Primary prevention high hyperlipidemias. Medical search. Frequent questions

Primordial prevention usually refers to healthy lifestyle choices to prevent the development of coronary risk factors. (medscape.com)
Secondary prevention of myocardial infarction, stroke, unstable angina, and revascularization in people with established coronary artery disease. (wikipedia.org)
Myocardial infarction and stroke prevention in people with type 2 diabetes A 2014 meta-analysis showed high-dose statin therapy was significantly superior compared to moderate or low-intensity statin therapy in reducing plaque volume in patients with acute coronary syndrome. (wikipedia.org)
My primary interest is in the treatment of coronary heart disease and its prevention. (spirehealthcare.com)
I have cardiovascular research experience and have been an investigator for numerous national and international studies and trials, particularly in the management of hypertension, hyperlipidemia and coronary artery disease. (spirehealthcare.com)
It is a critical risk factor in the development of diabetes, hypertension and hyperlipidaemia, each of which is a major risk factor for coronary heart disease. (takeheart.co.uk)
In the UK, which has one of the highest coronary mortality rates in the world, 61% of men and 52% of women have a BMI greater than 25, including 16% of men and 8% of women who have a BMI greater than 30. (takeheart.co.uk)
The prevention and management of overweight and obesity should be central to the primary and secondary prevention of coronary heart disease. (takeheart.co.uk)
This finding of a low high-density lipoprotein (HDL) cholesterol level can be useful as an independent factor in assessing coronary artery disease (CAD) risk and further management. (medscape.com)
Specifically, on an a priori basis, we hypothesized that patients with acute coronary syndromes who had lower CRP levels as a result of statin therapy would have a lower risk of recurrent myocardial infarction or death from coronary causes than those who had higher CRP levels, even after we controlled for the achieved levels of LDL cholesterol. (natap.org)
The very high-risk patient is one who has multiple major ASCVD [atherosclerotic cardiovascular disease] risk events, something such as an acute coronary syndrome, prior heart attack, peripheral arterial disease, and ischemic stroke. (consultantlive.com)
The primary outcome was a composite of cardiovascular death, nonfatal stroke, nonfatal MI, or coronary revascularization and was assessed after a median follow-up of 41 months. (joulecma.ca)
The incidence of target organ damage associated to CVD increases with age, and gender studies show global higher incidence in men for stroke and coronary artery disease (CAD) [ 10 ]. (hindawi.com)
Studies of both men and women have shown that the higher your HDL, the lower your risk of coronary artery disease. (medlineplus.gov)
Primary endpoint was a composite of three major adverse cardiac events (MACE): MI, stroke, or coronary revascularization. (medscape.com)
The aim of this study was to compare the predictive value, clinical effectiveness, and cost-effectiveness of high-sensitivity C-reactive protein (hs-CRP)-screening in addition to traditional risk factor screening in apparently healthy persons as a means of preventing coronary artery disease. (cambridge.org)
Despite advances in understanding the pathogenesis and prevention of atherosclerotic cardiovascular disease (ASCVD), coronary heart disease (CHD) remains the leading cause of death in the United States. (questdiagnostics.com)
Our primary objective is to assess cardioprotective effects of diet supplementation with dried bilberry or with bioprocessed oat bran, with a secondary explorative objective of assessing their combination, compared with a neutral isocaloric reference supplement, initiated within 5 days following percutaneous coronary intervention (PCI) for AMI. (lu.se)

The primary uses of atorvastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease: Hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Fredrickson types IIa and IIb) to reduce total cholesterol, LDL-C, apo-B, triglycerides levels, and CRP as well as increase HDL levels. (wikipedia.org)
I also have a specialist interest in the treatment of high blood pressure and raised cholesterol. (spirehealthcare.com)
The ATP III reported, "When a low HDL cholesterol is associated with high triglycerides (200-499 mg/dL), secondary priority goes to achieving the non-HDL cholesterol goal. (medscape.com)
Results: Patients in whom statin therapy resulted in LDL cholesterol levels of less than 70 mg per deciliter (1.8 mmol per liter) had lower event rates than those with higher levels (2.7 vs. 4.0 events per 100 person-years, P=0.008). (natap.org)
However, a virtually identical difference was observed between those who had CRP levels of less than 2 mg per liter after statin therapy and those who had higher levels (2.8 vs. 3.9 events per 100 person-years, P=0.006), an effect present at all levels of LDL cholesterol achieved. (natap.org)
Conclusions: Patients who have low CRP levels after statin therapy have better clinical outcomes than those with higher CRP levels, regardless of the resultant level of LDL cholesterol. (natap.org)
High cholesterol is significant risk factor for cardiovascular disease, along with high blood pressure and smoking. (contemporaryclinic.com)
Hyperlipidemia is an elevation of total cholesterol (TC) or non-high-density-lipoprotein (HDL) cholesterol (TC minus HDL-cholesterol). (contemporaryclinic.com)
High cholesterol is one of the leading modifiable risk factors for prevention of ASCVD events. (uky.edu)
The 2013 American College of Cardiology/American Heart Association guidelines recommend treatment of high cholesterol as primary prevention for ASCVD in adults by lifestyle changes, CV risk estimation with an ASCVD calculator, and intensity dosing of statin medication. (uky.edu)
This project evaluated patients between the ages of 21 and 75 with an active diagnosis of high cholesterol and those that met the requirement for statin therapy according to the 2013ACC/AHA guidelines. (uky.edu)
According to the results of this review 36% of patients with high cholesterol were not receiving the recommended statin therapy supported by the 2013-guideline grade A or B recommendations. (uky.edu)
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You may have inherited your high cholesterol, but diet and lifestyle choices can also be the cause. (webmd.com)
To keep your spending down, research the financial costs of reducing high cholesterol and shop around to keep out-of-pocket costs manageable. (webmd.com)
A blood test called a lipid panel or lipid profile will show if your cholesterol is too high. (webmd.com)
For some people with high cholesterol, treatment is all about the medications. (webmd.com)
But if you take several of them for a long time, or take one of the expensive newer drugs for high cholesterol, your out-of-pocket cost can add up. (webmd.com)
You want your HDL cholesterol to be high. (medlineplus.gov)
Most people with high cholesterol or triglycerides do not feel sick. (bidrx.com)
10) National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). (guiasalud.es)
Compared with the control subjects, the case participants with metabolic syndrome were more likely to have a higher blood pressure, body mass index, waist circumference, total and LDL cholesterol, triglycerides, fasting glucose, uric acid, glomerular filtration rate, and a lower HDL cholesterol level. (biomedcentral.com)
As your provider recommends if you are taking medicines to control high cholesterol. (medlineplus.gov)
Respondents were defined as having hypertension, dyslipidemia, or impaired fasting glucose if they responded "yes" to a question asking if a doctor, nurse, or other health professional ever told them they had a specific condition (e.g., high blood pressure, high blood cholesterol, diabetes, pre-diabetes, or borderline diabetes). (cdc.gov)
The World Health Organization (WHO) asserts that it is possible to prevent 75% of premature CVDs [ 3 , 7 ] by measuring and intervening on some of its main risk factors such as unhealthy diet, inactivity, smoking, and alcohol consumption, risk factors which can lead to hypertension, high blood sugar (hyperglycemia), high cholesterol (hyperlipidemia) and overweight and obesity. (biomedcentral.com)
2 This guideline's unique approach was to shift away from the practice of treating lipid targets to specific goals (i.e., for low-density lipoprotein cholesterol [LDL-C] and non-high-density lipoprotein cholesterol [non-HDL-C]). Instead, the guideline recommended moderate- to high-intensity statin therapy for four groups of patients most likely to achieve maximal net benefit based on their increased risk. (aafp.org)
[10] NA also increases serum high-density lipoprotein cholesterol (HDL-C), commonly referred to as "good cholesterol," leading to a more desirable cholesterol ratio in the hyperlipidemic patient. (allergyresearchgroup.blog)
People with familial hypercholesterolaemia, or inherited high cholesterol, are at increased risk of developing CVD. (web.app)
Hyperlipidemia or elevated bad cholesterol is so common around the globe especially for those who are obese and have a sedentary lifestyle. (web.app)
One in four Americans aged 45 and over take cholesterol-lowering statin drugs, despite the fact that the risks are very high, and "high" cholesterol is not always the enemy it's made out to be. (web.app)
Key contributors to risk reduction for cardiovascular disease (CVD) include management of traditional risk factors (eg, smoking, high blood pressure) and lowering low-density lipoprotein cholesterol (LDL-C). 2 Earlier interventions provide greater benefits. (questdiagnostics.com)
The most recent AHA/ACC guidelines for the Primary Prevention of CVD (2019) 2 and those for the Management of Blood Cholesterol (2018) 14 include measurement of ApoB to further define risk in intermediate risk patients. (questdiagnostics.com)
2,7-9 Risk factors for CVD include abdominal obesity, insulin resistance/glucose intolerance, hypertension, high cholesterol, physical inactivity, a high-fat diet, smoking, alcohol and other drug use, which are all over-represented in the SMI group. (racgp.org.au)
It is used in the treatment of high blood cholesterol and triglycerides (fats) levels. (practo.com)
Low levels of high-density lipoprotein cholesterol (HDL), or hypoalphalipoproteinemia (HA), includes a variety of conditions, ranging from mild to severe, in which concentrations of alpha lipoproteins or high-density lipoprotein (HDL) are reduced. (medscape.com)
For men, a high-risk HDL cholesterol level is still less than 40 mg/dL, but for women, the high-risk HDL cholesterol level is less than 50 mg/dL. (medscape.com)
The data will be used to monitor the status of hyperlipidemia and the success of the National Cholesterol Education Program. (cdc.gov)
The primary endpoint is the difference in LDL cholesterol change between the intervention groups after 3 months. (lu.se)
If bilberry and/or oat, in addition to standard medical therapy, can lower LDL cholesterol and inflammation more than standard therapy alone, this could be a cost-effective and safe dietary strategy for secondary prevention after AMI. (lu.se)

Factors that may contribute to this greater platelet reactivity are not completely elucidated and include metabolic abnormalities as hyperglycemia, hyperlipidemia, insulin resistance, and conditions as oxidative stress, inflammation, and endothelial dysfunction [ 3 ]. (hindawi.com)
People with diabetes have high blood sugar because their pancreas doesn't make enough insulin or their muscle, fat, and liver cells don't respond to insulin normally. (kelsey-seybold.com)
Young people with insulin- dependent diabetes mellitus (IDDM) may have a higher prevalence of eating disorders, such as anorexia nervosa and bulimia, and adults with longstanding diabetes and major medical complications have a higher prevalence of symptoms of depression and anxiety. (cdc.gov)
Elderly persons who have non-insulin-dependent diabetes mellitus (NIDDM) and other symptomatic medical conditions may also have a higher risk of developing psychological problems. (cdc.gov)
Dietary intake habits of fatty acids, including consumption of foods with high saturated fat and high transfat contents, are associated with insulin resistance and hyperlipidemia [ 3 ]. (biomedcentral.com)
LDL-C cutpoints and targets may underestimate the risk of developing ASCVD, particularly in conditions associated with very high TG levels, such as insulin resistance, diabetes, metabolic syndrome, and obesity (see Sidebar). (questdiagnostics.com)
The guidelines recommend insulin treatment in all patients who present with ketosis or extremely high blood glucose levels because it may not be clear initially whether these patients have type 2 or type 1 diabetes. (medscape.com)

In the three subgroups of patients with dyslipidemia (high risk, moderate risk, diabetes mellitus (DM), 6 out of 7 patients (86%) in the high-risk group (LDL-c>190) were on the correct type and dosage of a high intensity statin medication. (uky.edu)

This study occurred in China, where the recurrent stroke rate was higher (near 10%) than the rate seen in primary stroke centers in more developed countries (3% to 5%), perhaps because of less emphasis on secondary risk prevention (including hypertension and hyperlipidemia) in China. (the-hospitalist.org)
Since in many of the common diseases, such as diabetes, hypertension and hyperlipidemia, both environmental factors (such as life style) and heredity factors are deeply involved, if the genetic risk factor becomes clear, it is thought that personal prevention and delay of disease onset may be possible. (tmd.ac.jp)

For the prevention of cardiovascular disease, statins are a first-line treatment. (wikipedia.org)
There is evidence from systematic review and meta-analyses that statins, particularly atorvastatin, reduce both decline in kidney function (eGFR) and the severity of protein excretion in urine, with higher doses having greater effect. (wikipedia.org)
Some studies found evening dose of both short and long half-life statins was significantly superior to morning dose for lowering LDL-C. Geriatric: Plasma concentrations of atorvastatin in healthy elderly subjects are higher than those in young adults, and clinical data suggests a greater degree of LDL-lowering at any dose for people in the population as compared to young adults. (wikipedia.org)
An important addition to the guidelines is the emphasis on risk-enhancing factors if present, put someone into a higher cardiovascular risk category they might be considering about statins and primary prevention. (consultantlive.com)
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Evidence for Statins in Secondary & Primary Prevention 2/27/2013 1 Evidence for Statins in Secondary & Primary Prevention Jennifer G. Robinson, MD, MPH Professor, Departments of Epidemiology & Medicine (Cardiology) Taking Statin Drugs Inhibits Vitamin K2 - Mercola.com By Dr. Mercola. (web.app)

Heterozygous familial hypercholesterolemia in children Homozygous familial hypercholesterolemia Hypertriglyceridemia (Fredrickson Type IV) Primary dysbetalipoproteinemia (Fredrickson Type III) Combined hyperlipidemia Primary prevention of heart attack, stroke, and need for revascularization procedures in people who have risk factors such as age, smoking, high blood pressure, low HDL-C, and a family history of early heart disease, but have not yet developed evidence of coronary artery disease. (wikipedia.org)
The risk-enhancing factors include premature atherosclerotic disease in the family, primary hypercholesterolemia that doesn't quite meet that 190 mg/dL LDL [low-density lipoprotein] threshold, metabolic syndrome or that conglomeration of factors that was just mentioned, chronic kidney disease, chronic inflammatory conditions such as lupus, rheumatoid arthritis, HIV. (consultantlive.com)

Predictors of myocardial infarction (MI) were examined in a population-based study that included approximately 400,000 persons who were not taking lipid-lowering therapy (primary prevention group) and approximately 40,000 patients with established atherosclerosis who were receiving statin treatment (secondary prevention group). (questdiagnostics.com)
Prevention of injuries in targeted organs during 1st stage of the disease (myocardial infarction, stroke, angiogenesis of retina, nephropathy, etc. (normalbreathing.com)

The primary target is prevention of the disease in high risk individuals, with current risk factors for diagnosis including hypertension, hyperlipidemia, diabetes, overweight or obesity, smoking history, low physical activity levels, nutrient-poor diet and chronic stress. (medium.com)
These effects for primary high blood pressure or for cases that are not exacerbated by other health conditions (cancer, diabetes, COPD, obesity, and so forth). (normalbreathing.com)

Despite this high prevalence, evidence increasingly suggests that the atherosclerotic process can be greatly slowed and its consequences markedly reduced by preventive measures. (medscape.com)
This issue of American Family Physician includes a review of patient-centered evidence supporting the use of lipid-lowering therapy for the prevention of atherosclerotic cardiovascular disease (ASCVD). (aafp.org)

2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations. (guiasalud.es)
Respondents were defined as eligible for intensive behavioral counseling for CVD prevention if they were overweight or obese, and had one or more CVD risk factors (hypertension, dyslipidemia, or impaired fasting glucose). (cdc.gov)

Populations with food provision in excess of requirements, with more than 30% dietary energy from fat and low levels of physical activity are those with the highest prevalence of overweight. (takeheart.co.uk)
Overweight or obese people with diabetes, hypertension or hyperlipidaemia or who are current smokers should receive priority to lose weight as they are at greatly increased risk of CHD. (takeheart.co.uk)
AIM: The purpose of this project was to evaluate a 12-week evidence-based diabetes prevention education program integrated into a primary care behavioral health setting for adults with SMI, diabetes, or prediabetes, and who were overweight or obese. (johnshopkins.edu)
In August 2014, the U.S. Preventive Services Task Force (USPSTF) recommended that adults who are overweight or obese and have additional CVD risk factors be offered or referred to intensive behavioral counseling interventions to promote a healthful diet and physical activity for CVD prevention ( 2 ). (cdc.gov)

If you have private insurance that counts a physical as preventive care , a primary care doctor's visit may cost you nothing. (webmd.com)
A US RCT found that a care management approach delivered by nurses in primary care improved preventive care and increased referrals to evidence-based services for cardiometabolic conditions in the intervention group. (racgp.org.au)

We identified 98,819 patients who were diagnosed with hyperlipidemia between January 1, 2007, and December 31, 2013, and had at least 1 triglyceride measurement annually for 4 consecutive years from the Chang Gung Research Database in Taiwan. (lww.com)
Subgroup analysis showed that this association was more pronounced among the patients with a higher neutrophil-to-lymphocyte ratio ( P for trend = 0.022). (lww.com)
The role of chronic administration of antiplatelet drugs in primary prevention of arterial vascular events is known to be less clear than in secondary prevention, and, also in diabetic patients, the decision to give primary prophylaxis should be taken on an individual-patient basis, after a careful evaluation of the balance between the expected benefits and the risk of major bleedings. (hindawi.com)
Although, currently, treatment has proven useful in reducing vascular events, diabetic patients continue to have a higher risk of adverse cardiovascular events compared with those in nondiabetic patients. (hindawi.com)
This paper reviews the role of currently available antiplatelet drugs in primary and secondary prevention of vascular events in diabetic patients and the limitations of these drugs, and it discusses the role of novel and more potent antiplatelets and of new agents currently under clinical development. (hindawi.com)
However, although the currently available treatments have proven to be useful in reducing ischemic events, diabetic patients continue to have a higher risk of adverse events compared with those in non-diabetic patients. (hindawi.com)
High on his wish list is a UKPDS-like outcomes study that uses advanced diabetes drug classes to normalize blood glucose in patients very recently-diagnosed with type 2 - we were hooked. (closeconcerns.com)
This publication is designed to help the primary care practitioner in the day-to-day management of patients with diabetes. (cdc.gov)
In our primary prevention cohort, we know there are different groups of patients who are at higher risk that we can't quite put our finger on. (consultantlive.com)
But the intensity of LDL lowering depends on the recommendations based on the absolute risk of the patient, for higher risk patients we recommend even more intensive LDL lowering. (consultantlive.com)
Also, as you mentioned in secondary prevention, there are tiers of secondary prevention with certain patients being at very high risk who need the most aggressive LDL lowering. (consultantlive.com)
The retail health clinic setting provides a unique opportunity to identify patients with hyperlipidemia and related cardiovascular risk factors. (contemporaryclinic.com)
Based on the results from this chart review there is room for improvement for PCPs in the treatment and evaluation of hyperlipidemia patients for primary prevention of ASCVD. (uky.edu)
Chronic drugs to lower high blood pressure kidney disease caused by 50% of patients with high blood pressure and low list of hypertension drug blood pressure. (cnrs.fr)
Does bempedoic acid reduce the likelihood of cardiovascular events in high-risk patients with hyperlipidemia? (joulecma.ca)
The standardized incidence ratio of head and neck SCC in patients with esophageal SCC after endoscopic resection was extremely high compared to the general population. (bvsalud.org)
Higher strength medicines are used for the highest risk patients. (medlineplus.gov)
Is There Time for Management of Patients With Chronic Diseases in Primary Care? (annfammed.org)
METHODS We applied guideline recommendations for 10 common chronic diseases to a panel of 2,500 primary care patients with an age-sex distribution and chronic disease prevalences similar to those of the general population, and estimated the minimum physician time required to deliver high-quality care for these conditions. (annfammed.org)
It is, however, possible to estimate the minimum time required for primary care physicians to deliver high-quality medical management of chronic disease to their patients according to nationally accepted guidelines. (annfammed.org)
To estimate the time required to manage chronic disease, we considered 3 elements: (1) the most common chronic diseases in the general US population, (2) the number of patients with these conditions in a representative primary care practice, and (3) the recommendations of national guidelines for high-quality clinical care of the chosen conditions. (annfammed.org)
However, patients with hyperlipidemia had a lower risk for severe outcome (aOR 0.17). (cdc.gov)
Our novel finding that Legionnaires' disease patients with hyperlipidemia had a lower risk for severe outcome deserves further study to confirm the observation and ascertain the underlying reason. (cdc.gov)
This project highlights the important role that primary care providers can play in providing health education to patients with SMI. (johnshopkins.edu)
Health care professionals have a role in counseling patients about physical activity for CVD prevention. (cdc.gov)
As of the functional outcome, around 7% of 5131 minor stroke and TIA patients in the Clopidogrel in High-risk Patients with Acute Non-disabling Cerebrovascular Events (CHANCE) trial were functionally dependent (modified Rankin Scale, mRS ≥3) at 3 months. (bmj.com)
9 In addition to conventional vascular risk factors included in commonly used risk stratification tools, higher inflammatory level is also associated with higher risks of stroke relapse in TIA and minor stroke patients. (bmj.com)
9 For instance, in a subgroup analysis of the CHANCE trial, TIA and minor stroke patients with elevated high-sensitive C reactive protein (hsCRP, a marker of inflammation) had higher risks of ischaemic stroke (12.5% vs 9.3%) and a composite of cardiovascular events and vascular death (13.6 vs 9.7%) within 1 year, compared with otherwise. (bmj.com)
However, the last 18 months have witnessed the identification of a mutation in the pseudokinase domain of JAK2 in a significant number of patients 1 , - 4 and the results of two informative clinical studies: the European Collaborative Study of Low dose Aspirin in Polycythemia Vera (ECLAP) 5 and Medical Research Council Primary Thrombocythemia 1 (MRC-PT1). (ashpublications.org)
[25] Another possible side effect of high-dose NA is a transient, modest, and reversible rise in fasting glucose and hemoglobin A1C (HbA1c), which occurs more typically in dysglycemic patients. (allergyresearchgroup.blog)
Our members are the frontline of patient care, expanding access to care for underserved patients and developing key prevention strategies. (ama-assn.org)
Reduction of cardiovascular mortality and morbidity in addition to diet in patients with moderate or severe hypercholesterolaemia and a high risk of a first cardiovascular event. (gl-pharma.com)
Reduction of post-transplant hyperlipidaemia in patients receiving immunosuppressive therapy after organ transplantation. (gl-pharma.com)
ALT elevations are clearly more frequent in patients taking higher doses of simvastatin (40 and 80 mg daily). (nih.gov)

Antiplatelet agents are effective in primary and secondary prevention of arterial thrombosis (cardiovascular events, ischaemic stroke, and peripheral arterial occlusive disease). (hindawi.com)
Does loading clopidogrel with aspirin reduce recurrent stroke after moderate to high-risk transient ischemic attack (TIA) or minor stroke if started within 24 hours of primary event? (the-hospitalist.org)
Recurrent stroke risk is highest during the first few weeks after TIA or minor stroke. (the-hospitalist.org)
Adding clopidogrel to aspirin reduced recurrent cerebrovascular event after high-risk TIA or minor ischemic stroke in China, but generalizability to other patient populations is not clear. (the-hospitalist.org)
He highlighted non-significant p-values for interaction - 0.2 for all-cause death and 0.79 for the primary outcome of three-point MACE (non-fatal MI, non-fatal stroke, or CV death). (closeconcerns.com)
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More often for people with diabetes, high blood pressure, heart disease, stroke, or blood flow problems to the legs or feet. (medlineplus.gov)
First, the most important complication from HTN is stroke , and BB have the least efficacy for prevention of stroke , compared with other blood pressure lowering medications. (medscape.com)

include new advice for lipid-lowering therapy in people at high risk for cardiovascular disease (CVD). (pharmacytimes.com)

[1] , [2] Niacin is inexpensive and therapeutically comparable with statin drugs in cases of hyperlipidemia. (allergyresearchgroup.blog)

Treatment of primary hypercholesterolaemia or mixed dyslipidaemia, in addition to diet, when response to diet and other non-pharmacological measures (e.g. exercise, weight loss) is inadequate. (gl-pharma.com)

Or if you have one of those along with some other high-risk features, like age over 65, diabetes, hyperlipidemia, hypertension, chronic kidney disease, you're a current smoker, or persistently elevated LDL or triglycerides, or history of heart failure. (consultantlive.com)

The first, the 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8) , 1 has made the news for its simplified approach to hypertension (HTN) treatment. (pharmacytimes.com)
The Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC) issued its first recommendations concerning HTN in 1976. (pharmacytimes.com)
Hypertension, commonly referred to as high blood pressure, is a risk factor for heart disease. (kelsey-seybold.com)
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Effective strategies to support these recommendation exist in the clinical practice guidelines but evidence suggest use of the ASCVD calculator for risk estimation and statin intensity dosing in primary care is not being implemented by primary care practitioners (PCP) consistently. (uky.edu)
The purpose of this study was to evaluate current hyperlipidemia practices in a Norton Medical Associates Clinic (NMA) to establish baseline use of educational material, cardiovascular risk estimate with an ASCVD calculator, and statin prescribing methods. (uky.edu)
These statin benefit groups have been identified based on rigorous analysis of data from randomized controlled trials (RCTs) for primary (groups 2, 3, and 4) and secondary (group 1) prevention of ASCVD. (aafp.org)
2 Such goals must be defined, because indiscriminate use of expensive monoclonal antibodies (i.e., the current cost of therapy is approximately $14,000 per year) for primary and secondary prevention of ASCVD will have a deep impact on health care costs. (aafp.org)

Platelets have a "key role" in atherogenesis and its thrombotic complications in subjects with DM [ 3 ], and the concomitant presence of multiple "classical" cardiovascular risk factors (arterial hypertension, cigarette smoking, and hyperlipidemia) in diabetic subjects contributes to enhanced atherothrombotic risk. (hindawi.com)
I feel confident that this strategic plan will serve as a guidance & path for prevention & control of the NCDs and their risk factors for the coming five years. (who.int)
While genes don't dictate the disease, and we need to consider traditional risk factors of disease, the study of genetic variants in an individual with high risk of CAD may provide direction for targeted therapeutic interventions and promote change in lifestyle patterns as a means to reduce the risk of developing the disease in addition to improving outcomes associated with the condition. (medium.com)
Preventative interventions, such as pharmaceutical and dietary/lifestyle changes that influence common CAD risk factors like hyperlipidemia and hypertension, for example, may be implemented early, which not only attenuates the higher cumulative risk of more serious outcomes, but does so in a more cost effective manner by sparing long-term, more intensive medical care. (medium.com)
Diabetes is considered one of the seven primary modifiable risk factors for CVD. (nursingce.com)

For saturated fat, monounsaturated fat and transfat, the higher the concentration the higher the risk for metabolic syndrome: participants in the highest quintile had a 2.22-fold (95% confidence interval [CI], 1.66 to 2.97) higher risk of metabolic syndrome. (biomedcentral.com)
In addition, the participants in higher EPA quintiles were less likely to have the risk of metabolic syndrome (adjusted risk, 0.46 [0.34 to 0.61] for the fifth quintile). (biomedcentral.com)
Participants in the highest risk group (low EPA and high transfat) had a 2.36-fold higher risk of metabolic syndrome (95% CI, 1.38 to 4.03), compared with those in the lowest risk group (high EPA and low transfat). (biomedcentral.com)
With regards to the absolute amount of fatty acids, participants with metabolic syndrome were more likely to have higher levels of saturated fatty acid, n-6 fatty acid, polyunsaturated fatty acid, and transfat. (biomedcentral.com)
However, after adjusting for total fatty acid intake, the case participants with metabolic syndrome tended to have higher levels of saturated fat, monounsaturated fatty acid, and lower n-6 fatty acid, n-3 fatty acid, marine fatty acid, polyunsaturated fatty acid, and EPA and DHA concentrations compared with the control subjects. (biomedcentral.com)
Although SMI affects a small proportion of the population (2-3%), rates of cardiovascular disease (CVD) and metabolic syndrome in this group are 2.5 times higher than in the general community, 2,3 and people with SMI under the age of 50 years are six times more likely to die from CVD. (racgp.org.au)

A study by Pande et al suggests millions of US adults with peripheral arterial disease (PAD) are not receiving secondary prevention therapies. (medscape.com)
Females, older adults, and Chinese people may be at higher risk. (bidrx.com)
This analysis indicated that 36.8% of adults were eligible for intensive behavioral counseling for CVD prevention. (cdc.gov)
In 2013, an estimated 36.8% of U.S. adults met criteria to be classified as eligible for intensive behavioral counseling for CVD prevention, including 40.0% of men and 33.5% of women ( Table 1 ). (cdc.gov)
And Dr. Alhazzani is the primary author of the Surviving Sepsis Campaign: rapid guidelines on the management of critically ill adults with Corona virus disease 2019. (cdc.gov)

VLDL contains the highest amount of triglycerides. (medlineplus.gov)

Despite relatively recent declines in age-adjusted mortality, in 2013, cardiovascular disease (CVD) was the primary cause in nearly 801,000 deaths (30.8% of total deaths) in the United States. (medscape.com)
We chose chronic diseases that (1) are the most commonly occurring and with the highest morbidity and mortality, and, among these, diseases that (2) do not typically have a specialist as the primary physician (eg, cancer, pediatric diabetes), (3) have available measures of national prevalence (in the general population), and (4) have published clinical guidelines. (annfammed.org)

5. Dr. Michael Farkouh discussed best practice lipid management for people with diabetes, highlighting a key role for PCSK9 inhibitors in treating individuals in the highest stratum of CV risk. (closeconcerns.com)
The successes are mainly attributed to efforts of Ministry of Health (MOH) and its partners in the areas of malaria control, control of vaccine preventable diseases and improvement in prevention and case management of the main childhood killer diseases. (who.int)

F or the obese patient at high risk of cardiovascular disease and in whom dietary measures over several months have not produced weight loss of at least 10% of body weight, drug treatment may be indicated. (takeheart.co.uk)
The closely interwoven lifestyle elements of sedentary behaviors and high dietary intake of saturated or trans fats are the most often seen secondary causes. (contemporaryclinic.com)

This strategic plan has considered the successes already achieved in the health sector, the global focus on non-communicable diseases, the Brazzaville declaration on prevention and control of Noncommunicable diseases in the WHO African region, the political declaration on NCDs, World Health Assembly resolutions on NCDs, the WHO Global NCD Action Plan 2013-2020 and the global NCD monitor. (who.int)
The importance of surveillance and monitoring of progress made in the prevention and control of NCDs was emphasized during the High-level Meeting of the General Assembly on the Prevention and Control of Non-Communicable Diseases, which was held on 19 and 20 September 2011 in New York. (who.int)
prepare recommendations for a set of voluntary global targets for the prevention and control of NCDs. (who.int)
As part of the Agenda, heads of state and government committed to develop ambitious national responses, by 2030, to reduce premature deaths from NCDs by one third through prevention and treatment (SDG target 3.4). (who.int)

Discussion: Controlling hyperlipidemia and inflammation is critical to preventing new cardiovascular events, but novel pharmacological treatments for these conditions are expensive and associated with negative side effects. (lu.se)

The recommendations relate to the prevention, detection, and treatment of the major complications of diabetes. (cdc.gov)
High impact essential NCD interventions can be delivered through a primary health care approach to strengthen early detection and timely treatment. (who.int)

Large clinical trials have shown that antiplatelet agents are effective in the prevention of recurrent cardiovascular events in diabetes. (hindawi.com)
In 2011, the IOM issued a statement indicating, "Because of the large number of clinical practice guidelines available, practitioners and other guideline users find it challenging to determine which guidelines are of high quality. (pharmacytimes.com)
In order to find out more about the situation, and what can be done within Primary Care, Doctors Sara and Lisa talk to Dr David McKelvey who is a GP from Salford and NHS Greater Manchester Integrated Care Clinical Lead in Sustainability in Primary Care. (gmpcb.org.uk)
Doctors Sara and Lisa talk to a GP involved in Primary Care Research Dr Imran Ghafoor and Ewa Grzegorska, a Research Support Facilitator from the National Health and Clinical Research Institute about Research in Primary Care. (gmpcb.org.uk)
Risk estimation and the prevention of cardiovascular disease: a national clinical guideline. (guiasalud.es)
MAIN OUTCOMES AND MEASURES: ICU-attributable S aureus clinical cultures (primary outcome), MRSA clinical cultures, and all-cause bloodstream infections were evaluated using proportional hazard models to assess differences from baseline to intervention periods between the strategies. (cdc.gov)
Based on the clinical decision analysis, both individuals with elevated hs-CRP-levels and those with hyperlipidemia have a similar gain in life expectancy following statin therapy. (cambridge.org)
2019 ACC/AHA Guideline on the primary prevention of cardiovascular disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. (medlineplus.gov)
Using PRS, it has been proposed that as much as 8% of the population has a greater than three-fold risk of CAD, which would have been difficult to predict as many of these individuals do not present with any of the high-risk mutations or clinical factors that precede a diagnosis. (medium.com)
We have already started the collaborative studies with several clinical labs and institutes, to realize the high-quality data collection and its linkage and association analyses. (tmd.ac.jp)
Abella Heart offers a unique primary care experience that's tailored to focus entirely on you and your individual needs-one that combines professional, clinical excellence with a personal touch. (abellaheart.com)
[24] While this is of very significant concern, occurrences in clinical studies are still rare, suggesting that utilizing NA at therapeutic doses of 2 to 4 g/day as a treatment for hyperlipidemia can be done safely under medical supervision and appropriate monitoring. (allergyresearchgroup.blog)

2 The guideline became statin-centric because most high-quality RCTs were statin trials. (aafp.org)

Atorvastatin, sold under the brand name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and to treat abnormal lipid levels. (wikipedia.org)
In this multi-institutional cohort study, high triglyceride variability was associated with an increased risk of first attack of acute pancreatitis, independent of baseline and mean triglyceride levels. (lww.com)
Reducing low-density lipoprotein (LDL) levels is the primary goal. (medscape.com)
Certain hormones act to protect bone tissue, and when hormone levels are abnormal, bones can lose calcium and weaken, putting you at higher risk of bone fractures. (kelsey-seybold.com)
Vasoconstriction, with the high levels of oxidized LDL, lowers the release of vasodilator nitric oxide from damaged endothelial walls and raises platelet aggregation and thromboxane release. (contemporaryclinic.com)
and hyperlipidemia (high levels of fat in the blood). (who.int)
High serum levels of apolipoprotein B-100 (ApoB), the primary apolipoprotein attached to atherogenic particles (LDL-C and others), are associated with increased risk of CHD. (questdiagnostics.com)
9,10 In persons with these conditions, high TG levels lead to high levels of TG-rich lipoproteins and ApoB levels that are disproportionally high relative to LDL-C. Consequently, LDL-C may be normal, but the overall lipid profile is atherogenic. (questdiagnostics.com)
70 mg/dL) may also benefit from measurement of ApoB if their TG levels and, hence, total atherogenic particle concentration remain high. (questdiagnostics.com)

to evaluate prevention and treatment programs targeting cardiovascular disease in the U.S. (cdc.gov)

Intervention intensity and treatment goals are tailored to overall risk, with those at highest risk receiving the most intense risk-lowering interventions. (aafp.org)
These data can inform the planning and implementation of health care interventions for CVD prevention that are based on physical activity. (cdc.gov)
Pharmacological and non-pharmacological interventions are available and can be used in primary care for CVD risk reduction in people with SMI. (racgp.org.au)
6 There is a need for detailed evaluation of current interventions that could reduce CVD risk, further adaptation of this knowledge for people with SMI and support for implementation within primary care. (racgp.org.au)

The 1982 publication of The Prevention and Treatment of Five Complications of Diabetes: A Guide for Primary Care Practitioners was an initial attempt to provide straightforward and practical information that primary care practitioners could immediately apply in their practice in the diagnosis and prevention of complications of diabetes. (cdc.gov)
We are interested in the study of discovering the genetic and environmental causes of the diseases, which leads the primary prevention, molecular diagnosis, and development of new medicine in the near future. (tmd.ac.jp)

Centers for Disease Control and Prevention. (cdc.gov)
Cardiovascular disease (CVD) is the leading cause of death among men and women of most racial and ethnic groups in the US, with approximately 697,000 deaths each year or one death every 34 seconds (The Centers for Disease Control and Prevention [CDC], 2022a). (nursingce.com)
I'm Commander Ibad Khan and I'm representing the Clinician Outreach and Communication Activity, COCA with the emergency risk communication branch at the Centers for Disease Control and Prevention. (cdc.gov)

This includes trials powered for superiority and trials that look more closely at primary prevention. (closeconcerns.com)
First, much of the data used to develop previous prevention guidelines came from trials that enrolled few or no women, making it difficult to perform a meaningful analysis of results by sex. (aafp.org)
In addition, new guidelines were necessitated by the publication of results from several large CVD prevention trials, most notably the Women's Health Initiative trial, which confirmed the lack of cardiovascular protection afforded by estrogen use in women after menopause. (aafp.org)
Two recently completed randomised controlled trials (RCTs) emphasise an important role for primary care in tackling this major health problem. (racgp.org.au)

[21] Additionally, research has shown that eating a medium- to large-sized apple before high-dose NA intake will mitigate this benign yet bothersome cutaneous flushing. (allergyresearchgroup.blog)
The entire family should be encouraged to adopt healthier lifestyle habits such as participation in daily exercise and decreasing the intake of high-calorie, high-fat foods. (medscape.com)

Available antiplatelet agents, such as cyclooxygenase-1 (COX-1) inhibitors (aspirin), ADP P2Y 12 receptor antagonists, and GP IIb/IIIa receptor inhibitors, are effective and save in the treatment and prevention of thrombotic events, these drugs interfere with the platelet activation process, including adhesion, release, and aggregation. (hindawi.com)

Despite the high dosage, the 40 mg pravastatin study arm in the REVERSAL trial failed to halt plaque progression, which suggests other factors such as which statin is used, duration and location of the plaque may also affect plaque volume reduction and thereby plaque-stabilization. (wikipedia.org)

Increased risk of adverse events should also be taken into account when considering high-dose statin therapy. (wikipedia.org)
A meta-analysis of 21 RCTs confirmed that high dose (80 mg) atorvastatin therapy is more effective than regular dose or low dose statin therapy at preventing CI-AKI. (wikipedia.org)
1. Stanford's Dr. Kenneth Mahaffey discussed a subgroup analysis of CANVAS suggesting consistent CV and renal benefits to Invokana (canagliflozin) therapy across primary and secondary prevention cohorts. (closeconcerns.com)
Amgen's Repatha (evolocumab) and Sanofi/Regeneron's Praluent (alirocumab) haven't quite broken into diabetes treatment algorithms, but Dr. Farkouh sees a clear niche for these more potent lipid-lowering agents - people with comorbid diabetes and hyperlipidemia despite maximally-tolerated statin therapy. (closeconcerns.com)
Women at high risk for CVD and without contraindications should receive aspirin, beta blockers, and an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker in addition to pharmacologic therapy for hyperlipidemia, hypertension, and diabetes. (aafp.org)
To date, correlations with the presence of this mutation and significantly longer duration of disease, a higher rate of complications (fibrosis, hemorrhage, and thrombosis), and treatment with cytoreductive therapy have only been identified by one group. (ashpublications.org)
Niacin therapy has long been recognized as a treatment option in addressing hyperlipidemia. (allergyresearchgroup.blog)

In her discussant, Oxford's Dr. Angelyn Bethel was skeptical that Invokana's benefits to three-point MACE apply in a primary prevention population (she posed important questions related to mechanism to build her argument), but she expressed more confidence that the drug's heart failure and renal benefits do translate. (closeconcerns.com)
The American Heart Association guidelines for CVD prevention in women provide physicians with a clear plan for assessment and treatment of CVD risk and personalization of treatment recommendations. (aafp.org)
10 Black and Hispanic women are less likely than white women to be aware that heart disease is the primary cause of death in women. (aafp.org)
We found that chronic renal failure/impairment (adjusted odds ratio [aOR] 4.09), chronic pulmonary diseases (aOR 3.22), malignancy (aOR 3.04), and heart diseases (aOR 2.15) were independently associated with a higher risk for severe Legionnaires' disease. (cdc.gov)
At Abella Heart we focus on health promotion and disease prevention. (abellaheart.com)
Abella Heart is a leading advocate for disease prevention in Miami, offering health screenings for men and women as well as providing health education and counseling. (abellaheart.com)

Concerns with 2003 JNC 7 took center stage because many primary care clinicians found that JNC 7's BP-lowering recommendations were too aggressive. (pharmacytimes.com)
They also work closely with your primary care physician to control and monitor blood sugar and prevent related health problems. (kelsey-seybold.com)
Join Dr Sara MacDermott and Dr Lisa Adams, two GPs in the Greater Manchester area, on the Primary Care Knowledge Boost podcast as they interview specialists from different subject areas with the aim of improving the confidence and knowledge of local primary care clinicians. (gmpcb.org.uk)
But if you are uninsured or have Medicare (which does not pay for annual physicals), a primary care doctor's visit in the U.S. usually costs $100 to $200. (webmd.com)
Physician time constraints in primary care are likely one cause. (annfammed.org)
The result was compared with time available for patient care for the average primary care physician. (annfammed.org)
CONCLUSIONS Current practice guidelines for only 10 chronic illnesses require more time than primary care physicians have available for patient care overall. (annfammed.org)
7 Time constraints in primary care have been shown to limit the delivery of preventive services 8 and likely also limit the delivery of care for chronic disease. (annfammed.org)
A list of the most common and burdensome chronic diseases was created from a combination of the main causes of death and chronic disease burden in the United States 9 , 10 and the most common diagnoses in primary care. (annfammed.org)
The action plan for the global strategy for the prevention and control of noncommunicable diseases addresses key components: surveillance, prevention, and health care. (who.int)
2018). Advanced practice registered nurses (APRNs) must understand the basis for the underlying pathophysiological processes, strategies for and challenges associated with managing CVD risk in T2DM, and the evidence-based prescribing guidelines for lowering cardiovascular (CV) risk to provide optimal care to this high-risk patient population (Nestro, 2023). (nursingce.com)
What Sets Abella Health Apart From Other Primary Care Providers? (abellaheart.com)
Get Your Primary Care Here! (abellaheart.com)
As your primary care provider, Abella Heart's focus is on disease prevention and wellness. (abellaheart.com)
We are committed to providing exceptional, high quality patient-centered care. (abellaheart.com)
The Best Diagnostic Testing in Miami: Expert Primary Care, Treatment, and Medical Advice and Advocacy - All Under One Roof! (abellaheart.com)

Diseases4

Chemicals and Drugs8

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Psychiatry and Psychology1

Disciplines and Occupations1

Information Science1

Health Care5

Coronary18

Cholesterol44

Insulin7

Diabetes Mellitus1

Hypertension and hyperlipidemia2

Statins6

Hypercholesterolemia2

Myocardial2

Obesity2

Atherosclerotic2

Dyslipidemia2

Overweight4

Preventive Care2

Patients34

Stroke8

Lipid-lowerin1

Statin drugs1

Dyslipidaemia1

Chronic kidney1

Blood pressure21

ASCVD4

Risk factors5

Metabolic6

Adults5

Triglycerides1

Mortality2

Management2

Dietary2

NCDs4

Inflammation1

Detection2

Clinical12

Guideline1

Levels9

Evaluate1

Interventions4

Diagnosis2

Centers3

Trials4

Intake2

Inhibitors1

Reduction1

Therapy7

Heart6

Care16