Phosphorylation repressor proteins. Medical search. Frequent questions

MSY3 is a DNA binding protein, which acts as a transcriptional repressor. (biomedcentral.com)
One member of this family, Activating Tanscription Factor 3 (ATF3), is expressed during skeletogenesis and acts as a transcriptional repressor, but the function of this protein in chondrogenesis is unknown. (biomedcentral.com)

Mutation of phosphorylation sites within this region of the NTD showed that phosphorylation of serine 400 was required for the partial agonist activity of RU486 stimulated by JDP-2, but was not required for activity of hormone agonist, either in the presence or absence of JDP-2. (nih.gov)
however, phosphorylation of serine 400 was not required, indicating that JDP-2 and Cdk2/cyclin A act by distinct mechanisms. (nih.gov)
We conclude that PR bound to RU486 and associated with JDP-2 adopts an active conformation in a subregion of the NTD requiring phosphorylation of serine 400 that is distinct from that promoted by progestin agonists. (nih.gov)
Using a directed RNAi screen we find that protein phosphatase 1 (PP1), a ubiquitous serine/threonine phosphatase, is a novel potent positive physiologic regulator of the Wnt/beta-catenin signaling pathway. (duke.edu)
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. (biossusa.com)
Activated nongenomically by L-thyroxine (T4), mitogen-activated protein kinase (MAPK) complexed in 19-20 min with endogenous nuclear thyroid hormone receptor (TRβ1 or TR) in nuclear fractions of 293T cells, resulting in serine phosphorylation of TR. (tmu.edu.tw)
Treatment of cells with the MAPK kinase inhibitor, PD 98059, prevented both T4-induced nuclear MAPK-TR co-immuno-precipitation and serine phosphorylation of TR. (tmu.edu.tw)
Transfection into CV-1 cells of TR gene constructs in which one or both zinc fingers in the TR DNA-binding domain were replaced with those from the glucocorticoid receptor localized the site of TR phosphorylation by T4-activated MAPK to a serine in the second zinc finger of the TR DNA-binding domain. (tmu.edu.tw)
Thus, T4 activates MAPK and causes MAPK-mediated serine phosphorylation of TRβ1 and dissociation of TR and the co-repressor SMRT. (tmu.edu.tw)
In addition, phosphorylation of a serine in a conserved short stretch within an acidic domain of T. reesei CRE1 has been demonstrated to regulate its DNA binding [ 13 ]. (biomedcentral.com)
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. (bvsalud.org)

PcG proteins are known to form protein complexes and function as transcription repressors. (wikipedia.org)
This protein has been shown to interact with some PcG proteins and act as a transcription repressor. (wikipedia.org)
More than 95% of individuals with RTT have mutations in methyl-CpG-binding protein 2 (MECP2), whose protein product modulates gene transcription. (bmj.com)
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. (genetex.com)
In principle, development of small molecule inhibitors of interactions of specific transcriptional activators (or repressors) with DNA or with the basal transcription machinery could provide highly selective regulators of gene expression and thus highly selective therapeutic agents (e.g., antiviral agents based on disabling essential viral gene expression). (mtu.edu)
The Y-box protein MSY3/Csda represses myogenin transcription in skeletal muscle by binding a highly conserved cis-acting DNA element located just upstream of the myogenin minimal promoter (myogHCE). (biomedcentral.com)
MSY3 (MSY4, YB-2, CSDA, dbpA, ZONAB) is a member of the cold shock domain (CSD) family of proteins also known as Y-box proteins, which are evolutionarily conserved proteins that function as transcription factors and regulators of RNA metabolism and protein synthesis. (biomedcentral.com)
Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. (biossusa.com)
Proteins inhibitor of turned on STAT1 (PIAS1) is normally a SUMO E3 ligase is one of the PIAS proteins family that's well examined in the disease fighting capability [8 9 Through LY2784544 (Gandotinib) ligase activity-dependent or -unbiased system PIAS1 regulates the experience of distinctive proteins including transcription elements [10]. (molecularcircuit.com)
The key co-repressor complex components HDAC-2, Mi-2α/β and mSin3a are all critical to the regulation of gene transcription. (biomedcentral.com)
Gene transcription is tightly regulated by a highly complex and dynamic set of processes central to which is the recruitment of co-repressors to promoter bound sequence specific transcription factors [ 1 - 3 ]. (biomedcentral.com)
The c-Jun dimerization protein 2, JDP2 is an AP-1 repressor protein that potently inhibits AP-1 transcription. (biomedcentral.com)
One example is the activating transcription factor/cyclicAMP response element-binding protein (ATF/CREB) family that is defined by the ability of its members to bind to the cyclicAMP response element (CRE) in target promoters. (biomedcentral.com)
These repressors could down-regulate CRE-dependent transcription and thus cause delay of cell cycle progression and/or promote cell cycle exit during terminal differentiation. (biomedcentral.com)
Protein arginine methyltransferases (PRMTs) were recently added to the list of enzymes that are critical for regulating transcription in hepatic gluconeogenesis. (e-enm.org)
Type II PRMTs (PRMT5, PRMT7, and PRMT9) are less well characterized and may function as transcriptional repressors, although some reports suggest that they can function as activators of transcription. (e-enm.org)
They further link to the activation of protein kinase C- (PKC-) induced generation of reactive oxygen species (ROS) [ 6 , 7 ], which further mediates the activation of downstream transcription factor nuclear factor kappa-light-chain enhancer of activated B cells (NF- κ B). Thus, the main treatments of DN refer to modulate glycemic and blood pressure through insulin and RAS inhibitors. (hindawi.com)
We observe that each gene and its products have a unique set of DNA, RNA or protein motifs that encode a regulatory program to define the logical circuitry that guides the life cycle of these biomolecules, from transcription to degradation. (biomedcentral.com)

Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. (genetex.com)
Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. (biossusa.com)
Furthermore Hes-1 phosphorylation by calmodulin-dependent proteins kinase II delta transforms it from a repressor for an activator that's needed is for neuronal stem cell differentiation [5]. (molecularcircuit.com)
In many organs, cell proliferation and differentiation are antagonistically regulated by multiple basic helix-loop-helix (bHLH) activator and repressor genes. (biologists.com)

In C2C12 myogenic cells, blocking the IGF1/PI3K/Akt pathway using LY294002 inhibitor reduced MSY3 phosphorylation levels resulting in its accumulation in the nuclei. (biomedcentral.com)
Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. (biossusa.com)
Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. (biossusa.com)

Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. (icr.ac.uk)

The mammalian Hes basic helix-loop-helix repressor genes play central roles in these processes by maintaining progenitor cells in an undifferentiated state and by regulating binary cell fate decisions. (biologists.com)
In particular,the Hes bHLH repressor genes play an essential role in the development of many organs by maintaining progenitor cells and by regulating binary cell fate decisions. (biologists.com)
In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. (icr.ac.uk)
A substantial portion of the regulatory interactions in the higher eukaryotic cell are mediated by simple sequence motifs in the regulatory segments of genes and (pre-)mRNAs, and in the intrinsically disordered regions of proteins. (biomedcentral.com)
Among CRE1 repressed transcripts, genes encoding unknown proteins and transport proteins were overrepresented. (biomedcentral.com)

Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)

Inhibition of PP1 leads to enhanced phosphorylation of specific sites on axin by casein kinase I. Axin phosphorylation markedly enhances the binding of glycogen synthase kinase 3, leading to a more active beta-catenin destruction complex. (duke.edu)
This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). (biossusa.com)
This effect characterized by a fast short-term inhibition followed by drastic and irreversible run-down is not relayed by G proteins. (mdm2-inhibitors.com)
Thus activation of the vasoactive G protein-coupled Amphotericin B receptor Amphotericin B UT triggers functional inhibition and endocytosis of GABAAR in CHO and human astrocytes its receptor C-terminus. (mdm2-inhibitors.com)
The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis. (bvsalud.org)

Extracellular signal-regulated kinase (ERK) is a part of the mitogen-activated protein kinase (MAPK) signaling pathway which allows the transduction of various cellular signals to final effectors and regulation of elementary cellular processes. (mdpi.com)
In fact, biological outcomes are often due to physical interactions between proteins that are so highly selective that seemingly minor chemical modifications (i.e. methylation, acetylation or phosphorylation) can completely abolish biomolecular recognition processes and redirect signaling pathways. (mtu.edu)
At an intermediate level, amino acids and insulin stimulate the phosphorylation of Thr36, Thr45, and Thr69 via mTOR-dependent processes that function independently of other sites in PHAS-I. At the third level, the extent of phosphorylation of one site modulates the phosphorylation of another. (umn.edu)
Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:11896197, PubMed:30290153). (icr.ac.uk)
The run-down partially entails Ca2+ and phosphorylation processes requires dynamin and results from GABAAR internalization. (mdm2-inhibitors.com)

Polycomb group RING finger protein 6 is a protein that in humans is encoded by the PCGF6 gene. (wikipedia.org)
The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. (wikipedia.org)
MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation" (PDF). (wikipedia.org)
The Sox9 gene is required for the differentiation of mesenchymal precursor cells to chondrocytes and, together with the related L-Sox5 and Sox6 proteins, controls chondrocyte-specific gene expression [ 4 , 5 ]. (biomedcentral.com)

Skeletal muscle and myogenic C2C12 cells were used to study the effects of MSY3 phosphorylation in vivo and in vitro on its sub-cellular localization and activity, by blocking the IGF1/PI3K/Akt pathway, by Akt depletion and over-expression, and by mutating potential MSY3 phosphorylation sites. (biomedcentral.com)
Recently, a large number of signaling proteins reported play an important key role in the process of LPLI-induced cell proliferation, probably due to the fact that the molecular events they are involved in are the basic response of the cells to extracellular stimuli. (biomedcentral.com)
Violin plots show distribution of expression levels for Dual specificity tyrosine-phosphorylation-regulated kinase 2 (SMED30002728) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
Expression of Dual specificity tyrosine-phosphorylation-regulated kinase 2 (SMED30002728) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
Violin plots show distribution of expression levels for Dual specificity tyrosine-phosphorylation-regulated kinase 2 (SMED30002728) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
Although the senescent cells remain viable, they show typical changes with enlarged and flattened cell bodies, apoptosis resistance, increased activity of senescence-associated β -galactosidase (SA- β -gal), and upregulation of cyclin-dependent kinase (CDK) inhibitors including p16 INK4A , ARF proteins, and p21 [ 13 - 16 ]. (hindawi.com)

Scholars@Duke publication: Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. (duke.edu)
A20 is a ubiquitin-modifying protein that negatively regulates NF-κB signaling. (bvsalud.org)
MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. (biossusa.com)
Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. (biossusa.com)
In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. (biossusa.com)
mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. (biossusa.com)

In this study, we provide multiple lines of evidence showing that the post-translational phosphorylation of MSY3 by Akt kinase modulates the MSY3 repression of myogenin. (biomedcentral.com)
History and (Hes-1) is a transcriptional repressor that has an important function in neuronal differentiation and advancement but post-translational adjustments of Hes-1 are significantly less known. (molecularcircuit.com)
Post-translational adjustment of protein with little ubiquitin-like modifier (SUMO) continues to be recognized as a significant mechanism for legislation of various mobile features [6]. (molecularcircuit.com)
Control of the translational repressor, PHAS-I, was investigated by expressing proteins with Ser/Thr → Ala mutations in the five (S/T)P phosphorylation sites. (umn.edu)
HE ubiquitin pathway catalyzes the post-translational modification of substrate proteins with the small protein ubiquitin, and it includes the enzymes catabo-lizing ubiquitylated proteins and additional proteins regulating the process. (1library.net)
Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. (mcw.edu)

SUMO is normally a polypeptide about 100 proteins in length that's covalently mounted on substrate proteins over the lysine (Lys) residue. (molecularcircuit.com)
The SUMO E3 ligases after that transfer the SUMO molecule from UBC9 to particular substrate proteins [7]. (molecularcircuit.com)

Furthermore Hes-1 SUMOylation was unbiased of Hes-1 phosphorylation and and (Hes-1) is normally a transcriptional repressor is one of the simple helix-loop-helix (bHLH) proteins family members and was proven to play a pivotal function in legislation of cell differentiation and proliferation in a variety of cell types during advancement [1]. (molecularcircuit.com)

Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2. (icr.ac.uk)
Consequently, the oxidative phosphorylation of mitochondria, as well as parallel dysregulated pathways, could be major sources of produced ROS/RNS. (encyclopedia.pub)

Protein arginine methyltransferases (PRMTs) comprise a group of enzymes that catalyze the transfer of methyl groups to the amino acid arginine or the arginine residues of proteins in eukaryotic species. (e-enm.org)

Jun dimerization protein-2 (JDP-2) is a progesterone receptor (PR) coregulatory protein that acts by inducing structure and transcriptional activity in the disordered amino-terminal domain (NTD) of PR. (nih.gov)
Wnt-regulated changes in axin phosphorylation, mediated by PP1, may therefore determine beta-catenin transcriptional activity. (duke.edu)

2007). Substrate specificity appears to be determined in large part by the nature of the F-box protein present. (1library.net)

In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation. (icr.ac.uk)

ETS2 repressor factor (ERF) insufficiency causes craniosynostosis (CRS4) in humans and mice. (ox.ac.uk)
Wild type, PI3Kγ knock-out (PI3Kγ -/- ) and PI3K kinase dead knock-in (PI3Kδ D910/A910 ) transgenic mice were exposed to cigarette smoke for 3 days and the expression levels of the co-repressor complex components HDAC-2, mSin3a, Mi-2α and Mi-2β and HDAC-2 activity in the lungs were assessed. (biomedcentral.com)
Both mSin3a and Mi-2α protein expression was reduced in smoke-exposed mice. (biomedcentral.com)
Budesonide alone protected mSin3a protein expression with no additional effect seen with abrogation of PI3Kγ/δ activity, however Mi-2α, but not Mi-2β, expression was protected in both PI3Kδ D910/A910 and PI3Kγ -/- budesonide-treated smoke-exposed mice. (biomedcentral.com)
Most of the important insights regarding the specific function of AP-1 proteins have been established through the use of mice with either loss- or gain-of-function manipulations of various members of the bZIP protein family [ 13 ]. (biomedcentral.com)
To demonstrate the flexibility and modular nature of the liposome system, 10 recombinant surface antigens representing distinct influenza virus strains were bound simultaneously to generate a highly multivalent protein particle that with 5 ng individual antigen dosing induced antibodies in mice that specifically recognized the constituent immunogens and conferred protection against heterologous H5N1 influenza virus challenge. (cdc.gov)

Both the mSin3a and Mi-2/NuRD co-repressor complexes are large multi-component complexes in which not all of the components and their functions have been identified [ 2 , 6 ]. (biomedcentral.com)
The impact of oxidative stress on key components of the co-repressor complexes have only just started to be explored, with the very recent publication highlighting the impact of oxidative stress driven protein kinase-CK2 activation on co-repressor activity and HDAC2 function [ 20 ]. (biomedcentral.com)
After translation, where is a protein localised, and what complexes should it join? (biomedcentral.com)

Ubiquitin is ultimately transferred to a lysyl residue within a substrate protein or to one or more lysyl residues of a previously attached ubiquitin, forming a polyubiquitin chain. (1library.net)
Many of the surface residues of erh are conserved, including patches of hydrophobic and charged residues, suggesting protein-protein interaction interfaces. (ncsu.edu)
While all three types of PRMTs are capable of catalyzing monomethylation of arginine residues, type I PRMTs can transfer a second methyl group to the monomethylated nitrogen atom of the guanidino group of monomethyl arginine, resulting in the formation of proteins containing one or more asymmetric dimethylarginine residues. (e-enm.org)
Type II PRMTs transfer a methyl group to the unmodified nitrogen atom of the guanidine group of monomethyl arginine to form proteins with symmetric dimethylarginine residues. (e-enm.org)

53BP1 (p53-binding protein 1) facilitates ATM-dependent DSB repair but is largely dispensable for ATM activation or checkpoint arrest. (birmingham.ac.uk)
The adenovirus E1A protein mimics the LxDLFD motif and competes with E2F for binding to Rb, promoting E2F activation and cell proliferation. (eu.org)
LPLI-induced cell cycle progression can be regulated by the activation or elevated expressions of cell cycle-specific proteins. (biomedcentral.com)
GABAA receptor (GABAAR) appearance level is inversely correlated with the proliferation price of astrocytes after heart stroke or during malignancy of astrocytoma resulting in the hypothesis that GABAAR appearance/activation may are a cell proliferation repressor. (mdm2-inhibitors.com)
The biological actions of URP and UII are mediated through activation of the G protein-coupled receptor named UT. (mdm2-inhibitors.com)

Thecul1-7mutation affects the C terminus of the protein, results in reduced cul1-7 levels, and interferes with RBX1 interaction.cul1-7seedlings are defective in degradation of an endogenous SCF substrate, Repressor ofga1-3(RGA), and have altered responses to gibberellins.cul1-7seedlings exhibit slower degradation of the light-labile red/far-red photoreceptor phytochrome A and are photomorpho-genic in the dark. (1library.net)

These data underscore the structural flexibility of the NTD of PR, and the ability of steroid ligands together with interacting proteins to affect the conformation and activity of the NTD. (nih.gov)

A phosphorylation downstream to the core motif acts as a switch that binds to a positively charged pocket only present in p107/p130. (eu.org)
In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. (icr.ac.uk)

Pocket proteins Rb, p107 and p130 play central roles in cell cycle progression and differentiation. (eu.org)
Pocket proteins play essential roles in cell cycle progression, quiescence and differentiation, and their functional disruption is associated with human cancer. (eu.org)

However, each of the sites influences mRNA translation, either directly by modulating the binding affinity of PHAS-I and eIF4E or indirectly by affecting the phosphorylation of other sites. (umn.edu)

Amongst the dysregulated pathophysiological pathways in AD, oxidative stress seems to play a critical role in the pathogenesis progression of AD, with a dominant role of nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein-1 (Keap1)/antioxidant responsive elements (ARE) pathway. (encyclopedia.pub)

Our latest finding signifies that phosphorylation of Hes-1 at Ser263 by c-Jun N-terminal kinase 1 (JNK1) stabilizes the Hes-1 proteins and enhances its suppressing influence on α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acidity receptor subunit GluR1 appearance [3]. (molecularcircuit.com)
The F-box protein is the variable subunit of the complex and interacts directly with the substrate. (1library.net)

Two putative CKII phosphorylation sites are highly ordered in the structure and are predicted to disrupt dimerization and protein-protein interactions. (ncsu.edu)

We observed that, as skeletal muscle progressed from perinatal to postnatal and adult developmental stages, MSY3 protein became gradually dephosphorylated and accumulated in the nucleus. (biomedcentral.com)
Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus. (icr.ac.uk)

It is increasingly becoming apparent that dynamic control of phosphorylation and dephosphorylation underlies the proper spatial and temporal activities of many signaling circuits including Notch (N). Emerging evidence suggests that protein kinase CK2 mediates the effects of N during Drosophila eye and bristle development via phosphorylation of E(spl) repressors. (wvu.edu)

The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. (wikipedia.org)
MSY3 phosphorylation by Akt in vitro impaired its binding at the MyogHCE element, while blocking Akt increased MSY3 binding activity. (biomedcentral.com)
These results support the hypothesis that MSY3 phosphorylation by Akt interferes with MSY3 repression of myogenin circuit activity during muscle development. (biomedcentral.com)
The repression activity of Hes-1 SSI-1 could be controlled by proteins phosphorylation. (molecularcircuit.com)
The restoration of glucocorticoid function coincided with the protection of both HDAC activity and mSin3a and Mi-2α protein expression. (biomedcentral.com)
Cigarette smoke exposure induced glucocorticoid insensitivity and alters co-repressor activity and expression which is prevented by blockade of PI3K signaling with glucocorticoid treatment. (biomedcentral.com)
this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). (icr.ac.uk)
This UII-induced disappearance of the repressor activity of GABAAR may play a key role in the initiation of astrocyte proliferation. (mdm2-inhibitors.com)

The most studied function of the Rb protein is in the regulation of cell cycle progression at the G1/S boundary ( Giacinti,2006 ). (eu.org)
Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. (icr.ac.uk)
Finally, we contrast the regulatory properties of protein motifs and the regulatory elements of DNA and (pre-)mRNAs, advocating that co-regulation, co-operativity, and motif-driven regulatory programs are common mechanisms that emerge from the use of simple, evolutionarily plastic regulatory modules. (biomedcentral.com)

AIM2 is an interferon-inducible HIN-200 protein family member and is well-documented for its roles in innate immune responses as a DNA sensor. (bvsalud.org)

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human AE Binding Protein 1 (AEBP1) in tissue homogenates, cell lysates and other biological fluids. (kits-elisa.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human AE Binding Protein 1 (AEBP1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (kits-elisa.com)
The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is a candidate vaccine antigen that binds angiotensin-converting enzyme 2(ACE2), leading to virus entry. (cdc.gov)

The LxCxE motif binds to all pocket proteins and is present in chromatin regulators such as HDAC and KDM5A and in viral proteins. (eu.org)
Binds to the caspase-cleaved p110 isoform of CDC2L1 and CDC2L2, p110C, but not the full-length proteins (PubMed:12624090). (icr.ac.uk)

This control is represented by Ser64 phosphorylation, which depends on the phosphorylation of all three TP sites. (umn.edu)

Cross-talk of the MAPK signaling pathway with other proteins and signaling pathways have a crucial impact on clinical outcomes of targeted therapies and plays important role during development of drug resistance in cancers. (mdpi.com)

Description: A sandwich quantitative ELISA assay kit for detection of Human AE Binding Protein 1 (AEBP1) in samples from tissue homogenates, cell lysates or other biological fluids. (kits-elisa.com)

Many aspects of plant biology depend on the ubiquitin proteasome system for degradation of regulatory proteins. (1library.net)

Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A/C". Biochem. (wikipedia.org)

Anatomy15

Organisms15

Chemicals and Drugs126

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes74

Information Science3

Acts as a transcriptional repressor2

Serine11

Transcription18

Activator4

Inhibitor3

Calmodulin-dependent1

Genes5

Receptors1

Inhibition5

Processes5

Gene4

Cells6

Regulates6

Translational6

Substrate proteins2

BHLH1

Mitochondria2

Eukaryotic1

Transcriptional activity2

Specificity1

Inactivation1

Mice6

Complexes3

Residues4

Activation5

Endogenous1

Ligands1

Downstream2

Differentiation2

MRNA1

Oxidative1

Subunit2

Dimerization1

Nucleus2

Dephosphorylation1

Activity8

Regulation3

Roles1

Enzyme3

Binds2

Sites1

Signaling pathways1

Lysates1

Regulatory1

UBC91