• Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. (wikipedia.org)
  • Pirin is a protein that in humans is encoded by the PIR gene. (wikipedia.org)
  • Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene. (wikipedia.org)
  • Ligand binding of the renatured protein was quantified by fluorescence quenching and floor plasmon resonance spectroscopy. (ncbcs.org)
  • The fluorescence properties of a labeled protein and free dye are very similar. (forextrading-madeeasy.com)
  • In embryonic cells, Nfix has been shown to regulate intermediate progenitor cell (IPC) generation by promoting the transcription of the protein inscuteable (INSC). (wikipedia.org)
  • The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. (wikipedia.org)
  • In abstract, a framework was developed to supply useful human full-length GLP-1R by recombinant expression in E. coli as a prerequisite for eventual construction willpower and a rigorous biophysical characterization together with protein variants. (ncbcs.org)
  • ECE1cK6R behaved as a highly stable protein in all cell lines, and its expression promoted self-renewal and the enrichment of a stem-like population characterized by enhanced neurospheroid formation, as well as increased expression of stem-like surface markers. (bvsalud.org)
  • The voltage-dependent anion channel 1 (VDAC1), localized at the outer mitochondrial membrane (OMM) is a central protein in controlling energy production, cell growth, Ca 2+ homeostasis, and apoptosis. (pdbwiki.org)
  • To alter the cross-talk between the mitochondria and the nucleus, we used specific siRNA to silence the expression of VDAC1 in glioblastoma (GBM) U87-MG and U118-MG cell-derived tumors, and then monitored the nuclear localization of mitochondrial proteins and the methylation and acetylation of histones. (pdbwiki.org)
  • Mitochondria supply metabolites for epigenetic modifications and other nuclear-associated activities and certain mitochondrial proteins were found in the nucleus. (pdbwiki.org)
  • The effects of an imidazoline compound (BL11282) on protein expression in rat pancreatic islets were investigated with a proteomic approach. (researchgate.net)
  • PROTAC is a heterobifunctional small molecule compound that specifically degrades target proteins using the ubiquitin-proteasome pathway in living organisms. (bocsci.com)
  • The degradation of a protein via the ubiquitin proteasome pathway involves a discrete two-step process - the first step requires the tagging of the protein with ubiquitin molecules and the second step recognises the specifically tagged protein and subsequently destroys the protein in the proteasome. (raci.org.au)
  • Serine-threonine/tyrosine-protein kinase, catalytic domain [Interproscan]. (ntu.edu.sg)
  • Most small molecule inhibitors and antibodies act by occupancy-driven effect, i.e., by binding to the active site of the target protein and competing with endogenous substrates to inhibit the function of the protein. (bocsci.com)
  • Using well-established medicinal chemistry techniques, I can design a small molecule that will be able to interact with our POI with sufficient potency and efficacy, and have the appropriate properties to enable inhibition of the function of the protein in vivo. (raci.org.au)
  • In recent years, BOC Sciences has strongly developed the PROTACĀ® protein degradation technology platform. (bocsci.com)
  • PROTAC is "event-driven" in that it mediates the degradation of the target protein, rather than affecting the function of the target. (bocsci.com)
  • PROTAC may induce degradation of proteins without active sites, such as scaffold proteins, as long as they have a moderately effective target binding capacity, which greatly increases the range of targets. (bocsci.com)
  • The 2004 Chemistry Nobel Prize-winning work of Ciechanover, Hershko, Rose and others has delineated the molecular mechanisms involved in the ubiquitin pathway of protein degradation and it is upon this work the Crews group has developed the concept of PROTACs. (raci.org.au)
  • As a leading CRO in the pharmaceutical field, BOC Sciences is dedicated to the design, screening, discovery and synthesis of effective PROTACs, assisting our customers in expanding the range of targets for targeted protein degraders and developing new PROTAC molecules. (bocsci.com)
  • This is especially true of protein kinases for which there is an increasing body of literature describing a variety of their non-catalytic roles, such as scaffolding, allosteric regulation of other proteins and even protein-DNA interactions. (raci.org.au)
  • PROTAC acts as a "catalyst", mediating the proximity of the target protein and the E3 ligase at low doses and in multiple cycles. (bocsci.com)
  • The key step in the ubiquitination of the protein involves an enzyme called an E3 ligase. (raci.org.au)
  • It is this E3 ligase that catalyses the transfer of the ubiquitin molecule from the ubiquitin-containing enzyme to an available lysine on the protein that is to be degraded. (raci.org.au)
  • 3. CXXC5 (retinoid-inducible nuclear factor, RINF) is a potential therapeutic target in high-risk human acute myeloid leukemia. (nih.gov)
  • protein_coding" "Cz01g20080.t1","No alias","Chromochloris zofingiensis","Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [Interproscan]. (ntu.edu.sg)
  • These targets typically include proteins with no enzymatic function, which account for about 80% of the body's proteins. (bocsci.com)
  • Ian Linney shares his perspective on finding protein targets for drug discovery programs. (raci.org.au)
  • protein_coding" "Cz02g21410.t1","No alias","Chromochloris zofingiensis","Domain of unknown function DUF1990 [Interproscan]. (ntu.edu.sg)
  • Fundamental understanding of specific disease biology can pinpoint proteins that may be involved in a disease of interest. (raci.org.au)
  • We then compare the knock-out animal with its wild-type cousin in models of our disease of interest to assess the impact of removing protein X. (raci.org.au)
  • If the knock-out animal shows an improvement in the progression, severity or in some cases immunity of disease, then X becomes a protein of interest (POI). (raci.org.au)
  • Nfix has been shown to interact with SKI protein and it is also known to interact with AP-1. (wikipedia.org)
  • The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. (wikipedia.org)