Plasma oxidation lipid peroxidation. Medical search. Frequent questions

Unlike its allozymes PON1 and PON3 are bound with HDL in circulatory vessels protecting LDL against oxidation, PON2 is ubiquitously located in subcellular structures, such as perinuclear region, endoplasmic reticulum (ER), and mitochondria, compartments that are crucial for balancing intracellular oxidative stress. (hindawi.com)
However, MTF reduces oxidative stress by constraining the protein oxidation and lipid peroxidation, and increases antioxidant reserve by increasing the ferric reducing ability of plasma and reducing glutathione levels. (ac.ir)
Furthermore, buy Depo Testosterone Cypionate oxidative stress was observed in the S group, as indicated by an increase in the plasma OxLDL, as well as by lipid peroxidation and oxidation of proteins in the liver. (organize2020.org)
Oxidative stress can produce profound alterations to cellular membrane lipids, impairing cell metabolism and viability. (kipdf.com)
Oxidative stress generates dangerous free radicals, which affect human health and exposing them to disease by altering the naturally structured cellular lining of human body subsequently causing lipid peroxidation and effects on enzyme activity as well as producing carcinogenesis. (ijpsonline.com)
In such conditions, elevated concentrations of lipid peroxidation products are found in plasma and urine, suggesting that oxidative stress with its multiple facets, most notably lipid peroxidation (LPO), is a major contributor to the development of atherosclerosis. (retrotope.com)

Malondialdehyde (MDA) is lipid peroxidation end product. (ajol.info)
Subjects who received GPLC were also noted as having lower levels of malondialdehyde, a lipid peroxidation biomarker indicating free radical mediated oxidation of lipids. (wikipedia.org)
With both dosages, the post-intervention level of malondialdehyde, a marker of lipid peroxidation, was decreased as compared to pre-intervention values. (wikipedia.org)
Malondialdehyde (MDA) concentration and glutathione peroxidase (GPx) activity represent the lipid peroxidation and spermicidal antioxidant, respectively. (ijbs.com)

We then examined, in the plasma and thymus, oxidative damage biomarkers, including lipid peroxidation, protein oxidation, reactive oxygen species, calcium and antioxidant defence systems, mitochondrial potential and apoptosis-inducing factors (caspase 3, p53 and p21). (nih.gov)
The total antioxidant capacity, measured through the ferric reducing ability of plasma (FRAP, µmol/equivalent FeSO4) and oxygen radical absorbance capacity (ORAC, plasma trolox equivalents), lipid peroxidation, as serum levels of the thiobarbituric acid reactive substances (TBARs, µmol MDA) and the degree of protein oxidation, as advanced Oxidation Protein Products (AOPP, µmol/g protein), were measured. (ecco-ibd.eu)
Activities (nmol/min/mg of protein) of the main antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR), glutathione S-Transferase (GST) and catalases (CAT) were evaluated in PMNs cells and plasma. (ecco-ibd.eu)
In support of the above, previous work involving the individual components of GPLC has noted decreased protein and lipid peroxidation following glycine use, with potent antioxidant properties noted for propionyl-L-carnitine. (wikipedia.org)
Both treatments favourably and similarly modified plasma MDA (lipid peroxidation marker), GC (protein oxidation marker) and CAT activity. (iosrphr.org)
The effects of Yucca schidigera and Quillaja saponaria on DNA damage, protein oxidation, lipid peroxidation, and some biochemical parameters in streptozotocin-induced diabetic rats. (personalhealthzone.com)
Concentration in the plasma protein "acute phase" of ceruloplasmin in the control group increased from 297,8 ± 63,2 to 416,1 ± 104,1 to ten days. (rv.ua)

Oxidative damage by reactive oxygen species (generated by free globin chains and labile plasma iron) is believed to be one of the main contributors to cell injury, tissue damage, and hypercoagulability in patients with thalassemia. (hindawi.com)
There are a number of reactive nitrogen oxide species, such as N2O3 and ONOO-, that can alter critical cellular components under high local concentrations of NO. However, NO can also abate the oxidation chemistry mediated by reactive oxygen species such as H2O2 and O2- that occurs at physiological levels of NO. In addition to the antioxidant chemistry, NO protects against cell death mediated by H2O2, alkylhydroperoxides, and xanthine oxidase. (researchgate.net)
In cell preparations from 7 gliomas, reactive oxygen species (ROS), morphology and plasma membrane integrity were monitored +/-18-36 microM AA for 15-120 min using flow cytometry. (ed.ac.uk)
The plasma parameters were determined by enzymatic and non-enzymatic antioxidant defense units: activity of superoxide dismutase (SOD) and catalase, the concentration of alpha-tocopherol, and the concentration of lipid peroxidation products - TBA-reactive products (TBA-RP). (rv.ua)
Reactive oxygen species (ROS) induced lipid peroxidation is associated with sperm function. (ijbs.com)
We therefore aimed to investigate peroxidation, measured as thiobarbituric the correlation between hypercholesterol- acid-reactive substance (TBARS). (who.int)

Increased serum MDA concentration, as a biomarker of lipid peroxidation, low serum bilirubin and antioxidant capacity were observed in patients with angiographically defined CAD. (ajol.info)
Immunofluorescence studies show that KYC treatment reduces the formation of chlorotyrosine (ClTyr), a fingerprint biomarker of MPO oxidation, nitrotyrosine (NO 2 Tyr), and 4-hydroxynonenal (4HNE) in MCAO mice. (biomedcentral.com)

Lipid peroxidation is a major outcome of free radical-mediated injury to brain, where it directly damages membranes and generates a number of oxidized products. (omega-research.com)

The lipid peroxidation (TBARS) and the enzymatic activity of catalase (CAT) were measured in the cardiac muscle. (bvsalud.org)

Hypercholesterolaemia is frequently sayed on the same day for the determination associated with enhanced lipid peroxida- of glutathione peroxidase activity and lipid tion [3]. (who.int)

Vitamin E supplements and plasma high-density lipoprotein cholesterol. (vitalraadet.dk)
Using data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). (cdc.gov)

Lipoprotein oxidation induced in vitro in whole plasma is expected to be a more relevant model of the lipoprotein oxidation in the arterial wall than the in vitro oxidation of single isolated lipoproteins, e.g., low density lipoprotein (LDL). (iospress.com)
Role of vitamin E in preventing the oxidation of low-density lipoprotein. (vitalraadet.dk)
Results from our study contribute to a growing body of literature identifying key determinants of plasma lipoprotein concentrations and could provide insight into the biological mechanisms underlying serum lipid and cholesterol concentrations. (cdc.gov)
The genetic basis for elevation in lipid levels is not well understood, but substantial heritability has been demonstrated in twin [ 9 ] and family-based [ 10 - 12 ] studies, which have estimated that approximately 43% to 83% of the variance in blood lipid and lipoprotein levels is attributable to genetic factors. (cdc.gov)

Relationship between serum lipid peroxidation products in hypercholesterolemic subjects and vitamin E status. (vitalraadet.dk)
The identification of genetic variants related to blood lipid levels within a large, population-based and nationally representative study might lead to a better understanding of the genetic contribution to serum lipid levels in the major race/ethnic groups in the U.S. population. (cdc.gov)

Age, and sex-adjusted plasma MDA levels had negative correlations with TAC (r = -0.30, p = 0.001) and total bilirubin (r = -0.30, p = 0.002) concentrations. (ajol.info)
Plasma vitamin E concentrations were also evaluated. (kipdf.com)
Decades of research have demonstrated that serum concentrations of blood lipids are associated with increased risk for cardiovascular disease and mortality [ 1 - 4 ]. (cdc.gov)

Advanced glycation is a major pathway for the posttranslational modification of plasma and tissue proteins. (iospress.com)
16 Furthermore, its oxidation products can act as electrophiles to bind specific proteins , resulting in the modification of their cellular functions. (rsc.org)

Discussions focus on fatty acid synthesis, turnover of complex lipids, arterial wall and atherosclerosis, cholesteryl ester metabolism, and solubilization. (elsevier.com)

The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells. (researchgate.net)
Effects of a 50 Hz electric field on plasma lipid peroxide level and antioxidant activity in rats med. (emf-portal.org)
Spermatozoa are rich in polyunsaturated fatty acids as well as susceptible to be attacked by ROS or membrane lipid peroxide ion. (ijbs.com)

Different physiological parameters, such as viability, mitochondrial activity, intracellular ROS levels, plasma membrane lipid peroxidation, and intracellular pH, for egg quality evaluation have been successfully assessed in sea urchins and mussels by using specific fluorescent dyes and detecting the fluorescent signals in eggs through fluorescence spectroscopy. (biomedcentral.com)

Supplementation of human plasma with different antioxidants (albumin, urate, ascorbate, bilirubin, \alpha ‐tocopherol and ubiquinol‐10) in vitro decreased its oxidizability. (iospress.com)
Supplementation of Watanabe heritable hyperlipidaemic rabbits with different antioxidants (vitamin E, ubiquinone‐10, probucol, carvedilol) in vivo lowered the oxidizability of rabbit plasma in comparison with rabbits fed standard diet. (iospress.com)
Vitamin E supplementation, plasma lipids and incidence of restenosis after percutaneous transluminal coronary angioplasty PTCA. (vitalraadet.dk)
Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation. (vitalraadet.dk)

Khosrowbeygi A, Zarghami N, Deldar Y. Correlation between sperm quality parameters and seminal plasma antioxidants status. (ac.ir)

Oxygen free radicals are naturally produced by mitochondrial and sperm plasma membrane and have beneficial and detrimental effects that cannot be overlooked. (scialert.net)

To counteract the negative effects of excess ROS, spermatozoa and seminal plasma have several mechanisms to neutralize free radicals. (scialert.net)
To counteract oxidative damage, spermatozoa and seminal plasma have several mechanisms to neutralize free radicals. (scialert.net)
Atig F, Raffa M, Ali HB, Abdelhamid K, Saad A, Ajina M. Altered antioxidant status and increased lipid per-oxidation in seminal plasma of tunisian infertile men. (ac.ir)

Plasma MDA, serum bilirubin, total homocysteine and total antioxidant capacity (TAC) levels were measured. (ajol.info)
Hepatotoxicity was verified by remarkable increase in plasma levels of aminotransferases and alkaline phosphatase activity and liver histology 10 days after the BDL surgery. (ac.ir)
Pre-treatment of the rats once daily for 3 days with the triterpene at doses of 50 and 100 mg/kg reduced by approximately 18% plasma levels of endogenous lipid peroxides, at both doses, and by 6.5% and 19%, respectively, the susceptibility of plasma to lipid peroxidation. (nuojiabio.com)
Lipid peroxidation and changes in vitamin E levels during coronary artery bypass grafting. (vitalraadet.dk)
They found decreases in total and LDL cholesterol levels in blood plasma of hyper-cholesterolemic patients with enhancement in gastrointestinal symptoms of patients. (personalhealthzone.com)
Recent candidate gene studies [ 13 - 16 ], as well as genome-wide association studies [ 17 - 25 ], have identified polymorphisms that account for a portion of the variation in blood lipid levels. (cdc.gov)
High lipid peroxidation as represented by MDA levels may cause changes in the sperm and diminish fertility [ 5 ]. (ijbs.com)
Dichloroacetate is another compound used with these agents, because levels of lactate are lowered in plasma and cerebrospinal fluid (CSF). (medscape.com)

Behavioral testing, ischemic damage, blood-brain-barrier disruption, apoptosis, neutrophils infiltration, microglia/macrophage activation, and MPO oxidation were analyzed within a 7-day period after MCAO. (biomedcentral.com)
Arachidonic acid (AA) and Gamma linolenic acid have been shown to limit glioma cell growth, stimulate apoptosis and lipid peroxidation. (ed.ac.uk)

Reversely, prostaglandin F2a (PGF2a), which has been believed for decades to be exclusively formed by the COX-catalyzed oxidation of arachidonic acid, is now considered to be formed non-enzymatically as well. (retrotope.com)

0.0001)) after adjustment for lipid status parameters and traditional risk factors in this study population. (ajol.info)

The text then examines the effects of ethanol ingestion on lipid metabolism, including fatty acid oxidation and ketogenesis, lipid peroxidation, plasma triacylglycerols and lipoproteins, phospholipid metabolism, and cholesterol and bile acids. (elsevier.com)
The publication takes a look at lipid metabolism in liver and selected tissues and in the whole body of ruminant animals and the effect of caval shunts on lipid metabolism. (elsevier.com)
Topics include adaptation and regulation of lipid metabolism in the whole animal, lipid metabolism in specific tissues, and the effects of caval shunts on tissue lipids. (elsevier.com)
The text also ponders on lipid metabolism in the neonatal ruminant, as well as transfer of lipids across the placenta, maternal contribution to fetal lipid requirements, and placental lipid metabolism. (elsevier.com)
Spermatozoa are rendered dysfunctional by lipid peroxidation and altered membrane function, together with impaired metabolism, morphology, and motility [ 2 ]. (ijbs.com)

Bilirubin may act as an antioxidant that suppresses lipid oxidation. (ajol.info)

Malonyldialdehyde (MDA, nmol/ml ), an end-product of lipid peroxidation, and RBC antioxidant systems were measured, including RBC a-tocopherol ( RBC vitamin E, mg/l ), RBC glutathione (GSH, nmol/mgHb), and RBC superoxide dismutase activity (SOD, U/mgHb). (kipdf.com)

Our finding showed that treatment with MTF markedly reduced plasma alkaline phosphatase and alleviated liver injury indices ( P ≤ 0.05). (ac.ir)

Characteristic changes in oxidation-antioxidant system of plasma were a tendency to increase the concentration of TBA-rp on the first day after surgery by 16%, decreasing to 10 th day before 1,06 ± 0,33 nmol / ml (2.4 times) and gradual decrease in activity of enzyme systems. (rv.ua)
Lipid peroxidation triggers the loss of membrane integrity, causing increased cell permeability, enzyme inactivation, structural damage to DNA, and cell death [ 3 ]. (ijbs.com)
GPx, a selenium-containing antioxidative enzyme scavenging system, act directly as an antioxidant and an inhibitor of lipid peroxidation. (ijbs.com)
RÉSUMÉ L'objectif de la présente étude était d'évaluer l'efficacité d'un programme d'exercice sur tapis roulant électronique sur le malondialdéhyde, en tant que marqueur de la peroxydation lipidique et sur une enzyme antioxydante, le glutathion peroxydase, chez des adolescents atteints du Syndrome de Down. (who.int)

Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. (omega-research.com)
Some of the chemically and metabolically stable oxidation products are useful in vivo biomarkers of lipid peroxidation. (omega-research.com)

Sperm cell membranes are high in polyunsaturated fatty acids and are sensitive to oxygen free radical induced damage mediated by lipid peroxidation. (scialert.net)
The plasma oxidizability also correlated positively with plasma oxidizable fatty acid and negatively with plasma antioxidant content. (iospress.com)
Polyunsaturated fatty acid in the phospholipids of the human spermatozooa is highly susceptible to peroxidation. (ijbs.com)

Although the precise mechanisms underlying HIV lipodystrophy are not well understood, several hypotheses based on in vitro and human studies may explain the pathogenesis of the lipid changes that take place. (medscape.com)

OBJECTIVE: To compare the effects of D-004 and SP extracts on the International Prostate Symptoms Score (IPSS) and plasma oxidative variables in men with benign prostate hyperplasia (BPH) METHODS: This randomized, double-blind study was conducted in patients with moderate BPH. (iosrphr.org)

Many genes involved in metabolic pathways have been found to contribute to lipid level variability [ 14 , 26 , 27 ]. (cdc.gov)

At the end of each four-week period, resting blood samples were obtained, in addition to blood samples following Isometric exercise, showing significant increases in plasma nitrate/nitrite among those who were given GPLC. (wikipedia.org)

When plasma from hyperlipidaemic patients with or without coronary heart disease and from age‐matched healthy controls was studied, the plasma oxidizability was found to be highest in the patients with coronary heart disease and lowest in the controls. (iospress.com)
As an example, creatinine corrected urinary excretion of the F2-isoprostane (F2-IsoP) 8-iso-prostaglandin F2a (8-iso-PGF2a) and its b-oxidation metabolite 2,3-dinor-5,6-dihydro-8-iso-PGF2a was found to be almost 2-fold elevated in coronary heart disease patients compared to healthy age- and gender-matched subjects. (retrotope.com)

We measured the oxidizability of whole plasma diluted 150‐fold as an absorbance increase at 234 nm known to reflect the level of conjugated dienes in the samples. (iospress.com)

However, spermatozoa's lipids are the main substrates for peroxidation, which may provoke severe functional disorder of sperm. (scialert.net)

The concentration of alpha-tocopherol in plasma remained virtually unchanged before and after surgery did not significantly differing in both groups. (rv.ua)

2313 lipid peroxidation results in profound structural and functional cellular alterations. (kipdf.com)

MDA, an end product of lipid peroxidation, represented the level of lipid peroxidation. (ijbs.com)

in a model of oxidative status induced by CCl4, which induces lipid peroxidation. (nuojiabio.com)
This group was retested to confirm important role in the pathophysiology of their blood lipid status before participating several vascular diseases, including athero- in the study. (who.int)

Variants within APOE (rs7412, rs429358), PON1 (rs854560), ITGB3 (rs5918), and NOS3 (rs2070744) were found to be associated with one or more blood lipids in at least one race/ethnic group in crude and adjusted analyses. (cdc.gov)
We report the significant associations of blood lipids with variants and haplotypes in APOE , ITGB3, NOS3 , and PON1 in the three main race/ethnic groups in the U.S. population using a large, nationally representative and population-based sample survey. (cdc.gov)

Oxidizability of human plasma measured in the presence of Cu(II) was found to correlate with the oxidizability of LDL measured in the common Cu(II)‐based LDL oxidation assay. (iospress.com)
conducted an exhaustive study about the antioxidant properties of several pentacyclic triterpenic diols and acids on LDL particles isolated from human plasma. (nuojiabio.com)

Maslinic acid not only retarded the initiation and decreased the rate of CuSO4-induced LDL oxidation, but also showed peroxyl radical scavenging activity and a slight metal (copper) chelating effect. (nuojiabio.com)
Second, several antioxidative defences are altered in haemodialysis patients: a reduction in the activity of Cu/Zn SOD in erythocytes [7-9] and of GPX in plasma [7,10]. (kipdf.com)
Seminal GPx activity was measured by oxidation of reduced nicotinamide-adenine dinucleotide. (ijbs.com)

More work using GPLC to combat resistance exercise-induced lipid peroxidation has also noted favorable findings (unpublished data). (wikipedia.org)

In contrast, quantification of IsoPs in plasma and urine of AD patients has yielded inconsistent results. (omega-research.com)

We first studied the effects of the combination of these four nutrients on immune function by examining cell proliferation in immune organs (spleen and thymus) and immunomodulating factors in the plasma. (nih.gov)

Alpha-tocopherol: Effect on plasma lipoproteins in hypercholesterolemic patients. (vitalraadet.dk)

Background: Lipid extracts of Roystonea regia (D-004) and saw palmetto (SP) fruits have been shown to prevent experimentally-induced prostate hyperplasia in rodents, and to produce antioxidant effects in experimental and clinical studies. (iosrphr.org)

Anatomy20

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Malondialdehyde4

Protein7

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