Lipoprotein-Associated Phospholipase A2ProteinCytosolic Phospholipase A2EnzymeInhibitorSecretory phospholipaseHydrolyzesPhospholipidsPla2Phosphatidylinositol-specificProteinsReceptorOverexpressionRegulationEnzymesDiacylglycerolSPLAPhospholipidActivationActivityVenomPrimarilyDeltaGroupPropertiesRoleHealthQuantityMajor
Lipoprotein-Associated Phospholipase A21
- Adjusted HR for lipoprotein-associated phospholipase A2 (mass) (HR 1.53, 95% CI 1.14-2.04 vs. HR 1.05, 95% CI.99-1.12) was higher for incident isolated AAA compared to incident isolated AD, respectively. (lu.se)
Protein10
- Phospholipase C delta 4 (PLCδ4) is a nuclear protein involved in cell proliferation and senescence in mesenchymal stromal stem cells. (nih.gov)
- Human non-pancreatic secreted phospholipase A 2 (hnps PLA 2 ) is a small (14 kDa) secreted protein of considerable biomedical interest. (soton.ac.uk)
- The microtubule protein tubulin regulates adenylyl cyclase and phospholipase Cβ 1 (PLCβ 1 ) signaling via transactivation of the G-protein subunits Gαs, Gαi1, and Gαq. (jneurosci.org)
- Peptide fragment from phospholipase A 2 (PLA 2 ) activating protein (PLAP) that activates phospholipase A 2 in a dose-dependent manner (10-fold at 1 µg/ml). (enzolifesciences.com)
- In patients with Crohn's disease, serum phospholipase A2 activity decreased in parallel with clinical improvement, and correlated with serum C-reactive protein and erythrocyte sedimentation rate. (bmj.com)
- Serum phospholipase A2 activity in patients with ulcerative colitis tends to increase in relation with endoscopic severity, and may be a more sensitive laboratory index than serum C-reactive protein and erythrocyte sedimentation rate to evaluate disease activity. (bmj.com)
- Secreted phospholipase A2 (sPLA2) is a protein secreted by Clonorchis sinensis and is a component of excretory and secretory products ( Cs ESPs). (biomedcentral.com)
- The physiological activator of protein kinase C (PKC), diacylglycerol, is formed by hydrolysis of phosphoinositides (PI) by phospholipase C (PLC) or phosphatidylcholine by phospholipase D (PLD). (reading.ac.uk)
- Dual phospholipase C/diacylglycerol requirement for protein kinase D1 activation in lymphocytes. (figshare.com)
- Our previous study demonstrated that the reduction of cytosolic phospholipase A2 alpha (cPLA2α) protein overexpression and activation in the spinal cord of a mouse model of ALS, hmSOD1 G93A, inhibited CD40 upregulation in microglia . (bvsalud.org)
Cytosolic Phospholipase A21
- The study was based on the hypothesis that poultry PM would induce the release of inflammatory cytokine interleukin-8 (IL-8) by respiratory epithelial cells under the upstream regulation by cytosolic phospholipase A2 (cPLA2) activation and subsequent formation of cyclooxygenase (COX)- and lipoxygenase (LOX)-catalyzed arachidonic acid (AA) metabolites (eicosanoids). (cdc.gov)
Enzyme9
- A phospholipase is an enzyme that hydrolyzes phospholipids into fatty acids and other lipophilic substances. (wikipedia.org)
- Phospholipase A2 is an enzyme present in the venom of bees, blennies and viper snakes. (wikipedia.org)
- A simple statistical mechanical model of lipid bilayers is proposed to account for the non-equilibrium action of the enzyme phospholipase A 2 . (edpsciences.org)
- 3-[3-Amino-4-(indan-2-yloxy)-5-(1-methyl-1 H -indazol-5-yl)-phenyl]-propionic acid (AK106-001616) is a novel, potent, and selective inhibitor of the cytosolic phospholipase A 2 (cPLA 2 ) enzyme. (aspetjournals.org)
- Raised serum activity of phospholipase A2 immunochemically related to group II enzyme in inflammatory bowel disease: its correlation with disease activity of Crohn's disease and ulcerative colitis. (bmj.com)
- The results suggest that raised serum phospholipase A2 activity in patients with Crohn's disease and ulcerative colitis was mainly attributed to the two forms of phospholipase A2 immunochemically related to group II enzyme. (bmj.com)
- Here, we analyze the role of human group IIA secreted phospholipase A2 (sPLA2-IIA), a bactericidal enzyme induced during acute inflammation, in innate immunity against GBS. (pasteur.fr)
- Phospholipase A1 (PLA1) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids. (st-andrews.ac.uk)
- The PLCG2 gene provides instructions for making an enzyme called phospholipase C gamma 2 (PLCγ2). (medlineplus.gov)
Inhibitor1
- However, suppression of the WNT pathway using the acetyltransferase porcupine inhibitor C59 did not reverse EMT whereas a dominant negative form of TCF4 as well as inhibition of phospholipase C using U73122 were able to do so. (cnrs.fr)
Secretory phospholipase3
- The intrinsic overexpression of secretory phospholipase A2 (sPLA 2 ) in various pro-inflammatory diseases and cancers has the potential to be exploited as a therapeutic strategy for diagnostics and treatment. (rsc.org)
- Group IIE secretory phospholipase A2, also known as GIIE sPLA2, sPLA2-IIE, Phosphatidylcholine 2-acylhydrolase 2E and PL. (targetmol.com)
- Varespladib 是选择性group IIA, secretory phospholipase A2(sPLA2)抑制剂，其IC50=9 nM。它对大鼠，兔，豚鼠和人等 (targetmol.com)
Hydrolyzes3
- Phospholipase A2 acts on the intact lecithin molecule and hydrolyzes the fatty acid esterified to the second carbon atom. (wikipedia.org)
- Phospholipase A 1 (PLA 1 ) hydrolyzes phospholipid acyl chains at the sn -1 position of membrane phospholipids, phospholipase A 2 (PLA 2 ) hydrolyzes acyl chains at the sn -2 position, phospholipase C (PLC) hydrolyzes the glycerol-phosphodiester bond, and phospholipase D (PLD) hydrolyzes the polar group-phosphodiester bond. (nih.gov)
- The metal-independent lipase from Streptomyces albidoflavus NA297 (SaPLA1) is a phospholipase A1 as it preferentially hydrolyzes the sn-1 acyl ester in glycerophospholipids, yielding a fatty acid and 2-acyl-lysophospholipid. (rcsb.org)
Phospholipids2
- Phospholipases typically hydrolyze glycerol phospholipids, but loss of iPLA2-VIA does not affect the phospholipid composition of brain tissue but rather causes an elevation in ceramides. (nih.gov)
- Secreted phospholipases A 2 (sPLA 2 s) (EC 3.1.1.4) are a structurally related group of low-molecular-mass enzymes (14-18 kDa) that catalyse the hydrolysis of glycerophospholipids (phospholipids hereafter) at their sn -2 position, to produce lysophospholipids and free fatty acids. (ijbs.com)
Pla21
- Phospholipase A2 (Pla2) is required for memory retrieval, and its inhibition in the hippocampus has been reported to impair memory acquisition in rats. (springer.com)
Phosphatidylinositol-specific1
- 5'-monophosphate deaminase from Streptomyces murinus, D-allulose 3-epimerase from Arthrobacter globiformis expressed in Escherichia coli , carbohydrate-derived fulvic acid, jagua (genipin-glycine) blue (Jagua blue), lipase from Mucor javanicus and phosphatidylinositol-specific phospholipase C expressed in Pseudomonas fluorescens ). (who.int)
Proteins1
- A phosphoinositide phospholipase C subtype that is primarily regulated by its association with HETEROTRIMERIC G-PROTEINS. (curehunter.com)
Receptor3
- Antigen receptor activation of wild type PKD is dependent on phospholipase C (PLC)/diacylglycerol (DAG) and PKC, whereas PKD-S744E/S748E is only dependent on PLC/DAG but no longer requires PKC. (figshare.com)
- The anti-phospholipase-a2-receptor-pla2r measures anti-phospholipase A2 receptor levels in the blood for detecting membranous glomerulonephritis and nephrotic syndrome. (redcliffelabs.com)
- The M-type phospholipase A2 receptor (PLA2R) in the glomerular podocyte has been identified as the major target antigen in deposited immune-complexes. (msdmanuals.com)
Overexpression1
- Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells. (nih.gov)
Regulation1
- Regulation of phospholipases C and D in rat ventricular myocytes: stimulation by endothelin-1, bradykinin and phenylephrine. (reading.ac.uk)
Enzymes3
- This gene encodes a member of the delta class of phospholipase C enzymes. (nih.gov)
- Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. (nih.gov)
- Ivanušec A, Šribar J, Križaj I. Secreted Phospholipases A 2 - not just Enzymes: Revisited. (ijbs.com)
Diacylglycerol1
- Phospholipase C - cleaves before the phosphate, releasing diacylglycerol and a phosphate-containing head group. (wikipedia.org)
SPLA1
- Secreted phospholipases A 2 (sPLA 2 s) participate in a very broad spectrum of biological processes through their enzymatic activity and as ligands for membrane and soluble receptors. (ijbs.com)
Phospholipid1
- Phospholipase D (PLD) is a key player in phospholipid metabolism. (biovisi.com)
Activation2
- This suggests that a WNT-independent mechanism of beta-catenin activation via phospholipase C is involved in the EMT induced by Cyclin A2 depletion. (cnrs.fr)
- We have measured activation of these phospholipases by endothelin-1 (ET-1), bradykinin (BK), or phenylephrine (PE) in ventricular myocytes cultured from neonatal rat. (reading.ac.uk)
Activity9
- Rouault M, Bollinger JG, Lazdunski M, Gelb MH, Lambeau G: Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity. (hmdb.ca)
- Calcium dependent phospholipase A2 activity in the mixed micelles of 1-palmitoyl-2-oleoyl-phosphatidylglycerol and cholate was measured in sera of 39 patients with Crohn's disease, 40 patients with ulcerative colitis, and 40 healthy controls. (bmj.com)
- The phospholipase A2 activity was significantly raised in those sera of the patients with active Crohn's disease and those with moderate and severe ulcerative colitis. (bmj.com)
- The major phospholipase A2 activity derived from the sera was separated into two peaks by reverse phase high performance liquid chromatography. (bmj.com)
- The results suggest that serum phospholipase A2 activity may serve as an additional indicator of disease activity. (bmj.com)
- BioVision's Phospholipase D Activity Assay Kit provides a simple and sensitive method of measuring PLD activity using colorimetry (OD 570 nm). (biovisi.com)
- The assay can detect phospholipase D (PLD) Activity less than 1 mU/ml in various sample types. (biovisi.com)
- RESULTS: Phospholipase and proteinase activity were observed in 100% of the C. albicans strains. (bvsalud.org)
- In the non-albicans species, proteinase and phospholipase activity were observed in 25 and 43% of the studied strains, respectively. (bvsalud.org)
Venom1
- Studies on phospholipase A in Trimeresurus flavoviridis venom. (eurekamag.com)
Primarily1
- Endothelial lipase is primarily a phospholipase. (wikipedia.org)
Delta1
- It is structurally related to PHOSPHOLIPASE C DELTA with the addition of C-terminal extension of 400 residues. (curehunter.com)
Group1
- The phospholipase A2 active fractions were immunochemically characterised using specific antibody directed against human group II phospholipase A2 purified from rheumatoid synovial fluid. (bmj.com)
Properties1
- Baker, Sharon Felicity (1998) Studies of the interfacial and heparin binding properties of secreted phospholipases A2. (soton.ac.uk)
Role1
- Regulatory role of cytosolic phospholipase A 2 alpha in the induction of CD40 in microglia. (bvsalud.org)
Health1
- Tappia, Paramjit S. & Dhalla, Naranjan S. (Editors): Phospholipases in Health and Disease. (wikipedia.org)
Quantity1
- CONCLUSION: The virulence of Candida strains in G. mellonella is related to the quantity of proteinases and phospholipases production of each strain. (bvsalud.org)
Major1
- There are four major classes, termed A, B, C, and D, which are distinguished by the type of reaction which they catalyze: Phospholipase A Phospholipase A1 - cleaves the sn-1 acyl chain (where sn refers to stereospecific numbering). (wikipedia.org)