• Sunitinib was the first cancer drug simultaneously approved for two different indications. (wikipedia.org)
  • mometasone topical decreases effects of aldesleukin by unspecified interaction mechanism. (medscape.com)
  • beclomethasone, inhaled decreases effects of aldesleukin by Other (see comment). (medscape.com)
  • budesonide decreases effects of aldesleukin by pharmacodynamic antagonism. (medscape.com)
  • Avoid combination because corticosteroids can potentially diminish the antineoplastic effects of aldesleukin. (medscape.com)
  • Comment: Corticosteroids may interfere with antitumor effects of aldesleukin. (medscape.com)
  • Did you experience many side effects while taking this drug? (rxwiki.com)
  • Aldesleukin can cause serious side effects. (rxwiki.com)
  • This is not a complete list of aldesleukin side effects. (rxwiki.com)
  • High-dose drug effects on myelosuppression may be reduced. (interactionsguide.com)
  • Possible additive effects of herb and drug allow sparing of drug, reduction of drug side effects, and enhanced therapeutic responses. (interactionsguide.com)
  • Avoid or Use Alternate Drug. (medscape.com)
  • Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient. (medscape.com)
  • The type of immunotherapy, dose, and treatment schedule your doctor recommends will depend on many factors. (cancer.net)
  • Aldesleukin treats kidney cancer and a certain type of skin cancer. (rxwiki.com)
  • Aldesleukin is a type of drug known as biosynthetic interleukin-2. (rxwiki.com)
  • Many checkpoint inhibitors are approved by the U.S. Food and Drug Administration (FDA) for specific cancers. (cancer.net)
  • In the case of aldesleukin there are no specific foods that you must exclude from your diet when receiving aldesleukin. (rxwiki.com)
  • Aldesleukin is used for the treatment of adults with metastatic renal cell carcinoma (metastatic RCC). (rxwiki.com)
  • Natural killer (NK) cell number and activity increased by long-term administration. (interactionsguide.com)
  • PROLEUKIN ® (aldesleukin) is indicated for the treatment of adults with metastatic renal cell carcinoma (metastatic RCC). (druglib.com)
  • The following schedule has been used to treat adult patients with metastatic renal cell carcinoma (metastatic RCC) or metastatic melanoma. (druglib.com)
  • Proleukin is a prescription medicine used to treat kidney cancer that has spread, known as metastatic renal cell carcinoma (metastatic RCC). (rxwiki.com)
  • When reconstituted with 1.2 mL Sterile Water for Injection, USP, each mL contains 18 million IU (1.1 mg) PROLEUKIN, 50 mg mannitol, and 0.18 mg sodium dodecyl sulfate, buffered with approximately 0.17 mg monobasic and 0.89 mg dibasic sodium phosphate to a pH of 7.5 (range 7.2 to 7.8). (nih.gov)
  • When reconstituted with 1.2 mL Sterile Water for Injection, USP, each mL contains 18 million International Units (1.1 mg) aldesleukin, mannitol (50 mg), sodium dodecyl sulfate (0.19 mg), buffered with disodium hydrogen phosphate dihydrate (1.12 mg) and sodium dihydrogen phosphate dihydrate (0.19 mg) to a pH of 7.5 (range 7.2 to 7.8). (nih.gov)
  • Therapy with PROLEUKIN ® (aldesleukin) for injection should be restricted to patients with normal cardiac and pulmonary functions as defined by thallium stress testing and form al pulmonary function testing. (nih.gov)
  • PROLEUKIN ® (aldesleukin) for injection, a human recombinant interleukin-2 product, is a highly purified protein with a molecular weight of approximately 15,300 daltons. (nih.gov)
  • The recommended PROLEUKIN ® (aldesleukin) for injection treatment regimen is administered by a 15-minute IV infusion every 8 hours. (druglib.com)
  • Proleukin (aldesleukin) for injection is a sterile, preservative-free white to off-white, lyophilized powder, which has a cake-like appearance, supplied in single-dose vials for intravenous administration after reconstitution. (nih.gov)
  • PROLEUKIN is indicated for the treatment of adults with metastatic melanoma. (druglib.com)
  • Metastatic RCC patients treated with this schedule received a median of 20 of the 28 doses during the first course of therapy. (druglib.com)
  • PROLEUKIN, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. (nih.gov)
  • and d) the aggregation state of PROLEUKIN is likely to be different from that of native interleukin-2. (nih.gov)
  • PROLEUKIN biological potency is determined by a lymphocyte proliferation bioassay and is expressed in International Units (IU) as established by the World Health Organization 1st International Standard for Interleukin-2 (human). (nih.gov)
  • PROLEUKIN ® (aldesleukin) has been shown to possess the biological activities of human native interleukin-2. (nih.gov)
  • Proleukin biological potency is determined by a lymphocyte proliferation bioassay and is expressed in International Units as established by the World Health Organization 1st International Standard for Interleukin-2 (human). (nih.gov)
  • Proleukin is a type of drug known as biosynthetic interleukin-2. (rxwiki.com)
  • have shown that, in chronic infections, administration of the cytokine interleukin (IL)-2 triggers an alternative differentiation path of stem-like T cells towards a distinct population of 'better effector' CD8+ T cells similar to those generated in an acute infection5. (bvsalud.org)
  • PROLEUKIN is supplied as a sterile, white to off-white, lyophilized cake in single-use vials intended for intravenous (IV) administration. (nih.gov)
  • Evaluation of clinical studies to date reveals that patients with more favorable ECOG performance status (ECOG PS 0) at treatment initiation respond better to PROLEUKIN, with a higher response rate and lower toxicity (see " CLINICAL PHARMACOLOGY " section, " Clinical Experience " subsection and " ADVERSE REACTIONS " section). (druglib.com)
  • Consequently, preexisting bacterial infections should be adequately treated prior to in itiation of PROLEUKIN therapy. (nih.gov)
  • Decisions to stop, hold, or restart PROLEUKIN therapy must be made after a global assessment of the patient. (druglib.com)
  • In this original research, we investigated the systemic and local pharmacokinetics in the brain of healthy rats after either intravenous (IV) or intracerebroventricular (ICV) administration of EGFRvIII-T-Cell bispecific (TCB), a bispecific monoclonal antibody. (bvsalud.org)
  • It's a biologic drug that's not currently available in a generic or biosimilar form. (medicalnewstoday.com)
  • A generic drug, on the other hand, is an exact copy of the active drug in a brand-name medication. (medicalnewstoday.com)
  • Generic drugs are exact copies of brand-name medications that are made using chemicals in a lab. (medicalnewstoday.com)
  • The in vitro biological activities of the native nonrecombinant molecule have been reproduced with PROLEUKIN. (nih.gov)
  • The manufacturing process for PROLEUKIN involves fermentation in a defined medium containing tetracycline hydrochloride. (nih.gov)
  • Tecentriq is a brand-name prescription drug that's used to treat certain types of cancer. (medicalnewstoday.com)
  • The Food and Drug Administration (FDA) approves prescription drugs such as Tecentriq to treat certain conditions. (medicalnewstoday.com)
  • Proleukin may lower blood cells required for your body to fight infection. (rxwiki.com)
  • Proleukin may lower blood cells that are needed for blood clotting. (rxwiki.com)
  • Following 9 days of rest, the schedule is repeated for another 14 doses, for a maximum of 28 doses per course, as tolerated. (druglib.com)
  • Off-label use is when a drug that's approved to treat one condition is used to treat a different condition. (medicalnewstoday.com)
  • Careful patient selection is mandatory prior to the administration of PROLEUKIN. (druglib.com)
  • However, the development of these drugs against neurological disorders where the drug target is located in the brain is challenging and requires a good understanding of the local drug concentration in the brain. (bvsalud.org)
  • How was your experience with Proleukin? (rxwiki.com)
  • It's an immunotherapy drug, which means it works with your immune system to fight off cancer. (medicalnewstoday.com)
  • Biosimilar medications are considered to be as safe and effective as the original biologic drug. (medicalnewstoday.com)