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CarboxylesteraseCarboxylic Ester HydrolasesParaoxonProdrugsEsterasesHydrolysisPhenylmethylsulfonyl FluorideIsoflurophateCamptothecinPalmitoyl-CoA HydrolaseNitrophenolsMalathionCaprolactamMicrosomes, LiverPhenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) EsterPyrethrinsUmbelliferonesAntineoplastic Agents, PhytogenicChemical Warfare AgentsInsecticide ResistanceSomanOrganophosphatesNaphthaleneacetic AcidsButyrylcholinesteraseAcetyl-CoA HydrolaseChlorpyrifosSubstrate SpecificityAlicyclobacillusUrethaneEstersMonoacylglycerol LipasesCholinesterase InhibitorsLiverCholatesBiotransformationInsecticidesHydroxymercuribenzoatesMolecular Sequence DataLoperamideOchrobactrum anthropiAcetylcholinesteraseAmino Acid SequenceOrganophosphorus CompoundsAntibodies, MonoclonalImmunomagnetic SeparationAntibody SpecificityEpitopes
PhospholipaseEsterasePutativeEnzymeSource:HGNC SymboHypothetical proteinSpeciesSequenceNCBICentrosomal proteinRecombinantFamilySubstrateEnzymesAcyl-carrierGeneticLiverReceptorMutationsSpliceResiduesRibosomalEncodesCarbamateCellularDeficiencyActivityBacteriumCytoplasmBiomarkersInflammationHumanExpressionBindTRNA
Phospholipase1
  • syringae (strain B728a) phospholipase/carboxylesterase precursor , pseu2-q4zs84 Pseudomonas syringae pv. (inrae.fr)
Esterase4
  • The protein is also historically known as serine esterase 1 (SES1), monocyte esterase and cholesterol ester hydrolase (CEH). (wikipedia.org)
  • Carboxylesterase 1 is a serine esterase and member of a large multigene carboxylesterase family. (wikipedia.org)
  • esterase fromdeep-sea hydrothermal vent of the East Pacific Rise (EprEst) uncultured bacterium pet-28a est-OKK esterase , 9bact-a0a0k1z4z5 uncultured bacterium Alpha/beta hydrolase fold protein LIPESV12_26 , 9bact-g3c5s4 uncultured bacterium. (inra.fr)
  • syringae (strain B728a) esterase/lipase/thioesterase family protein , pseu2-q4zuv2 Pseudomonas syringae pv. (inrae.fr)
Putative4
  • syringae (strain B728a) putative hydrolase signal peptide protein , pseu2-q4zt74 Pseudomonas syringae pv. (inrae.fr)
  • Putative neuronal cell surface protein involved in cell-cell-interactions. (nih.gov)
  • 10614) putative ABC transport system permease protein BBZA01000001 CDS ARMA_0010 complement(10625. (go.jp)
  • 11353) putative ABC transport system ATP-binding protein BBZA01000001 CDS ARMA_0011 complement(11350. (go.jp)
Enzyme9
  • Liver carboxylesterase 1 also known as carboxylesterase 1 (CES1, hCE-1 or CES1A1) is an enzyme that in humans is encoded by the CES1 gene. (wikipedia.org)
  • Microsomal carboxylesterase activity in lung microsomes from 10 patients ranged from 19.02 ± 2.28 to 48.18 ± 4.34 nmol/mg protein/min, and was significantly decreased (25-45%) in microsomes incubated with phenylmethylsulfonyl fluoride, an inhibitor of the carboxylesterase enzyme. (aspetjournals.org)
  • Irinotecan (CPT-11) is an anticancer agent for the treatment of colon cancer, CPT-11 can be considered as a prodrug, since it needs to be activated into the toxic drug SN-38 by the enzyme carboxylesterase. (johnshopkins.edu)
  • In addition a secreted tumour-targeted form of carboxylesterase should prevent leakage of the enzyme from the site of the tumour into the circulation. (johnshopkins.edu)
  • The protein was secreted by transfected cells and showed both enzyme activity and efficient CPT-11 activation. (johnshopkins.edu)
  • From NCBI Gene: This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. (nih.gov)
  • Because of high levels in the urine of male domestic cats, this enzyme is also called cauxin (carboxylesterase-like urinary excreted protein). (nih.gov)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Peripheral Myelin Protein 22 (PMP22) in tissue homogenates, cell lysates and other biological fluids. (worldcarecouncil.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Peripheral Myelin Protein 22 (PMP22) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (worldcarecouncil.org)
Source:HGNC Symbo1
Hypothetical protein45
  • 4628 hypothetical protein BBZA01000001 CDS ARMA_0005 5077. (go.jp)
  • 5685 hypothetical protein BBZA01000001 CDS ARMA_0006 5873. (go.jp)
  • 7021 hypothetical protein BBZA01000001 CDS ARMA_0007 complement(7097. (go.jp)
  • 7504) hypothetical protein BBZA01000001 CDS ARMA_0008 complement(7590. (go.jp)
  • 11958) hypothetical protein BBZA01000001 CDS ARMA_0012 12170. (go.jp)
  • 578 hypothetical protein BBZA01000002 CDS ARMA_0016 684. (go.jp)
  • 2342 hypothetical protein BBZA01000002 CDS ARMA_0017 2339. (go.jp)
  • 3094 hypothetical protein BBZA01000002 CDS ARMA_0018 3478. (go.jp)
  • 4371 hypothetical protein BBZA01000002 CDS ARMA_0019 complement(4468. (go.jp)
  • 5751) hypothetical protein BBZA01000002 CDS ARMA_0021 complement(5880. (go.jp)
  • 6020) hypothetical protein BBZA01000002 CDS ARMA_0020 6069. (go.jp)
  • 7490 hypothetical protein BBZA01000002 CDS ARMA_0022 complement(7569. (go.jp)
  • 10130) hypothetical protein BBZA01000002 CDS ARMA_0023 10363. (go.jp)
  • 12985 hypothetical protein BBZA01000002 CDS ARMA_0025 13067. (go.jp)
  • 13828 hypothetical protein BBZA01000002 CDS ARMA_0026 13840. (go.jp)
  • 15584 hypothetical protein BBZA01000003 CDS ARMA_0028 complement(2147. (go.jp)
  • 2662) hypothetical protein BBZA01000003 CDS ARMA_0030 complement(2909. (go.jp)
  • 3070) hypothetical protein BBZA01000003 CDS ARMA_0029 3089. (go.jp)
  • 3247 hypothetical protein BBZA01000003 CDS ARMA_0031 3817. (go.jp)
  • 11054 hypothetical protein BBZA01000003 CDS ARMA_0036 11082. (go.jp)
  • 11983 hypothetical protein BBZA01000003 CDS ARMA_0038 complement(11960. (go.jp)
  • 12616) hypothetical protein BBZA01000003 CDS ARMA_0039 12726. (go.jp)
  • 13859 hypothetical protein BBZA01000003 CDS ARMA_0040 13859. (go.jp)
  • 14554 hypothetical protein BBZA01000003 CDS ARMA_0041 14582. (go.jp)
  • 15289 hypothetical protein BBZA01000003 CDS ARMA_0042 15306. (go.jp)
  • 15746 hypothetical protein BBZA01000003 CDS ARMA_0043 complement(15750. (go.jp)
  • 16253) hypothetical protein BBZA01000003 CDS ARMA_0044 complement(16376. (go.jp)
  • 16723) hypothetical protein BBZA01000003 tRNA ARMA_tRNA01 complement(16745. (go.jp)
  • 17762 hypothetical protein BBZA01000003 CDS ARMA_0046 17875. (go.jp)
  • 19373 hypothetical protein BBZA01000003 CDS ARMA_0048 complement(19431. (go.jp)
  • 20651) hypothetical protein BBZA01000003 CDS ARMA_0049 20873. (go.jp)
  • 21793 hypothetical protein BBZA01000003 CDS ARMA_0050 21812. (go.jp)
  • 24549 hypothetical protein BBZA01000003 CDS ARMA_0052 24709. (go.jp)
  • 25812 hypothetical protein BBZA01000003 CDS ARMA_0053 25854. (go.jp)
  • 27638 hypothetical protein BBZA01000003 CDS ARMA_0054 27690. (go.jp)
  • 29561 hypothetical protein BBZA01000003 CDS ARMA_0055 29551. (go.jp)
  • 30963 hypothetical protein BBZA01000003 CDS ARMA_0056 30956. (go.jp)
  • 32158 hypothetical protein BBZA01000003 CDS ARMA_0057 32158. (go.jp)
  • 35130 hypothetical protein BBZA01000003 CDS ARMA_0058 35127. (go.jp)
  • 35501 hypothetical protein BBZA01000003 CDS ARMA_0059 35523. (go.jp)
  • 38051 hypothetical protein BBZA01000003 CDS ARMA_0060 38048. (go.jp)
  • 38443 hypothetical protein BBZA01000003 CDS ARMA_0061 38445. (go.jp)
  • 40466 hypothetical protein BBZA01000003 CDS ARMA_0063 complement(40556. (go.jp)
  • 42784) hypothetical protein BBZA01000004 CDS ARMA_0066 23. (go.jp)
  • 493 hypothetical protein BBZA01000004 CDS ARMA_0067 664. (go.jp)
Species3
  • Protein levels in sputum were determined by ELISA, and As species were analyzed in first morning void urine. (nih.gov)
  • Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EEB1 . (yeastrc.org)
  • Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 16.8 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
Sequence4
  • The protein contains an amino acid sequence at its N-terminus that sends it into the endoplasmic reticulum where a C-terminal sequence can bind to a KDEL receptor. (wikipedia.org)
  • The material has not been definitively identified, but it has been reported to react to antibodies for carboxylesterase and the Ym1 sequence of the Ym2 protein. (nih.gov)
  • We have constructed a secreted form of human liver carboxylesterase-2 by deletion of the cellular retention signal and by cloning the cDNA downstream of an Ig kappa leader sequence. (johnshopkins.edu)
  • To obtain a secreted, tumour-targeted form of carboxylesterase-2 the cDNA encoding the human scFv antibody C28 directed against the epithelial cell adhesion molecule EpCAM, was inserted between the leader sequence and carboxylesterase-2. (johnshopkins.edu)
NCBI1
  • Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
Centrosomal protein2
Recombinant4
  • CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
  • Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
  • In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
  • Importantly, in combination with CPT-11 both recombinant carboxylesterase proteins exerted strong antiproliferative effects on human colon cancer cells. (johnshopkins.edu)
Family6
  • Carboxylesterase 1 is a member of a large family of carboxylesterases that are responsible for the hydrolysis of ester and amide bonds (1, 2). (rndsystems.com)
  • The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. (cancerindex.org)
  • This gene encodes a member of the carboxylesterase large family. (nih.gov)
  • Carboxylesterase BioH family. (expasy.org)
  • This gene encodes a member of the type-B carboxylesterase/lipase protein family. (nih.gov)
  • The encoded protein belongs to a family of neuronal cell surface proteins. (nih.gov)
Substrate1
  • β-Nap-caprylate MOLECULAR BIOLOGY GRADE White to off-white crystalline powder Chromogenic substrate for carboxylesterase and lipase. (thomassci.com)
Enzymes3
  • Previous studies have shown that CYP2E1 and carboxylesterase enzymes contributed to vinyl carbamate (VC) metabolism in murine lung. (aspetjournals.org)
  • Here we have tested the hypothesis that CYP2E1 and carboxylesterase enzymes are involved also in VC metabolism in human lung. (aspetjournals.org)
  • Over the last years, several protein engineering strategies have been reported to tailor the enzymes for the non-natural polymeric substrates, thus improving the enzymatic hydrolysis of synthetic polymers. (frontiersin.org)
Acyl-carrier1
  • 14478 3-oxoacyl-[acyl-carrier protein] reductase fabG BBZA01000001 CDS ARMA_0014 complement(14430. (go.jp)
Genetic2
  • Lamarckian genetic algorithm methodology was employed for docking of 12 ligands with 13 different target proteins using AutoDock 4.2 program. (dovepress.com)
  • Association study of genetic polymorphisms in proteins involved in oseltamivir transport, metabolism, and interactions with adverse reactions in Mexican patients with acute respiratory diseases. (cdc.gov)
Liver3
  • Mice were sacrificed and the following parameters were analyzed: whole blood gene expression, blood and bronchoalveolar lavage (BAL) differentials, serum protein profiling by immunoplex and proteomics, and gene expression analysis in the lung and extrapulmonary tissues including aorta, heart and liver. (cdc.gov)
  • This was followed by an acute phase response including CRP, SAA-1, SAP and haptoglobin as shown by elevated serum protein levels and liver gene expression. (cdc.gov)
  • At 28d, serum acute phase proteins with immune function including complement C3, apolipoprotein A-I and A-II, alpha2-marcoglobulin, serotransferrin and liver carboxylesterase N were increased. (cdc.gov)
Receptor3
  • Proteins in mouse lung-lining fluid whose expression was consistently altered by As included glutathione- S -transferase (GST)-omega-1, contraspin, apolipoprotein A-I and A-IV, enolase-1, peroxiredoxin-6, and receptor for advanced glycation end products (RAGE). (nih.gov)
  • 18. Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma. (nih.gov)
  • G protein-coupled receptor. (gsea-msigdb.org)
Mutations1
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
Splice1
Residues1
  • This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. (nih.gov)
Ribosomal2
  • 23209 ribosomal protein S12 methylthiotransferase rimO BBZA01000003 CDS ARMA_0051 23344. (go.jp)
  • Ribosomal protein L11, N-terminal [Interproscan]. (ntu.edu.sg)
Encodes2
  • Encodes a protein with 3-deoxy-8-phosphooctulonate synthase (KDOP synthase) activity which is involved in the biosynthesis of KDO, a component of cell wall rhamnogalacturonan II. (or.jp)
  • Encodes a Fhit protein. (or.jp)
Carbamate1
  • In this study, a protein annotated as a carbamate C-N hydrolase was identified in the methomyl-degrading strain Aminobacter aminovorans MDW-2, and the encoding gene was termed ameH. (usda.gov)
Cellular2
  • His laboratory recently discovered a cellular phenomenon termed "exodosis" which occurs when resident proteins within a cell's endoplasmic reticulum are secreted in response to calcium depletion. (nih.gov)
  • Here we examine the secretion of ER-resident proteins and activation of the UPR under combined exposure to MDMA and caffeine in a cellular model of hyperthermia. (nih.gov)
Deficiency2
  • Carboxylesterase 1 deficiency may be associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia. (wikipedia.org)
  • Deficiency of the small mitochondrial protein frataxin causes Friedreich's ataxia, a severe neurodegenerative pathology. (cnr.it)
Activity4
  • The inhibition kinetics of dichlorvos on carboxylesterase and acetylcholinesterase (AChE) activity extracted from Liposcelis bostrychophila and L. entomophila (Psocoptera: Liposcelididae) were compared. (bioone.org)
  • The results showed that L. entomophila had significantly greater specific activity of carboxylesterase than L. bostrychophila (0.045 versus 0.012 µmoles /mg /min). (bioone.org)
  • NDMA demethylase activity in lung microsomes from 10 patients ranged from 36.9 ± 1.0 to 82.4 ± 2.4 pmol/mg protein/min. (aspetjournals.org)
  • Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). (nih.gov)
Bacterium20
  • Lipolytic protein estC55-165 , 9bact-estC55.241 uncultured bacterium. (inra.fr)
  • Lipolytic protein estC55-241 , 9bact-estC76.137 uncultured bacterium. (inra.fr)
  • Lipolytic protein estC55-25 , 9bact-estC55.76 uncultured bacterium. (inra.fr)
  • Lipolytic protein estC55-76 , 9bact-estC55.20 uncultured bacterium. (inra.fr)
  • Lipolytic protein , 9bact-estC55.4n1 uncultured bacterium. (inra.fr)
  • Lipolytic protein , 9bact-estC76.263 uncultured bacterium. (inra.fr)
  • Lipolytic protein estC55-100 estC76-263 , 9bact-estC55.227 uncultured bacterium. (inra.fr)
  • Lipolytic protein estC55-227 , 9bact-estC55.159 uncultured bacterium. (inra.fr)
  • Lipolytic protein estC55-159 , 9bact-estC55.51 uncultured bacterium. (inra.fr)
  • Lipolytic protein estC55-51 , 9bact-estC55.31 uncultured bacterium. (inra.fr)
  • Lipolytic protein estC55-31 , 9bact-estC55.215 uncultured bacterium. (inra.fr)
  • Lipolytic protein estC55-215 , 9bact-estC55.244 uncultured bacterium. (inra.fr)
  • Lipolytic protein estC55-244 , 9bact-estC55.81 uncultured bacterium. (inra.fr)
  • Lipolytic protein estC55-81 , 9bact-estC55.15 uncultured bacterium. (inra.fr)
  • Lipolytic protein estC55-15 , 9bact-estC55.231 uncultured bacterium. (inra.fr)
  • Lipolytic protein estC55-231 , 9bact-estC76.266n2 uncultured bacterium. (inra.fr)
  • Lipolytic protein estC76-28_2 estC76-266_2 , 9bact-estC76.28n1 uncultured bacterium. (inra.fr)
  • Lipolytic protein estC76.28_1 , 9bact-estC76.177 uncultured bacterium. (inra.fr)
  • Lipolytic protein estC76-266_1 , 9bact-estC76.248 uncultured bacterium. (inra.fr)
  • Alpha/beta hydrolase fold protein , 9bact-estC55.96 uncultured bacterium. (inra.fr)
Cytoplasm1
  • The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. (nih.gov)
Biomarkers2
  • Our objective was to identify potential pulmonary protein biomarkers in the lung-lining fluid of mice chronically exposed to low-dose As and to validate these protein changes in human populations exposed to As. (nih.gov)
  • Biomarkers of CPO exposure inhibited in maternal tissues included brain acetylcholinesterase (AChE), red blood cell acylpeptide hydrolase (APH), and plasma butyrylcholinesterase (BChE) and carboxylesterase (CES). (nih.gov)
Inflammation1
  • 1 Neurodegeneration in AD, and other neurodegenerative diseases appear to be multifactorial, in that a complex set of deleterious reactions including glutamatergic neurotoxicity, increases in iron and nitric oxide, reduced expression of trophic factors, dysfunction of the ubiquitin-proteasome system, depletion of endogenous antioxidants, expression of proapoptotic proteins, and inflammation leads to the decease of neurons. (dovepress.com)
Human2
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Peripheral Myelin Protein 22 (PMP22) in samples from tissue homogenates, cell lysates or other biological fluids. (worldcarecouncil.org)
  • Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1. (nih.gov)
Expression2
  • An inducer of ß-galactosidase used to promote the expression of proteins in cells controlled by the lac operator system. (thomassci.com)
  • Hyperthermia activates the UPR but the addition of MDMA or caffeine does not alter the canonical UPR gene expression despite the drug effects on ER exodosis of UPR-related proteins. (nih.gov)
Bind1
  • We have related how such an ability to bind cations on a relatively large area through an electrostatic mechanism could be a valuable asset for protein function. (cnr.it)
TRNA2
  • protein_coding" "Cz03g05060.t1","No alias","Chromochloris zofingiensis","tRNA methyltransferase TRMD/TRM10-type domain [Interproscan]. (ntu.edu.sg)
  • protein_coding" "Cz08g16110.t1","No alias","Chromochloris zofingiensis","tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14 [Interproscan]. (ntu.edu.sg)