Populations histocompatibility antigens. Medical search. Frequent questions

In this study, we have used tetrameric major histocompatibility complex-peptide complexes to directly visualize antigen-specific cluster of differentration (CD)8+ T cells during the primary immune response to Epstein-Barr virus (EBV) infection in humans. (ox.ac.uk)
High-dimensional approaches have revealed heterogeneity amongst dendritic cells (DCs), including a population of transitional DCs (tDCs) in mice and humans. (stanford.edu)

HLA antigens are substances, usually a protein, found on the surface of our cells that stimulate the production of antibodies. (hrsa.gov)
In the case of an organ transplant, the body will recognize the HLA antigens on the transplanted organ as not being the same as its own, and form specific antibodies against those particular HLA antigens. (hrsa.gov)
Second, because of previous medical events, some patients have already developed antibodies to specific HLA antigens. (hrsa.gov)
Immunization with Mt 10 vaccine completely protected mice against CVB3-induced myocarditis and pancreatitis by inducing VP1-reactive virus-neutralizing antibodies and antigen-specific T cell responses. (unl.edu)
or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
Such chronic injury is usually mediated by anti-human leukocyte antigen antibodies. (medscape.com)
cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)

HLA is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)
Genetic association studies underscored the importance of human leucocyte antigen (HLA) genes within major histocompatibility complex (MHC) as susceptibility loci for DA. (cdc.gov)
Association of BRC with the HLA-A29 major tissue histocompatibility (MHC) antigen was first reported in 1982, 2 years after the entity was originally described. (bmj.com)
An association between Human Leukocyte Histocompatibility Antigen B-27 (HLA-B27) and major arthritis syndromes such as Ankylosing Spondylitis and Reactive Arthritis is well documented (Khan et al. (cdc.gov)
CeD is triggered by gluten consumption in genetically susceptible individuals carrying certain major histocompatibility complex (MHC) class II human leukocyte antigen (HLA) variants ( 5 , 6 ). (frontiersin.org)
T cells recognize antigens presented to them by the major histocompatibility complex of antigen-presenting cells via the TCRs expressed on their surface. (hindawi.com)
[14] In addition, a direct relationship between AS and the major histocompatibility human leukocyte antigen (HLA)-B27 has also been determined. (physio-pedia.com)
Brix T.H., Kyvik K.O., Christensen K., Hegedus L. Evidence for a major role of heredity in Graves' disease: A population-based study of two Danish twin cohorts. (rusmedserv.com)
Linkage disequilibrium between the human leukocyte antigen class II region of the major histocompatibility complex and Graves' disease: Replication using a population case control and family-based study. (rusmedserv.com)
Human leukocyte antigen B27 ( HLA-B27 ) is the major genetic susceptibility marker in AS. (molvis.org)
A small fraction of T cells recognizes alloantigen as antigenic peptide(s) presented by other major histocompatibility complex class I molecules and tolerance can be induced in this population by soluble alloantigen. (uni-muenchen.de)
This population is not affected by tolerance induction to the soluble major histocompatibility complex class I molecule. (uni-muenchen.de)
These sanctions were, however, seen as weak by anti for major and minor histocompatibility antigen recognition. (iboard.my)
Second, we identified the immunogenic epitopes in the viral protein (VP)1 of CVB3 and used this information to create major-histocompatibility complex class II dextramers and tetramers, which allowed us to analyze antigen-specific T cell responses in CVB infections. (unl.edu)
Estimates of TCR diversity imply a repertoire that can bind a universe of self and foreign peptides embedded within self-major histocompatibility complex molecules (pMHC) (Davis and Bjorkman, 1988). (siamtech.net)
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. (lookformedical.com)
Major histocompatibility complex (MHC) class I and II molecules which are called human leukocyte antigens (HLA), play an important role in the immune response (16). (ac.ir)
Moreover, DNA extracted from the blood samples was amplified for analysis of the genetic diversity in the major histocompatibility complex, class II, DQ Alpha ( MHC-DQA ) gene. (biomedcentral.com)
At the genetic level, the diversity of the major histocompatibility complex ( MHC ) is an essential reference index for monitoring the rabbit scabies. (biomedcentral.com)
Associations between a large number of diseases and markers within the major histocompatibility complex (MHC) have been described. (ox.ac.uk)
Here, we showed that harnessing iNKT cells with a second TCR specific for a tumor-associated peptide generated bispecific effectors for CD1d- and major histocompatibility complex (MHC)-restricted antigens in vitro. (unimib.it)
Chimeric antigen receptors (CARs) endow T cells with antigen-specific recognition, activation, and proliferation independent of major histocompatibility complex ( 1 - 3 ). (snmjournals.org)
Multiple genetic susceptibility loci have been identified in genomic studies, and specific major histocompatibility complexes are also linked to lupus. (lww.com)
7 It is possible that these major histocompatibility complexes bind antigens in such a way that they increase the likelihood of T-cells mounting an immune response to self-antigens. (lww.com)
Understanding the structure and variability of adaptive loci such as the major histocompatibility complex (MHC) genes is a primary research goal for evolutionary and conservation genetics. (biomedcentral.com)
The genes of the major histocompatibility complex (MHC) are crucial for the immune response in vertebrates [ 1 , 2 ]. (biomedcentral.com)
The interaction between the T cell receptor (TCR) and the antigen-presenting major histocompatibility complex (pMHC) on a contacting T cell and APC, is widely accepted to be the key interaction. (lu.se)

Several environmental, genetic, and immune factors create a "perfect storm" for the development of coeliac disease: the antigen gluten, the strong association of coeliac disease with HLA, the deamidation of gluten peptides by the enzyme transglutaminase 2 (TG2) generating peptides that bind strongly to the predisposing HLA-DQ2 or HLA-DQ8 molecules, and the ensuing unrestrained T cell response. (frontiersin.org)
This calls for the incomplete intracellular degradation of self and nonself protein into 8-14 amino acidity peptides launching the peptides towards the antigen binding groove from the MHC course I (MHC-I) or course II (MHC-II) and CORM-3 translocating the complicated towards the cell surface area for screen1. (healthweeks.com)

Polymorphisms in MHC-I protein sequences across human populations significantly affect viral peptide binding capacity, and thus alter T cell immunity to infection. (elsevierpure.com)
By weighing individual MHC allele-specific SARS-CoV-2 binding capacity with population frequency in 23 countries, we discover a strong inverse correlation between predicted population SARS-CoV-2 peptide binding capacity and mortality rate. (elsevierpure.com)

Lawler's work on human leukocyte antigens (HLA) provided evidence that choriocarcinomas may arise from an earlier rather than simply the antecedent pregnancy. (wikipedia.org)
HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
Limiting dilution analysis revealed that T cells reacting with the human histocompatibility leukocyte antigens (HLA) of the FLD were undetectable in the CD8+ T cell population and barely measurable in the CD4+ subset. (rupress.org)
Human leukocyte antigen B27 (HLAB 27) positive patients in particular -mostly those in the subgroup with ankylosing spondylitis- are affected. (molvis.org)
HLA stands for Human Leukocyte Antigen. (hrsa.gov)
In the uveitis group, etiologic diagnoses included human leukocyte antigen (HLA)-B27-associated ( n = 71) and idiopathic ( n = 49) AAU. (biomedcentral.com)
Here, we discuss the leukocyte populations that can promote immune tolerance after cell or solid-organ transplantation. (ox.ac.uk)
The majority of the antigen-specific cells had an activated/memory phenotype, with expression of human histocompatibility leukocyte antigen (HLA) DR, CD38, and CD45RO, downregulation of CD62 leukocyte (CD62L), and low levels of expression of CD45RA. (ox.ac.uk)
A strong pharmacogenetic association has been reported in Chinese patients with these HR and Human Leukocyte Antigen (HLA)-B*1502 and with HLA- A*3101 in caucasians. (usp.br)

In particular, susceptibility to several autoimmune disorders, including type I diabetes mellitus and rheumatoid arthritis, is linked to genes within the MHC and strong population associations are demonstrable between certain HLA class II alleles and these conditions. (ox.ac.uk)
We determined the allelic and nucleotide diversity for MHC class I and class II genes using samples of 250 individuals from eight breeding population of Snowy Plovers. (biomedcentral.com)

Spondyloarthropathies (SpA) encompass a group of chronic inflammatory diseases sharing common genetic and clinical features, including the association with HLA-B27 antigen, the involvement of both the axial and the peripheral skeleton, the presence of dactylitis, enthesitis, and typical extra-articular manifestations such as psoriasis, inflammatory bowel disease, and acute anterior uveitis (AAU). (hindawi.com)
Spondyloarthropathies (SpA) embrace different chronic inflammatory diseases sharing common genetic (association with HLA-B27 antigen) and clinical features. (hindawi.com)
A genetic predisposition has been identified and, in White populations, localized to a shared epitope in the HLA-DRB1 locus of class II histocompatibility antigens. (merckmanuals.com)
As a result of our study, angiotensin converting enzyme gene I/D polymorphism DD genotype could be a genetic marker in ankylosing spondylitis in a Turkish study population. (molvis.org)
Genetic mapping of HLA susceptibility loci has traditionally relied on the use of phenotypic markers defined by alloantisera, cellular typing reagents and biochemical analysis of histocompatibility antigens. (ox.ac.uk)
The rarity of private alleles across populations is consistent with high natal and breeding dispersal and the low genetic structure previously observed at neutral genetic markers in this species. (biomedcentral.com)
The loss of adaptive genetic diversity has been associated with an increase in the risk of extinction, especially in species with low population sizes [ 11 ]. (biomedcentral.com)

Phenotypic and functional alterations in lupus T cells including expansion of the Th17 population, perturbations of the physiology of T-cell receptors (TCRs) and postreceptor downstream signalling, oxidative stress, and epigenetic changes result in exaggeration of TCR response to stimuli and the propensity of lupus T cells to get activated [ 6 ]. (hindawi.com)

These data demonstrate that T cells become tolerant to autologous and allogeneic HLA antigens expressed in the thymus via two different mechanisms: hematopoietic cells present in the thymus induce tolerance to "self"-antigens by clonal deletion, whereas thymic epithelial cells induce tolerance by clonal energy and possibly deletion of high affinity clones. (rupress.org)
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. (lookformedical.com)

However, while up to 40% of the general population in Western countries express one of the predisposing HLA molecules, the global prevalence of CeD is just 1% ( 8 ). (frontiersin.org)
These molecules of cell surface play a critical role in antigen processing and T cell activity. (ac.ir)
Introduction Antigen display requires the appearance CORM-3 of main histocompatibility complicated (MHC) molecules. (healthweeks.com)

Evidence for a Graves' disease susceptibility locus at chromosome Xp11 in a United Kingdom population. (rusmedserv.com)

Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
On the other hand, CD4+ and CD8+ T cells reactive to the HLA antigens of the FTD were readily detectable. (rupress.org)
Glial cells, comprising astrocytes, oligodendrocytes, and microglia, are the non-neuronal cell population of the central nervous system (CNS). (atlasantibodies.com)
In fact, as antigen-presenting cells (APC), microglia are endowed with the ability to release pro-inflammatory cytokines and chemokines into the CNS tissue microenvironment. (atlasantibodies.com)
However, recent studies emphasize that the individual contribution of each of these cell subsets is not sufficient and that interactions between these different populations of T cells and the simultaneous activation of innate and adaptive immune pathways in distinct gut compartments are required to promote disease immunopathology. (frontiersin.org)
Stimulation of TCRs upon antigen binding triggers downstream signalling pathways which enables various physiological functions of the T cells. (hindawi.com)
Tissues, cells or organs transplanted between genetically identical individuals, i.e. members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (nih.gov)
The innate immune system is the "first line of defense" against pathogens and includes macrophages and dendritic cells that function in part to present antigens to the cells in the adaptive immune system. (mhmedical.com)
The molecular components of pathogens that are recognized by T and B cells are referred to broadly as antigens. (mhmedical.com)
Dendritic cells (DCs) are highly specialized and efficient antigen-presenting cells (APCs). (mhmedical.com)
These data imply the presence of two populations of alloreactive cytolytic T cells. (uni-muenchen.de)
T cells remember immunity-inducing fragments, called antigens, from the pathogens they have encountered. (siamtech.net)
Little is well known about what occurs to a specific kind of T cellthe Compact disc4+ T cellsas people age group, despite the fact that this population performs a critical part in providing additional immune system cells with comprehensive guidelines on when and how exactly to battle a pathogen. (siamtech.net)
However, those Compact disc4+ T cells that stay are more most likely than Compact disc4+ T cells from young mice to have the ability to understand multiple antigens. (siamtech.net)
Alternatively, while there may be more CD4+ T cells that can multitask by recognizing multiple antigens, their ability to respond appropriately to infections or vaccinations may be diminished. (siamtech.net)
Such populations include regulatory T cells, B cells and macrophages, as well as myeloid-derived suppressor cells, dendritic cells and mesenchymal stromal cells. (ox.ac.uk)
Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo. (ox.ac.uk)
We show that massive expansion of activated, antigen-specific T cells occurs during the primary response to this virus. (ox.ac.uk)
After recovery from AIM, the frequency of antigen-specific T cells fell in most donors studied, although populations of antigen-specific cells continued to be easily detectable for at least 3 yr. (ox.ac.uk)
Different from pre-cDCs, tDCs have less turnover, capture antigen, respond to stimuli and activate antigen-specific naive T cells, all characteristics of differentiated DCs. (stanford.edu)
CD1d-restricted invariant natural killer T (iNKT) cells actively participate in tumor immunosurveillance by restricting suppressive myeloid populations in the TME. (unimib.it)
Upon in vivo transfer, TCR-engineered iNKT (TCR-iNKT) cells showed the highest efficacy in restraining the progression of multiple tumors that expressed the cognate antigen compared with nontransduced iNKT cells or CD8+ T cells engineered with the same TCR. (unimib.it)
TCR-iNKT cells achieved robust cancer control by simultaneously modulating intratumoral suppressive myeloid populations and killing malignant cells. (unimib.it)
There remains an urgent need for the noninvasive tracking of transfused chimeric antigen receptor (CAR) T cells to determine their biodistribution, viability, expansion, and antitumor functionality. (snmjournals.org)
Their encoded proteins are involved in presenting antigen derived from pathogens to immune cells, which then trigger a cascade of immune responses [ 3 , 4 ]. (biomedcentral.com)
Interactions between immune cells such as T cells and antigen-presenting cells (APCs) are integral for mounting an adaptive immune response. (lu.se)

Transplant centers enter these unacceptable antigens for their candidates. (hrsa.gov)
When a transplant coordinator enters the unacceptable antigens for a patient, the CPRA calculator automatically calculates the CPRA value. (hrsa.gov)
Whenever a transplant coordinator updates a patient's unacceptable antigens, the system will automatically recalculate the value. (hrsa.gov)
Following cell and organ transplantation, it is essential to control both the innate immune response triggered by the injured tissue and the adaptive immune response stimulated by mismatched donor and recipient histocompatibility antigens to enable the transplant to survive and function. (ox.ac.uk)

Polymerase chain reaction sequence-specific oligonucleotide (PCR-SSO) typing combines the ability to define the finest of HLA specificities, by analysis of the corresponding DNA sequences, with the possibility of study large populations of normal and affected individuals. (ox.ac.uk)

However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs. (lookformedical.com)

A few studies have been conducted regarding the relationship between HLA alleles and the incidence of recurrent aphthous stomatitis in different human populations especially in the Iranian population (15). (ac.ir)

If present, private alleles generally occurred at very low frequencies in each population, except for the private alleles of MHC class I in one island population (Puerto Rico, lineage tenuirostris ). (biomedcentral.com)

Amount 5 VM DA neurons insert and screen antigen VM DA neuronal eliminating by CTLs We initial examined the capability of CTLs to react to MHC-I induced SN neurons by pursuing CTL proliferation using 5-bromo-2-deoxyuridine (BrdU) incorporation. (healthweeks.com)

The Gag-AI9/H-2K(d) epitope elicited high-avidity CD8 T cell populations with architecturally diverse clonotypic repertoires that displayed potent lytic activity in vivo. (nih.gov)
Although low-dose vaccination enhanced the functional profiles of both epitope-specific CD8 T cell populations, greater polyfunctionality was apparent within the Pol-LI9/H-2D(d) specificity. (nih.gov)
However, there were no noteworthy phenotypic differences between epitope-specific CD8 T cell populations across vaccine doses or time points. (nih.gov)
Collectively, these data indicate that the functional and phenotypic properties of vaccine-induced CD8 T cell populations are sensitive to dose manipulation, yet constrained by epitope specificity in a clonotype-dependent manner. (nih.gov)

Entering unacceptable antigens for candidates increases the efficiency of organ allocation by screening off incompatible donors. (hrsa.gov)

That way a potential donor with the unacceptable antigen will not even be considered for that candidate. (hrsa.gov)
Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (lookformedical.com)

In the present study, we assess the relationship between observed SARS-CoV-2 population mortality and the predicted viral binding capacities of 52 common MHC-I alleles. (elsevierpure.com)
Most alleles were present in more than one population. (biomedcentral.com)

Antigens that exist in alternative (allelic) forms in a single species. (lookformedical.com)

Combining serologic and virologic screening might enable monitoring of discrete population immunologic markers and their implications for emergent variant transmission. (cdc.gov)

This is the first publication to examine HFE allele frequencies in an unbiased sample of the Caucasian population. (nih.gov)
They find that a composite population-level metric combining predicted MHC allele SARS-CoV-2 binding capacity and endemic allele frequencies is inversely correlated with deaths per million. (elsevierpure.com)

We characterized two immunodominant CD8 T cell populations generated in response to immunization of BALB/c mice with a replication-deficient adenovirus serotype 5 vector expressing the HIV-derived Gag and Pol proteins at equivalent levels. (nih.gov)
Despite the presence of H-2Kk antigen, these mice were still able to generate an H-2Kk-specific T-cell response. (uni-muenchen.de)
In contrast, only transgenic mice failed to generate a cytolytic T-cell response to soluble H-2Kk antigen expressed by recombinant vaccinia virus and presented by the H-2Db molecule. (uni-muenchen.de)

The lifetime cumulative incidence of acute anterior uveitis in a normal population and its relation to ankylosing spondylitis and histocompatibility antigen HLA-B27. (qxmd.com)
The lifetime cumulative incidence of acute anterior uveitis (AAU) was determined in a sample of a large population (n = 10,500). (qxmd.com)
Acute anterior uveitis (AAU) is the most common type of uveitis among the general population. (biomedcentral.com)

For example, if a candidate has developed a specific antibody to the HLA antigen A2, that person is said to be "sensitized" to the A2 antigen. (hrsa.gov)

One of the main functions of the innate immune system is to present antigens to the adaptive immune system to orchestrate a functional immune response. (mhmedical.com)

It is associated with the histocompatibility antigen HLAB51 and is driven by T cell activation. (deepdyve.com)
The properties of transmembrane and soluble transplantation antigens were compared with respect to the induction of tolerance and the selection of the T-cell repertoire. (uni-muenchen.de)
This analysis led us to identify unique sets of transcription factors in each cell population that could potentially be targeted for therapy. (unl.edu)
HLA polymorphism can directly affect the bonding capacity of antigens and thus affect antigen-specific T-cell response (17). (ac.ir)
The magnitude of the antigen-specific component versus the bystander component of a primary T cell response remains controversial. (ox.ac.uk)
Selective T cell ablation in vivo with 177 Lu-AABD seems feasible for clustered T-cell populations. (snmjournals.org)
These results led us to examine whether neuronal antigen-loaded MHC-I was proficient to result in CTL mediated cell death. (healthweeks.com)
This is measured on individual cell-SLB contacts, providing an accurate new means of measuring binding affinity and to study differences in the 2D Kd in the cell population. (lu.se)

The observed frequency of the concurrence of AAU and ankylosing spondylitis (AS) was 0.4% in the HLA-B27-positive population and 0.02% in the HLA-B27-negative population. (qxmd.com)
To our knowledge, angiotensin converting enzyme ( ACE ) gene I/D polymorphisms have not yet been investigated in AS patients in Turkish population.This study was conducted in Turkish patients with AS to determine the frequency of I/D polymorphism genotypes of angiotensin converting enzyme gene. (molvis.org)

The present study aimed to examine the relationship between one of the histocompatibility antigens (HLA DRB1) and its sub-groups with the incidence of recurrent aphthous ulcers in North East of Iran (Mashhad) population. (ac.ir)
To examine antigen display by cultured neurons we taken out all resources of bovine serum albumin (BSA) in the media and shown VM neuronal civilizations to poultry OVA. (healthweeks.com)

HLA-B27 has been extensively studied clinically but there is limited population-level data available. (cdc.gov)

A Strategic Plan for the Elimination of Tuberculosis in the United States Message to the Readers of Morbidity and Mortality Weekly Report I am pleased to provide you with 'A Strategic Plan for the Elimination of Tuberculosis in the United States' describing actions necessary to achieve the goal by the year 2010, with an interim target of a case rate of 3.5 per 100,000 population by the year 2000. (cdc.gov)
The committee urges the nation to establish the goal of tuberculosis elimination (a case rate of less than one per million population) by the year 2010, with an interim target of a case rate of 3.5 per 100,000 population by the year 2000. (cdc.gov)
The prevalence of systemic lupus erythematosus (SLE) ranges from 7.4 to 159.4 per 100,000 of population, with the highest rates among United Kingdom residents of Afro-Caribbean descent, and non-White populations elsewhere. (lww.com)

The study population consisted of 140 workers exposed to diisocyanate s of which 73 were diagnosed with DA based on a positive specific inhalation challenge and 67 were asymptomatic workers exposed to hexamethylene diisocyanate (HDI). (cdc.gov)

[14] [15] The exact role of this antigen is unknown but is believed to act as a receptor for an inciting antigen leading to AS. (physio-pedia.com)
The RAS etiology is less described, despite the overall agreement about the role of autoimmune reaction to oral mucosa or cross-reactive antigens. (ac.ir)

Anatomy32

Organisms13

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Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes49

Disciplines and Occupations2

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Major27

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Peptide2

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Genes2

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Molecules3

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Cells26

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Uveitis3

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Cell8

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Examine2

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100,0003

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