• Of primary adrenal tumors, ACC is less common than cortical adenoma and pheochromocytoma. (cap.org)
  • Advanced imaging techniques often reveal adrenal tumors in asymptomatic patients. (cap.org)
  • It is important to distinguish the histological variants of conventional ACC as they share similar features to secondary tumors that not infrequently involve the adrenal gland. (cap.org)
  • Tumors of the parapharyngeal space (PPS), a potential space lateral to the upper pharynx, are uncommon, making up less than 1% of all head and neck neoplasms. (medscape.com)
  • Both benign and malignant tumors may arise from any of the structures contained in this space. (medscape.com)
  • Of PPS tumors, 70-80% are benign, and 20-30% are malignant. (medscape.com)
  • Other means of assessing PPS tumors include the balloon occlusion test, nuclear scanning, and a metastatic workup. (medscape.com)
  • Objectives: This study aimed to evaluate the stability, safety, and efficacy of alpha-targeted therapy with [225Ac]Ac-DOTATATE in patients with grade 1/2 metastatic neuroendocrine tumors (NETs). (bvsalud.org)
  • Pancreatic endocrine tumor, also known as pancreatic neuroendocrine tumor (PNET), describes a group of endocrine tumors originating in the pancreas that are usually indolent and benign, but may have the potential to be malignant. (findzebra.com)
  • Wiedemann-Beckwith syndrome is related to abnormalities on chromosome 11p15 and characterized by multiple craniofacial anomalies, abdominal wall defects, and tumors of the genitourinary tract, liver, adrenal gland, and central nervous system among other abnormalities. (abdominalkey.com)
  • Although pheochromocytomas have classically been associated with 3 syndromes-von Hippel-Lindau (VHL) syndrome, multiple endocrine neoplasia type 2 (MEN 2), and neurofibromatosis type 1 (NF1)-there are now 10 genes that have been identified as sites of mutations leading to these tumors. (medscape.com)
  • When such tumors arise outside of the adrenal gland, they are termed extra-adrenal pheochromocytomas, or paragangliomas. (medscape.com)
  • Because of excessive catecholamine secretion, pheochromocytomas may precipitate life-threatening hypertension or cardiac arrhythmias. (medscape.com)
  • A pheochromocytoma (see the image below) is a rare, catecholamine-secreting tumor that may precipitate life-threatening hypertension. (medscape.com)
  • Incidentally found adrenal masses can be further classified as benign or malignant and primary adrenal versus metastatic using radiologic-cytologic or pathologic correlation. (cap.org)
  • However, specific histologic features help to differentiate adrenal pheochromocytomas with a potential for biologically aggressive behavior from those that behave in a benign fashion. (medscape.com)
  • A group of disorders having a benign course but exhibiting clinical and histological features suggestive of malignant lymphoma. (lookformedical.com)
  • Pseudolymphoma is characterized by a benign infiltration of lymphoid cells or histiocytes which microscopically resembles a malignant lymphoma. (lookformedical.com)
  • Curiously this decodes to "an abnormality is present, but it could either be a benign (non-cancerous) growth or a malignant cancerous growth of the follicular cells. (ronnyallan.net)
  • In particular, human organic cation transporter 2 (hOCT2) and multidrug and toxin extrusion proteins 1 and 2-K (hMATE1/2-K) likely mediate renal secretion of mIBG, whereas hOCT1 and hOCT3 may contribute to mIBG uptake into normal tissues such as the liver, salivary glands, and heart. (aspetjournals.org)
  • Pancreatic neuroendocrine neoplasms (pNENs) are an increasingly common group of malignancies that arise within the endocrine tissue of the pancreas. (rarediseases.org)
  • Nonfunctioning neuroendocrine neoplasms can still cause symptoms relating to tumor size and location such as obstruction or internal bleeding. (rarediseases.org)
  • Diagnosed with Metastatic Neuroendocrine Cancer in 2010. (ronnyallan.net)
  • and there is a type of thyroid tumour related to Neuroendocrine Neoplasms - Medullary Thyroid Carcinoma (MTC) including a familial variant - and not forgetting the parathyroid which is common in familial cases of MEN , and NETs have a habit of metastasizing to strange places. (ronnyallan.net)
  • Results: Patients had 73% (n=8) lymph node metastases, 91% (n=10) liver metastases, 36% (n=4) lung metastases, and 73% (n=8) bone metastases. (bvsalud.org)
  • This case first appeared as Performance Improvement Program in Surgical Pathology (PIP) 2018, Case 23, and is an adrenal cortical carcinoma of the adrenal gland. (cap.org)
  • These findings are consistent with adrenal cortical carcinoma (ACC). (cap.org)
  • Approximately 20% of all salivary lesions in the PPS are malignant, with carcinoma ex pleomorphic adenoma and adenoid cystic carcinoma being the most frequently reported. (medscape.com)
  • Data set for reporting of carcinoma of the adrenal cortex: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting. (ukw.de)
  • These different genes produce pheochromocytomas with different ages of onset, secretory profiles, locations, and potential for malignancy. (medscape.com)
  • Only the presence of metastases defines malignancy. (medscape.com)
  • [ 10 ] The prevalence of neoplasms that arise within the deep lobe of the parotid gland is identical to that of those that arise in the superficial lobe. (medscape.com)
  • Neoplasms that arise from endocrine tissue may also secrete hormones, resulting in excessive levels of these hormones in the body and potentially a wide variety of symptoms. (rarediseases.org)
  • A p heochromocytoma is another, rarer type of NET that usually develops in the adrenal gland , but can also arise in other parts of the body. (findzebra.com)
  • Radiologic and FNA cytologic studies are also useful in staging patients with possible metastatic lesions. (cap.org)
  • Neoplasms of salivary gland origin are located in the prestyloid parapharyngeal space (PPS) and account for 40-50% of PPS lesions. (medscape.com)
  • Neurilemmomas are the most commonly encountered lesions, followed in frequency by paragangliomas and neurofibromas. (medscape.com)
  • Methods: This retrospective cohort included patients (n=11) with metastatic NETs from different primary sites (bronchial, pancreatic, nonpancreatic gastroenteropancreatic NETs, paraganglioma, and unknown primary site) treated with [225Ac]Ac-DOTATATE with a mean activity of 8.2±0.6 MBq (range: 7.5-10.0 MBq) at our institution between November 2019 and March 2022. (bvsalud.org)
  • Pancreatic cancer as a general term usually refers to pancreatic adenocarcinoma, an aggressive malignant cancer with a poor prognosis. (rarediseases.org)
  • Although vascular and capsular invasion cannot be assessed, cytologic features on fine needle aspiration (FNA) such as hypercellularity, necrosis, and cellular dyscohesion, in conjunction with radiologic features of tumor size (greater than 4.0 cm), heterogeneity, and enhancement, favor ACC over other adrenal neoplasms. (cap.org)
  • Among the features that suggest a malignant course are large tumor size and an abnormal DNA ploidy pattern (aneuploidy, tetraploidy). (medscape.com)
  • This is followed by coverage of neoplasms in the more traditional categories of epithelial, mesenchymal, and other categories. (abdominalkey.com)
  • For patients with advanced-stage metastatic castration-resistant prostate cancer (mCRPC) who do not respond to [177Lu]Lu-PSMA therapy, there are limited treatment options. (bvsalud.org)
  • About 30% of pheochromocytomas occur as part of hereditary syndromes. (medscape.com)
  • A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. (lookformedical.com)
  • Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL). (lookformedical.com)
  • The thyroid gland does in fact get mentioned frequently in NET patient discussions but many of the conversations I monitored didn't seem to fit my scenario - cue relentless study! (ronnyallan.net)
  • nonfunctioning neoplasms may produce hormones, but no systemic symptoms. (rarediseases.org)
  • Approximately 10% of pheochromocytomas and 35% of extra-adrenal pheochromocytomas are malignant. (medscape.com)
  • Common locations for extra-adrenal pheochromocytomas include the organ of Zuckerkandl (close to the origin of the inferior mesenteric artery), bladder wall, heart, mediastinum, and carotid and glomus jugulare bodies. (medscape.com)
  • The most common prestyloid PPS lesion is pleomorphic adenoma, which represents 45-64% of salivary neoplasms in the PPS. (medscape.com)
  • Conclusion: PTC was the most common type of DTC and presented with considerable rates of lymph node and pulmonary metastases. (bvsalud.org)
  • Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. (lookformedical.com)
  • However, prospective studies are needed to determine the impact of treatment on overall survival and to uncover potential side effects. (bvsalud.org)
  • Patients with lymph node and pulmonary metastases were more likely to have extrathyroidal extension and lymphovascular invasion. (bvsalud.org)
  • A pheochromocytoma (see the image below) is a rare, catecholamine-secreting tumor derived from chromaffin cells. (medscape.com)
  • The term pheochromocytoma (in Greek, phios means dusky, chroma means color, and cytoma means tumor) refers to the color the tumor cells acquire when stained with chromium salts. (medscape.com)
  • Imaging shows a large right adrenal mass, which is resected. (cap.org)
  • The tumor is malignant in 10% of cases but may be cured completely by surgical removal. (medscape.com)
  • The current World Health Organization (WHO) endocrine edition distinguishes adult ACC from adrenal adenoma based on the Weiss criteria. (cap.org)