• Randomized clinical trials that enrolled preterm infants with a gestational age younger than 37 weeks treated with intravenous or oral indomethacin, ibuprofen, or acetaminophen vs each other, placebo, or no treatment for a clinically or echocardiographically diagnosed hemodynamically significant PDA. (mcmaster.ca)
  • RESULTS: In 68 randomized clinical trials of 4802 infants, 14 different variations of indomethacin, ibuprofen, or acetaminophen were used as treatment modalities. (mcmaster.ca)
  • A review study in Pain found both Tylenol (1,000 mg dose) and ibuprofen (400 mg dose) to be better than placebo at easing moderate to severe tension headaches (using the parameter of being pain-free two hours after taking the medication). (drukfurniture.com)
  • Indomethacin and ibuprofen are commonly used for medical closure of patent ductus arteriosus. (fortuneonline.org)
  • Targeted early treatment of symptomatic PDA is still being practiced by many clinicians, as studies have shown that this offers short term benefits such as reduction in pulmonary haemorrhage, improvement in respiratory status and weight gain [5] Indomethacin and ibuprofen are the only licenced medications for PDA closure in preterm infants. (fortuneonline.org)
  • Indomethacin and ibuprofen both inhibit prostaglandin synthesis. (fortuneonline.org)
  • Ibuprofen has been shown to be as effective as indomethacin with similar closure rates and fewer renal side effects [9]. (fortuneonline.org)
  • Data is limited, with RCTs to date comparing with indomethacin/ibuprofen. (c19early.org)
  • CORP 2 randomized 240 patients who had had multiple bouts of pericarditis to either colchicine or placebo on top of conventional therapy-namely aspirin , ibuprofen , or indomethacin . (medscape.com)
  • Some evidence suggests that intravenous NSAIDs, such as indomethacin, administration on the first day of life to all preterm infants reduces the risk of developing a PDA and the complications associated with PDA. (wikipedia.org)
  • Intravenous Indomethacin treatment in premature infants also may reduce the need for surgical intervention. (wikipedia.org)
  • Indomethacin has been reported to diminish basal and CO 2 stimulated cerebral blood flow in healthy volunteers following acute oral and intravenous administration. (nih.gov)
  • The following additional adverse reactions in neonates have been reported from the collaborative study, anecdotal case reports, from other studies using rectal, oral, or intravenous indomethacin for treatment of patent ductus arteriosus or in marketed use. (medlibrary.org)
  • They were randomly allocated to receive either NAC (group A, 84 cases), rectal indomethacin (group B, 138 cases), NAC + rectal indomethacin (group C, 115 cases) or placebo (group D, 95 cases). (scielo.br)
  • The inclusion criteria were randomised or quasi-randomised comparisons of individual NSAIDs with either each other or placebo for treatment of postoperative pain, with relevant postoperative renal outcome measures, in adult surgical patients with normal renal function. (cochrane.org)
  • NSAIDs reduced creatinine clearance by 16 mL/min (95% CI 5 to 28) and potassium output by 38 mmol/day (95% CI 19 to 56) on the first day after surgery compared to placebo. (cochrane.org)
  • OBJECTIVES: To identify and evaluate all randomised controlled trials (RCTs) comparing the use of topical NSAIDs with placebo or any alternative analgesic interventions in adults with traumatic corneal abrasions (including corneal abrasions arising from foreign body removal), to reduce pain, and its effects on healing time. (beaumont.org)
  • SELECTION CRITERIA: RCTs comparing topical NSAIDs to placebo or any alternative analgesic interventions in adults with traumatic corneal abrasions. (beaumont.org)
  • Four trials, that included data on 481 participants receiving NSAIDs or control (placebo/standard care), reported on the use of 'rescue' analgesia at 24 hours as a proxy measure of pain control. (beaumont.org)
  • No significant changes were demonstrated for the other NSAIDs when compared either with the placebo-treated eyes or with the fellow eyes. (unime.it)
  • We investigated whether the trophic actions of prostaglandins, omeprazole, and indomethacin on gastric mucosa lead to accelerated healing of gastric ulcers in the rat. (nih.gov)
  • An investigation was designed to determine whether this protection is related to the production of inhibitory prostaglandins, such as prostaglandin E2 (PGE2), by studying the effect of the cyclooxygenase inhibitor indomethacin on the protection afforded by inhaled frusemide against exercise induced asthma. (ox.ac.uk)
  • Cerebral blood flow (CBF) has been measured using a non-invasive Xenon133 clearance technique in six normal subjects after 2 days pretreatment with oral indomethacin at a dose of 100 mg/day. (bmj.com)
  • Infusions of epoprostenol (prostacyclin, PGI2) at a dose of 5 ng/kg/min resulted in a reduction of CBF of about 10% after placebo but no significant change in CBF after indomethacin. (bmj.com)
  • Orally administered indomethacin capsules are virtually 100% bioavailable, with 90% of the dose absorbed within 4 hours. (nih.gov)
  • A single 50 mg dose of indomethacin oral suspension was found to be bioequivalent to a 50 mg indomethacin capsule when each was administered with food. (nih.gov)
  • Indomethacin has been shown to be an effective anti-inflammatory agent, appropriate for long-term use in rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. (nih.gov)
  • A variety of additional adverse experiences have been reported in adults treated with oral indomethacin for moderate to severe rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute painful shoulder and acute gouty arthritis (see package insert for oral indomethacin for additional information concerning adverse reactions and other cautionary statements). (medlibrary.org)
  • Effect of indomethacin on cerebral blood flow, carbon dioxide reactivity and the response to epoprostenol (prostacyclin) infusion in man. (bmj.com)
  • In one study after one week of treatment with orally administered indomethacin, this effect on basal cerebral blood flow had disappeared. (nih.gov)
  • Indomethacin suppresses inflammation in rheumatoid arthritis as demonstrated by relief of pain, and reduction of fever, swelling and tenderness. (nih.gov)
  • Indomethacin may enable the reduction of steroid dosage in patients receiving steroids for the more severe forms of rheumatoid arthritis. (nih.gov)
  • Intraocular pressure, ocular circulation, and visual function were monitored pretreatment, after unilateral monotherapy (day 7), bilateral ocular therapy (day 14), and coadministered oral indomethacin (day 28). (duke.edu)
  • The inhibitory effect of frusemide on the response to exercise, assessed as change in FEV1 over 30 minutes, was significantly greater with placebo (62%) than indomethacin (13%) pretreatment. (ox.ac.uk)
  • In a double-blind, placebo-controlled trial of 405 premature infants weighing less than or equal to 1,750 g with evidence of large ductal shunting, in those neonates treated with indomethacin (n=206), there was a statistically significantly greater incidence of bleeding problems, including gross or microscopic bleeding into the gastrointestinal tract, oozing from the skin after needle stick, pulmonary hemorrhage, and disseminated intravascular coagulopathy. (medlibrary.org)
  • The neonates treated with Indomethacin for Injection had a significantly higher incidence of transient oliguria and elevations of serum creatinine (greater than or equal to 1.8 mg/dL) than did the neonates treated with placebo. (medlibrary.org)
  • The incidences of retrolental fibroplasia (grades III and IV) and pneumothorax in neonates treated with Indomethacin for Injection were no greater than in placebo controls and were statistically significantly lower than in surgically-treated neonates. (medlibrary.org)
  • The rates are calculated from a database that contains experience of 849 indomethacin-treated neonates reported in the medical literature, regardless of the route of administration. (medlibrary.org)
  • One year follow-up is available on 175 neonates and shows no long-term sequelae that could be attributed to indomethacin. (medlibrary.org)
  • In controlled clinical studies, only electrolyte imbalance and renal dysfunction (of the reactions listed below) occurred statistically significantly more frequently after Indomethacin for Injection than after placebo. (medlibrary.org)
  • Efficacy and tolerability of gastric-retentive gabapentin for the treatment of postherpetic neuralgia: results of a double-blind, randomized, placebo-controlled clinical trial. (medscape.com)
  • Clinical Trial: A Multistrain Probiotic Preparation Significantly Reduces Intestinal Discomfort in a Double-Blind Placebo-Controlled Study. (wnf-amr.org)
  • Indomethacin is eliminated via renal excretion, metabolism, and biliary excretion. (nih.gov)
  • As renal function may be reduced by Indomethacin for Injection, consider reducing the dosage of those medications that rely on adequate renal function for their elimination. (medlibrary.org)
  • Following single oral doses of indomethacin capsules 25 mg or 50 mg, indomethacin is readily absorbed, attaining peak plasma concentrations of about 1 and 2 mcg/mL, respectively, at about 2 hours. (nih.gov)
  • Indomethacin 25 mg capsule twice a day for 10 continuous days followed by a taper of 25 mg on days 2 and 5. (candlehillshepherds.com)
  • ABSTRACT Background This multicenter multinational RCT designed to compare the efficacy of suppository indomethacin and NAC for prevention of PEP. (scielo.br)
  • There was no significant difference in the odds of mortality, necrotizing enterocolitis, or intraventricular hemorrhage with use of placebo or no treatment compared with any of the other treatment modalities. (mcmaster.ca)
  • placebo or no treatment did not significantly change the likelihood of mortality, necrotizing enterocolitis, or intraventricular hemorrhage. (mcmaster.ca)
  • The combination of indomethacin and PGI2 has been proposed as a treatment of cerebral artery spasm and the findings suggest that the combination therapy would not be accompanied by undesirable intracerebral steal. (bmj.com)
  • Compared with placebo, omeprazole accelerated ulcer healing as indicated by a smaller ulcer area [1.1 +/- 0.2 vs. 4.8 +/- 1.2 mm2 (mean +/- SEM)] and smaller ulcer depth (383 +/- 31 vs. 488 +/- 41 microns) after 10 days of treatment. (nih.gov)
  • The loss of significance of intraocular pressure reduction with brimonidine during indomethacin treatment may be clinically important. (duke.edu)
  • On day 4 of treatment with 50 mg taper and placebo, all patients had lost more than 90% of their baseline body weight. (candlehillshepherds.com)
  • In post-marketing experience, bleeding has been reported in patients on concomitant treatment with anticoagulants and Indomethacin for Injection. (medlibrary.org)
  • Indomethacin is the most studied pharmacologic agent for the treatment of PDA and has been shown to be effective in up to 70% of the cases [7, 8]. (fortuneonline.org)
  • An investigation where different treatments (including placebo or no treatment) are compared in the same person over different time periods. (goutpal.com)
  • The results were compared with placebo given in a double blind balanced cross-over design. (bmj.com)
  • Doody et al (2013) conducted a double-blind, placebocontrolled trial in which 1,537 patients with probable AD underwent randomization to receive 100 mg of semagacestat, 140 mg of semagacestat, or placebo daily. (kipdf.com)
  • 2.15] Madden JA et al.Effect of probiotics on preventing disruption of the intestinal microflora following antibiotictherapy: a double-blind, placebo-controlled pilot study. (wnf-amr.org)
  • The multicenter, double-blind, placebo-controlled trial builds on the results of CORP , which demonstrated significant reductions in pericarditis recurrence in patients developing pericarditis for the first time. (medscape.com)
  • Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) that exhibits antipyretic and analgesic properties. (nih.gov)
  • In both acute and chronic pain local and systemic adverse events and withdrawal from the study related to the drug had a low incidence and were no different from placebo. (bmj.com)
  • No significant differences between groups were detected for plasma concentrations of doxycycline, where to buy indomethacin gout creatinine, total cholesterol and triglycerides, or liver biochemistry (Table). (candlehillshepherds.com)
  • Patients randomized to taper and placebo were then matched to repeat the taper with doxycycline 100 mg. (candlehillshepherds.com)
  • For comparison with patients randomized to placebo, the percent losses or increases in body weight were calculated for a total of four patients. (candlehillshepherds.com)
  • RESULTS Of 11 evaluable patients randomized, 6 were randomized to taper and 6 placebo. (candlehillshepherds.com)
  • Patients randomized to taper lost more than 50% of their initial body weight on average by day 24 compared with in the 12-week study compared with placebo. (candlehillshepherds.com)
  • In this study, 327 patients with acute or chronic gastritis who had one or more gastric erosions on endoscopy and subjective symptoms were randomized into three groups receiving fexuprazan 20 mg once a day (q.d.), fexuprazan 10 mg twice a day (b.i.d.), or placebo for 2 weeks. (gutnliver.org)
  • Patients with symptomatic (painful ≥1 year, Lequesne Index between 3 and 10) hip OA (American College of Rheumatology criteria) and a minimum joint space width (JSW) of the target hip between 1 and 4 mm on a pelvic radiograph were randomly assigned to 300 mg/day ASU-E or placebo. (bmj.com)
  • At six months, pericarditis had recurred in 21.6% of colchicine-treated patients and in 42.5% of placebo-treated patients (p=0.0009). (medscape.com)
  • We sought reports of randomised controlled trials of topical non-steroidal anti-inflammatory drugs in which pain was an outcome and included those that compared topical non-steroidal anti-inflammatory drug(s) with placebo, with another topical non-steroidal, or with an oral non-steroidal. (bmj.com)
  • Indomethacin capsules, USP for oral administration contains 25 mg of indomethacin. (nih.gov)
  • Methods: During a 6-month period, all of the ERCP cases in seven referral centers were randomly assigned to receive either 1200 mg oral NAC, indomethacin suppository 100 mg, 1200 mg oral NAC plus indomethacin suppository 100 mg or placebo 2 hours before ERCP. (scielo.br)
  • After another week, oral indomethacin 25 mg four times a day, commenced for 2 more weeks. (duke.edu)
  • Ten healthy volunteers participated in four different intervention periods: 7-day oral intake of either L. plantarum WCFS1, CIP48 (CIP104448), TIFN101 (CIP104450) or placebo, proceeded by a 4 weeks wash-out period. (wur.nl)
  • Indomethacin was found to result in a reduction in resting CBF of about 25% but the reactivity of the cerebrovascular circulation to carbon dioxide was preserved at normal levels. (bmj.com)
  • In acute conditions like strains and sprains topical non-steroidals were significantly better than placebo over 1 week with a number needed to treat of 3.9 (3.4 to 4.4). (bmj.com)
  • There was no significant difference in serum creatinine on the first day (0 μmol/L, 95% CI -3 to 4) compared to placebo. (cochrane.org)
  • Indomethacin had no significant effect on ocular perfusion or visual function measures. (duke.edu)
  • There was no significant difference on mean JSW loss (−0.638 mm vs −0.672 mm, p=0.72, in the ASU-E and placebo groups, respectively) but there were 20% less progressors in the ASU-E than in the placebo group (40% vs 50%, respectively, p=0.040). (bmj.com)
  • One eye was randomly treated with the study drug and the fellow eye was treated with placebo. (unime.it)
  • Lactulose-rhamnose ratio (an indicator of small intestinal permeability) increased after intake of indomethacin, which was given as an artificial stressor of the gut mucosal barrier (mean ratio 0.06±0.04 to 0.10±0.06, p=0.001), but was not significantly affected by the bacterial interventions. (wur.nl)
  • Acarpia (Madeira, Portugal) provided the study drug and placebo as an unrestricted grant. (medscape.com)
  • All the drugs caused a mean burning sensation greater than the placebo. (unime.it)
  • In acute pain conditions (soft tissue trauma, strains, and sprains) placebo controlled trials had a relative benefit of 1.7 (1.5 to 1.9), the number needed to treat was 3.9 (3.4 to 4.4). (bmj.com)
  • Indomethacin usually does not influence the hypoprothrombinemia produced by anticoagulants. (medlibrary.org)
  • The percent losses or increases in body weight were calculated from the mean loss of body weight in the taper group as compared with the mean increase in body weight the placebo group. (candlehillshepherds.com)
  • Cryoulcers were produced in the corpus area and treated with 16,16-dimethyl prostaglandin E2 (5 or 100 micrograms/kg b.i.d., intragastrically), omeprazole (40 mumol/kg once daily, subcutaneously), indomethacin (2 mg/kg b.i.d., subcutaneously), or placebo. (nih.gov)
  • These trials assessed: betamethasone (1 trial), thalidomide (5 trials), pentoxifylline (1 trial), clofazimine (3 trials), indomethacin (2 trials), and levamisole (1 trial). (cochrane.org)