AnatomyDiseasesChemicals and Drugs
Neoplasms, Plasma CellPlasmacytomaMultiple MyelomaPlasma CellsAdenoma, OxyphilicHistiocytic Disorders, MalignantLeukemia, Plasma CellNeoplasm ProteinsPerivascular Epithelioid Cell Neoplasms
Hematologic neoplasmsMyeloproliferativePrecursor cellsBone marrowImmunohistochemicalMalignantSoft-tissueEosinophilicLeukemiasVascularAntibodiesDiagnosticMyelomaElectrophoresisLymphoma cellsImmuneCancerDiagnosisAntibodyDifferentiationAggressiveInfectionDiseasesAnemiaPresenceWhite bloodBloodResearchPresentSingleSitesFormType
Hematologic neoplasms1
  • Acute myeloid leukemias (AMLs) are heterogeneous hematologic neoplasms characterized by myeloblast or promyelocyte proliferation without normal differentiation. (koreamed.org)
Myeloproliferative3
  • 1. A referral to p. 57 has been added to the table title, to refer the reader to the Myeloproliferative neoplasm, unclassifiable section, to which this table relates. (who.int)
  • The diagnosis of myeloproliferative neoplasm (MPN), The diagnosis of myeloproliferative neoplasm (MPN), unclassifiable, requires that either all 3 criteria are met. (who.int)
  • Myeloproliferative neoplasms are caused by genetic mutations. (msdmanuals.com)
Precursor cells1
  • and neoplasm = new abnormal growth, such as a precancer or cancer), the blood-producing cells in the bone marrow (precursor cells, also called stem cells) develop and reproduce excessively or are crowded out by an overgrowth of fibrous tissue. (msdmanuals.com)
Bone marrow11
  • It forms in tissue such as bone marrow and causes blood cells to be produced and enter the bloodstream. (cancersupportcommunity.org)
  • Acute lymphocytic leukemia (ALL), sometimes called acute lymphoblastic leukemia, is a type of cancer that begins in the immature white blood cells in the bone marrow, the hollow space inside of your bones where blood is made. (cancersupportcommunity.org)
  • The leukemia cells do not function like normal blood cells, and they grow quickly inside the bone marrow, overtaking the space there. (cancersupportcommunity.org)
  • Bone marrow smear and biopsy showed active hyperplasia, immature lymphocytes accounting for 3%, and heterotypic large cells having a scattered distribution (Figure 4 ). (hindawi.com)
  • Flow cytometry analysis showed lymphocytes accounting for 6.8% and suggested phenotypic abnormal NK cells in the bone marrow. (hindawi.com)
  • Plasma cell myeloma (multiple myeloma, myelomatosis, medullary plasmacytoma) is a bone marrow-based, malignant disorder of postgerminal center B-cells that is characterized by a clonal proliferation of plasma cells, with associated serum and/or urine monoclonal proteins. (medscape.com)
  • Asymptomatic plasma cell myeloma is a plasma cell neoplasm defined by the presence of serum monoclonal protein of 3.0 gm/dL or greater (by electrophoresis) and/or clonal plasma cells in the bone marrow of 10% or greater, without evidence of end-organ damage (hypercalcemia, renal insufficiency, anemia, lytic lesions of bone). (medscape.com)
  • Symptomatic plasma cell myeloma is a plasma cell neoplasm defined as the presence of end-organ damage (hypercalcemia, renal insufficiency, anemia, lytic lesions of bone) in a patient with a monoclonal protein (of any amount) and clonal plasma cells in the bone marrow (of any amount) or plasmacytoma. (medscape.com)
  • Anemia results from bone marrow replacement by plasma cell myeloma and/or the loss of erythropoietin as a result of renal injury. (medscape.com)
  • Platelets (sometimes called thrombocytes) are cell fragments produced in the bone marrow that circulate in the bloodstream and help blood to clot. (msdmanuals.com)
  • Thrombopoietin, primarily produced in the liver, stimulates the bone marrow to make large cells (megakaryocytes), which in turn make platelets from material inside their cell body (cytoplasm). (msdmanuals.com)
Immunohistochemical2
  • Immunohistochemical staining of neoplasms was performed from biopsies samples. (hindawi.com)
  • Immunohistochemical analysis that demonstrates the endothelial nature of the neoplasm is frequently positive for specific vascular markers (CD31, CD34, factor VIII), and keratin 1,2,5,6 . (bvsalud.org)
Malignant3
  • Epithelioid angiosarcoma is a rare malignant neoplasm found in vascular endothelial cells. (bvsalud.org)
  • Angiosarcoma is a rare malignant vascular neoplasm which constitutes less than 1% of all sarcomas. (bvsalud.org)
  • Epithelioid angiosarcoma (EA) is a rare variant of angiosarcoma, which is characterized by a high-grade malignant neoplasm, which consists of an atypical, multilayered, or solid endothelial proliferation and vasoformative architecture, presenting necrosis and an area of hemorrhage 1-5 . (bvsalud.org)
Soft-tissue3
  • Head computed tomography (CT) and magnetic resonance imaging (MRI) scans revealed soft-tissue density neoplasms that occupied the sphenoidal sinus and further invaded to destroy the clivus. (hindawi.com)
  • Computed tomography (CT) scanning revealed soft-tissue density neoplasms filling the sphenoidal sinus (Figure 1 ). (hindawi.com)
  • [ 1 ] Extraosseous solitary plasmacytoma of bone is a localized, soft-tissue plasma cell neoplasm that occurs in a location other than the bone and does not have evidence of plasma cell myeloma or marrow plasmacytosis. (medscape.com)
Eosinophilic1
  • The cells are usually large and polygonal, containing abundant eosinophilic cytoplasm, a large nucleus with open chromatin, a prominent eosinophilic nucleolus, and an occasional intracellular lumina containing red blood cells 1,4-7 . (bvsalud.org)
Leukemias1
  • Leukemias are cancers of white blood cells or of cells that develop into white blood cells. (msdmanuals.com)
Vascular1
  • The common causes of unilateral abducens nerve palsy are neoplasm and vascular disease in middle-aged people [ 1 ]. (hindawi.com)
Antibodies1
  • Plasma cells develop from B cells ( B lymphocytes), a type of white blood cell that normally produces antibodies. (msdmanuals.com)
Diagnostic1
  • Explore our series of high-quality proteins covering comprehensive diagnostic indicators in order to facilitate the in vitro diagnostic research of neurological diseases. (acrobiosystems.com)
Myeloma8
  • Background: Plasma cell myeloma (PCM) is caused by immune dysregulation. (koreamed.org)
  • Plasma cell lesions are the neoplastic (clonal) proliferation of plasma cells involving single bones (plasmacytoma) or multiple bones (multiple myeloma). (medscape.com)
  • Osseous solitary plasmacytoma of bone is a localized bone tumor of plasma cells, without evidence of plasma cell myeloma or marrow plasmacytosis. (medscape.com)
  • An estimated 20,180 new cases of plasma cell myeloma were expected to be diagnosed in the United States in 2010, with a median age at diagnosis of 70 years. (medscape.com)
  • [ 6 ] In addition, plasma cell myeloma occurs more commonly in Americans of African descent than of European descent. (medscape.com)
  • It is also seen more commonly in males than females but presents in a younger patient than those with plasma cell myeloma, with a median age at diagnosis of 55 years. (medscape.com)
  • In either form of plasma cell myeloma, immune dysfunction, cytopenias and lytic bone lesions occur as a result of direct cellular interactions (cytokines, growth factors) and/or mass effect. (medscape.com)
  • Plasma cell myeloma presents with generalized marrow involvement, with or without lytic lesions of bone. (medscape.com)
Electrophoresis1
  • Whether it is for protein electrophoresis or western blot, our pre-stained protein markers help you quickly determine the molecular weight of the target protein or evaluate the transfer efficiency. (acrobiosystems.com)
Lymphoma cells1
  • The lymphoma cells were positive for EBER in situ hybridization. (hindawi.com)
Immune3
  • We evaluated the expression of immune checkpoint programmed cell death protein-1 (PD-1) on T cell subsets in PCM patients according. (koreamed.org)
  • There are many blood disorders, and they can affect the quantity as well as the function of the cells in the blood (blood cells) or proteins in the blood clotting system or immune system. (msdmanuals.com)
  • White blood cells (leukocytes) are an important part of the body's defense against infectious organisms and foreign substances ( the immune system). (msdmanuals.com)
Cancer2
Diagnosis1
  • The pathological diagnosis was extranodal natural killer (NK)/T-cell lymphoma (ENKL), nasal type, associated with Epstein-Barr virus (EBV). (hindawi.com)
Antibody1
  • The resulting group of genetically identical cells (called a clone) produces a large quantity of a single type of antibody (immunoglobulin). (msdmanuals.com)
Differentiation1
  • Explore our series of recombinant neural factors to support the culture and differentiation of nerve cells. (acrobiosystems.com)
Aggressive1
  • Prior literature reports that this neoplasm takes on an aggressive course and has a strong tendency to recur locally and to metastasize. (bvsalud.org)
Infection2
Diseases1
  • Pre-formed fibrils are an invaluable preclinical model for exploring pathogenesis of neurological diseases through aggregation of misfolded proteins. (acrobiosystems.com)
Anemia1
  • Anemia is a condition in which the number of red blood cells is low. (msdmanuals.com)
Presence1
  • The histologic hallmark of AE is represented by the presence of sheets and groups of atypical endothelial cells with prominent epithelioid morphologies. (bvsalud.org)
White blood1
  • The blood cells grow and divide abnormally, producing large numbers of white blood cells that do not function properly. (cancersupportcommunity.org)
Blood2
  • Iron is essential for life, so the body usually tightly controls iron absorption from food and recycles the iron from red blood cells. (msdmanuals.com)
  • Sometimes, blood-producing cells appear and reproduce in the spleen and liver. (msdmanuals.com)
Research2
  • Protein markers are an essential component in biological research and drug development. (acrobiosystems.com)
  • We offer a wide array of products pre-conjugated with streptavidin to support your research as well as biotinylated proteins. (acrobiosystems.com)
Present1
  • T-cell large granular lymphocytic leukemia (T-LGLL) can present as a form of post-transplant lymphoproliferative disorder. (koreamed.org)
Single1
  • They begin when a single plasma cell multiplies excessively. (msdmanuals.com)
Sites1
  • Streptavidin is a tetrameric protein providing 4 high-affinity biotin binding sites. (acrobiosystems.com)
Form1
Type1
  • Extranodal natural killer (NK)/T-cell lymphoma (ENKL), nasal type, is the common nasal lymphoma in Asian and South America male adults [ 2 ]. (hindawi.com)