• Finding the identity of these genes will be key to developing complete models linking genotype to phenotype. (escholarship.org)
  • Mastrangelo M, Leuzzi V. Genes of early-onset epileptic encephalopathies: from genotype to phenotype. (medscape.com)
  • Major breakthroughs in medical genomics have been enabled by the implementation of clinical exome sequencing (ES) for molecular diagnosis, by genomics approaches for understanding the genetic basis of complex traits and diseases, and by progress in understanding genotype–phenotype relationships. (cdc.gov)
  • Some bacterial pathogens have been shown to substantially modify their surface components in response to the host immune system and modify their energy metabolism and transport pathways to allow efficient growth within the host. (cdc.gov)
  • This suggests that the organism's networks are established so that noise can exist in one phenotypic level like metabolism and not permeate up or down to different phenotypic levels. (escholarship.org)
  • The increase in electron transfer rate and yield in KN400 may be due to changes in carbon flux towards oxidation pathways and to changes in ATP metabolism, both of which indicate that the overall energy state of the cell may be different. (biomedcentral.com)
  • PPARγ mediated regulation of peroxisomal lipid metabolism was shown as a key regulator of intracellular lipid storage and further drove chemoresistance and cancer stem like phenotypes. (monash.edu)
  • For example, growth of G. metallireducens with different electron donors and electron acceptors were studied using the genome-scale metabolic model, which provided a fast and cost-effective way to understand the metabolism of G. metallireducens. (elsevierpure.com)
  • Among the over-represented pathways were drug or xenobiotic metabolism, complement and coagulation cascades, NRF2-mediated oxidative stress, melatonin degradation and glutathione metabolism.Conclusions: Our data provide new insights and perspectives on the genetic basis of feed efficiency in cattle. (unesp.br)
  • Furthermore, given the high conservation of central carbon metabolism across species between the three domains of life, what are analogs of the effects of high fat and high sugar diets in prokaryotic systems and what metabolic syndromes do they manifest? (peerj.com)
  • Using Escherichia coli as model organism, this work would heterologously express genes and pathways involved in mammalian fat metabolism in E. coli to help understand how a combined high fat and high glucose diet would interact in mediating prokaryotic version of diabetes and high cholesterol syndrome. (peerj.com)
  • But, what is perhaps more intriguing is tracing the evolutionary pathway that connects dysregulated sugar and fat metabolism in bacteria to their homologous clinical manifestations in mammalian systems. (peerj.com)
  • mTOR promotes cell growth and controls central metabolic pathways including protein biosynthesis, autophagy and glucose and lipid homoeostasis. (nih.gov)
  • Moreover, genetic and simple obesity share similar structural and functional features of dysbiosis, such as higher production of toxins with known potential to induce metabolic deteriorations (e.g. trimethylamine-N-oxide and indoxyl sulphate), higher abundance of genomes containing genes coding enzymes involved in the production of these toxic co-metabolites and higher abundance of pathways for biosynthesis of bacterial antigens (such as endotoxin) [13-15]. (deepdyve.com)
  • Polyoxin, a peptidyl nucleoside antibiotic, consists of three building blocks including a nucleoside skeleton, polyoximic acid (POIA), and carbamoylpolyoxamic acid (CPOAA), however, little is known about the "pathway redundancy" of the metabolic networks directing the CPOAA biosynthesis in the cell factories of the polyoxin producer. (biomedcentral.com)
  • Here we report the genetic characterization of CPOAA biosynthesis with revealing a "pathway redundancy" in metabolic networks. (biomedcentral.com)
  • It is unveiled that argA and argB in L-arginine biosynthetic pathway contributed to the "pathway redundancy", more interestingly, argB in S. cacaoi is indispensible for both polyoxin production and L-arginine biosynthesis. (biomedcentral.com)
  • The proposed CPOAA biosynthetic pathway (A) and Genetic organization of the polyoxin biosynthetic gene cluster (B). The initial two steps involved in CPOAA biosynthesis are overlapped with those of L-Arginine pathway. (biomedcentral.com)
  • In particular, the study presented focuses on PPARγ signalling network in BRAFV600E driven colorectal cancers through regulation of peroxisomal phospholipid biosynthesis pathways. (monash.edu)
  • Here, transcriptome analysis and fatty acid profiling from developing V. galamensis seeds were integrated to uncover the critical metabolic pathways responsible for high EFA accumulation and identify the targets that could be used in assembly of EFA biosynthesis pathway in existing oilseed crops. (researchsquare.com)
  • The L-arginine biosynthetic pathway was distinctly characterized in bacteria including E. coli and Streptomyces [ 11 ]. (biomedcentral.com)
  • An increased carbon flux and exploitation of metabolic pathways for the rapid generation of biosynthetic precursors is a common phenotype observed in breast cancer. (northwestern.edu)
  • Overview of Porphyrias Porphyrias are rare disorders in which there are defects in the pathway of heme synthesis due to genetic or acquired deficiencies of enzymes of the heme biosynthetic pathway. (msdmanuals.com)
  • Overview of Cutaneous Porphyrias Cutaneous porphyrias result from deficiency (and in one case, excess) of certain enzymes in the heme biosynthetic pathway (see table ), resulting in a relatively steady production of phototoxic. (msdmanuals.com)
  • However, little is known about how genetic diversity can control stochastic variation within more non-cell autonomous phenotypes. (escholarship.org)
  • This genetic diversity included loci specific for the stochastic variation of each phenotypic class that did not affect the other phenotypic classes or the average phenotype. (escholarship.org)
  • The genetic influence over stochastic variation within the metabolome was highly metabolite specific, with neighboring metabolites in the same metabolic pathway frequently showing different levels of noise. (escholarship.org)
  • Genetic origin of a disease is often discovered once its phenotype has been clearly defined. (embnet.org)
  • Experimentally characterized genetic interaction networks in model organisms provide important insights into relationships between different biological functions. (researchgate.net)
  • We describe a computational methodology allowing to systematically and quantitatively characterize a Boolean mathematical model of a biological network in terms of genetic interactions between all loss of function and gain of function mutations with respect to all model phenotypes or outputs. (researchgate.net)
  • We demonstrate this methodology on three published models for each of which we derive the genetic interaction networks and analyze their properties. (researchgate.net)
  • In genetic interactions, synergy occurs when the contribution of two mutations to the phenotype of a double mutant exceeds the expectations from the additive effects of the individual mutations [74]. (researchgate.net)
  • In addition, it can be used to predict genetic interactions [3] by comparing the sensitivity value of a double gene mutation from the value predicted from single mutations, and reveal the network intervention [4] by applying the state-flip mutation subject to a single gene. (researchgate.net)
  • The genetic architecture of traits can be explored through the estimation of genetic parameters, genome-wide association studies (GWAS), gene networks and metabolic pathways. (purdue.edu)
  • An alternative approach to explore the genetic and biological connection between traits is based on principal component analysis (PCA), which generates novel "pseudo-phenotypes" and biological types (biotypes). (purdue.edu)
  • It is a network-based approach designed to explore the topological relationship between genes (signaling- or enzymatic-genes) and metabolites, representing a powerful tool to investigate the genetic landscape and regulatory networks of metabolic phenotypes. (tu-dortmund.de)
  • For example, cancer, the quintessential genetic disease, is being redefined by metabolic abnormalities, endowing tumours with the ability to outcompete normal cells in the tumour microenvironment. (ddw-online.com)
  • A dding fuel to the fire, there is early evidence that directing the metabolic programming of immune cells may improve the efficacy and durability of immunotherapies that are completely agnostic to cancer's genetic drivers. (ddw-online.com)
  • The savvy healthcare provider should therefore endeavour to understand both the genetic and metabolic drivers of a disease to really see the full picture (Figure 1). (ddw-online.com)
  • They can be assembled into profiles and collated phenotypes that provide a functional readout for interpreting biological behaviour, in the context of both genetic and environmental factors. (ddw-online.com)
  • While animal models could be used to probe the above hypothesized interplay between high fat diet and high glucose intake in mediating diabetes incidence, complex genetic background of the mammalian system seriously hamper the deciphering of the interconnection between phenotype and genes through analysis of functional genomic and epidemiological data. (peerj.com)
  • Recent developments in molecular genetics, such as platforms for genome-wide genotyping and sequencing, provide an opportunity to identify genes and pathways that influence production traits. (unesp.br)
  • We potentially identified genes and pathways that play key roles in hepatic metabolic adaptations to oxidative stress such as those involved in antioxidant mechanisms. (unesp.br)
  • Insights such as what are the genes differentially expressed during metabolization of high sugar and high fat diet by bacterial cells would hopefully inform the search for mammalian genes that predispose to metabolic syndrome by illuminating hitherto unknown genes and pathways implicated in the disease. (peerj.com)
  • To support this metabolic phenotype, cancer cells adaptively regulate the expression of glycolytic enzymes and nutrient transporters. (northwestern.edu)
  • In particular, vitamin B1 (thiamine) is utilized as an essential cofactor for metabolic enzymes that intersect at critical junctions within the glycolytic network. (northwestern.edu)
  • The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
  • Mete Civelek uses big data analytics to understand the molecular pathways of disease and develops personalized medicine approaches to cardiovascular and metabolic disorders. (virginia.edu)
  • Understanding the impact of SNPs associated with autism spectrum disorder on biological pathways in the human fetal and adult cortex. (cdc.gov)
  • No changes in metabolic or insulin signalling genes were observed. (nottingham.ac.uk)
  • In the hands of skilled scientists, these tools are revealing changes in metabolic pathways that are providing new insights into disease progression. (ddw-online.com)
  • Given a list of genes, e.g. those composing a metabolic pathway, we lead a phenotypic and miRNAs-based analysis by calculating distances among gene pairs. (embnet.org)
  • This may suggest a causal relationship between the lifespan of an organism and its metabolic phenotype. (nih.gov)
  • Interactions among genes together with their expression level determine a phenotype in a given organism. (embnet.org)
  • The Parkinson's disease genes pink1 and parkin , which encode a mitochondrially targeted protein kinase, and an E3 ubiquitin ligase, respectively, participate in a key mitochondrial quality-control pathway that eliminates damaged mitochondria. (sdbonline.org)
  • In line with this notion, mitochondria are highly dynamic organelles that undergo fission and fusion and move into the cell along the microtubules to generate the mitochondrial network [ 6 ]. (hindawi.com)
  • Amoêdo ND, Rodrigues MF, Pezutto P, Lourenço MVC, Madeiro da Costa RF, Oliveira MF, Galina A, Rumjanek FD, El-Bacha T (2010) Metabolic reprogramming of lung cancer cell induced by sodium butyrate: Studies on mitochondrial physiology and bioenergetics. (mitophysiology.org)
  • Failure of the PN is associated with broad range of diseases including cancer, neurodegeneration, and immunological and metabolic disorders [ 1 ]. (hindawi.com)
  • The additional information generated by whole genome studies goes far beyond that derived by characterizing in isolation more genes and gene products, because analysis of the whole genome allows complete regulatory networks to be identified and characterized. (cdc.gov)
  • New metabolic engineering approaches have recently been developed to modulate carotenoid content, including the employment of CRISPR technologies for single-base editing and the integration of exogenous genes into specific "safe harbors" in the genome. (frontiersin.org)
  • The genome of KN400 was compared to wildtype with the goal of discovering how the network for extracellular electron transfer has changed and how these two strains evolved. (biomedcentral.com)
  • Genome-scale metabolic network reconstruction of model animals as a platform for translational research. (scilifelab.se)
  • Genome-scale metabolic models (GEMs) are used extensively for analysis of mechanisms underlying human diseases and metabolic malfunctions. (scilifelab.se)
  • RESULTS: The genome-scale metabolic model of G. metallireducens was constructed to include 747 genes and 697 reactions. (elsevierpure.com)
  • CONCLUSION: We have developed a genome-scale metabolic model for G. metallireducens that features both metabolic similarities and differences to the published model for its close relative, G. sulfurreducens. (elsevierpure.com)
  • A new field of research, known as systems biology if applied to model systems or network medicine if applied to human beings, has emerged over the past decade or so, to address biological complexity in a holistic, integrated way. (ersjournals.com)
  • In this State of the Art review we present the basic concepts of systems biology, use some examples to illustrate the potential of network medicine to address complex medical problems, and review some recent publications that show how a systems-based research strategy can contribute to improve our understanding of multimorbidity and age-related respiratory diseases. (ersjournals.com)
  • Systems biology-inspired computational methods for translating metabolomics data into fluxomics provide a direct functional, dynamic readout of metabolic networks. (mdpi.com)
  • Systems biology combines mechanistic modelling with quantitative experimentation in studies of networks and better understanding of the interaction of multiple components in disease processes. (biomedcentral.com)
  • We outline how DD may be investigated more effectively by employing a systems biology approach that considers the disease network as a whole rather than focusing on any specific single molecule. (biomedcentral.com)
  • Mitochondria are highly dynamic organelles that provide essential metabolic functions and represent the major bioenergetic hub of eukaryotic cell. (hindawi.com)
  • These cells can suffer metabolic reprogramming, resulting in distinct bioenergetic phenotypes, generally enhancing glycolysis channelled to lactate production [1]. (mitophysiology.org)
  • Metabolic reprogramming allows the tumor cells to switch between phenotypes under changing growth condition that help these tumors to evolve and develop resistance against the therapeutic regimens. (ncl.res.in)
  • The regulation of the stem cell-like properties by several important signaling pathways have been found to endow the tumor cells with an increased level of tumorigenicity, chemoresistance, and metastatic ability. (molcells.org)
  • In this review, we will discuss the recent findings on hepatic CSCs, with special emphasis on their putative origins, relationship with hepatitis viruses, regulatory signaling networks, tumor microenvironment, and how these factors control the stemness of hepatic CSCs. (molcells.org)
  • This review summarizes recent discoveries relevant to liver CSCs, with emphasis on discussing their putative cellular origins, the roles of hepatitis viruses, tumor microenvironment and signaling network in controlling the stemness of CSCs. (molcells.org)
  • Virtually every area of life science research will benefit in some way from increased knowledge of the metabolic networks that underlie their relevant cellular processes. (ddw-online.com)
  • The challenge right now is that we don't understand the discrete and overlapping endotypes that underlie the phenotypes or domains" of PsA, said Christopher Ritchlin, MD, MPH, professor of medicine in the division of allergy/immunology and rheumatology and the Center of Musculoskeletal Research at the University of Rochester (N.Y.), who spoke about PsA at the annual research symposium of the National Psoriasis Foundation. (medscape.com)
  • Elementary Flux Modes (EFMs) provide a rigorous basis to systematically characterize the steady state, cellular phenotypes, as well as metabolic network robustness and fragility. (mdpi.com)
  • The role of cellular objectives and selective pressures in metabolic pathway evolution. (ucsd.edu)
  • Thus, it is possible to begin dissecting the stochastic variation of whole organismal phenotypes in multi-cellular organisms. (escholarship.org)
  • Metabolomics uses sophisticated analytical chemistry techniques, combined with software that provides computational methods, to reconstruct cellular pathways of interest. (ddw-online.com)
  • These proteins are involved in ER-stress, cytokine signaling, T-Cell activation, Activation of NLRP3 Inflammation by SARS-CoV-2, JAK-STAT, IL-4, IL-13 pathways, MAPK signaling pathways, Activation of NMDA receptor & postsynaptic events and TGF-β signaling pathways. (fortunejournals.com)
  • Noncommunicable diseases, including cardiovascular, metabolic and respiratory diseases, among others, are the major medical challenge of the 21st century. (ersjournals.com)
  • It is well known that microRNAs (miRNAs) expressions strongly affect phenotypes sometimes causing diseases. (embnet.org)
  • Starting from matrices of phenotypic and drugs similarities,the tool provides users an interface to establish those miRNAs, known to be responsible for the regulation of genes involved in a disease, associated with other diseases showing similar phenotypes. (embnet.org)
  • The study of metabolic impairments in neuropsychiatric diseases including depression, schizophrenia and Alzheimer's disease. (duke.edu)
  • Most human phenotypes can be found in the database OMIM (Online Mendelian Inheritance in Man). (embnet.org)
  • When more patients were described, the phenotype was expanded to include the renal tubular defects that comprise Fanconi syndrome , and an X-linked inheritance pattern was noted. (medscape.com)
  • The compound inheritance gene dosage model shows that haploinsufficiency does not cause the phenotype whereas a homozygous null allele is lethal. (cdc.gov)
  • However, the identification of relevant genes without known homologs, and the elucidation of the lignocellulolytic pathways and protein complexes for different microorganisms remain challenging. (biomedcentral.com)
  • Specifically, through integrative analysis of Mouse1 with RNA-sequencing data from brain tissues of transgenic mice we identified a coordinated up-regulation of lysosomal GM2 ganglioside and peptide degradation pathways which appears to be a signature metabolic alteration in Alzheimer's disease (AD) mouse models with a phenotype of amyloid precursor protein overexpression. (scilifelab.se)
  • The OCRL1 protein is an inositol polyphosphate 5-phosphatase primarily located in the trans- Golgi network (TGN), on endosomes, and at the endocytic clathrin coated pits. (medscape.com)
  • In the second step, we calculate the phenotypic distance matrix between any two genes according to the their common phenotypes. (embnet.org)
  • Or could activation of an enhanced lipid recycling pathway serve as a response to high fat infusion in bacteria? (peerj.com)
  • The subject of the present study is the design of an environment in which microRNAs-drugs-phenotypes relationships can be deduced using more advanced network-based techniques. (embnet.org)
  • The post-transcriptional regulation imposed by microRNAs on the metabolic genes was studied using graph theoretical approach. (ncl.res.in)
  • We specifically focus on distinct roles of isoforms and splice variants across the mTOR network. (nih.gov)
  • Build a network of all genes that are involved in the pathway Evaluate the consistency of the prior regulatory information Remove inconsistent prior information-the denoising step Estimate pathway activity Pearson correlations were first computed between regulatory genes at the level of transcription and a gene expression data set. (wikipedia.org)
  • Gene pairs with significant correlation will be considered relevant in the network. (wikipedia.org)
  • The performance measure Vij accounts for the significance of correlation between pathways, the direction of correlation, and the weights in the magnitude of the correlation. (wikipedia.org)
  • The comprehensive analysis of mouse knockout studies targeting these variants does not support a tight correlation between lifespan prolongation and improved metabolic phenotypes and questions the strict causal relationship between them. (nih.gov)
  • We propose a software tool that using gene-phenotypes association techniques in connection with gene network-based correlation algorithms allows the identification of statistically significant microRNA-phenotype-drug associations. (embnet.org)
  • We propose that the dynamic binding and release of FNR from TROL can control the flow of photosynthetic electrons prior to activation of the pseudo-cyclic electron transfer pathway. (nature.com)
  • This is known as the linear electron transfer (LET) pathway 1 . (nature.com)
  • Genes known to be involved in electron transport, those used in the metabolic cell model, and those that exhibit changes in expression during growth in microbial fuel cells were examined in detail. (biomedcentral.com)
  • In order to gain a holistic perspective of the pathway behavior and condition specific changes in the metabolic network of glioblastoma, a constraint-based metabolic model was formulated and analyzed. (ncl.res.in)
  • This thesis focused on unraveling metabolic reprogramming in human tumours. (monash.edu)
  • Different approaches have been taken to highlight the identification of relevant pathway in order to provide better gene expression prediction. (wikipedia.org)
  • Dietary restriction increases lifespan and delays ageing phenotypes as well and mTOR has been assigned a major role in this process. (nih.gov)
  • In this review, we cover the current view on the contribution of the different elements of the mTOR signalling network to lifespan and age-related metabolic impairment. (nih.gov)
  • The Pink1/parkin pathway plays a role in the quality control mechanism aimed at eliminating defective mitochondria, and the failure of this mechanism results in a reduced lifespan and impaired locomotor ability, among other phenotypes. (sdbonline.org)
  • In the present thesis, the alternate routes of therapeutic escape, opportunistic mode of nutrient acquisition, and evolving metabolic routes to sustain oncogenic phenotypes under various growth conditions have been studied by formulating and analyzing computational and mathematical models. (ncl.res.in)
  • Regulation of the Nampt-mediated NAD salvage pathway and its therapeutic implications in pancreatic cancer. (frontiersin.org)
  • When global gene expression profiles were further examined it was evident that whilst cultured myotubes retained many characteristics of skeletal muscle tissue, the phenotype appeared to be closer to fetal than adult muscle. (nottingham.ac.uk)
  • 61. Rambold AS, Kostelecky B, Elia N, Lippincott-Schwartz J. Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. (frontiersin.org)
  • This strategy substantially improves unsupervised predictions of pathway activity that are based on a prior model, which was learned from a different biological system or context. (wikipedia.org)
  • A linear regression model was then applied to estimate the pathway activation levels. (wikipedia.org)
  • In addition, we suggest several computational tools for studying the distribution of double mutants in the space of model phenotype probabilities. (researchgate.net)
  • There have been many in silico studies based on a Boolean network model to investigate network sensitivity against gene or interaction mutations. (researchgate.net)
  • This study established an in vivo PINK1 / Parkin -induced photoreceptor neuron degeneration model in Drosophila with the aim of dissecting the PINK1/Parkin pathway in detail. (sdbonline.org)
  • Inhibition of parkin or Pink1 through the induction of stable RNAi transgene in the Ddc-Gal4-expressing neurons results in such phenotypes to model PD. (sdbonline.org)
  • Compared to the G. sulfurreducens model, the G. metallireducens metabolic model contains 118 unique reactions that reflect many of G. metallireducens' specific metabolic capabilities. (elsevierpure.com)
  • SPIA (Signaling Pathway Impact analysis) is a method that uses the phenotype information to evaluate the pathway activity between two phenotypes. (wikipedia.org)
  • Furthermore, when metabolic gene expression networks were analysed using pathway based analysis, it was apparent that expression of genes involved in oxidative phosphorylation, insulin signalling and glucose transport were markedly reduced in cultured cells. (nottingham.ac.uk)
  • Thus, significant insights into microbial evolution have been gained through the analysis and comparison of reconstructed metabolic networks. (ucsd.edu)
  • The PCs were also used as pseudo-phenotypes in the GWAS analysis, which identified important candidate genes and metabolic pathways linked to each biotype. (purdue.edu)
  • Networks and Graphs Discovery in Metabolomics Data Analysis and Interpretation. (who.int)
  • part of these networks is also established by contacts of the mitochondria with organelles (e.g., with endoplasmic reticulum, plasma membrane, and peroxisomes) [ 7 - 9 ]. (hindawi.com)
  • While several hypotheses have been put forward to explain the mechanisms by which FFAs and ECs may cause insulin resistance, there are still many potential signalling pathways which may be involved that have not yet been examined. (nottingham.ac.uk)
  • Some previously identified mechanisms were supported and new pathways controlling feed efficiency in Nelore cattle were discovered. (unesp.br)
  • These results improve our understanding of the metabolic mechanisms underlying feed efficiency in beef cattle and will help develop strategies for selection towards the desired phenotype. (unesp.br)
  • But while interventions can be tailored to some extent to these domains, or phenotypes, there are limitations without an understanding of the different pathophysiology and mechanisms driving the heterogeneity in tissue involvement. (medscape.com)
  • Ritchlin draws inspiration from pulmonology, which subtyped asthma into various phenotypes (for example, eosinophilic, allergic, intrinsic, exercise-induced) and "drilled down" on understanding underlying mechanisms to guide more specific treatment. (medscape.com)
  • In the first case study, we observed that the real biological networks were most sensitive to overexpression/state-flip and edge-addition/-reverse mutations among node-based and edgetic mutations, respectively. (researchgate.net)
  • Gut microorganisms are the source of many bioactive products that play key functions in human host pathways and microbe-microbe interactions [2]. (deepdyve.com)
  • However, changes in a single gene can lead to significant changes in biomolecular networks through the gain and loss of many molecular interactions. (ucsd.edu)
  • We classify the obtained interactions according to their class of epistasis, dependence on the chosen initial conditions and phenotype. (researchgate.net)
  • We further explored this network to identify and triangulate the key proteins, metabolic pathways and associated risk factors that can regulate moderate to severe Covid-19 infections. (fortunejournals.com)
  • These data should provide an example for the research on the "pathway redundancy" in metabolic networks, and lay a solid foundation for targeted enhancement of polyoxin production with synthetic biology strategies. (biomedcentral.com)
  • Together these metabolic models provide an important resource for improving strategies on bioremediation and bioenergy generation. (elsevierpure.com)
  • Cognitive phenotypes such as developmental delay/intellectual disability (DD/ID), autism, and schizophrenia are complex traits. (cdc.gov)
  • These GEMs represent the most comprehensive coverage of the metabolic network by considering both orthology-based pathways and species-specific reactions. (scilifelab.se)
  • In this review, we propose that DD is a disease of several networks rather than of a single gene, and show that this accounts for the experimental observations obtained to date from a variety of sources. (biomedcentral.com)
  • Similar phenotype-endotype research has been done for chronic obstructive pulmonary disease , he said at the meeting, pointing to a phase 3 randomized controlled trial, published in the New England Journal of Medicine, that found dupilimab (Dupixent) was effective for patients with COPD who had type 2 inflammation as indicated by elevated eosinophil counts. (medscape.com)
  • However, the number of EFMs typically grows exponentially with the size of the metabolic network, leading to excessive computational demands, and unfortunately, a large fraction of these EFMs are not biologically feasible due to system constraints. (mdpi.com)
  • This scenario is further complicated by the altered molecular phenotype featuring AT in obesity-induced inflammation and insulin resistance. (medscape.com)
  • Human phenotypes can be easily described by their observable features. (embnet.org)
  • This metabolic shift was further validated with proteomics data from transgenic mice and cerebrospinal fluid samples from human patients. (scilifelab.se)
  • Genomic Variability in the Survival Motor Neuron Genes (SMN1 and SMN2): Implications for Spinal Muscular Atrophy Phenotype and Therapeutics Development. (cdc.gov)
  • The DART algorithm has been shown to be a strong method for estimating the pathway activity and perturbation signature activity in breast and lung cancer gene expression data sets. (wikipedia.org)
  • Specifically, does manifestation of diabetes in bacteria results from epigenetic changes that mistune metabolic pathway and networks in an inheritable fashion? (peerj.com)
  • Social and medical needs of rare metabolic patients: results from a MetabERN survey. (cdc.gov)