• the expression level of ZNF326 was inversely associated with advanced pTNM stage (P = 0.002), positive lymph node metastasis (P = 0.004), poor prognosis in patients with breast cancer (P = 0.0097), and ER/PR/Her2 status (P = 0.013). (cancerindex.org)
  • Prostate Cancer Central Nervous System Metastasis in a Contemporary Cohort. (ucdenver.edu)
  • Bladder cancer Metastasis Staging Radical cystectomy Uro-oncology Urothelial carcinoma Computed tomography Urothelial carcinoma of the bladder (UCB) ranks globally as the 11th most common. (karger.com)
  • Metastatic cancer or also known as metastasis is the most dreadful one. (healthybladderclub.com)
  • 3. For metastatic rcc, ipsilateral adrenal metastasis. (umbc.edu)
  • This demonstrates that distant metastasis can occur during the early phase of tumor growth in these aggressive lesions. (biomedcentral.com)
  • Bladder cancer is a common urologic cancer that has the highest recurrence rate of any malignancy. (medscape.com)
  • Natural History T1, GIII TCC Natural history of T1, G3: -69-80% recurrence rate -53% progression rate -21% develop upper tract TCC "Rule of 30%" a.) 30% never recur b.) 30% die of metastatic TCC c.) 30% require deferred cystectomy Cookson et al. (slidesfinder.com)
  • Serum Antibodies to HPV16 Early Proteins Warrant Investigation as Potential Biomarkers for Risk Stratification and Recurrence of HPV-Associated Oropharyngeal Cancer. (uchicago.edu)
  • Journal for ImmunoTherapy of Cancer. (wustl.edu)
  • After 40 years of treating metastatic bladder cancer with chemotherapy as a primary treatment, scientists now present a new approach using immunotherapy combinations. (medicalxpress.com)
  • OBJECTIVE: To systematically evaluate evidence regarding the efficacy and safety of immunotherapy in elderly patients with prostate cancer, UC, or RCC. (mcmaster.ca)
  • Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF. (ucdenver.edu)
  • It is the most common type of bladder cancer and cancer of the ureter, urethra, and urachus. (wikipedia.org)
  • TCC can arise anywhere in the urinary tract, including the renal pelvis, ureter, bladder, and urethra, but it is usually found in the urinary bladder. (medscape.com)
  • It is the second most common type of kidney cancer, but accounts for only five to 10 percent of all primary renal malignant tumors. (wikipedia.org)
  • Tumors or cancer of the URINARY BLADDER. (musc.edu)
  • The biological role and underlying mechanism of action of zinc-finger protein 326 (ZNF326) in malignant tumors, including breast cancer, are still not clear. (cancerindex.org)
  • Although this most common gynecologic cancer carries the best prognosis, it is important to differentiate between the classic endometrioid tumors that tend to be estrogen dependent and well differentiated, from other less common high-risk uterine malignancies, such as uterine papillary serous carcinomas (UPSCs), clear cell carcinomas, mixed mullerian tumors (MMTs), or sarcomas, which appear to have a different biology. (medmuv.com)
  • Mutation of the transforming growth factor (TGF) beta receptor type II gene is common in RER+ colon and gastric cancers, but uncommon in RER+ endometrial cancers even those arising in HNPCC kindreds, suggesting that the genesis of RER+ tumors even within the same familial cancer syndrome is not the same. (medmuv.com)
  • Although inactivation of both alleles of either hMSH2 or MLH1 (DNA mismatch repair genes) appears to underlie microsatellite instability in tumors of HNPCC kindreds, similar to the findings in sporadic colon cancers, sporadic endometrial cancers were not associated with mutations of any of the four known human mismatch repair genes. (medmuv.com)
  • Notable was the almost complete absence of Ki-ras mutations in an aggressive form of endometrial cancer, UPSC, when compared to the usual endometrioid tumors. (medmuv.com)
  • Colonic neuroendocrine neoplasms (NENs) are relatively rare tumors with an incidence rate of 0.11-0.21/100,000. (biomedcentral.com)
  • Neuroendocrine neoplasms (NENs) are rare tumors originating from neuroendocrine cells and include a series of heterogeneous tumors. (biomedcentral.com)
  • Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
  • When the term "urothelial" is used, it specifically refers to a carcinoma of the urothelium, meaning a transitional cell carcinomas of the urinary system. (wikipedia.org)
  • Signs and symptoms of transitional cell carcinomas depend on the location and extent of the cancer. (wikipedia.org)
  • Thus, urothelial carcinomas are more common in the context of chronic urinary stone disease, chronic catheterization (as in patients with paraplegia or multiple sclerosis), and chronic infections. (wikipedia.org)
  • Some particular examples are listed below: Certain drugs, such as cyclophosphamide, via the metabolites acrolein and phenacetin, may predispose to the development of transitional cell carcinomas (the latter especially with respect to the upper urinary tract). (wikipedia.org)
  • Transitional cell bladder carcinomas associated with this sSMS are more aggressive and invasive than those not associated with it. (wikipedia.org)
  • The 1973 WHO grading system for transitional cell carcinomas (papilloma, G1, G2 or G3) is most commonly used despite being superseded by the 2004 WHO grading for papillary types (papillary neoplasm of low malignant potential [PNLMP], low grade, and high grade papillary carcinoma). (wikipedia.org)
  • It proved to be a valid biomarker especially in detecting squamous intraepithelial lesions in cervical liquid-based samples and in discerning these lesions from their mimickers, as well as in ovarian, endometrial, vulvar, primary and metastatic melanomas, breast, pancreatic and renal cell carcinomas. (medsci.org)
  • Kirsten (Ki)-ras activating point mutations in codons 12 and 13 have been implicated in the development of atypical endometrial hyperplasias and endometrioid carcinomas in Japanese women, as well as in colon cancers. (medmuv.com)
  • More than 90% of invasive vulvar cancers are squamous cell carcinomas. (cancer.gov)
  • Diagnosis includes urine analysis and imaging of the urinary tract (cystoscopy). (wikipedia.org)
  • Various authors have explored the improved temporal and spatial resolution that MSCT has brought to the kidneys and urinary tract. (diagnosticimaging.com)
  • The role of alpha-blockers in the management of lower urinary tract symptoms in prostate cancer patients treated with radiation therapy. (ucdenver.edu)
  • PSA is of proven value in differentiating benign from malignant disease in men with lower urinary tract signs & symptoms (e.g., hematuria, slow urine stream, hesitancy, urgency, frequency, nocturia & incontinence) as well as with patients with palpably abnormal prostate glands on physician exam, and in patients with other laboratory or imaging studies that suggest the possibility of a malignant prostate disorder. (codemap.com)
  • Generally, for patients with lower urinary tract signs or symptoms, the test is performed only once per year unless there is a change in the patient's medical condition. (codemap.com)
  • Urothelial carcinoma (UC) is one the most common malignancies derived from the urothelium of the lower urinary tract. (medsci.org)
  • Improved Survival With Prostate Radiation in Addition to Androgen Deprivation Therapy for Men With Newly Diagnosed Metastatic Prostate Cancer. (ucdenver.edu)
  • Transitional cell carcinoma, also called urothelial carcinoma, is a type of cancer that typically occurs in the urinary system. (wikipedia.org)
  • H&E stain Papillary transitional cell carcinoma, low grade Histopathology of urothelial carcinoma of the urinary bladder, showing a nested pattern of invasion. (wikipedia.org)
  • High incidence of lung cancer after non-muscle-invasive transitional cell carcinoma of the bladder: implications for screening trials. (ucdenver.edu)
  • Chemical exposure, such as those sustained by workers in the petroleum industry, the manufacture of paints and pigments (e.g., aniline dyes), and agrochemicals are known to predispose one to urothelial cancer. (wikipedia.org)
  • American Cancer Society: Cancer Facts and Figures 2023. (cancer.gov)
  • American Cancer Society, 2023. (cancer.gov)
  • Forty-five patients with prior treatments will be enrolled in three expansion cohorts: 15 anti-PD1 naive renal and urothelial patients 15 anti-PD1 resistant renal and urothelial patients (defined as patients with transient clinical response or without clinical response to prior immune-checkpoint inhibition), and 15 patients with androgen-sensitive or castration-resistant prostate cancer. (bcan.org)
  • DBC1 promotes castration-resistant prostate cancer by positively regulating DNA binding and stability of AR-V7. (cancerindex.org)
  • Constitutively active AR-V7, one of the major androgen receptor (AR) splice variants lacking the ligand-binding domain, plays a key role in the development of castration-resistant prostate cancer (CRPC) and anti-androgen resistance. (cancerindex.org)
  • a thin, flexible tube with a light and camera is inserted into the bladder through the urethra. (healthybladderclub.com)
  • A radical cystectomy involves removal of the bladder, tissue around the bladder, the prostate, and seminal vesicles in men and the uterus, fallopian tubes, ovaries, anterior vaginal wall, and urethra in women. (healthybladderclub.com)
  • During a TUR, a urologist inserts a thin, lighted tube called a cystoscope into the bladder through the urethra to examine the lining of the bladder. (healthybladderclub.com)
  • Hricak et al (1991) used MRI for diagnostic evaluation of the female urethra in a series of patients and found that primary or metastatic urethral neoplasms were detected in every patient who was clinically found to have disease. (medscape.com)
  • Are higher follicle-stimulating hormone levels before androgen deprivation therapy for prostate cancer associated with oncological and cardiac outcomes and overall survival? (elsevierpure.com)
  • In prostate cancer, sipuleucel-T improves survival (median age >70 yr) and similar results were seen in the PROSTVAC phase 2 trial. (mcmaster.ca)
  • Gleason stratifications prognostic for survival in men receiving definitive external beam radiation therapy for localized prostate cancer. (ucdenver.edu)
  • Survival Outcomes of Whole-Pelvic Versus Prostate-Only Radiation Therapy for High-Risk Prostate Cancer Patients With Use of the National Cancer Data Base. (ucdenver.edu)
  • Survival outcomes of radiotherapy with or without androgen-deprivation therapy for patients with intermediate-risk prostate cancer using the National Cancer Data Base. (ucdenver.edu)
  • Survival outcomes of combined external beam radiotherapy and brachytherapy vs. brachytherapy alone for intermediate-risk prostate cancer patients using the National Cancer Data Base. (ucdenver.edu)
  • Improved survival with the addition of radiotherapy to androgen deprivation: questions answered and a review of current controversies in radiotherapy for non-metastatic prostate cancer. (ucdenver.edu)
  • Prostate brachytherapy, either alone or in combination with external beam radiation, is associated with longer overall survival in men with favorable pathologic Group 4 (Gleason score 8) prostate cancer. (ucdenver.edu)
  • Urothelial carcinoma Bladder cancer Inflammatory biomarker Age Senescence Survival Cystectomy With around 593,393 newly diagnosed patients worldwide, bladder cancer. (karger.com)
  • They are interested to know the survival rate of this cancer because their lives are at stake. (healthybladderclub.com)
  • Survival for prostate cancer is generally good, particularly if you are diagnosed early. (healthyprostateclub.com)
  • Find the survival rates for prostate cancer here. (healthyprostateclub.com)
  • The earlier the detection of prostate cancer, the better the patients chance of survival is. (healthyprostateclub.com)
  • Overexpression of HER-2/neu has been associated with advanced stage, deep myometrial invasion, and poor survival in endometrial cancers in several studies. (medmuv.com)
  • A 2-stage phase II study was conducted to assess the activity and toxicity profile of pazopanib in patients with metastatic, urothelial carcinoma. (johnshopkins.edu)
  • Chemotherapy may be used for patients with metastatic prostate cancer, with the aim of slowing any further spread of cancer and improving quality of life. (healthyprostateclub.com)
  • Bladder perforation Neoplasm Urothelial carcinoma Transurethral resection Clinical Data Warehouse. (karger.com)
  • In some cases, stage II bladder cancer may also be controlled by transurethral resection if the cancer is small enough and does not extend far into the bladder wall. (healthybladderclub.com)
  • The treatment of non-muscle-invasive bladder cancer (Ta, T1, carcinoma in situ [CIS]) begins with transurethral resection of bladder tumor (TURBT). (medscape.com)
  • Urodrill - a novel MRI-guided endoscopic biopsy technique to sample and molecularly classify muscle-invasive bladder cancer without fractionating the specimen during transurethral resection. (lu.se)
  • The ectopic forms result from abnormal expression of the AVP-NPII gene by primary or metastatic malignancies. (medicaltalk.net)
  • The INTERLACE phase III trial assessed whether a short course of induction chemotherapy (IC) prior to chemoradiation (CRT) could reduce the rate of relapse and death among patients with locally advanced cervical cancer. (medicalxpress.com)
  • Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open-label, phase 3 trial. (canceropole-est.org)
  • Is 6 Months the Optimal Duration of Adjuvant Chemotherapy for Pancreatic Cancer? (cancerdiagnosisprognosis.org)
  • Alternatively, a bladder-sparing approach of TURBT followed by concurrent radiation therapy and systemic chemotherapy (trimodality therapy) may be used. (medscape.com)
  • This study will investigate the safety and tolerability of MAGE-A4ᶜ¹º³²T cell therapy in subjects who have the appropriate HLA-A2 tissue marker and whose urinary bladder, melanoma, head and neck, ovarian, non-small cell lung, esophageal, gastric, synovial sarcoma, or myxoid/round call liposarcoma (MRCLS) tumor has the MAGE-A4 protein expressed. (mycancergenome.org)
  • The growth phase of melanoma was vertical in 13 (92.9%) patients and radial phase in one (7.1%) patient. (magiran.com)
  • Racial differences in the risk of second primary bladder cancer following radiation therapy among localized prostate cancer patients. (musc.edu)
  • Predictors of rectal tolerance observed in a dose-escalated phase 1-2 trial of stereotactic body radiation therapy for prostate cancer. (ucdenver.edu)
  • Stereotactic body radiation therapy for low and intermediate risk prostate cancer-Results from a multi-institutional clinical trial. (ucdenver.edu)
  • Early and multiple PSA bounces can occur following high-dose prostate stereotactic body radiation therapy: Subset analysis of a phase 1/2 trial. (ucdenver.edu)
  • Participant must have histologically confirmed, locally advanced (i.e., not amenable to curative surgery and/or radiation therapy) or metastatic cancer that has progressed during or after at least 1 prior therapeutic regimen. (ucsd.edu)
  • Chromosome 18q contains the DCC gene, a putative tumor suppressor gene frequently mutated in colon cancers. (medmuv.com)
  • These data strongly suggest that some gene on chromosome 18, is a tumor suppressor gene in endometrial cancers. (medmuv.com)
  • The group has described the genomic landscape of head & neck squamous cell carcinoma, esophageal cancer and medullary thyroid cancer, and has developed assays using tumor DNA as a biomarker in saliva and plasma. (uchicago.edu)
  • One patient with metastatic disease died shortly after diagnosis, the other was lost to follow-up. (karger.com)
  • PSA is also a marker used to follow the progress of prostate cancer once a diagnosis has been established, such as detecting metastatic or persistent disease in patients who may require additional treatment. (codemap.com)
  • PSA testing may also be useful in the differential diagnosis of men presenting with as yet undiagnosed disseminated metastatic disease. (codemap.com)
  • A TUR is an operation that is performed for both the diagnosis and management of bladder cancer. (healthybladderclub.com)
  • One in seven men in the united states will receive a prostate cancer diagnosis during his lifetime. (healthyprostateclub.com)
  • The Impact of Tonsillectomy upon the Risk of Oropharyngeal Carcinoma Diagnosis and Prognosis in the Danish Cancer Registry. (uchicago.edu)
  • Among sporadic endometrial cancers, when present, the microsatellite instability is confined to the malignant cells, and is not seen in the adjacent normal epithelium. (medmuv.com)
  • In contrast, 25% of uterine sarcomas, an entity not recognized to be part of a familial cancer syndrome, exhibits microsatellite instability that may be related to a mutation in the hMSH2 gene. (medmuv.com)
  • The impact of definitive local therapy for lymph node-positive prostate cancer: a population-based study. (ucdenver.edu)
  • The increasing indications of FDG-PET/CT in the staging and management of Invasive Bladder Cancer. (musc.edu)
  • Intravesical rAd-IFNa/Syn3 for Patients With High-Grade, Bacillus Calmette-Guerin-Refractory or Relapsed Non-Muscle-Invasive Bladder Cancer: A Phase II Randomized Study. (musc.edu)
  • Cancers will recur in 30-80% of cases, with a progression to muscle invasive disease of 1-45% within 5 year [ 2 , 3 ]. (medsci.org)
  • non-invasive molecular tests, such as Cxbladder , which measure gene expression to detect or rule out bladder cancer. (healthybladderclub.com)
  • Radical cystectomy is a standard treatment for invasive bladder cancer. (healthybladderclub.com)
  • Endometrioid cancers arising in Japanese women tend to be high grade and deeply invasive, are less common than in the United States , and are not generally associated with hormonal exposure. (medmuv.com)
  • This summary addresses squamous cell cancer of the vulva and vulvar intraepithelial neoplasias (VIN), some of which are thought to be precursors to invasive squamous cell cancers. (cancer.gov)
  • Invasive and preinvasive neoplasms of the vulva may be HPV-induced, and the carcinogenic effect may be widespread in the vulvar epithelium. (cancer.gov)
  • Effectiveness of postoperative radiotherapy after radical cystectomy for locally advanced bladder cancer. (musc.edu)
  • Prognostic Value of Pretreatment Inflammatory Markers in Patients Receiving Radical Cystectomy for Urothelial Bladder Cancer: Does Age Matter? (karger.com)
  • With the creation of artificial bladders, referred to as continent reservoirs or neobladders, that preserve voiding function, a radical cystectomy is now a far more acceptable procedure. (healthybladderclub.com)
  • Approximately 50-80% of patients with stage II - III bladder cancer are cured after undergoing a radical cystectomy. (healthybladderclub.com)
  • 1-4 Low-dose excretory phase scans enable assessment of the renal pelvis and ureters. (diagnosticimaging.com)
  • thus the hereditary form of endometrial cancer alone does not appear to portend a worse prognosis than the sporadic form. (medmuv.com)
  • Unlike most other cancers studied so far, endometrial cancer is not characterized by a small number of loci that are involved by loss of heterozygosity. (medmuv.com)
  • While no mutations were found in the exons of the DCC gene in endometrial cancers, chromosome 18 was found to be capable of suppressing tumorigenicity of endometrial cancer cells in nude mice by the procedure of microcell fusion, with DCC expression elevated in most of the suppressed hybrids. (medmuv.com)
  • Abbas F, Civantos F, Benedetto P, Soloway MS: Small cell carcinoma of the bladder and prostate. (karger.com)
  • Autocrine signaling by receptor tyrosine kinases in urothelial carcinoma of the bladder. (musc.edu)
  • Cross-section through the bladder, uterus, and vagina with squamous cell carcinoma of the bladder infiltrating through the bladder wall into the vaginal wall. (medscape.com)
  • Human papillomavirus (HPV) infection: In many cases, the development of vulvar cancer is preceded by condyloma or squamous dysplasia. (cancer.gov)
  • The use of ultrasound in the search for the primary site of unknown primary head and neck squamous cell cancers. (uchicago.edu)
  • Therefore, we concluded that ZNF326 is highly expressed in breast cancer, is associated with poor prognosis, and plays a vital role in promoting the malignant phenotype of breast cancer cells by interacting with DBC1. (cancerindex.org)
  • The prognosis for prostate cancer, as with any cancer, depends on how advanced the cancer has become, according to established stage designations. (healthyprostateclub.com)
  • Chromosome 17p is frequently involved, which contains the p53 gene known to confer a poor prognosis in endometrial cancers when mutated or deleted, and which plays an important role in the transition to carcinoma from atypical hyperplasia. (medmuv.com)
  • Clinical lung cancer. (elsevierpure.com)
  • After lung cancer, prostate cancer causes th. (healthyprostateclub.com)
  • Its one of the deadliest types of cancer for women in the united states, second only to lung cancer. (healthyprostateclub.com)
  • Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA. (uchicago.edu)
  • This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. (cancerindex.org)
  • Management and Outcomes of Pancreatic Cancer in French Real-World Clinical Practice. (canceropole-est.org)
  • Renal cell cancer is the most frequently encountered malignant tumor in the kidney. (diagnosticimaging.com)
  • 3. Prostate cell carcinoma - progressive disease, locally advanced or metastatic disease (enrolling only at IUSCC and its affiliates). (bcan.org)
  • Robotic Appleby modified procedure for locally advanced pancreatic cancer (with video). (canceropole-est.org)
  • EULEXIN (flutamide) Capsules are indicated for use in combination with LHRH agonists for the management of locally confined Stage B 2 -C and Stage D 2 metastatic carcinoma of the prostate . (rxlist.com)
  • Corresponding author: Dr. Maria Gabriella Malzone, Pathology and Cytopathology Unit, National Cancer Institute "Fondazione G. Pascale", via Mariano Semmola, 80131 Napoli, Italy. (medsci.org)
  • Urinary Bladder Neoplasms" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)
  • The replication error (RER+) phenotype is characteristic of cancers arising in HNPCC kindreds (a familial cancer syndrome with a high incidence of colon, endometrial, gastric, and a lower incidence of ovarian and pancreatic cancers), and is also found in approximately 20% of sporadic endometrial cancers. (medmuv.com)
  • However, self-reported urinary and fecal incontinence rates at 1 year were significantly higher in the adjuvant radiotherapy group vs the observation group, 60% of whom had not received salvage radiotherapy at that time. (medscape.com)
  • This test is also an aid in the management of prostate cancer patients and in detecting metastatic or persistent disease in patients following treatment. (codemap.com)
  • Cervical cancer develops in the squamo-columar junction of the cervices, and most lesions are induced by high-risk (HR) HPV types. (bvsalud.org)
  • Other frequently involved regions include 10q, 3p, and 18q, with no significant differences found in the chromosomal regions involved in endometrial from cervical cancers. (medmuv.com)
  • For more information, see Cervical Cancer Treatment . (cancer.gov)
  • Cases of colonic NECs are very unusual and data from the Norwegian Registry of Cancer from 1993-2004 showed that the incidence rate of colonic NENs was 0.25/100,000 and 31.5% of colonic NENs were classified as NECs [ 2 ]. (biomedcentral.com)
  • Urinary Cytology Voided or urine washing 40-60% sensitivity (as high as 90% in G3 Lesions) Dependent on grade of tumor Incidence of + urine cytology according to grade Heney et al. (slidesfinder.com)
  • As with most epithelial cancers, physical irritation has been associated with increased risk of malignant transformation of the urothelium. (wikipedia.org)
  • Almost all bladder cancers originate in the urothelium, which is a 3- to 7-cell mucosal layer within the muscular bladder. (medscape.com)
  • Adjuvant radiotherapy after radical prostatectomy provided no meaningful benefit in patients with prostate cancer but increased the risk for urinary and bowel morbidity compared with men followed with observation alone, according to the latest results from the phase 3 RADICALS-RT trial. (medscape.com)
  • The approach of early salvage radiotherapy spared morbidity [from] radiation in the vast majority of patients, and further bowel and bladder toxicity is reduced in the setting of salvage radiotherapy," said Sandhu, an associate professor and consultant medical oncologist at Peter MacCallum Cancer Centre, Victoria, Australia. (medscape.com)
  • The aim of the RADICALS-RT study was to clarify the optimal timing for radiotherapy after radical prostatectomy in men with prostate cancer, which previously had been uncertain. (medscape.com)
  • Toxicity assessment of pelvic intensity-modulated radiotherapy with hypofractionated simultaneous integrated boost to prostate for intermediate- and high-risk prostate cancer. (ucdenver.edu)
  • Hypofractionated external-beam radiotherapy for prostate cancer. (ucdenver.edu)
  • External Validation of the Benefit of Adjuvant Radiotherapy for Pathologic N1M0 Prostate Cancer. (ucdenver.edu)
  • External-beam radiotherapy for differentiated thyroid cancer locoregional control: A statement of the American Head and Neck Society. (uchicago.edu)
  • PowerPoint is the world's most popular presentation software which can let you create professional Superficial Bladder Cancer powerpoint presentation easily and in no time. (slidesfinder.com)
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