• As many as 30% of myeloma patients may present with a pathologic fracture, and up to two-thirds with bone pain alone as the initial symptom of disease [7]. (crimsonpublishers.com)
  • The bone fracture probabilities were obtained from a cohort study of 3614 women from USA with PMO treated with RIS-GR (1807) or ALN (1807) (Thomasius, 2022). (bvsalud.org)
  • This expert opinion discussed the current level I evidence on the experimental pharmacological agents used to favor bone fracture healing. (bvsalud.org)
  • All the randomized clinical trials investigating pharmacological agents for bone fracture healing were accessed. (bvsalud.org)
  • EXPERT OPINION: Calcitonin could favor bone fracture healing. (bvsalud.org)
  • Risk of a fat embolism is greatest in the first 48 hours after the fracture of a long bone. (rnpedia.com)
  • citation needed] There are two main causes of osteomalacia: insufficient calcium absorption from the intestine because of lack of dietary calcium or a deficiency of, or resistance to, the action of vitamin D, or due to undiagnosed celiac disease. (wikipedia.org)
  • Absorption of calcium from the gastrointestinal (GI) tract has been found to decrease in the acute period following injury. (medscape.com)
  • Osteomalacia is a disease characterized by the softening of the bones caused by impaired bone metabolism primarily due to inadequate levels of available phosphate, calcium, and vitamin D, or because of resorption of calcium. (wikipedia.org)
  • This marked increase in urine calcium is the direct result of an imbalance between bone formation and bone resorption. (medscape.com)
  • In addition, the increased bone resorption precedes the increase in osteoblastic activity. (medscape.com)
  • However, while bone is continuously remodeling by resorption/neoformation during life, tooth's hard tissues are not. (bvsalud.org)
  • Aminobisphosphonates (N-BPs) that include pamidronate, zoledronate, or alendronate, are the first-line treatment of bone-related diseases including osteoporosis and bone malignancies. (bvsalud.org)
  • Vitamin D should always be administered in conjunction with calcium supplementation (as the pair work together in the body) since most of the consequences of vitamin D deficiency are a result of impaired mineral ion homeostasis. (wikipedia.org)
  • Technically considered a plasma cell dyscrasia, multiple myeloma is the most common primary malignancy of bone [7,8]. (crimsonpublishers.com)
  • The impairment of bone metabolism causes inadequate bone mineralization. (wikipedia.org)
  • Osteoporosis in persons with spinal cord injury was first studied in relation to calcium metabolism and the associated hypercalcemia and renal calculi that followed. (medscape.com)
  • The differences between osteoporosis induced by spinal cord injury and other causes of bone loss (disuse), such as prolonged bed rest, space travel, and lower motor neuron disorders, have since become clearer. (medscape.com)
  • This model at the skeletal level following spinal cord injury resembles the high bone turnover rate seen in postmenopausal osteoporosis. (medscape.com)
  • [ 11 ] These other factors further separate spinal cord injury-induced osteoporosis from other causes of disuse demineralization. (medscape.com)
  • The result is an increase in bone reabsorption or osteoporosis related to parathyroid dysfunction in the chronic stages of spinal cord injury. (medscape.com)
  • Even so, in the past, dietary calcium reduction was commonly recommended as a way to decrease calcium excretion and prevent the complications of hypercalciuria. (medscape.com)
  • In addition to low systemic levels of circulating mineral ions (for example, caused by vitamin D deficiency or renal phosphate wasting) that result in decreased bone and tooth mineralization, accumulation of mineralization-inhibiting proteins and peptides (such as osteopontin and ASARM peptides), and small inhibitory molecules (such as pyrophosphate), can occur in the extracellular matrix of bones and teeth, contributing locally to cause matrix hypomineralization (osteomalacia/odontomalacia). (wikipedia.org)
  • Vitamin D and calcium supplements are measures that can be used to prevent and treat osteomalacia. (wikipedia.org)
  • Most of the time, the only alleged symptom is chronic fatigue, while bone aches are not spontaneous but only revealed by pressure or shocks. (wikipedia.org)
  • Diagnosis should include a detailed history, physical examination, and routine laboratory tests, in addition to symptom-directed workup with cultures. (lecturio.com)
  • Primary bone lesions are more commonly identified in patients under the age of 40, and can be subdivided into benign and malignant lesions. (crimsonpublishers.com)
  • Stored samples from a prior clinical trial aimed at analyzing the effect of alendronate on bone mineral density, provided further evidence of alendronate-mediated latency reversal and activation of immune effector cells. (bvsalud.org)
  • Symptoms: Diffuse joint and bone pain (especially of spine, pelvis, and legs) Muscle weakness Difficulty walking, often with a waddling gait Hypocalcemia (positive Chvostek sign) Compressed vertebrae and diminished stature Pelvic flattening Weak, soft bones Easy fracturing Bending of bones Osteomalacia in adults starts insidiously as aches and pains in the lumbar (lower back) region and thighs before spreading to the arms and ribs. (wikipedia.org)
  • The pain is symmetrical, non-radiating and accompanied by sensitivity in the involved bones. (wikipedia.org)
  • Signs and symptoms can include diffuse body pains, muscle weakness, and fragility of the bones. (wikipedia.org)
  • The loss of bone also may be enhanced by lack of muscle traction on bone or by other neural factors associated with spinal cord injury. (medscape.com)
  • Physical signs include deformities like triradiate pelvis and lordosis. (wikipedia.org)
  • At Hamilton Health Care System, we have dedicated our lives to serving people's physical, spiritual and mental needs. (hamiltonhealth.com)
  • The presence of multiple osteolytic bone lesions is a defining trademark of the disease. (crimsonpublishers.com)
  • INTRODUCTION: Pharmacological strategies might influence bone healing in terms of time to union or quality of mature bone. (bvsalud.org)
  • To the best of our knowledge, this is the first large longitudinal study to evaluate the relations of bone density, bisphosphonate use, fractures, and risk of hearing loss," report Sharon Curhan, MD, and colleagues in research published online in the Journal of the American Geriatric Society . (medscape.com)
  • Pathologic fractures due to weight bearing may develop. (wikipedia.org)
  • Even more significant, oral-facial trauma from sports injuries will result in facial bone fractures, concussion, permanent brain injury, temporomandibular dysfunction, blinding eye injuries, and even death. (nih.gov)
  • In this large nationwide longitudinal study of nearly 144,000 women with up to 34 years of follow-up, we found that osteoporosis or low bone density was independently associated with higher risk of incident moderate or worse hearing loss," the authors write. (medscape.com)
  • In addition to low systemic levels of circulating mineral ions (for example, caused by vitamin D deficiency or renal phosphate wasting) that result in decreased bone and tooth mineralization, accumulation of mineralization-inhibiting proteins and peptides (such as osteopontin and ASARM peptides), and small inhibitory molecules (such as pyrophosphate), can occur in the extracellular matrix of bones and teeth, contributing locally to cause matrix hypomineralization (osteomalacia/odontomalacia). (wikipedia.org)
  • Most commonly, this is seen when at least one of the following clinical manifestations are present: hypercalcemia, renal dysfunction, anemia, or bone pain accompanied by lytic lesions. (nih.gov)
  • Osteoporosis in persons with spinal cord injury was first studied in relation to calcium metabolism and the associated hypercalcemia and renal calculi that followed. (medscape.com)
  • The discordant findings between these skeletal sites may reflect differences in composition and metabolism of bones in the spine and hip and could provide insight into the pathophysiological changes in the ear that may lead to hearing loss," they add. (medscape.com)
  • Symptoms: Diffuse joint and bone pain (especially of spine, pelvis, and legs) Muscle weakness Difficulty walking, often with a waddling gait Hypocalcemia (positive Chvostek sign) Compressed vertebrae and diminished stature Pelvic flattening Weak, soft bones Easy fracturing Bending of bones Osteomalacia in adults starts insidiously as aches and pains in the lumbar (lower back) region and thighs before spreading to the arms and ribs. (wikipedia.org)
  • This chronic-stage mechanism of osteoporosis is balanced by an increase in bone mineral in regions of the body in which weight bearing is resumed (eg, in the upper extremities, spine) and adds to the demineralization observed in regions that are chronically non-weight-bearing (eg, the pelvis, lower extremities). (medscape.com)
  • The result is an increase in bone reabsorption or osteoporosis related to parathyroid dysfunction in the chronic stages of spinal cord injury. (medscape.com)
  • The aims of this study were to evaluate whether the association between arterial stiffness and bone demineralization is independent of age, and to explore putative mechanisms that may mediate their relationship. (nih.gov)
  • As a result of demineralization, the bones become less rigid. (wikipedia.org)
  • Bone loss as a consequence of spinal cord injury has been of secondary concern historically. (medscape.com)
  • Arterial stiffness was assessed by carotid-femoral pulse wave velocity (PWV) and cross-sectional cortical bone area (cCSA) was assessed at the level of the mid-tibia with computed tomography (CT) imaging. (nih.gov)