Praziquantel. Medical search. Frequent questions

Schistosomiasis caused by trematodes of the genus Schistosoma: As of 2005, praziquantel is the primary treatment for human schistosomiasis, for which it is usually effective in a single dose. (wikipedia.org)
Praziquantel is effective in reducing schistosomiasis during pregnancy. (wikipedia.org)
Praziquantel can exacerbate central nervous system pathology due to schistosomiasis. (nih.gov)
Praziquantel is an anthelmintic agent with activity against a broad spectrum of trematodes and cestodes that is used predominantly in the therapy of schistosomiasis, liver flukes, and cysticercosis. (nih.gov)
Praziquantel was approved for use in the United States in 1982 for schistosomiasis and subsequently for clonorchiasis. (nih.gov)
However, millions of people have been treated with praziquantel as a part of large scale control strategies in China where schistosomiasis Japonica is endemic. (nih.gov)
The control of schistosomiasis emphasizes preventive chemotherapy with praziquantel, which aims at decreasing infection intensity and thus morbidity in individuals, as well as transmission in communities. (plos.org)
The drug praziquantel is used against the parasitic disease schistosomiasis. (plos.org)
We put together a database from various studies of the efficacy of praziquantel against schistosomiasis. (plos.org)
In continued efforts to ensure the government of Liberia is prepared to respond to vector borne infections such as Schistosomiasis and lymphatic filariasis, the World Health Organization (WHO) in Liberia with support from the WHO African Regional Office and HQ, today donated 2,512,000 tablets of praziquantel and 12,450 testing strips for Filariasis to the Ministry of Health in Liberia. (who.int)
Something old, something new: is praziquantel enough for schistosomiasis control? (cdc.gov)
UNLABELLED: Each year, millions of African children receive praziquantel (PZQ) by mass drug administration (MDA) to treat schistosomiasis at a standard single dose of 40 mg/kg of body weight, a direct extrapolation from studies of adults. (lancs.ac.uk)
Practical dosing of praziquantel for schistosomiasis in preschool-aged children. (ox.ac.uk)
Schistosomiasis is known to occur in preschool-aged children, but achieving accurate dosing of praziquantel in its current form is challenging. (ox.ac.uk)
Controlling schistosomiasis with praziquantel: How much longer without a viable alternative? (biomedcentral.com)
The current approach of morbidity control of schistosomiasis, a helminth disease of poverty with considerable public health and socioeconomic impact, is based on preventive chemotherapy with praziquantel. (biomedcentral.com)
Future treatments for schistosomiasis could include combining praziquantel with metrifonate, or with artesunate, but these need to be evaluated in high quality trials. (cochrane.org)
Praziquantel 40 mg/kg is the most studied drug for treating urinary schistosomiasis, and has the strongest evidence base. (cochrane.org)
Potential strategies to improve future treatments for schistosomiasis include the combination of praziquantel with metrifonate, or with antimalarial drugs with antischistosomal properties such as artesunate and mefloquine. (cochrane.org)

Praziquantel (PZQ), sold under the brandname Biltricide among others, is a medication used to treat a number of types of parasitic worm infections in mammals, birds, amphibians, reptiles, and fish. (wikipedia.org)
Praziquantel is available for human use in tablets of 600 mg generically and under the brand name Biltricide. (nih.gov)

Praziquantel is used to treat schistosoma (infection with a type of worm that lives in the bloodstream) and liver fluke (infection with a type of worm that lives in or near the liver). (medlineplus.gov)
Praziquantel (praz" i kown' tel) is a heterocyclic prazino-isoquinoline derivative with a broad spectrum of activity against several trematodes (Fasciola, Schistosoma) and cestodes (Taenia). (nih.gov)
We analyzed data from 24 studies conducted at African, Asian, and Latin American sites, enrolling overall 4,740 individuals infected with Schistosoma mansoni , S . haematobium , or S . japonicum , and treated with praziquantel at doses of 40-80 mg/kg. (plos.org)
British Library EThOS: Studies on the resistance of Schistosoma to Praziquantel, an anti-schistosomal drug. (bl.uk)
Ultrastructural observations were made of changes in the tegument and reproductive organs of Schistosoma japonicum and S. mansoni from ICR mice after treatment with praziquantel (PZQ), levo-PZQ, and dextro-PZQ at a single oral dose of 500 mg/kg body weight. (ajtmh.org)

Praziquantel is also sometimes used to treat certain other worm infestations, including tapeworm (a type of worm that may attach to the wall of the intestine or may move to different parts of the body). (medlineplus.gov)
Following exposure to praziquantel, the tapeworm loses its ability to resist digestion by the mammalian host. (hardypaw.com)
Do not use it if you had an allergic reaction to praziquantel, or if you have a tapeworm infection in your eye (ocular cysticercosis). (optionrx.com)
The common tapeworm of dogs and cats, Dipylidium caninum , is the usual target of this medication although praziquantel is also effective against less common types of tapeworms such as Taenia species and the more dangerous Mesocestoides species and Echinococcus species. (vin.com)
It has been reported that approximately one cat in ten will experience weakness, salivation, or nausea after a tapeworm injection with praziquantel, but such reactions have been seen far less frequently. (vin.com)
Prazikare (Praziquantel/Pyrantel Pamoate/Febantel) is commonly used to help manage roundworm and tapeworm in dogs. (unitedpharmacies.md)
Praziquantel causes the tapeworm to dissolve within the animals intestines and often digested before it passes. (fleameds.us)
The very first solution for tapeworm invasions in dogs as well as felines is praziquantel, available in dental, injectable as well as topical kinds. (olywave.com)

Containing 1.87% ivermectin and 14.03% praziquantel this dewormer is 100% effective against tapeworms. (paddocksaddlery.com)
Zimecterin Gold Paste Dewormer by Merial combines ivermectin, a leading ingredient that controls a wide variety of parasites, with praziquantel, an ingredient that specifically controls tapeworms. (paddocksaddlery.com)
Zimecterin Gold combines ivermectin and praziquantel to provide the broadest spectrum of parasite control available for horses. (logcabintack.com)
Iverfull - albendazole, ivermectin,praziquantel 6 Tbs. (petmedsmex.com)
The company has also registered and certified praziquantel and ivermectin in many countries. (chjyyy.com)

The dose of Prazikare (Praziquantel/Pyrantel Pamoate/Febantel) will depend on your dog`s medical condition as well as the condition to be treated. (unitedpharmacies.md)
Ensure your dog is free of fleas before using Prazikare (Praziquantel/Pyrantel Pamoate/Febantel), as fleas host worms, therefore unless your dog is flea free he or she will be re-infested with worms. (unitedpharmacies.md)
Do not give your dog Prazikare (Praziquantel/Pyrantel Pamoate/Febantel) if you believe he/she may be allergic to any of its ingredients. (unitedpharmacies.md)

Praziquantel tablets are marked with 3 notches so that they can easily be split. (medlineplus.gov)
tell your doctor and pharmacist if you are allergic to praziquantel, any other medications, or any of the ingredients in praziquantel tablets. (medlineplus.gov)
These highlights do not include all the information needed to use PRAZIQUANTEL TABLETS safely and effectively. (nih.gov)
See full prescribing information for PRAZIQUANTEL TABLETS. (nih.gov)
Droncit (Praziquantel) Feline 23 mg, 50 Tablets effectively treats the two most common types of tapeworms in cats. (vetdepot.com)
Plain praziquantel is available in non-prescription tablets that may be purchased at pet supply stores. (vin.com)
Praziquantel is available in non-prescription tablets that may be purchased at pet supply stores. (vin.com)

Ask your doctor what you should do if you miss a dose of praziquantel. (medlineplus.gov)
for this condition is a single dose of praziquantel , repeated in 10 days. (nih.gov)
A single dose of praziquantel (40 mg/kg) was administered to those positive. (researchsquare.com)
Praziquantel (PZQ) is the only available antiparasitic drug and is often given out, as a single oral dose (40 mg/kg), to school-aged children by mass drug administration (MDA) schemes operating within preventive chemotherapy campaigns as endorsed by the World Health Organization (WHO). (lancs.ac.uk)
Praziquantel , adults and children, 25mg/kg in a single-dose therapy. (cdc.gov)
The drug currently recommended for treatment is praziquantel, which can be given as a single dose, but other drugs such as metrifonate, artesunate, and mefloquine have also been evaluated. (cochrane.org)
On average, the standard dose of praziquantel cures around 60% of people at one to two months after treatment ( high quality evidence ), and reduces the number of schistosome eggs in the urine by over 95% ( high quality evidence ). (cochrane.org)
Two trials compared three doses of metrifonate with the single dose of praziquantel and found similar effects. (cochrane.org)
On average, a single 40 mg/kg dose of praziquantel reduced the proportion of people still excreting eggs in their urine by around 60% compared to placebo at one to two months after treatment (treatment failure: RR 0.42, 95% CI 0.29 to 0.59, 864 participants, seven trials, high quality evidence ). (cochrane.org)

Praziquantel is in the anthelmintic class of medications. (wikipedia.org)
Praziquantel has its side and anthelmintic activity to inhibit enzyme systems carbohydrate metabolism, increases the permeability of cell membranes to calcium, followed by muscle paralysis cestode, vacuolization and disintegration of the integument. (petmedsmex.com)
Praziquantel is classified as an isoquinolone anthelmintic. (drugs.com)

Ortiz JJ, Lopez Chegne N, Gargala G, Favennec L. Comparative clinical studies of nitazoxanide, albendazole and praziquantel in the treatment of ascariasis, trichuriasis and hymenolepiasis in children from Peru. (cdc.gov)
praziquantel increases levels of albendazole by unspecified interaction mechanism. (medscape.com)

Because of the minute levels of praziquantel in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. (nih.gov)
Plasma levels of praziquantel are affected by inducers (rifampin decreases drug levels) and inhibitors of P450 activity (cimetidine, ketoconazole and erythromycin can reduce drug levels). (nih.gov)

However, there is no definitive agreement as to how the efficacy of praziquantel is best expressed. (plos.org)
This study aims to determine the current prevalence of S. haematobium , the efficacy of praziquantel, and the re-infection in children from five villages with different water access. (researchsquare.com)
The efficacy of praziquantel and re-infection rates were monitored four weeks and seven months after treatment, respectively, in 226 children with a high intensity of infection at baseline. (researchsquare.com)

Quest Plus contains both Moxidectin and Praziquantel. (paddocksaddlery.com)

The combination of praziquantel preventive therapy and snail control has resulted in marked decreases in the prevalence of infection in the population with no evidence of significant toxicity. (nih.gov)

Because of this, whole tapeworms, including the scolex, are very rarely passed after administration of praziquantel. (hardypaw.com)
Morbidity has been strongly suppressed as a result of preventive chemotherapy that is the periodic large-scale administration of praziquantel to school-aged children and other high-risk groups without prior diagnosis [ 16 ]. (biomedcentral.com)

Praziquantel Powder is a highly effective medication when treating flukes and flatworms in both freshwater and saltwater environments. (angelfishusa.com)
Praziquantel is also effective against flukes. (vin.com)
Liquid praziquantel used in the treatment of external and internal parasites, flukes, flatworms and tapeworms. (nwgponds.com)

Praziquantel is primarily used against parasites known as cestodes (tapeworms). (vin.com)
praziquantel is known to be one of the safest, most effective pond fish treatments available for treating a vast array of external and internal parasites. (nwgponds.com)

This infection is usually treated with the drug praziquantel or oxamniquine. (nih.gov)

Take praziquantel exactly as directed. (medlineplus.gov)
Your doctor will probably tell you not to take praziquantel if you are taking this medication. (medlineplus.gov)
do not breastfeed on the day you take praziquantel and for 72 hours (3 days) after you take praziquantel. (medlineplus.gov)
Do not drive a car or operate machinery on the day you take praziquantel and the day after you take praziquantel. (medlineplus.gov)

Injectable praziquantel tends to sting more than most injections and it is not unusual for a pet to scratch at the site or express discomfort immediately following injection. (vin.com)

Each chewable flavoured tablet of INTERCEPTOR PLUS is formulated to provide a minimum of 0.5 mg/kg of milbemycin oxime and 5 mg/kg of praziquantel. (drugs.com)
INTERCEPTOR PLUS should be administered orally, once every month, at the minimum dosage of 0.5 mg/kg milbemycin oxime, and 5 mg/kg praziquantel. (drugs.com)

Since 2009, praziquantel has frequently been used as preventive chemotherapy in the form of mass administration to Senegalese school-aged children, despite reports of low cure rates and possible resistance in certain endemic countries. (researchsquare.com)

Another trial found that treatment with praziquantel did not increase the rates of low birthweight, fetal death, or congenital anomalies. (wikipedia.org)
Your doctor will probably tell you to stop taking rifampin four weeks before beginning treatment with praziquantel, and will tell you to start taking rifampin again one day after finishing treatment with praziquantel. (medlineplus.gov)
Expert opinion holds that lactation should not be a contraindication to maternal treatment with praziquantel. (nih.gov)
Praziquantel (40 mg/kg) has an impact on reducing the prevalence and intensity of S. haematobium infection four weeks after treatment. (researchsquare.com)
In mass prevention campaigns for which the World Health Organization (WHO) has determined that the benefit of treatment outweighs the risk, WHO encourages the use of praziquantel in any stage of pregnancy. (cdc.gov)
For individual patients in clinical settings, praziquantel should be used in breast-feeding women only when the risk to the infant is outweighed by the risk of disease progress in the mother in the absence of treatment. (cdc.gov)
The aim of the study is to explore the damaging hematological effects due to S.mansoni infection in albino mice before and after treatment with either Commiphora molmol extract or Praziquantel. (sohag-univ.edu.eg)
A single treatment of praziquantel should clear a Dipylidium caninum infection although a second treatment is sometimes recommended if it is felt that immediate re-infection is likely. (vin.com)
Liquid Praziquantel Treatment 8 fl.oz. (nwgponds.com)

Sensitivity reactions: Urticaria, rash, pruritus and eosinophilia in white blood cell counts Other locations/body as a whole: Lower back pain, myalgia, arthralgia, fever, sweating, various cardiac arrhythmias, and hypotension The WHO states praziquantel is safe during pregnancy. (wikipedia.org)

The target of this message is to doc an instance of feasible praziquantel-resistant Dipylidium caninum efficiently managed with nitroscanate. (olywave.com)

Therefore, the current study aimed to compare ameliorative effects of Commiphora molmol extract (Mirazid, MZD) and praziquantel (PZQ) on some biochemical parameters in S. mansoni-infected mice. (sohag-univ.edu.eg)

The praziquantel in Droncit dewormers interferes with the tapeworm's ability to withstand digestion in the intestines. (vetdepot.com)

The drug cimetidine heightens praziquantel bioavailability. (wikipedia.org)

Praziquantel is also commonly used in veterinary medicine. (nih.gov)

Praziquantel is believed to act by interference with tegument calcium transport, resulting in paralysis of the parasitic worms with subsequent loss of adherence to tissue, degradation and expulsion. (nih.gov)
Praziquantel is safer than most other anti-parasitic medications. (angelfishusa.com)

The antibiotic rifampicin decreases plasma concentrations of praziquantel. (wikipedia.org)
Concomitant administration of other CYP450 inducers, for example, antiepileptic drugs and dexamethasone, may also reduce plasma levels concentrations of praziquantel. (nih.gov)
Praziquantel is excreted in low concentrations in human milk. (cdc.gov)

Several existing organization product supply praziquantel along with various parasiticides. (olywave.com)

Praziquantel comes as a tablet to take by mouth with water and a meal. (medlineplus.gov)

Praziquantel Injection is a clear solution containing 56.8 milligrams of praziquantel per mL which has been formulated for subcutaneous or intramuscular use in dogs and cats for removal of tapeworms. (hardypaw.com)
Final thoughts Nitrosconate might be an effective solution for praziquantel-resistant dipylidiasis in dogs. (olywave.com)
When combined with various product, praziquantel might be 100% effective for dealing with tapeworms in dogs [4,5,6]. (olywave.com)

Praziquantel is also effective against Echinococcus multilocularis. (wikipedia.org)

Known hypersensitivity to praziquantel or any of its ingredients. (nih.gov)
Praziquantel has been rarely associated with clinically apparent liver injury, which generally accompanied hypersensitivity reactions such as rash and fever. (nih.gov)
Thus, mild acute liver injury can accompany systemic hypersensitivity reactions to praziquantel, but both the allergic reaction and the liver injury tend to be short-lived and resolve rapidly even without specific therapy. (nih.gov)

As of late 2007, praziquantel is also available in a topical combination with the anti-parasite drug emodepside. (vin.com)
Praziquantel acts by damaging the parasite's skin internally such that the parasite disintegrates and is removed by the host's immune system. (vin.com)
We argue that a broader anthelminthic approach supplementing praziquantel with new antischistosomals targeting different parasite development stages would not only increase efficacy but also reduce the risk for drug resistance. (biomedcentral.com)

Praziquantel is in a class of medications called anthelmintics. (medlineplus.gov)

There have been few studies of long term therapy with praziquantel, and most controlled trials of this agent have used one day courses without serum aminotransferase monitoring. (nih.gov)

The drug's mode of action is not exactly known at present, but experimental evidence indicates praziquantel increases the permeability of the membranes of schistosome cells towards calcium ions. (wikipedia.org)

A recently described one-day regimen of praziquantel (PZQ) therapy for neurocysticercosis (NCC), three doses of 25 mg/k given at 2 h intervals, was applied in eight patients with viable NCC cysts without any evidence of inflammation. (edu.pe)

Praziquantel is also available in combination with other single use oral dewormers as well as with more comprehensive monthly worm protection products. (vin.com)

The antischistosomal properties of antimalarial drugs (e.g., semisynthetic artemisinins, synthetic trioxolanes, trioxaquines and mefloquine) and of drugs being developed or registered for other purposes (e.g., moxidectin and miltefosin), administered alone or in combination with praziquantel, have been tested in the laboratory and clinical trials. (biomedcentral.com)

Working with partners including the private sector, WHO continues to advocate for increased access to praziquantel and test kits to curb such infections. (who.int)

Praziquantel therapy has been reported to cause serum aminotransferase elevations during therapy, but clinically apparent liver injury after its use is rare if it occurs at all. (nih.gov)
Praziquantel is extensively metabolized by the liver via the cytochrome P450 system and might cause hepatic injury as a result of a toxic intermediate of its metabolism. (nih.gov)
Praziquantel is usually well tolerated and clinically apparent liver injury due to its use is rare. (nih.gov)
Praziquantel Injection is absorbed, metabolized in the liver and excreted via the bile into the digestive tract where its cestocidal activity is exerted. (hardypaw.com)

Anatomy1

Organisms18

Diseases21

Chemicals and Drugs13

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Geographicals4

Schistosomiasis19

Biltricide2

Schistosoma5

Tapeworm8

Ivermectin5

Pyrantel Pamoate3

Tablets7

Dose9

Anthelmintic3

Albendazole2

Levels of praziquantel2

Efficacy of praziquantel3

Moxidectin and praziquantel1

Combination of praziquantel1

Administration of praziquantel2

Flukes3

Parasites2

Drug praziquantel1

Take praziquantel4

Injectable1

Milbemycin Oxime2

Preventive1

Treatment9

Cardiac arrhythmias1

Dipylidium1

Mansoni1

Droncit1

Cimetidine1

Veterinary medicine1

Parasitic2

Concentrations3

Parasiticides1

Tablet1

Dogs3

Echinococcus1

Hypersensitivity3

Parasite3

Anthelmintics1

Controlled trials1

Permeability1

Doses1

Worm1

Clinical1

Infections1

Liver4