostics than most types of breast cancer), very few studies examine its epidemiology and specific risk factors in depth and use any other therapeutic approaches than those commonly used for other breast cancer subtypes. (bvsalud.org)
With an average survival rate of three years, IBC accounts for about 2.5% of all breast cancer types in the US. (bvsalud.org)

The survival advantage conferred by islet macrophage infiltration may be related to their cytotoxic antitumour activity. (ersjournals.com)
Macrophage cells (RAW 264.7) were treated with a range of cerium oxide nanoparticle concentration in the presence and absence of LPS. (cdc.gov)

Committed myeloid progenitor cells and cells with long term reconstituting potential were lost from bone marrow within four days after poly injection. (biomedcentral.com)

ASK1 will be transported to the nucleus when UV-irradiation is used to treat the cell. (wikipedia.org)

They also believe it may be important to study variations in protein interactions among emerging SARS-CoV-2 variants. (asbmb.org)

Anatomy19

Organisms8

Diseases34

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Phenomena and Processes58

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science6

Health Care21

Squamous cell carc6

Kinase14

Cellular16

Amino acids1

Epithelial6

Gene24

Tumor21

Phosphorylation6

Overall survival7

Inflammation8

Proliferation5

Pathways6

Differentiation1

Importance of studying1

Encode2

MRNA and protein expression1

Antigen3

Amyloidosis11

Mutations2

Metabolism2

Oxidative7

Receptor5

Significantly7

Inhibitors4

Adenocarcinoma1

Immune6

Neurons4

Motor neuron4

Cancerous1

Progression-Free Sur1

Mitochondrial-releasi1

Regulate1

Patients29

Metastasis2

Receptors2

Spinal muscula1

Pathology1

Aggregation1

Cancers2

Hematopoietic4

Accumulate2

Median1

Crucial2

Pancreatic2

Regulation3

Researchers10

Homologs2

Mechanisms3

Tissue13

Tissues3

Promotes2

Ovarian3

Lymphoma2

Expression8

Ribosomal1

Tumour7

Extracellular4

Role11

Monoclonal plasma cell1

Lymphocytes1

Cancer31

Macrophage2

Myeloid proge1

ASK11

Variants1