• Phosphoenolpyruvate carboxykinase (PEPCK) is the metabolic enzyme that catalyzes the first committed step in gluconeogenesis and glyceroneogensis. (uwaterloo.ca)
  • The pckA gene, encoding the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK), was cloned by PCR amplification from the purple nonsulfur bacterium Rhodopseudomonas palustris No. 7. (asm.org)
  • Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the decarboxylation and phosphorylation of oxaloacetate (OAA) to form phosphoenolpyruvate (PEP) in most organisms. (asm.org)
  • In Escherichia coli , besides the PEPCK reaction, there is another pathway to form PEP from C 4 -dicarboxylic acid which involves the NAD- and NADP-dependent malic enzymes (MAEA and MAEB) and phosphoenolpyruvate synthase (PPS). (asm.org)
  • Recently, we demonstrated that an ethanol extract of Radix Paeoniae Rubra could suppress transcription of the hepatic phosphoenolpyruvate carboxykinase (PEPCK) gene [ 5 ]. (hindawi.com)
  • Results: Phosphoenolpyruvate carboxykinase (PEPCK) and associated transcription factors are up-regulated in HCV-infected Huh.8 cells. (ttu.edu)
  • The SIRT1 activators isonicotinamide (IsoNAM), resveratrol, fisetin, and butein repressed transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) (PEPCK-C). An evolutionarily conserved binding site for hepatic nuclear factor (HNF) 4α (-272/ -252) was identified, which was required for transcriptional repression of the PEPCK-C gene promoter caused by these compounds. (elsevierpure.com)
  • The enzyme phosphoenol pyruvate phosphatase (EC 3.1.3.60) catalyzes the reaction phosphoenolpyruvate + H2O ⇌ {\displaystyle \rightleftharpoons } pyruvate + phosphate This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. (wikipedia.org)
  • Pyruvate, orthophosphate dikinase (PPDK) and phosphoenolpyruvate synthetase (PEPS) catalyze the conversion of pyruvate to phosphoenolpyruvate (PEP). (scirp.org)
  • EC 2.7.9.1) catalyzes the reversible conversion of pyruvate to phosphoenolpyruvate (PEP) and is important in C 4 plants as it is generally recognized as catalyzing the rate-limiting step of C 4 photosynthesis [1]. (scirp.org)
  • The effect of glucocorticoids on expression of the gene coding for phosphoenolpyruvate carboxykinase in adipose tissue has been studied in vivo in rats and in vitro in adipose tissue organ culture and mouse 3T3 L1 adipocytes. (huji.ac.il)
  • The inhibitory effect of glucocorticoids on phosphoenolpyruvate carboxykinase gene expression was located at the level of transcription. (huji.ac.il)
  • As glucocorticoids are known to stimulate transcription of phosphoenolpyruvate carboxykinase gene in the liver and kidney, the inhibitory effect on its transcription in adipose tissue suggests that tissue specific transcription factors may modulate the effect of glucocorticoids. (huji.ac.il)
  • To overcome this substrate utilization defect, a predicted glcG gene, encoding enzyme II of the D-glucose phosphoenolpyruvate-dependent phosphotransferase system (PTS), was first disrupted in the ABE-producing model strain Clostridium acetobutylicum ATCC 824, resulting in greatly improved D-xylose and L-arabinose consumption in the presence of D-glucose. (hw.ac.uk)
  • Isolation and in silico analysis of phosphoenolpyruvate carboxylase gene and effects of indoleacetic acid and kinetin on sucrose production of sugarcane (Saccharum officinarum L. (upm.edu.my)
  • This study aims to isolate, identify and characterize the phosphoenolpyruvate carboxylase gene (PEPcase) and finding out the effects of indoleacetic acid and kinetin hormones on glucose productivity of sugarcane. (upm.edu.my)
  • Analyses of phosphoenolpyruvate carboxylase gene structure and expression in alfalfa nodules. (usda.gov)
  • A rare gluconeogenesis disorder that results from impairment in the enzyme phosphoenolpyruvate carboxykinase and comprised of cytosolic and mitochondrial forms of enzyme deficiency. (globalgenes.org)
  • Cytosolic Phosphoenolpyruvate carboxykinase is a key gluconeogenic enzyme which is expressed in a tissue specific manner in the liver, kidney and adipose tissue and is under hormonal control. (huji.ac.il)
  • Oxalacetate acetylhydrolase (OAH), a member of the phosphoenolpyruvate mutase/isocitrate lyase superfamily, catalyzes the hydrolysis of oxalacetate to oxalic acid and acetate. (rcsb.org)
  • In gluconeogenesis, aldolase catalyzes the reduction of phosphoenolpyruvate to fructose 1,6-bisphosphate. (medscape.com)
  • The enzymes phosphoenolpyruvate carboxylase (PEPC, EC 4.1.1.31) and NADH- glutamate synthase (NADH-GOGAT, EC 1.4.1.14) are pivotal in N and C metabolism. (usda.gov)
  • Alteration of growth yield by overexpression of phosphoenolpyruvate carboxylase and phosphoenolpyruvate carboxykinase in Escherichia coli. (yale.edu)
  • Complejo enzimático que cataliza la DESCARBOXILACIÓN oxidativa y la DESAMINACIÓN de la GLICINA en DIÓXIDO DE CARBONO, AMONÍACO, NADH y N5N10-metilenotetrahidrofolato. (bvsalud.org)
  • 1] "Lactose transport system of Streptococcus thermophilus: a hybrid protein with homology to the melibiose carrier and enzyme III of phosphoenolpyruvate-dependent phosphotransferase systems. (tcdb.org)
  • Manganese (Mn), necessary for healthy bone structure, is a component of several enzyme systems, including manganese -specific glycosyltransferases and phosphoenolpyruvate carboxykinase. (msdmanuals.com)
  • Phosphoenolpyruvate carboxykinase in cultured foetal hepatocytes from the rat. (unboundmedicine.com)
  • The phosphoenolpyruvate carboxykinase gene (PCK1) plays a significant role regulating glucose metabolism, and fatty acids are key metabolic regulators, which interact with transcription factors and influence glucose metabolism. (nih.gov)
  • Here, we show that melanoma TRCs cultured in three-dimensional soft fibrin gels reprogram glucose metabolism by hijacking the cytosolic enzyme phosphoenolpyruvate carboxykinase (PCK1), a key player in gluconeogenesis. (illinois.edu)
  • Liver-specific phosphoenolpyruvate carboxykinase (PEPCK) null mice, when fasted, maintain normal whole body glucose kinetics but develop dramatic hepatic steatosis. (elsevierpure.com)
  • In mammals, although glucose is believed to be an important energy source to drive V-ATPase, and phosphoenolpyruvate carboxykinase (PEPCK), a key enzyme for gluconeogenesis, is known to be activated in response to acidosis, the link between acid secretion and PEPCK activation remains unclear. (ntnu.edu.tw)
  • Biotin is known to regulate hepatic and pancreatic glucokinase expression at both transcriptional and translational levels, and to regulate hepatic phosphoenolpyruvate carboxykinase expression at the transcriptional level. (nih.gov)
  • This reaction is catalyzed by the enzyme phosphoenolpyruvate carboxykinase (PEPCK). (hmdb.ca)
  • The bioactive derivative of vitamin A, retinoic acid (RA) was shown to regulate a number of major metabolic genes including phosphoenolpyruvate carboxykinase, fatty acid synthase, carnitine palmitoyltransferase 1, and glucokinase among others. (nih.gov)
  • The phosphoenolpyruvate-carbohydrate phosphotransferase system (PTS) is a multistep chemical process that regulates the intake and use of carbohydrates by bacteria. (emerging-researchers.org)
  • Streptococcus salivarius urease expression: involvement of the phosphoenolpyruvate:sugar phosphotransferase system. (microbiologyresearch.org)
  • The AtxA crystal structure is multimodular with five distinct domains: two N-terminal DNA-binding domains, two phosphoenolpyruvate phosphotransferase system regulation domains (PRDs) and a C-terminal domain enabling protein dimerization. (nih.gov)
  • The maize phosphoenolpyruvate carboxylase promoter confers expression in the green tissues of the plant. (cbd.int)
  • One notable difference between CAM in quillworts and terrestrial plants is in the function of phosphoenolpyruvate carboxylase (PEPC). (cornell.edu)
  • GO:0009401 P:phosphoenolpyruvate-dependent sugar phospho. (tcdb.org)
  • Phosphoenolpyruvate (PEP) is an important chemical compound in biochemistry. (hmdb.ca)