• The growth of the special genomics and transcriptomics market is further accelerated due to the availability of automated sequencing methods like laser capture microdissection technique (LCM) to satisfy the requirement for nucleic acid sequencing of biological specimens. (maximizemarketresearch.com)
  • The segment dominance is due to the accessibility of automated sequencing methodologies to cater to the growing demand for nucleic acid sequencing of biological samples or single cells. (grandviewresearch.com)
  • Among the adult population, renal cell carcinoma (RCC) constitutes the most prevalent form of kidney neoplasm. (biomedcentral.com)
  • Among the adult population, renal cell carcinoma (RCC) constitutes the most prevalent form of kidney neoplasia, and can be pathologically classified into subtypes: the clear cell type, which constitutes 80% of all cases, the papillary type, at around 15%, and the remaining 5% of other histological types. (biomedcentral.com)
  • Brumell JH, Tang P, Zaharik ML, Finlay BB: Disruption of the Salmonella -containing vacuole leads to increased replication of Salmonella enterica serovar typhimurium in the cytosol of epithelial cells. (pcna-signal.com)
  • Recent findings suggest these microRNAs (miRNAs) have a critical role that affects the stroma rather than epithelial cells. (biomedcentral.com)
  • Altogether, these results suggested that systemic miR-143/miR-145 expression could support tumor growth and launched the hypothesis that these miRNAs affected the stroma rather than epithelial cells [ 4 ]. (biomedcentral.com)
  • To further explore the role of the tumor microenvironment, stromal cells were isolated and sorted, and the researchers found that endothelial cells, but not epithelial cells, were enriched in miR-143/miR-145. (biomedcentral.com)
  • We have shown recently that in breast and prostate tumors, as well as in breast tumor cell lines, HIF-1α has a crucial role in regulating, either directly or indirectly, the expression of pro-inflammatory genes. (biomedcentral.com)
  • These repressors could down-regulate CRE-dependent transcription and thus cause delay of cell cycle progression and/or promote cell cycle exit during terminal differentiation. (biomedcentral.com)
  • Reduction of CYP1B1 levels fail to prevent in vitro tumorigenicity such as proliferation, apoptosis, and cell cycle progression of RCC cells. (oncotarget.com)
  • In the present study, up-regulation of SOX9 was observed in both NPC tissues and different NPC cells. (cancerindex.org)
  • The high diagnostic potential of peptides and proteins from cells, tissues, and biological fluids is unquestionable. (genengnews.com)
  • Our team was the first to conduct an in-depth molecular comparison of cancer and normal tissues for the presence of cancer stem cells," says David M. Lubman, Ph.D., professor of surgery at the University of Michigan, Ann Arbor. (genengnews.com)
  • The wide range of manifestations observed in patients with mitochondrial disease results from varying fractions of abnormal mtDNA molecules in different cells and tissues, a phenomenon termed heteroplasmy. (jci.org)
  • However, the landscape of heteroplasmy across cell types within tissues and its influence on phenotype expression in affected patients remains largely unexplored. (jci.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Heat shock can trigger several signaling pathways known to protect cells against cellular insults. (uw.edu)
  • Biological assays showed that invasive and migratory behavior was strengthened by hypoxia only in GBM stem cells. (biomedcentral.com)
  • Sequencing of a nucleic acid of single cells or specific biological specimens has increased, which has driven the need for automated, robust, and scalable library preparation solutions. (grandviewresearch.com)
  • The determination of the spatial arrangement of molecules in cells and tissue samples is the basis for biological research and clinical practice and has gained the attention of several entities involved in the field of genetics. (grandviewresearch.com)
  • Spatial genomics and transcriptomics offer unique advantages in studying the spatial organization and interactions of cells within complex biological systems. (grandviewresearch.com)
  • Therefore, the cells present in the tumor stroma should be considered when studying the underlying biological mechanisms and therapeutic approaches for epithelial tumors. (biomedcentral.com)
  • The advantage of cryoEM is that the cells are vitrified in their pristine biological state, without any alteration of the cellular composition. (zeiss.com)
  • Increasing tumor size requires that GBM tumor cells maintain a balance between adaptation to hypoxia and cell death (apoptosis and central necrosis) through activation of hypoxia-inducible transcription factor 1 (HIF-1). (biomedcentral.com)
  • The Sox9 gene is required for the differentiation of mesenchymal precursor cells to chondrocytes and, together with the related L-Sox5 and Sox6 proteins, controls chondrocyte-specific gene expression [ 4 , 5 ]. (biomedcentral.com)
  • This will lead to the rise in the entry of players and this domain and will affect the molecular diagnostics market. (openpr.com)
  • Scientists have endeavored to peer into cells and disentangle their complex molecular makeup for hundreds of years. (technologynetworks.com)
  • We provide invaluable resource and tools to identify potential new molecular players involved in pollen-stigma interaction. (biomedcentral.com)
  • Analysis of immunophenotypically defined cell populations markedly increased specificity of liquid chromatography-tandem mass spectroscopy (LC-MS/MS). Over 375 differentially expressed proteins were analyzed by Ingenuity Pathway Analysis (Ingenuity Systems). (genengnews.com)
  • SOX9 promotes nasopharyngeal carcinoma cell proliferation, migration and invasion through BMP2 and mTOR signaling. (cancerindex.org)
  • Overexpression of SOX9 promoted NPC cell proliferation, migration and invasion. (cancerindex.org)
  • After differentiation, fully developed cereal endosperm makes up to 75% of the grain weight and covers four major cell types: aleurone, starchy endosperm, transfer cells, and the cells of the embryo surrounding region 1 . (nature.com)
  • However, usefulness of microdissection is often limited by the difficulties in identifying desired cell types by morphology alone. (genengnews.com)
  • Various instruments are used for the retro sigmoid approach to the CPA, including craniotomy instruments, retractors, high-speed surgical drills with a selection of cutting and diamond burrs, suction and suction-irrigation tips of the fenestrated and no fenestrated types, bipolar cautery, microdissection instruments, and a binocular operating microscope. (relien-web.com)
  • G allele was neither evenly nor randomly distributed across diverse cell types. (jci.org)
  • Formerly known as glioblastoma multiforme, the term "multiforme" reflects a robust heterogeneous variety of cell types coexisting within the tumor. (biomedcentral.com)
  • The aim of our study was to analyze the hypoxic and pro-inflammatory microenvironment in GBMs and to demonstrate that in a stem/progenitor cell line derived from human glioblastoma (GBM-SCs), hypoxia activates a coordinated inflammatory response, evidencing an invasive and migratory phenotype. (biomedcentral.com)
  • In the Brassicaceae, sophisticated mechanisms have evolved that allow the epidermal cells of the stigma, also known as papillae, to reject self (or incompatible) pollen while accepting non-self (or compatible) pollen. (biomedcentral.com)
  • During the past years considerable effort has been made to better understand the pathophysiological mechanisms underlying neuronal cell loss or alterations in synaptic transmission in neurological and psychiatric diseases [ 1 , 2 ]. (biomedcentral.com)
  • These results suggest that CYP1B1 up-regulation mediated by low miR-200c is one of the mechanisms underlying resistance of RCC cells to docetaxel. (oncotarget.com)
  • Understanding the mechanisms involved in preventing hair cell death may yield pharmacological advancements to protect sensory hair cells when these antibiotics are administered. (uw.edu)
  • We hypothesized that applying heat shock prior to exposing the hair cells to neomycin would inhibit damage by increasing cellular defense mechanisms as seen in other organisms. (uw.edu)
  • Most surgically removed tissue samples contain a low percentage of tumor cells embedded in a dense stroma. (genengnews.com)
  • This method allowed us to zero in on a small population of cancer stem cells expressing CD24, a specific cell surface biomarker shown to correlate with the development and metastasis of pancreatic cancer," continues Dr. Lubman. (genengnews.com)
  • We have also evidenced a similar pattern of overexpressed genes in GBM-SCs after hypoxic treatment, showing also a gain of invasive and migratory function that was lost when these stem cells differentiated. (biomedcentral.com)
  • The relevance of IEs has also been observed in a small population of cancer stem cells known as glioma stem cells (GSCs), which are thought to participate in GBM tumor initiation and drug resistance. (biomedcentral.com)
  • Identification of crucial cancer biomarkers requires analysis of a pure and homogeneous cell population. (genengnews.com)
  • In June 2021, The market player like Nanostring's Digital Spatial is boosting the research activities on SAR-CoV-2 as the company is operating into FFPE samples specimens invented for COVID-19 Autopsies. (maximizemarketresearch.com)
  • In an interview with Technology Networks, Lundberg discusses the evolution of spatial biology and her career, outlining how spatial insights can provide a deeper appreciation of the complex inner workings of cells. (technologynetworks.com)
  • High adoption compared to spatial genomic methods, for the transcriptomic study of single cells is a key segment driver. (grandviewresearch.com)
  • The combination of single-cell RNA sequencing and microdissection techniques that preserves positional information has become a major tool for spatial transcriptome analyses. (authorea.com)
  • Current pharmacological treatment focuses on the primary mechanism of injury and aims at modulating the immune system in order to prevent axonal damage and cell loss [ 8 - 10 ]. (biomedcentral.com)
  • Hypoxic stem cell lines showed a clear time-dependent activation of the entire panel of pro-inflammatory genes as compared to differentiated tumor cells. (biomedcentral.com)
  • We had shown earlier that transcription of the cell cycle genes cyclin D1 and cyclin A in chondrocytes is dependent on CREs. (biomedcentral.com)
  • Deciphering the specific transcriptomic response of both pollen and stigmatic cells during their interaction constitutes an important challenge to better our understanding of this cell recognition event. (biomedcentral.com)
  • This research aims to provide readers with a thorough understanding of the global cell counting consumables market's anticipated trajectory. (articlepedia.xyz)
  • Dr. Emma Lundberg , professor of bioengineering and pathology at Stanford University and the KTH Royal Institute of Technology, and director of the Cell Atlas portion of the Human Protein Atlas, has been a key figure in such developments. (technologynetworks.com)
  • Who are the major players in testing for the number two killer in the world? (kaloramainformation.com)
  • repetitive consumption across various workflow steps along with a large number of product offerings from key players are the major reason for revenue leadership. (grandviewresearch.com)
  • A hallmark of several major neurological diseases is neuronal cell death. (biomedcentral.com)
  • The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. (cancerindex.org)
  • GBM stem and differentiated cells were incubated under hypoxic conditions and analyzed for pro-inflammatory gene expression and for invasive/migratory behavior. (biomedcentral.com)
  • Further research may yield insight toward pharmacological advances that prevent antibiotic-induced hair cell damage. (uw.edu)
  • Our combined results indicate that differences in mortality between Nitrospinae and AOA, rather than thermodynamics, biomass yield and cell size, determine the abundances of these main marine nitrifiers. (nature.com)
  • All neuroectoderm-derived neural cells exhibited a high percentage of the mutant variant. (jci.org)
  • Restoration of docetaxel resistance by exogenous expression of CYP1B1 in miR-200c-over-expressing cells indicates that CYP1B1 is a functional target of miR-200c. (oncotarget.com)
  • There are many questions regarding how diatoms concentrate silicon in their cells, in which organelles, and to what concentrations. (zeiss.com)
  • This allows players to concentrate their efforts on regional markets with the potential for rapid growth shortly. (articlepedia.xyz)
  • Finally, alteration of miR-200c levels affects the chemosensitivity of RCC cells. (oncotarget.com)
  • Not only could they provide quantitative measurements of intracellular silicon levels, but they also found out that these cells keep a constant pool of this element in their cells. (zeiss.com)
  • Zebrafish are often used to study hair cells because fish have readily accessible hair cells on their exterior that are analogous to sensory hair cells within our inner ear. (uw.edu)
  • Dhirtek Business Research and Consulting most recent study on the cell counting consumables market provides a comprehensive view of the entire market. (articlepedia.xyz)
  • The comprehensive research study employs Porter's five forces analysis and SWOT analysis to provide readers with a clear picture of the global cell counting consumables market's expected direction. (articlepedia.xyz)
  • Furthermore, the study provides government forecasts for regional markets that affect the global cell counting consumables sector. (articlepedia.xyz)
  • The growth of the segment is attributed to the high adoption of the transcriptomics segment as compared to the genomics segment for the analysis of single-cell transcriptomics. (maximizemarketresearch.com)
  • However, high costs and time requirements, especially for experiments at the single cell scale, make it challenging for this approach to meet the demand for increased throughput. (authorea.com)
  • Here, we identify nonrandom distribution of a pathogenic mtDNA variant across a complex tissue using single-cell RNA-Seq, mitochondrial single-cell ATAC sequencing, and multimodal single-cell sequencing. (jci.org)
  • The JoVE video player is compatible with HTML5 and Adobe Flash. (jove.com)
  • Older browsers that do not support HTML5 and the H.264 video codec will still use a Flash-based video player. (jove.com)
  • The video player is blocked due to your tracking preferences. (zeiss.com)
  • Peptonics: a new family of cell-protecting surfactants for the recombinant expression. (authorea.com)
  • Previously, we identified inducible nitric oxide synthase (iNOS) as an essential enzyme for development and reversal of smoke-induced PH and emphysema, and showed that iNOS expression in bone-marrow-derived cells drives pulmonary vascular remodelling, but not parenchymal destruction. (ersjournals.com)
  • Despite high protein expression and enzymatic activity of cytochrome P450 1B1 (CYP1B1) in renal cell cancer (RCC), its functional significance has not been elucidated. (oncotarget.com)
  • Instead, alteration of CYP1B1 expression regulates the chemosensitivity of RCC cells to docetaxel suggesting its critical contribution to the chemoresistance. (oncotarget.com)
  • The SWOT analysis focuses on defining the global cell counting consumables market's strengths, weaknesses, opportunities, and threats, whereas Porter's five forces analysis emphasizes competitive competition. (articlepedia.xyz)
  • Analysts have provided clients with unbiased perspectives on the global cell counting consumables industry to assist them in making well-informed business decisions. (articlepedia.xyz)
  • We quantified the degree of damage to the hair cells 5 hours after neomycin treatment by scoring (ranking) hair cell clusters based on cluster size and counting the number of hair cells located in specific areas. (uw.edu)
  • These processes are regulated by a large number of endocrine, paracrine and autocrine hormones and growth factors that, to a large part, act on chondrocyte cell surface receptors. (biomedcentral.com)
  • A nitrogenous base cytoplasm the living contents of a cell, found in dna and rna. (dakne.co)
  • Sensory hair cells in our inner ear are necessary to detect sound, and hair cell death is the primary cause of hearing loss. (uw.edu)
  • A certain class of antibiotics, including neomycin, induces hair cell death. (uw.edu)
  • This project investigated the effects of heat shock on neomycin-induced hair cell death. (uw.edu)
  • Research in by TEMPO in 2006 revealed that 54% of US teenagers own MP3 players. (southwestvasectomyreversal.com)
  • The research report delves deeply into the global cell counting consumables market's drivers and restraints. (articlepedia.xyz)
  • The research report goes into great detail about the trends and consumer behavior patterns expected to shape the global cell counting consumables market's evolution. (articlepedia.xyz)
  • The global cell counting consumables market research study's type, application, and region components are divided into three parts. (articlepedia.xyz)
  • The entorhinal denervation in vitro model was used to assess dendritic changes of denervated mouse dentate granule cells. (biomedcentral.com)
  • Renal cell cancer (RCC) accounts for 2-3% of all tumor malignancies in human. (oncotarget.com)
  • Then, they developed a sophisticated procedure to measure the concentration of silicon with EDS, while taking advantage of the 3D information to understand where in the cell they are measuring. (zeiss.com)
  • Our results suggest that heat exposure partially inhibits neomycin-induced hair cell damage. (uw.edu)
  • Following compatible pollination, the dry pollen grain hydrates on the stigma papilla and ultimately germinates, producing a tube that penetrates the wall of the stigmatic cell and grows down to convey the male gametes towards the ovules for fertilization [ 1 , 2 ]. (biomedcentral.com)
  • These tiny cells can form an extracellular cell wall that is made from simple materials like silica or calcium carbonate with exquisite morphologies, unequaled by any man-made process. (zeiss.com)
  • Warm colors indicate higher Si concentrations both in the cell wall and the cell interior. (zeiss.com)
  • miR-143 and miR-145 have been considered ideal candidates for cancer therapy, and several strategies for delivery of these miRNAs into cells are being explored [ 3 ]. (biomedcentral.com)