• This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. (wikipedia.org)
  • PPIH enzyme is a precise factor of the complex that comprises pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. (prospecbio.com)
  • One critical step involves recruitment of the pre-assembled U4/U6.U5 tri-snRNP to Complex A, which engages 5′ and 3′ splice sites, to form the pre-catalytic Complex B. Complex B then undergoes profound structural and conformational changes that lead to catalytic activation and conversion to Complex B act , which initiates catalysis and nucleates the formation of Complex C, which completes the splicing reaction [ 3 , 4 ]. (biomedcentral.com)
  • The large ~280-kDa U5 snRNP protein PRPF8 is central to the dynamics of spliceosome assembly [ 11 ]. (biomedcentral.com)
  • Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the SNRPD1 gene. (wikipedia.org)
  • This process is carried out by the human spliceosome machinery, in which over 300 proteins sequentially assemble with uridine-rich small nuclear RNA molecules (U snRNAs) to form distinct small nuclear ribonucleoprotein complexes (snRNPs). (biomedcentral.com)
  • The core spliceosome component PRPF8 is essential for spliceosome assembly through its participation in ribonucleoprotein (RNP) complexes for splice-site recognition, branch-point formation and catalysis. (biomedcentral.com)
  • Other autoantibodies have proved to be valuable tools to study cellular processes in which the autoantigens are involved, such as the splicing of precursor messenger RNAs (pre-mRNAs) mediated by the autoantigenic U small nuclear ribonucleoprotein complexes (U snRNPs) [ 3 ]. (biomedcentral.com)
  • Similarly, small nuclear ribonucleoprotein polypeptide N (SNRPN) regulates neurodevelopment and cognitive ability. (bvsalud.org)
  • These proteins are commonly referred as Sm nuclear antigens due to their antigenic nature. (nih.gov)
  • Nuclear pore complex, NUP2/50/61 [Interproscan]. (ntu.edu.sg)