• Despite their crucial role as a link between innate and adaptive immunity, little is known about the modulation of pDC differentiation by other bone marrow (BM) cells. (nih.gov)
  • In this study, we investigated the modulation of pDC differentiation in Flt-3 ligand (Flt3L)-supplemented BM cultures, using highly purified mesenchymal stem cells (MSCs) that were FACS-isolated from murine BM based on surface marker expression and used after in vitro expansion. (nih.gov)
  • [ 1 ] Within the 2016 World Health Organization (WHO) category of "acute myeloid leukemia and related neoplasms," the related neoplasms derive from immature cells with evidence of myeloid differentiation, or from precursors of plasmacytoid dendritic cells. (medscape.com)
  • For the differentiation of dendritic cells from mouse bone marrow. (rndsystems.com)
  • Cytokines produced by DCs can also promote the differentiation of CD4 + T helper cells as part of immune activation. (rndsystems.com)
  • The CellXVivo ™ Mouse Dendritic Cell Differentiation Kit contains the media and cytokine components to generate immature and mature dendritic cells from mouse bone marrow. (rndsystems.com)
  • This kit contains the following optimized proteins and reagents to drive the efficient differentiation of mouse monocytes into dendritic cells. (rndsystems.com)
  • Mouse PBMCs were differentiated into immature mouse dendritic cells by culturing for 5 days in reagents included in the CellXVivo ™ Mouse Monocyte-derived Dendritic Cells Differentiation Kit. (rndsystems.com)
  • Immature dendritic cells (left, blue) and TNF-α-treated mature dendritic cells (right, red), derived from bone marrow cells cultured with the CellXVivo ™ Mouse Dendritic Cell Differentiation Kit, were stained for flow cytometry with antibodies for CD11c, B7-2/CD86, MHC class II (I-A/I-E), or CD40 (open histograms). (rndsystems.com)
  • Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. (joplink.net)
  • CD19 is expressed during all stages of B-cell maturation and differentiation, except on plasma cells. (bdbiosciences.com)
  • CD19 is a signal transduction molecule that regulates B cell development, activation, proliferation and differentiation. (bdbiosciences.com)
  • In this context, a new molecule, B-cell activating factor (BAFF), has emerged as a positive regulator of B cell survival and differentiation functioning through various signaling pathways and potentiating the activity of various receptor complexes through pleiotropic means. (medsci.org)
  • The main advantage of these protocols is that they facilitate the isolation of human monocytes and their differentiation into viable and functional monocyte derived cells. (jove.com)
  • A research team from the University Hospitals of Cleveland Medical Center in western Pennsylvania has discovered the existence of myeloid neoplasms (MNs) that can undergo plasmacytoid dendritic cell (PDC) differentiation. (news-medical.net)
  • Both categories of cells resulting from atypical PDC differentiation are thought to represent two ends of a spectrum of maturation. (news-medical.net)
  • Leukemic myoblast differentiation into PDCs occurs as a result of sharing a common hematopoietic precursor to dendritic cells, monocytes, and myeloid cells. (news-medical.net)
  • Lactoferrin Potentiates Inducible Regulatory T Cell Differentiation through TGF-β Receptor III Binding and Activation of Membrane-Bound TGF-β. (peprotech.com)
  • TNFSF4 is the ligand for CD134 and is expressed on cells such as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. (genscript.com)
  • CD70 costimulates T cell proliferation and differentiation. (biolegend.com)
  • It plays a role in the pDC-induced B cell differentiation. (biolegend.com)
  • Continuous ligation of LILRB1 modulated cellular differentiation, conferred a unique phenotype upon the resultant cells, induced a profound resistance to CD95-mediated cell death, and inhibited secretion of cytokines IL-10, IL-12p70, and TGF-β. (ashpublications.org)
  • 1 Activation of DCs through toll-like receptors (TLRs) for "infectious nonself" or other "danger" signals normally initiates a process of cellular differentiation resulting in "mature" DCs capable of stimulating T-cell and natural killer (NK)-cell responses. (ashpublications.org)
  • Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis (programmed cell death) lead to replacement of normal blood elements with malignant cells. (msdmanuals.com)
  • Autologous mature dendritic cells derived from peripheral blood monocytes were pulsed with the HLA-A2-binding MUC1 peptides (M1.1 and M1.2). (aacrjournals.org)
  • These monocytes isolation protocols can contribute to the development of reliable methods for the purification of human dendritic cells for research and clinical applications. (jove.com)
  • To isolate monocytes by the adherence method, culture five times 10 to the seven cells of the resulting PBMC pellet per 10 milliliters of complete medium in a new T75 flask for two hours at 37 degrees celsius and five percent carbon dioxide in a humidified incubator. (jove.com)
  • As a first-in-class antigen presenting cell (APC) activator, efti binds to MHC (major histocompatibility complex) Class II molecules on APC leading to activation and proliferation of CD8+ cytotoxic T cells, CD4+ helper T cells, dendritic cells, NK cells, and monocytes. (kdvr.com)
  • However, receptor studies have shown that P2Y12 is functionally expressed not only in platelets and the microglia but also in other cells of the immune system, such as in monocytes, dendritic cells, and T lymphocytes. (bvsalud.org)
  • Plasmacytoid dendritic cells (pDCs) are rare central regulators of antiviral immunity and unsurpassed producers of interferon-α (IFN-α). (nih.gov)
  • The precursors of plasmacytoid dendritic cells are the cells of origin for blastic plasmacytoid dendritic cell neoplasm (BPDCN), a clinically aggressive disease with a proclivity for the skin and leukemic involvement and for which no consensus currently exists regarding optimal treatment modalities. (medscape.com)
  • Importantly, activated MDMs in turn mediate strong activation of plasmacytoid dendritic cells (pDCs), leading to the secretion of high levels of IFN-α and TNF. (nature.com)
  • CD70 is expressed on activated T, B and NK cells, activated plasmacytoid dendritic cells (pDCs), and chronic B cell lymphocytic leukemia and large B cell lymphomas. (biolegend.com)
  • This study demonstrates that 200-nm sized biodegradable poly(gamma-glutamic acid) (gamma-PGA) nanoparticles (NPs) are activators of human monocyte-derived dendritic cells (MoDCs). (lu.se)
  • The overall goal of this study is to compare two different methods of human monocyte isolation for dendritic cell generation in vitro and to characterize the CT11c, CT14 cell surface expression of the resulting monocyte derived populations by imaging flow cytometry. (jove.com)
  • In addition, this is the first study to characterize the specific population of monocyte derived dendritic cells by single cell imaging flow cytometry. (jove.com)
  • Additionally cell surface marker characterization via flow cytometry differentiates them from hematopoetic cells, though no truly unique MSC molecule has been identified. (vin.com)
  • The objective of this study is to explore the long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) expression profiles of monocyte-derived dendritic cells (DCs) obtained from peripheral blood mononuclear cells (PBMCs). (frontiersin.org)
  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a malignancy derived from plasmacyoid dendritic cells. (medscape.com)
  • [ 4 , 5 ] Previously used terms for this disorder have included CD4+CD56+ hematodermic tumor and blastic natural killer (NK) cell lymphoma. (medscape.com)
  • Frequent sites of occurrence of blastic plasmacytoid dendritic cell neoplasm (BPDCN) include the skin, as well as the peripheral blood (PB) and bone marrow (BM). (medscape.com)
  • A diffuse infiltrate of medium-sized cells with dispersed chromatin ("blastic") is characteristic of blastic plasmacytoid dendritic cell neoplasm (BPDCN). (medscape.com)
  • Pathology of blastic plasmacytoid dendritic cell neoplasm (BPDCN).Skin involvement by blastic plasmacytoid dendritic cell neoplasm. (medscape.com)
  • The neoplastic cells in blastic plasmacytoid dendritic cell neoplasm (BPDCN) are typically positive for CD45, HLA-DR, CD43, CD4, CD56, and cutaneous lymphocyte-associated antigen (CLA). (medscape.com)
  • This work builds on existing knowledge that PDCs can be divided into two categories: mature PDC proliferations which result in myeloid neoplasms (MPDMN) and blastic plasmacytoid dendritic cell neoplasm (BPDCN). (news-medical.net)
  • Mononuclear phagocytes are a group of phenotypic distinct members, often referred to as either macrophages or dendritic cells (DC), that derive from myeloid precursors and that contribute to the functions of peripheral tissues [ 1 ]. (hindawi.com)
  • Cell separation studies showed that the increased arginase activity was limited to a specific subset of CD11b+, CD14−, CD15+ cells with a polymorphonuclear granulocyte morphology and markers, instead of macrophages or dendritic cells described in mouse models. (aacrjournals.org)
  • For the activation of CD4 + T-helper lymphocytes, dendritic cells were further incubated with the PAN-DR-binding peptide PADRE. (aacrjournals.org)
  • Furthermore, MP increased WBC and HGB counts and reduced the ratio of G0/G1 phase obviously, increased the proportion of S phase and G2/M phase in peripheral blood lymphocytes, increased the counts of CD4+ T cells and the ratio of CD4+/CD8+, and reduced the inhibition rate of splenic lymphocytes. (hindawi.com)
  • Binds to dendritic cells (DCs) via C1QR1, resulting in down-regulation of T-lymphocytes proliferation (PubMed:11086025, PubMed:17881511). (proteopedia.org)
  • Les IgIV intéragissent avec de nombreux composants du système immunitaire comme les récepteurs Fc, le complément, les cytokines, les lymphocytes T et B, les cellules dendritiques, les granulocytes et les cellules NK, ce qui explique en partie leurs effets anti-inflammatoires. (academie-medecine.fr)
  • 2 The interaction of IVIG with a large number of components of the immune system including Fc receptors, complement molecules, cytokines, B and T lymphocytes, neutrophils and NK cells, may explain at least in part their anti-inflammatory effects. (academie-medecine.fr)
  • Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
  • The ligand is specific for the 4-1BB RECEPTOR and may play a role in inducing the proliferation of activated peripheral blood T-LYMPHOCYTES. (bvsalud.org)
  • Besides surgery, radiotherapy and chemotherapy, immune activation by direct application of cytokines, antibodies or adoptive cell therapy are promising approaches. (frontiersin.org)
  • In this study, we addressed feeder cell-free expansion methods using common γ-chain cytokines, especially IL-15 and IL-21. (frontiersin.org)
  • In vivo development and survival of NK cells require cytokines ( 6 - 8 ). (frontiersin.org)
  • In this context, cytokines have been shown to activate NK cells potently during ex vivo expansion ( 9 - 12 ). (frontiersin.org)
  • CD150 binds to itself as the ligand to be involved in B cell costimulation, proliferation, immunoglobulin production, and signal transduction. (biolegend.com)
  • Vitamin D ameliorates stress ligand expression elicited by free fatty acids in the hepatic stellate cell line LX-2. (springer.com)
  • We found that human intestinal epithelial cells (IECs) triggered IgA(2) class switching in B cells, including IgA(1)-expressing B cells arriving from mucosal follicles, through a CD4(+) T cell-independent pathway involving a proliferation-inducing ligand (APRIL). (nih.gov)
  • Ligated DCs exhibited poor stimulatory activity for primary and memory T-cell proliferative responses, but this was substantially reversed by blockade of CD80 or its preferred ligand CTLA-4, or by depleting CD4 + CD25 + CD127 lo regulatory T cells. (ashpublications.org)
  • Finally, in vitro and in vivo functional assays using DCs exhibiting deregulated Arg2 expression indicated that Arg2-mediated arginine depletion in the extracellular milieu impairs T cell proliferation. (unige.ch)
  • Preincubation of naive T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. (cdc.gov)
  • This study compares two different methods of human monocyte isolation for obtaining in vitro dendritic cells (DCs). (jove.com)
  • Cross-presentation of cell-associated antigen by bone marrow-derived dendritic cells (BMDCs) was determined by CD8+ T cell proliferation assays in vitro and in vivo. (soton.ac.uk)
  • Mesenchymal stem cells clearly modulate immune responses, as demonstrated by both in vitro and in vivo studies. (vin.com)
  • These cells inhibited T cell proliferation in a standard in vitro mixed lymphocyte assay and, moreover, attenuated the development of vasculopathy mediated by autologous peripheral blood mononuclear cells in a functionally relevant humanized mouse transplant model. (lu.se)
  • Furthermore, MoDCs from allergic subjects stimulated in vitro with a mixture of gamma-PGA NPs and extract of grass pollen allergen Phleum pratense (Phl p) augment allergen-specific IL-10 production and proliferation of autologous CD4(+) memory T cells. (lu.se)
  • Dendritic cells (DCs) are key mediators of both innate and adaptive immune responses. (rndsystems.com)
  • Vitamin D receptors are expressed on the principal cell populations involved in the innate and adaptive immune responses. (springer.com)
  • Therefore, ex vivo NK cell expansion protocols are currently being developed. (frontiersin.org)
  • In a proof of concept in vivo study, we also observed a therapeutic effect of adoptively transferred IL-15 expanded and IL-21 boosted NK cells in combination with image guided high precision radiation therapy using a luciferase-transduced RMS xenograft model. (frontiersin.org)
  • In summary, this two-phased feeder cell-free ex vivo culturing protocol combined efficient expansion and high cytolytic functionality of NK cells for treatment of radiation-resistant RMS. (frontiersin.org)
  • A classification that sufficiently covers their phenotypic heterogeneity and plasticity during homeostasis and disease does not yet exist because cell culture-based phenotypes often do not match those found in vivo . (hindawi.com)
  • Why Differentiate Dendritic Cells ex vivo ? (rndsystems.com)
  • Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. (cdc.gov)
  • Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function. (cdc.gov)
  • Characterization of dendritic cells generated in vivo by an E. coli derived chimeric dual receptor agonist. (medscimonit.com)
  • Herein, we report morphologic, phenotypic and functional evaluation of Class II+/CD11c+ cells generated by in vivo administration of ProGP-4. (medscimonit.com)
  • receptors (Fc?Rs) reduced their ability to induce CD8+ T cell proliferation in vivo, suggesting the blockade of a mechanism which is intrinsic for DC maturation or migration. (soton.ac.uk)
  • Regulatory T cells (T(regs)) manipulated ex vivo have potential as cellular therapeutics in autoimmunity and transplantation. (lu.se)
  • A phase I trial was conducted to evaluate the feasibility, safety, and efficacy of a dendritic cell-based vaccination in patients with metastatic renal cell carcinoma (RCC). (aacrjournals.org)
  • Peripheral blood mononuclear cells from 123 patients with metastatic renal cell carcinoma, prior to treatment, were found to have a significantly increased arginase activity. (aacrjournals.org)
  • Under these M cells and in close proximity, B cells, CD4 + T cells, and APCs (including dendritic follicular cells [DFCs]) are found. (medscape.com)
  • They can be activated rapidly via germ-line encoded receptors that recognize the presence of stress ligands or absence of self-antigens on target cells ( 1 - 5 ). (frontiersin.org)
  • The roles of the M cells include absorption, transport, processing, and presentation of antigens to subepithelial lymphoid cells. (medscape.com)
  • M cells in the intestinal epithelium overlying Peyer patches allow transport of antigens to the lymphoid tissue beneath it. (medscape.com)
  • The degree of lymphocyte proliferation, regulatory T-cell generation and cytokine secretion were measured. (sciencedaily.com)
  • Additional reported applications for the relevant formats include: blocking of plasmacytoid dendritic cell induced B cell proliferation and Ig secretion 1 . (biolegend.com)
  • Hence, we established a two-phase expansion protocol with IL-15 to induce an early NK cell expansion, followed by short exposure to IL-21 that boosted the cytotoxic activity of NK cells against RMS cells. (frontiersin.org)
  • Furthermore, we discuss how published data supports the view that changing tissue environments induce the well-known different phenotypes of mononuclear phagocytes, a process that not only enforces each of the different environments but also explains the contribution of these cells to the different tissue pathologies. (hindawi.com)
  • Kit-derived Mature Mouse Dendritic Cells Induce Proliferation of Allogeneic T Cells. (rndsystems.com)
  • miR155 is known to be strongly induced in various mouse and human DC subsets in response to diverse maturation signals, and miR155-deficient DCs exhibit an impaired ability to induce Ag-specific T cell responses. (unige.ch)
  • Direct effects of carbon nanotube s on dendritic cells induce immune suppression upon pulmonary exposure. (cdc.gov)
  • Among their other immunological properties, MSC inhibit lymphocyte proliferation and cytokine production, suppress dendritic cell function and alter DC cytokine production, and decrease IFN-g production by NK cells. (vin.com)
  • It associates with the complement receptor 2 (CD21), TAPA-1 (CD81), Leu 13, and/or MHC class II to form a signal transduction complex on the surface of B cells. (bdbiosciences.com)
  • APOE associated to the LVP allows the initial virus attachment to cell surface receptors such as the heparan sulfate proteoglycans (HSPGs), syndecan-1 (SDC1), syndecan-1 (SDC2), the low-density lipoprotein receptor (LDLR) and scavenger receptor class B type I (SCARB1) (PubMed:12970454, PubMed:12356718, PubMed:12913001, PubMed:28404852, PubMed:22767607). (proteopedia.org)
  • These patients had a markedly decreased cytokine production and expressed low levels of T cell receptor CD3ζ chain. (aacrjournals.org)
  • IL-23 is secreted by activated dendritic cells and macrophages, and signals though a receptor comprised of IL-23R complexed with IL-12Rβ1. (peprotech.com)
  • RESULTS: Administration of this dual receptor agonist to mice resulted in dose-dependent increases in the numbers of total white blood cells and Class II+/CD11c+ cells in spleen and peripheral blood. (medscimonit.com)
  • OX40 is a T cell co-stimulatory molecule of the TNF receptor superfamily that coordinates with other co-stimulators (CD28, CD40, CD30, CD27 and 4-1BB) to manage the activation of the immune response. (genscript.com)
  • 3-5 LILRs are encoded by a set of genes within the leukocyte receptor cluster on chromosome 19q13.4, adjacent to the killer Ig-like receptor ( KIR ) genes that are responsible for controlling NK- and CD8 T-cell survival and effector functions. (ashpublications.org)
  • Without further manipulation or selection, the resultant population delayed skin allograft rejection mediated by polyclonal CD4(+) effectors or donor-reactive CD8(+) T cell receptor transgenic T cells and inhibited both effector cell proliferation and T cell priming for interferon-γ production. (lu.se)
  • El ligando es específico para el RECEPTOR 4-1BB y puede desempeñar un papel en la indución de la proliferación de los LINFOCITOS T activados de la sangre periférica. (bvsalud.org)
  • The peripheral blood mononuclear cells (PBMCs) have a round nucleus ( Delves, 2016 ). (frontiersin.org)
  • To achieve a proper separation of the peripheral blood mononuclear cells, load the blood onto the density gradient solution quickly, but carefully and without mixing the layers. (jove.com)
  • ProGP-4 possesses cross-species activity and treatment of mice with ProGP-4 results in increases in the number of WBC and Class II+/CD11c+ cells in both spleen and peripheral blood. (medscimonit.com)
  • On bone marrow aspirate smear preparations, the neoplastic cells may display cytoplasmic vacuoles that have been likened to a pearl necklace. (medscape.com)
  • In lymph nodes, the tumor cells infiltrate the interfollicular areas and medullary areas, often diffusely, whereas bone marrow evaluation may show variable degrees of infiltration ranging from sparse to significant. (medscape.com)
  • [ 3 , 4 ] Langerhans cells are stellate dendritic cells that arise from CD34-positive bone marrow stem cells [ 5 ] and are not a member of the mononuclear phagocytic system. (medscape.com)
  • Remission is when there are less than 5% blast cells in the bone marrow. (oncolink.org)
  • The group analyzed seven MN patients who presented with PDC proliferations comprising 5-26% of that blood cell or bone marrow. (news-medical.net)
  • Despite lower co-stimulatory molecule expression, ProGP-4-generated Class II+/CD11c+ cells stimulated proliferation of allogeneic T cells and an antigen-specific T cell hybridoma as efficiently as bone marrow derived dendritic cells from untreated mice. (medscimonit.com)
  • Adult stem cells can be obtained from many differentiated tissues including but not limited to bone marrow, bone, fat, and muscle. (vin.com)
  • Although it is possible to expand naturally occurring T(regs), an attractive alternative possibility, particularly suited to solid organ and bone marrow transplantation, is the stimulation of total T cell populations with defined allogeneic antigen-presenting cells (APCs) under conditions that lead to the generation or expansion of donor-reactive, adaptive T(regs). (lu.se)
  • Additionally, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells. (peprotech.com)
  • PLXNA4 inhibits T cell response, but promotes inflammatory cytokine production by macrophages. (wikipedia.org)
  • Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamide-induced liver fibrosis in rats. (springer.com)
  • Seeks to conduct and enable research and NJH aimed at stem cell characterization, regeneration of the lung, and the genetic editing of stem and other primary cells. (nationaljewish.org)
  • PLXNB1 promotes B cell survival, as well as macrophage recruitment. (wikipedia.org)
  • Thus, organ- and disease phase-specific microenvironments determine macrophage and dendritic cell heterogeneity in a temporal and spatial manner, which assures their support to maintain and regain homeostasis in whatever condition. (hindawi.com)
  • Overall, the present study describes a novel and potent pathway of pDC activation that is linked to the macrophage-mediated clearance of infected cells. (nature.com)
  • A more tissue-centric view of these processes, claiming that the tissues define phenotype and function of resident and infiltrating immune cells to meet tissues needs during homeostasis and disease, seems provocative [ 4 , 5 ]. (hindawi.com)
  • CTRC Core Laboratory Services support IRB-approved protocols for clinical research with a wide range of protocols requiring analysis of the function and phenotype of immunologic cells. (nationaljewish.org)
  • The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis found 16 significant regulated pathways in imDCs and 10 significant regulated pathways in mDCs, including the phagosome, cell adhesion signaling pathway, and inflammatory mediator regulation of TRP channels pathway. (frontiersin.org)
  • Affects various cell signaling pathways, host immunity and lipid metabolism (Probable). (proteopedia.org)
  • However, analogous effects of NET-EN treatment on antivirus immunity and host susceptibility to genital infection are much less explored. (stanford.edu)
  • and interleukin-10 (IL-10) that dampen the initiation of cytotoxic T cell (CTL) immunity and render T cells tolerant. (soton.ac.uk)
  • Dendritic cells (DCs) link innate and adaptive immunity, initiating and regulating effector cell responses. (ashpublications.org)
  • Notably, PDE inhibition also enhanced the enrichment of human Foxp3(+) CD4(+) T cells driven by allogeneic APCs. (lu.se)
  • mesenchymal stem cells are most commonly used because they are easy to obtain and present no ethical problems. (springer.com)
  • The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
  • In preclinical and clinical studies, progenitor cell therapy (cord blood and mesenchymal stem cells) has shown promise in reversing the underlying pathology of SNHL, the loss of cochlear sensory hair cells. (intechopen.com)
  • In particular, adult stem cells called mesenchymal stem cells can migrate to affected areas and may be able to support the growth of other stem cells as well as moderate the response of the immune system. (vin.com)
  • Mesenchymal stem cells are multipotent but not pluripotent, which means they can differentiate into some, or "multiple," but not all tissue types. (vin.com)
  • Mesenchymal stem cells or mesenchymal stromal cells (MSC) are plastic adherent and assume a fibroblast-like morphology during culture. (vin.com)
  • The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut. (peprotech.com)
  • All cases are otherwise negative for Epstein-Barr virus (EBV) (assayed using in situ hybridization for EBV-encoded ribonucleic acid [RNA] [EBER-ISH]), B-cell, T-cell, myeloid, and natural killer (NK) cell markers, as well as for cytotoxic proteins (assayed using IHC). (medscape.com)
  • In the last years, adoptive transfer of natural killer (NK) cells came into the focus of translational medicine, because of their high cytotoxic potential against transformed malignant cells. (frontiersin.org)
  • Progenitor cell therapy may also allow functional reorganization of the auditory pathways including primary auditory cortex (Heschl's gyrus). (intechopen.com)
  • We will present a summary of the effect of hearing loss on auditory development, existing preclinical and clinical data on progenitor cell therapy, and its potential role in the (re)habilitation of non-genetic SNHL. (intechopen.com)
  • The mechanism was perhaps related to inhibiting lymphocyte apoptosis and promoting the balance of Th1/Th2 cell subsets. (hindawi.com)
  • Histiocytic infiltration and proliferation within the synovium is a common finding associated with inflammatory processes. (medscape.com)
  • AGEs-Induced IL-6 Synthesis Precedes RAGE Up-Regulation in HEK 293 Cells: An Alternative Inflammatory Mechanism? (mdpi.com)
  • This active form of vitamin D can inhibit immune cell proliferation, promote an anti-inflammatory cytokine profile, expand regulatory T cells, enhance glucocorticoid actions, increase glutathione production, and inhibit hepatic stellate cells. (springer.com)
  • Apoptotic cells are cleared rapidly by professional phagocytes thus preventing the release of potentially inflammatory or immunogenic material into the surrounding environment. (soton.ac.uk)
  • CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)
  • This review reports what is known about the expression of P2Y12 in the cells of the immune system and the effect of P2Y12 activation and/or inhibition in inflammatory conditions. (bvsalud.org)
  • There are two hallmark phenotypes of allergic asthma: (1) inflammatory, due to a T helper cell type 2 (Th2)-mediated immune response resulting in elevated inflammatory cells in the airways, and (2) airway hyper-reactivity, during which volume and flow of inhaled air decreases as a consequence of airway constriction. (cdc.gov)
  • Dendritic cells (DCs) play pivotal roles in the initiation, regulation, and maintenance of immune responses. (ashpublications.org)
  • Recent studies have suggested a role for human leukocyte Ig-like receptors (LILRs, also known as ILT, LIR, or CD85) in regulating the function of myeloid cells, potentially implicating these molecules in the control of immune responses. (ashpublications.org)
  • After five dendritic cell injections, patients additionally received three injections weekly of low-dose interleukin-2 (1 million IE/m 2 ). (aacrjournals.org)
  • Langerhans cell granulomatosis cells are abnormal and coexpress S100 and CD1a, and these markers are used to separate this subpopulation of dendritic cells from other histiocyte-like cells. (medscape.com)
  • Dendritic cell vaccinations were done s.c. every 2 weeks for four times and repeated monthly until tumor progression. (aacrjournals.org)
  • The cellular makeup of these monocytoid/histocytic cells is heterogeneous and ranges from cells of lymphoid, histiocytic, and dendritic origin. (medscape.com)
  • MALT may consist of a collection of lymphoid cells, or it may include small solitary lymph nodes. (medscape.com)
  • Histopathologically, nephrogenic systemic fibrosis resembles scleromyxedema in that it manifests with a proliferation of dermal fibroblasts and dendritic cells, thickened collagen bundles, increased elastic fibers, and mucin deposition. (medscape.com)
  • Histiocytic/dendritic proliferations involving the synovial tissues are not uncommon. (medscape.com)
  • These lesions as well as the rare multicentric reticulohistiocytosis (MRH), a systemic monocytoid/histiocytic disorder with multinucleated giant cells, polyarthritis, and papulonodular skin lesions, should be considered in the differential diagnosis. (medscape.com)
  • It emphasizes the importance of immunocytochemistry to separate this histiocyte-like cell proliferation from true histiocytic and other dendritic cell types. (medscape.com)
  • Stimulation of B cells leads to the production of immunoglobulin A (IgA) and immunoglobulin M (IgM) within the Peyer patches, preventing adherence of bacteria and viruses to the epithelium and thus blocking entry to the subepithelial layers of the intestine. (medscape.com)
  • IECs released APRIL after sensing bacteria through Toll-like receptors (TLRs) and further increased APRIL production by activating dendritic cells via thymic stromal lymphopoietin. (nih.gov)
  • For most studies, the adult stem cell in question is actually a mesenchymal stem cell or mesenchymal stromal cell. (vin.com)
  • An immune-centric view assumes that a particular priming of phagocytes then causes a particular type of pathology in target tissues, conceptually similar to antigen-specific T-cell priming. (hindawi.com)
  • It was hypothesised that manipulation of this clearance pathway, which is normally employed to prevent autoimmunity, may alleviate immuno-suppression of apoptotic tumour cells and promote the expansion of a tumour antigen-specific T cell response. (soton.ac.uk)
  • Provides an integrated process for all areas of application in next-generation sequencing of RNA and DNA molecules from a variety of cell types as well as data analysis. (nationaljewish.org)
  • Apoptotic cells treated with DN-MFG-E8-Fc protein resulted in upregulation of costimulatory molecules, CD86 and CD70, when BMDCs were deficient for the inhibitory Fc?R, Fc?RIIb. (soton.ac.uk)
  • For example, MSC are poor antigen presenting cells and do not express MHC class II or co-stimulatory molecules and only low levels of MHC class I molecules. (vin.com)
  • Monocyte yield and viability along with MDDC viability, proliferation and CD11c/CD14 surface marker expression will be compared between both methods. (jove.com)
  • In fact, in patients suffering from severe COVID-19, massive infiltration of proinflammatory immune cells, including activated macrophages, was detected in infected lung tissue. (nature.com)
  • The biopsy specimen from the right maxillary sinus showed soft tissue infiltration with myeloid leukemic cells, consistent with a chloroma. (contemporarypediatrics.com)
  • Many culturing strategies are based on the addition of feeder or accessory cells, which need to be removed prior to the clinical application of the final NK cell product. (frontiersin.org)
  • However, recent successful preclinical and clinical trials have advocated for the significance of B cell-dependent immunopathogenic responses and has led to the development of novel biologicals that target specific B cell phenotypes. (medsci.org)
  • OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
  • In addition, none of the PDC proliferations satisfied the clinical or pathological criteria for BPDCN. (news-medical.net)
  • While no clinical data establishes causal link between HIV acquisition and use of this injectable progestin, prior work from our laboratory showed that DMPA comparably lowers genital levels of the cell-cell adhesion molecule desmoglein-1 (DSG1) and weakens genital epithelial barrier function in female mice and humans. (stanford.edu)
  • Stem cell therapy in particular is an innovative new field of scientific investigation and clinical application that holds promise for a variety of diseases in veterinary medicine as well as human medicine. (vin.com)
  • Numerous necrotic dendritic spheroids in the molecular layer with a cellular proliferation of Bergmann glia and of microgliosis. (cdc.gov)
  • A main challenge of NK cell therapy is that it requires a high amount of functional NK cells. (frontiersin.org)
  • A stem cell is a generic term referring to any unspecialized cell that is capable of long-term self-renewal through cell division but that can be induced to differentiate into a specialized, functional cell. (vin.com)
  • 4,6,7 It has been proposed that some of these MSC may actually differentiate into functional renal tubular epithelial cells, though this theory remains controversial. (vin.com)