Tumor Suppressor Protein p53Tumor Suppressor ProteinsGenes, Tumor SuppressorBrain NeoplasmsVon Hippel-Lindau Tumor Suppressor ProteinTumor Suppressor Protein p14ARFCell Line, TumorRetinoblastoma ProteinMolecular Sequence DataPhosphorylationProto-Oncogene Proteins c-mdm2Cell LineMutationProtein BindingAmino Acid SequenceTransfectionApoptosisNuclear ProteinsDNA-Binding ProteinsProtein-Serine-Threonine KinasesGene Expression Regulation, NeoplasticTumor Cells, CulturedSignal TransductionTranscription FactorsGenes, p53Proto-Oncogene ProteinsSerineCell CycleGliomaBlotting, WesternNeurofibromin 2Cell Cycle ProteinsBase SequenceCell ProliferationCells, CulturedPhosphoproteinsAdenomatous Polyposis Coli ProteinUbiquitin-Protein LigasesPTEN PhosphohydrolaseGlioblastomaPromoter Regions, GeneticProtein Structure, TertiaryProteinsCell Transformation, NeoplasticRNA, MessengerCyclin-Dependent Kinase Inhibitor p16Cell DivisionTranscription, GeneticCyclin-Dependent Kinase Inhibitor p21Binding SitesDNA DamageGenes, SuppressorEnzyme ActivationDown-RegulationNeoplasm ProteinsProtein KinasesAstrocytomaTranscriptional ActivationCarrier ProteinsNeoplasmsCyclinsHeLa CellsRepressor ProteinsRecombinant Fusion ProteinsGene Expression RegulationRNA, Small InterferingLigasesCell NucleusTumor Markers, BiologicalE2F Transcription FactorsModels, BiologicalFibroblastsRecombinant ProteinsIntracellular Signaling Peptides and ProteinsPhosphoserineRNA InterferenceBrain ChemistryTyrosineImmunohistochemistryMembrane ProteinsTrans-ActivatorsReverse Transcriptase Polymerase Chain ReactionImmunoblottingGene SilencingPrecipitin TestsMedulloblastomaTime FactorsMice, KnockoutEnzyme InhibitorsProto-Oncogene Proteins c-aktMice, Inbred C57BLSuppressor of Cytokine Signaling ProteinsDNA PrimersImmunoprecipitationE2F1 Transcription FactorMice, NudeGene DeletionCell SurvivalCyclin-Dependent KinasesAdaptor Proteins, Signal Transducing