reported that therapy with raloxifene, (an oestrogen-receptor modulator) was associated with an as much as 25 decrease inside the PRL level in 10/14 (71) sufferers with prolactinoma who were on stable doses of DAs, while two sufferers (14) normalised their serum prolactin levels [94]. (emlinhibitor.com)
The commonest is a prolactin-producing tumor (also called 'prolactinoma') which manifests as abnormal milk discharge from the breasts and stoppage of normal menstrual cycles. (sakraworldhospital.com)
In prolactinomas, for instance, endocrinologists can utilize dopamine agonists to treat any residual adenoma that might persist after resection. (cap.org)
15. Delgrange E, Trouillas J, Maiter D, Donckier J, Tourniaire J. Sex-related difference in the growth of prolactinomas: a clinical and proliferation marker study. (dergipark.org.tr)
18. Delgrange E, Sassolas G, Perrin G, Jan M, Trouillas J. Clinical and histological correlations in prolactinomas, with special reference to bromocriptine resistance. (dergipark.org.tr)
The clinical and therapeutic profiles of prolactinomas associated with germline pathogenic variants in the aryl hydrocarbon receptor interacting protein gene. (uliege.be)
Transsphenoidal1
Prolactinoma patients who underwent endoscopic transsphenoidal surgery at Istanbul University-Cerrahpasa, Neurosurgery clinics between 2013-2023 were included in this study. (dergipark.org.tr)
Serum1
The decreasing trend of serum prolactin and tumour size reduction in patients was noted, suggesting the beneficial impact of medical therapy as it is the first line treatment modality in these patients. (aku.edu)
Tumour size was decreased in 48.53% (33) patients and lesion completely disappeared in 16.18% (11) patients after 6 months of treatment and also almost similar trend in tumour size change was seen after one year. (aku.edu)
Prolactinomas, benign lesions that produce the hormone prolactin, are the most common hormone-secreting pituitary tumors. (medscape.com)
Nonfunctioning adenomas are associated with hypermethylation of p16 prolactinomas, and corticotropin-secreting tumors express galectin-3 (Gal-3), a gene involved in cell growth and apoptosis. (medscape.com)
Secretion2
Dopamine is the chemical that normally inhibits prolactin secretion, so clinicians may treat prolactinoma with drugs that act like dopamine such as bromocriptine and cabergoline. (wikipedia.org)
87] making use of the model of DRD2-/- mice found that the blockade of MAPK14 expression in mice significantly decreased prolactinoma formation and PRL production and secretion. (emlinhibitor.com)
Bromocriptine3
The objective of this study was to determine demographic profile of patients with prolactinomas, and to compare the outcomes in patients treated with Cabergoline versus those receiving Bromocriptine treatment. (aku.edu)
Bromocriptine (BEC) is generally considered to be the agent of choice in the treatment of prolactinoma. (medscape.com)
10] Bromocriptine (BEC) is generally considered to be the agent of choice in the treatment of prolactinomas because of its long track record and safety. (medscape.com)
Future therapeutic alternatives for aggressive prolactinoma according to the obtainable evidence. (emlinhibitor.com)
Hormone1
In the 2017 World Health Organization Classification of Tumours of Endocrine Organs , pituitary adenomas remain classified by hormone expression as assessed by IHC staining. (cap.org)
Infertility1
1] Causing hyperprolactinemia, prolactinomas can reduce estrogen levels in women and testosterone concentrations in men and may result in infertility. (medscape.com)
Duration1
The present study was designed to determine the effect of treatment duration on metabolism as well as metabolic alterations after treatment in comparison with baseline in patients with prolactinoma in Iranian individuals. (jdeponline.com)
Reduction4
Even in gigantic tumours a remarkable reduction of the tumour can often be achieved (Fig. 2). (uni-greifswald.de)
One year after the Pravidel treatment the MRI shows a considerable reduction of the tumour size. (uni-greifswald.de)
B: The MRI of 15.02.1994 under Pravidel therapy shows an excellent reduction in size of the tumour. (uni-greifswald.de)
We found a significant reduction in Met.S after normalization of PRL level in patients with prolactinoma. (jdeponline.com)
Treatment4
To investigate the differences between the characteristics of disease presentation and treatment outcomes on the basis of gender in patients with operated prolactinoma. (dergipark.org.tr)
The combination of dopamine agonist treatment and surgery may be the best option in challenging prolactinoma cases: a single-centre experience. (dergipark.org.tr)
The MRI 8 years after the Pravidel treatment reveals complete remission of the tumour. (uni-greifswald.de)
10. Akin S, Isikay I, Soylemezoglu F, Yucel T, Gurlek A, Berker M. Reasons and results of endoscopic surgery for prolactinomas: 142 surgical cases. (dergipark.org.tr)
Resistance1
Alternatively, the decrease expression of your ER level in male tumours in comparison with female tumours seems to confer a greater danger of extra aggressive tumours, recurrences, and resistance to remedy in males [568]. (emlinhibitor.com)
Results of the tumour size on initial MRI showed macroprolactinomas 52.9% (36), microprolactinomas in 33.8% (23), and giant prolactinomas in 13.3 % (9) patients. (aku.edu)
CONCLUSION: Most of the prolactinoma patients were females and the common the most frequent presenting complaint was headache. (aku.edu)
Other medical treatments for prolactinomas are available for patients who do not respond to BEC or for those who cannot tolerate the drug. (medscape.com)
In a prospective and longitudinal study, 27 consecutive patients with prolactinoma were assessed during 6 months. (jdeponline.com)
We suggest that it is important to consider the metabolic profile of patients with prolactinoma. (jdeponline.com)
Size2
Fortunately, the tumour rapidly reduced in size. (uni-greifswald.de)
However, the tumour did not reduce in size, but grew bigger. (uni-greifswald.de)
Growth1
The increasing and prolonged exposure of Bisphenol-A from childhood on, may contribute to the growth of a Prolactinoma. (wikipedia.org)
Therapy2
Dopamine agonist therapy for prolactinomas: do we need to rethink the place of surgery in prolactinoma management? (dergipark.org.tr)
If the medication therapy is not successful or the medication is not tolerated due to adverse reactions, microsurgical complete tumour removal is again the therapy of choice. (uni-greifswald.de)
Normal1
Other causes are other pituitary tumours and normal pregnancy and breastfeeding. (wikipedia.org)
BACKGROUND: Prolactinomas are the most common type of functional pituitary tumours. (aku.edu)
Likewise, within the Dutch transgender registry, there was identified a greater danger of prolactinomas in transwomen, compared to the common Dutch female population [92]. (emlinhibitor.com)
Produce1
Pituitary tumours that produce prolactin in an uncontrolled way are referred to as prolactinomas. (uni-greifswald.de)
Small1
There is only a small remaining tumour below the interbrain and in the region of the bony skull base. (uni-greifswald.de)
Volume1
sadly, tumour volume modifications were not reported [90]. (emlinhibitor.com)
Completely1
The optic chiasma is completely suppressed by the tumour and cannot be isolated any more. (uni-greifswald.de)