Propionibacterium fulminans acne vulgaris. Medical search. Frequent questions

If left untreated, Cutibacterium acnes bacteria can flourish causing comedones to degrade to papules or pustules as the bacteria breaks down the follicle walls and spreads, triggering a response from the immune system. (dermcollective.com)
There is no specific Cutibacterium acnes phylotype associated with acne fulminans, which may indicate that the acute inflammation associated with the disease may be more related to an abnormal cutaneous innate immunity activation, according to study results published in the Journal of the European Academy of Dermatology and Venereology . (dermatologyadvisor.com)

It can be the dermatologic manifestation of the synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome. (medscape.com)
Psoriatic rheumatism and a related new entity, SAPHO, synovitis-acne-pustulosis-hyperostosis-osteitis syndrome]. (globale-dermatologie.com)

Some authors note that elevated blood levels of testosterone may play an important role in the pathogenesis of acne fulminans. (medscape.com)
The influence of genetics and environmental factors in the pathogenesis of acne: a twin study of acne in women. (bmj.com)

[ 3 ] Acne fulminans is a syndrome of fulminant, necrotizing acne associated with bone lesions, constitutional symptoms, and laboratory abnormalities. (medscape.com)
Granulomas and crusted acne lesions in acne fulminans. (medscape.com)
Chronic inflammation in acne fulminans, characteristic to acne lesions, can also be accompanied by angiogenesis. (medscape.com)
Ultrastructural observations in acne vulgaris: the normal sebaceous follicle and acne lesions. (bmj.com)
Severe acne types include cystic and nodular acne which forms deep within tissue and is characterized by widespread, painful inflamed lesions. (dermcollective.com)
These are plugs of oil, dead skin cells and debris that form in hair follicles (pores) and are considered noninflammatory acne lesions. (dermcollective.com)
All these effects work together to help clear skin of acne lesions and help prevent future flare-ups. (dermcollective.com)
Acne is classified by its severity as well as the type of lesions present. (dermcollective.com)
Unlike comedones, papules and pustules which are superficial acne lesions, nodules and cysts can cause permanent damage to the skin. (progressivehealth.com)
elevated levels of IGF-1 (see insulin-like growth factor ) correlate with the total number of acne lesions. (altmeyers.org)
Closed comedones are the precursor lesions to inflammatory acne. (msdmanuals.com)

The grade and severity of the acne help in determining which of the following treatments, alone or in combination, is most appropriate. (medscape.com)
Depending on the severity of the breakout, acne can be classified as mild , moderate or severe. (progressivehealth.com)
In Germany, 70-80% of all adolescents show signs of acne vulgaris of varying severity. (altmeyers.org)
Bacteriologic samples were taken from each patient to analyze C acnes phylotype distribution and the therapeutic response was assessed using the Echelle de Cotation des Lésions d'Acné and Global Acne Severity scales. (dermatologyadvisor.com)

See Acne Conglobata , Acne Keloidalis Nuchae , Acne Vulgaris , and Acneiform Eruptions for complete information on these topics. (medscape.com)

Acne fulminans (AF), also known as acne maligna, was originally described as acute febrile ulcerative acne conglobata (AC). (medscape.com)
In 1958, at a meeting of the Detroit Dermatological Society, Burns and Colville presented a 16-year-old white boy with acute febrile disease and acne conglobata. (medscape.com)
Acne conglobata of the buttocks aggravated by mechanical and environmental factors. (globale-dermatologie.com)
Acne conglobata is a severe form of acne vulgaris. (progressivehealth.com)
What is Acne Conglobata? (progressivehealth.com)
Acne conglobata affects mostly men around between the ages of 18 and 30. (progressivehealth.com)
The cause of acne conglobata is unknown but since it appears mainly in men, it is believed to be caused high levels of androgens such as testosterone. (progressivehealth.com)
Another support for this theory comes from the fact that acne conglobata is commonly seen in men who abuse anabolic steroids and those who have recently stopped testosterone therapies. (progressivehealth.com)
People with androgen-releasing tumors, women with PCOS (polycystic ovarian syndrome) or those with Cushing's syndrome have a very high risk of developing acne conglobata. (progressivehealth.com)
Studies have also shown that acne conglobata runs in some families. (progressivehealth.com)
This points to a genetic cause and in fact, defects in XYY karyotype or chromosomal composition have been associated with severe forms of acne conglobata. (progressivehealth.com)
Yet another cause of acne conglobata is believed to be changed sensitivity of the skin to the acne-causing bacteria such as Propionibacterium acnes . (progressivehealth.com)
This last theory is the basis of antibiotic use in the treatment of acne conglobata. (progressivehealth.com)
Acne conglobata starts with blackheads appearing on the face in clusters of 2 - 3 comedones. (progressivehealth.com)
However, the large, engorged pimples of acne conglobata rupture and spread further. (progressivehealth.com)
Acne conglobata can leave either pitted, atrophic scars (with tissue loss like the typical ice pick acne scars) or raised, hypertrophic (with keloid structures formed from excess collagen as the body overcompensates for tissue loss). (progressivehealth.com)
While acne conglobata is a rare disease, acne arthritis due to acne conglobata is even rarer. (progressivehealth.com)
In severe cases (acne conglobata ), follicular ruptures due to comedone components lead to pronounced inflammatory processes deep into the dermis, with furunculoid, often confluent, painful abscesses (acne conglobata ). (altmeyers.org)

Severe acne can be notoriously difficult to treat because the inflammation is both deep within the dermis and extensive. (dermcollective.com)
This approach aims to kill C. acnes bacteria and calm inflammation, reduce sebum-producing activity, clear skin of pore-clogging debris and dead skin cells, and normalize hormone levels. (dermcollective.com)
Severe acne causes widespread inflammation which is likely to cause extensive scarring. (dermcollective.com)
Nodular acne develops when acne bacteria multiply and spread deep within skin tissue resulting in widespread inflammation and the formation of cysts and large, hard nodules. (dermcollective.com)
When the acne breakout is mild or moderate, there is only a little skin inflammation and a lot of papules, pustules and acne comedones such as whiteheads and blackheads . (progressivehealth.com)
Acne vulgaris is the formation of comedones, papules, pustules, nodules, and/or cysts as a result of obstruction and inflammation of pilosebaceous units (hair follicles and their accompanying sebaceous gland). (msdmanuals.com)
They recommended systemic corticosteroids from the onset of acne fulminans for rapid inflammation control. (dermatologyadvisor.com)

Acne vulgaris first presents as comedones, in the form of whiteheads or blackheads . (dermcollective.com)
It is described as an inflammatory skin disease presenting with acne comedones, nodules, inflamed pus-filled tissues and draining sinus tracts. (progressivehealth.com)
Blackheads are acne comedones which leave dark spots on the skin. (progressivehealth.com)
Papules and pustules occur when C. acnes colonizes the closed comedones, breaking down sebum into free fatty acids that irritate the follicular epithelium and eliciting an inflammatory response by neutrophils and then lymphocytes, which further disrupts the epithelium. (msdmanuals.com)

Regardless of strain, systemic corticosteroids and adjunctive isotretinoin were found to be the most effective treatment for acute acne fulminans. (dermatologyadvisor.com)
Systemic corticosteroids were given as first-line treatment in patients with (n=9) and without (n=6) isotretinoin-induced acne fulminans. (dermatologyadvisor.com)
The main subtype was acne fulminans with systemic symptoms, and most patients were treated with systemic corticosteroids. (bvsalud.org)

As a result of the plug-like closure of the follicular excretory duct and simultaneous seborrhea, the sebum is backed up into the follicular gland unit = comedo (acne comedonica ). (altmeyers.org)
Follicular pustules (acne papulopustulosa ) develop due to purulent melting. (altmeyers.org)

[ 7 ] In addition to testosterone, isotretinoin may also precipitate acne fulminans, possibly related to highly increased levels of C acnes (formerly P acnes ) antigens in the patient's immune system. (medscape.com)
Acne: therapeutic perspectives with an emphasis on the role of isotretinoin. (globale-dermatologie.com)
Treatment of severe acne with isotretinoin in patients with inflammatory bowel disease. (globale-dermatologie.com)
Of the patients, 9 (60%) had isotretinoin-induced acne fulminans . (dermatologyadvisor.com)
The median initial dose for patients with isotretinoin-induced acne fulminans was 0.47 mg/kg/day, and the median total treatment duration was 12.75 months. (dermatologyadvisor.com)

therapeutic agents include topical acne medications, systemic retinoids, hormonal therapy and antibiotics. (dermcollective.com)

Benzoyl peroxide products are also effective against C acnes , and bacterial resistance to benzoyl peroxide has not been reported. (medscape.com)

Acne may be the only clinical sign of androgen excess in men, and one report is available about a boy with acne fulminans and androgen excess due to late-onset congenital adrenal hyperplasia. (medscape.com)
Ovulatory patterns in women with juvenile and late-onset/persistent acne vulgaris. (globale-dermatologie.com)

Inflammatory acne develops when sebum (an oily substance secreted from the sebaceous glands to protect skin) combines with dead skin cells, debris and acne-causing bacteria. (dermcollective.com)
However, severe acne is characterized by the appearance of a lot of inflammatory acne bodies. (progressivehealth.com)
Nodules and cysts are other manifestations of inflammatory acne. (msdmanuals.com)
Acne fulminans is a severe and rare form of inflammatory acne. (bvsalud.org)

Fast Five Quiz: Acne Practice Essentials - Medscape - Jan 15, 2020. (medscape.com)

A family history of acne was found in 86.7% of patients. (dermatologyadvisor.com)
A personal and family history of acne vulgaris was reported for 97.63% and 54.90% of patients, respectively. (bvsalud.org)

Without intervention, bacteria spreads and causes worsening symptoms, resulting in significant tissue damage and acne scars. (dermcollective.com)

1. Koo J. The psychosocial impact of acne: patient's perceptions. (bmj.com)

When assessing the face and back, C acnes phylotypes IA1 was predominant, occurring in 9 patients (60%), followed by phylotype II (3 patients), phylotype IB (2 patients), and phylotype IA2 (1 patients). (dermatologyadvisor.com)

Severe acne is characterized by the presence of numerous pustules and cysts (sometimes very large) as well as hardened nodules that develop deep within tissue. (dermcollective.com)
The two major presentations of severe acne are nodules and cysts. (progressivehealth.com)

Genetic control of sebum excretion in acne - a twin study. (bmj.com)

Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne. (bmj.com)
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (bmj.com)
As such, severe acne can impact quality of life and self-esteem. (dermcollective.com)
What Is Severe Acne? (dermcollective.com)
Severe acne, like any acne, tends to form most often where there are the greatest number of sebaceous glands such as on the face, jawline , chest and upper back . (dermcollective.com)
Nodulocystic or cystic acne is only one form of severe acne vulgaris. (progressivehealth.com)
Those also classified to be at risk of developing this form of severe acne include those who are in remission from autoimmune diseases and those exposed to halogens or hydrocarbons. (progressivehealth.com)

Cystic acne is characterized by the formation of persistent, inflamed cysts that are red and pus-filled. (dermcollective.com)

Acne vulgaris in the United States: a descriptive epidemiology. (bmj.com)
14. Tan JK, Bhate K. A global perspective on the epidemiology of acne. (bmj.com)

In conclusion, acne fulminans mainly affects the face and trunk of male adolescents with a history of acne vulgaris. (bvsalud.org)

Acne arises from a complex interplay of various pathogenetic factors. (altmeyers.org)

Another theory postulates that acne fulminans may be an autoimmune complex disease because circulating immune complexes have been demonstrated in some patients with acne fulminans. (medscape.com)

Future studies are needed to assess the use of biologics and preventive strategies, as well as the effect of combined treatments in acne fulminans, the researchers concluded. (dermatologyadvisor.com)

Because antibiotic resistance is a concern, topical or oral antibiotics should not be used as monotherapy in patients with acne . (medscape.com)
Antibiotic resistance was studied for all strains of C acnes . (dermatologyadvisor.com)

Acne scars are considered difficult to treat . (dermcollective.com)

Acne fulminans could be induced by anabolic steroid use in a male bodybuilder. (medscape.com)

Scattered pustules appear on the face of this person with acne. (msdmanuals.com)

Acne fulminans has also been observed in patients with measles infection. (medscape.com)
Propionibacterium levels in patients with and without acne vulgaris. (bmj.com)
Steroid sulfatase activity in epidermis of acne-prone and non-acne-prone skin of patients with acne vulgaris. (globale-dermatologie.com)
Incidence of acne vulgaris in patients with infantile acne. (globale-dermatologie.com)
Current consensus recommends a combination of topical retinoid and antimicrobial therapy as first-line therapy for almost all patients with mild acne. (medscape.com)
The growth factor is elevated in acne patients. (altmeyers.org)
Investigators conducted a retrospective observational study of all patients with acne fulminans seen in the department of dermatology at the Centre Hospitalier Universitaire, Nantes, France, between 2008 and 2018. (dermatologyadvisor.com)
Staphylococcus aureus was identified in association with C acnes in 2 patients and alone in 2 other patients. (dermatologyadvisor.com)
The main aim was to describe the clinical and demographic characteristics of patients with acne fulminans. (bvsalud.org)

Acne is the most common skin disease in the US and affects 80% of the population at some point in life. (msdmanuals.com)

Prevalence of nodulocystic acne in white and Negro males. (bmj.com)

4 sets of identical twins who developed an identical pattern of acne fulminans have been documented. (medscape.com)
Identical twins have a high concordance with regard to acne. (altmeyers.org)

A polyetiological mechanism is postulated for the aetiopathogenesis of acne. (altmeyers.org)

Psychiatric aspects of the treatment of mild to moderate facial acne. (globale-dermatologie.com)

Experience in the therapy of acne with topical administration of spironolactone as an antiandrogen]. (globale-dermatologie.com)

S. aureus could play a role in the development of the acute inflammatory response in association with C. acnes but this remains to be confirmed," the investigators wrote. (dermatologyadvisor.com)

Spironolactone may also be used in the treatment of acne. (medscape.com)

Acne vulgaris is a common skin disease which shows as blemishes on the skin. (progressivehealth.com)

Guidelines of care for the management of acne vulgaris. (bmj.com)

Acne vulgaris: establishing effectiveness of drugs intended for treatment. (bmj.com)
15. Gollnick HP, Zouboulis CC, Akamatsu H. Pathogenesis and pathogenesis related treatment of acne. (bmj.com)
New Tunisian products in the treatment of acne]. (globale-dermatologie.com)
A comparative study of tea-tree oil versus benzoylperoxide in the treatment of acne. (globale-dermatologie.com)
Nasemann, Bernried, on practical treatment of acne]. (globale-dermatologie.com)
Treatment should be directed toward the known pathogenic factors involved in acne. (medscape.com)

Recurrent acne fulminans is extremely rare. (medscape.com)

Acne develops on the face and upper trunk. (msdmanuals.com)

Associations between acne exacerbations and inadequate face washing, masturbation, and sex are unfounded. (msdmanuals.com)

Women are more commonly affected by late acne or acne tarda than men. (altmeyers.org)

Acne vulgaris: a disease of western civilization. (bmj.com)
What does acne genetics teach us about disease pathogenesis? (bmj.com)

Anatomy3

Organisms5

Diseases11

Chemicals and Drugs9

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Technology, Industry, Agriculture1

Cutibacterium2

Synovitis-acne-pustulosis-hyperostosis-osteitis2

Pathogenesis of acne2

Lesions11

Severity4

Acneiform Eruptions1

Conglobata18

Inflammation7

Comedones4

Corticosteroids3

Follicular2

Isotretinoin5

Systemic1

Bacterial1

Late-onset2

Inflammatory acne4

Practice Essentials1

Family history of a2

Symptoms1

Patient's1

Predominant1

Nodules2

Sebum excretion1

Severe acne7

Cysts1

Epidemiology2

Adolescents1

Interplay1

Autoimmune1

Treatments1

Antibiotic2

Scars1

Anabolic1

Pustules1

Patients9

Affects1

Prevalence1

Identical2

Mechanism1

Mild1

Topical1

Acute1

Spironolactone1

Skin1

Guidelines1

Treatment6

Rare1

Develops1

Face1

Commonly1

Disease2