• The post-hoc analysis across LN biopsy classes from the open-label Phase 2 MISSION clinical trial was presented as a poster presentation at the National Kidney Foundation (NKF) Spring Clinical Meeting 2023, which took place April 11-15, 2023 in Austin, Texas. (businesswire.com)
  • The complete MISSION Phase 1b/2 results, along with a post hoc subgroup analysis in the Phase 2 Hispanic/Latino population, were presented as a poster presentation at the Pan American League of Associations for Rheumatology (PANLAR) 2023 Congress, which took place April 26-29, 2023 in Rio de Janeiro, Brazil. (businesswire.com)
  • The complete MISSION Phase 1b/2 results were presented as an oral presentation at the LUPUS & KCR 2023 meeting, which took place May 17-20, 2023 in Seoul, Korea. (businesswire.com)
  • The complete MISSION Phase 2 results, MISSION Phase 2 uCD163 data, and the unmet need of European patients with LN were presented as poster presentations at the European Alliance of Associations for Rheumatology (EULAR) 2023 Congress, which took place May 31 - June 3, 2023 in Milan, Italy. (businesswire.com)
  • The post-hoc analysis of MISSION Phase 2 patients with nephrotic range proteinuria and the unmet need of European patients with LN were presented as oral presentations at the 60th European Renal Association (ERA) Congress, which took place June 15-18, 2023 in Milan, Italy. (businesswire.com)
  • The acute form of hepatitis, generally caused by viral infection, is characterized by constitutional symptoms that are typically self-limiting. (wikipedia.org)
  • The complication more frequently occurs in instances of hepatitis B and D co-infection at a rate of 2-20% and in pregnant women with hepatitis E at rate of 15-20% of cases. (wikipedia.org)
  • The disease often is associated with other autoimmune diseases, but autoimmune hepatitis cannot be explained on the basis of chronic viral infection, alcohol consumption, or exposure to hepatotoxic medications or chemicals. (medscape.com)
  • Risk factors for liver cancer include gender, ethnicity, chronic viral hepatitis (Hep-B or Hep-C) infection, cirrhosis, alcohol use and metabolic syndrome. (merck.com)
  • Hepatitis B vaccination is the most effective measure to prevent HBV infection and its consequences. (cdc.gov)
  • Other components include routine screening of all pregnant women for hepatitis B surface antigen (HBsAg) and postexposure immunoprophylaxis of infants born to HBsAg-positive women, vaccination of children and adolescents who were not previously vaccinated, and vaccination of unvaccinated adults at increased risk for infection. (cdc.gov)
  • Most cases of hepatitis are caused by viral infection. (britannica.com)
  • We examined whether MBL2 variants influence the outcome of hepatitis C virus (HCV) infection. (biomedcentral.com)
  • In the United States, chronic hepatitis C virus (HCV) infection is a leading cause of cirrhosis, end-stage liver disease and hepatocellular carcinoma. (biomedcentral.com)
  • All patients with cirrhosis require Q 6 monthly ultrasound surveillance for hepatocellular carcinoma, even in those with Hepatitis C virus who have cleared the infection. (cirrhosiscare.ca)
  • In the SAPPHIRE-I (N=631) and SAPPHIRE-II (N=394) placebo-controlled studies, adult, non-cirrhotic patients with chronic genotype 1 (GT1) hepatitis C virus (HCV) infection receiving the investigational AbbVie regimen with ribavirin (RBV) for 12 weeks achieved sustained virologic response rates 12 weeks post-treatment (SVR 12 ) of 96.2 percent (n=455/473) and 96.3 percent (n=286/297), respectively. (abbvie.com)
  • Hepatocellular carcinoma (HCC) usually occurs in patients with cirrhosis and is common in areas where infection with hepatitis B and C viruses is prevalent. (msdmanuals.com)
  • Terms and Abbreviations Used in This Publication Acute hepatitis C Newly acquired symptomatic hepatitis C virus (HCV) infection. (cdc.gov)
  • Furthermore, Th22 cells are associated with inflammatory conditions and numerous autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) [ 12 , 13 ]. (hindawi.com)
  • Regulatory T cells (Tregs) are important regulators of immune tolerance to self-antigens [ 14 , 15 ], and their impairment has been associated with the development of autoimmune diseases [ 16 , 17 ]. (hindawi.com)
  • Symptoms and physical examination findings may stem from extrahepatic diseases associated with autoimmune hepatitis. (medscape.com)
  • We'll assess the prospects of the main companies involved in three major autoimmune diseases: RA, psoriasis/psoriatic arthritis (Ps/PsA) and IBD. (moneyweek.com)
  • The market for many RA drugs is larger than it appears since they are also effective against other autoimmune diseases. (moneyweek.com)
  • One sample only tested positive for DFS70 but the positivity was associated with anti-ENA antibodies, a combination that can be found in systemic autoimmune rheumatic diseases. (bmj.com)
  • The SWORD Phase III results represent an important step forward in our efforts to deliver a two-drug regimen that may help simplify dosing regimens and reduce pill burden for people living with HIV," says Lawrence M. Blatt, Global R&D Head, Infectious Diseases & Vaccines, Janssen. (jnj.com)
  • This discovery really prompted additional thinking about how researchers could use nucleic acid vaccines not just for infectious diseases, but also for immunotherapy to treat cancers and chronic infectious diseases - like HIV, hepatitis B and herpes - as well as autoimmune disorders and even for gene therapy. (nextgov.com)
  • Genetic variations in MBL2 that reduce circulating levels and alter functional properties of the mannose binding lectin (MBL) have been associated with many autoimmune and infectious diseases. (biomedcentral.com)
  • Some Hepatitis C patients can now be treated by Primary Care (after seeking advice from hepatology, infectious diseases or gastroenterology - as required by insurance provider). (cirrhosiscare.ca)
  • Revive's cannabinoid pharmaceutical portfolio focuses on rare inflammatory diseases and the company was granted FDA orphan drug status designation for the use of Cannabidiol (CBD) to treat autoimmune hepatitis (liver disease) and to treat ischemia and reperfusion injury from organ transplantation. (psychedelicalpha.com)
  • Chronic hepatitis may progress to scarring of the liver (cirrhosis), liver failure, and liver cancer. (wikipedia.org)
  • Autoimmune hepatitis may present as acute or chronic hepatitis or as well-established cirrhosis. (medscape.com)
  • Prolongation of the international normalized ratio (INR) and hypoalbuminemia: These markers of severe hepatic synthetic dysfunction may be observed in patients with acute severe autoimmune hepatitis or decompensated cirrhosis. (medscape.com)
  • Liver transplantation can save the lives of patients dying from decompensated cirrhosis caused by autoimmune hepatitis. (medscape.com)
  • Careful attention to co-morbidities (especially active Hepatitis B), drug-drug interactions and determining the presence or absence of decompensated cirrhosis should now be the focus of a pre-treatment clinical assessment. (cirrhosiscare.ca)
  • Incorporation of HBV-DNA into the host's genome may initiate malignant transformation, even in the absence of chronic hepatitis or cirrhosis. (msdmanuals.com)
  • Seromarkers with a mean age of 52.2 (SD 8.9) years for HBV (hepatitis B surface antigen and and male/female ratio 5/4. (who.int)
  • Fever, when present, is most common in cases of hepatitis A and E. Late in this phase, people can experience liver-specific symptoms, including choluria (dark urine) and clay-colored stools. (wikipedia.org)
  • All cases of hepatitis A and E are expected to fully resolve after 1-2 months. (wikipedia.org)
  • Few cases of hepatitis C will resolve completely. (wikipedia.org)
  • Complications of acute viral hepatitis include fulminant hepatitis, which is a very severe, rapidly developing form of the disease that results in severe liver failure, impaired kidney function, difficulty in the clotting of blood, and marked changes in neurological function. (britannica.com)
  • 19 years who were born in countries with intermediate and high levels of HBV endemicity, adopting hepatitis B vaccine requirements for school entry, and integrating hepatitis B vaccination services into settings that serve adolescents. (cdc.gov)
  • Active phases of systemic vasculitides like panarteritis nodosa (treatment duration should be limited to two weeks in cases of concomitant positive hepatitis B serology). (medicines.org.uk)
  • Hepatitis has a broad spectrum of presentations that range from a complete lack of symptoms to severe liver failure. (wikipedia.org)
  • For two years, I led an international NIH R01 project investigating the dynamics of the biggest YF outbreak in Brazil, including the description of a new syndrome, Late-relapsing hepatitis after yellow fever (DOI 10.3390/v12020222), and risk factors for severe YF. (stanford.edu)
  • SAN RAFAEL, Calif. - BioMarin Pharmaceutical Inc. (NASDAQ: BMRN) today announced positive results from its ongoing global Phase 3 GENEr8-1 study of valoctocogene roxaparvovec, an investigational gene therapy for the treatment of adults with severe hemophilia A. This is the largest global Phase 3 study to date for any gene therapy in hemophilia, with 134 participants. (checkorphan.org)
  • Posterior reversible encephalopathy syndrome in a child during an accelerated phase of a severe APECED phenotype due to an uncommon mutation of AIRE. (lu.se)
  • Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy presenting with severe keratopathy in an Egyptian patient with a homozygous R139X mutation. (lu.se)
  • Some people or animals with hepatitis have no symptoms, whereas others develop yellow discoloration of the skin and whites of the eyes (jaundice), poor appetite, vomiting, tiredness, abdominal pain, and diarrhea. (wikipedia.org)
  • Chronic hepatitis presents similarly, but can manifest signs and symptoms specific to liver dysfunction with long-standing inflammation and damage to the organ. (wikipedia.org)
  • Acute viral hepatitis follows three distinct phases: The initial prodromal phase (preceding symptoms) involves non-specific and flu-like symptoms common to many acute viral infections. (wikipedia.org)
  • The recovery phase is characterized by resolution of the clinical symptoms of hepatitis with persistent elevations in liver lab values and potentially a persistently enlarged liver. (wikipedia.org)
  • Both drug-induced hepatitis and autoimmune hepatitis can present very similarly to acute viral hepatitis, with slight variations in symptoms depending on the cause. (wikipedia.org)
  • The signs and symptoms of acute viral hepatitis result from damage to the liver and are similar regardless of the hepatitis virus responsible. (britannica.com)
  • Caregiver interviews were done to obtain information on symptoms and health-care utilisation for the hepatitis illness, medical history, illness in close contacts or at school or daycare, diet, travel, and other potential exposures. (bvsalud.org)
  • An 8-year-old boy with autoimmune hepatitis and Candida onychosis as the first symptoms of autoimmune polyglandular syndrome (APS1): identification of a new homozygous mutation in the autoimmune regulator gene (AIRE). (lu.se)
  • Autoimmune regulator-1 messenger ribonucleic acid analysis in a novel intronic mutation and two additional novel AIRE gene mutations in a cohort of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients. (lu.se)
  • HCV RNA Hepatitis C virus ribonucleic acid. (cdc.gov)
  • The aetiology of autoimmune hepatitis (AIH) is uncertain but the disease can be triggered in susceptible patients by external factors such as viruses or drugs. (wjgnet.com)
  • In April, 2022, following multiple reports of hepatitis of unknown aetiology and adenovirus viraemia in immunocompetent children in the USA and UK, the US Centers for Disease Control and Prevention (CDC) and jurisdictional health departments initiated national surveillance of paediatric acute hepatitis of unknown aetiology. (bvsalud.org)
  • We aimed to describe the clinical and epidemiological characteristics of children identified with hepatitis of unknown aetiology between Oct 1, 2021, and Sept 30, 2022, in the USA and to compare characteristics of those who tested positive for adenovirus with those who tested negative. (bvsalud.org)
  • FINDINGS: Surveillance identified 377 patients from 45 US jurisdictions with hepatitis of unknown aetiology with onset from Oct 1, 2021, to Sept 30, 2022. (bvsalud.org)
  • Initial treatment of autoimmune disorders like systemic lupus erythematodes. (medicines.org.uk)
  • Immune thrombocytopenic purpura (ITP) is one of the most common autoimmune disorders. (medscape.com)
  • METHODS: In this national surveillance investigation in the USA, children were identified for investigation if they were younger than 10 years with elevated liver transaminases (>500 U/L) who had an unknown cause for their hepatitis and onset on or after Oct 1, 2021. (bvsalud.org)
  • The IgG4 dosage (18 mg/dl) was within normal limits, excluding a possible autoimmune hepatitis/pancreatitis syndrome . (doctorsmedicalopinion.com)
  • Novel and recurrent mutations in the AIRE gene of autoimmune polyendocrinopathy syndrome type 1 (APS1) patients. (lu.se)
  • Detection of a complete autoimmune regulator gene deletion and two additional novel mutations in a cohort of patients with atypical phenotypic variants of autoimmune polyglandular syndrome type 1. (lu.se)
  • Autoimmune polyendocrine syndrome type I in Slovakia: relevance of screening patients with autoimmune Addison's disease. (lu.se)
  • Autoimmune polyendocrine syndrome type 1 in Norway: phenotypic variation, autoantibodies, and novel mutations in the autoimmune regulator gene. (lu.se)
  • IgG autoantibody testing of a subsample of stored serum from phase 1 (1988-91) NHANES III participants was conducted to estimate the prevalence and specificities of selected autoantibodies in the US population. (cdc.gov)
  • Testing of IgG autoantibodies to human cellular antigens was performed by the HEp-2 cell immunofluorescence assay using slides from INOVA Diagnostics, San Diego, CA (Cat # 508100) following the manufacturer's instructions and evaluated primarily using their NOVA View system. (cdc.gov)
  • Cases of drug-induced hepatitis can manifest with systemic signs of an allergic reaction including rash, fever, serositis (inflammation of membranes lining certain organs), elevated eosinophils (a type of white blood cell), and suppression of bone marrow activity. (wikipedia.org)
  • We report here a multicentre study carried out by an Italian interdisciplinary group (Forum Interdisciplinare per la Ricerca sulle Malattie Autoimmuni) for the validation of new automated reading systems for ANA detection by indirect immunofluorescence on HEp-2 cells (HEp-2 IFA). (bmj.com)
  • Another complication is chronic hepatitis, which is characterized by liver cell death and inflammation over a period greater than six months. (britannica.com)
  • Hepatitis is most commonly caused by the virus hepatovirus A, B, C, D, and E. Other viruses can also cause liver inflammation, including cytomegalovirus, Epstein-Barr virus, and yellow fever virus. (wikipedia.org)
  • This report is the first of a two-part statement from the Advisory Committee on Immunization Practices (ACIP) that updates the strategy to eliminate hepatitis B virus (HBV) transmission in the United States. (cdc.gov)
  • Hepatitis B virus (HBV) is a bloodborne and sexually transmitted virus. (cdc.gov)
  • In this study, we focus on seven common exclusion criteria in cancer trials: prior malignancy, human immunodeficiency virus, hepatitis B, hepatitis C, psychiatric illness, drug/substance abuse, and autoimmune illness. (catalyzex.com)
  • These data show very promising results in people who are infected with either subtype of the GT1 hepatitis C virus and who are either new to therapy or treatment-experienced. (abbvie.com)
  • HBV Hepatitis B virus. (cdc.gov)
  • HCV Hepatitis C virus. (cdc.gov)
  • and · antiviral therapy during pregnancy for the prevention of perinatal hepatitis B virus (HBV) transmission. (cdc.gov)
  • Hepatitis B virus (HBV) is transmitted via blood or sexual contact. (cdc.gov)
  • For participants in the dose-finding phase, a minimum washout period of at least 5 half-lives between the last dose of tyrosine kinase inhibitor (TKI) therapy and the first dose of study treatment is required. (dana-farber.org)
  • Now actively recruiting patients, our PALIZADE and PORTOLA clinical trials are designed to demonstrate zetomipzomib's potential to be a steroid-sparing, immunomodulating treatment for multiple autoimmune conditions. (businesswire.com)
  • The study comprises two separate parts: Phase 1b (Part A) and Phase 2 (Part B).The study parts differ in design, objectives and treatment. (bcan.org)
  • This phase I/II trial studies the side effects and best dose of bosutinib when given together with inotuzumab ozogamicin and to see how well it works in treating patients with acute lymphoblastic leukemia or chronic myeloid leukemia that has come back or does not respond to treatment. (survivornet.com)
  • Treatment is discussed further below but is not normally undertaken in the acute phase other than supportive measures and alcohol avoidance. (oxfordmedicaleducation.com)
  • Following the oral initiation phase to assess the tolerability of the medicines, cabotegravir and rilpivirine injections could reduce the number of days of treatment per year from 365 down to 12 for the once-monthly or 6 for the once every 2-months dosing regimen, representing a paradigm shift in how we are able to treat and manage the condition. (natap.org)
  • London, 6 March 2020 - ViiV Healthcare, the global specialist HIV company majority owned by GlaxoSmithKline plc ("GSK"), with Pfizer Inc. and Shionogi Limited as shareholders, today presented positive long-term data from its global phase IIIb ATLAS-2M study of the first complete, long-acting regimen of cabotegravir and rilpivirine for the treatment of HIV. (viivhealthcare.com)
  • Merck is discontinuing the Phase 3 KEYNOTE-641 trial evaluating KEYTRUDA ® (pembrolizumab), Merck's anti-PD-1 therapy, in combination with enzalutamide and androgen deprivation therapy (ADT) for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) based on the recommendation of an independent Data Monitoring Committee. (ridgwayrecord.com)
  • Merck also announced that the Phase 3 KEYNOTE-789 trial evaluating KEYTRUDA in combination with pemetrexed plus platinum-based chemotherapy did not meet its dual primary endpoint of OS for the treatment of patients with metastatic nonsquamous non-small cell lung cancer (NSCLC), with epidermal growth factor receptor (EGFR)-genomic tumor mutations, who have previously progressed on a tyrosine kinase inhibitor (TKI), including osimertinib. (ridgwayrecord.com)
  • M.D., Ph.D., Chief of the Division of Gastroenterology and Hepatology, University of Hong Kong, and a lead investigator of this Phase 2a clinical trial, stated, "These preliminary data are very encouraging and we look forward to additional follow-up of these patients which will provide insight into the possibility of a functional cure with this combination treatment regimen. (arbutusbio.com)
  • With the FDA approval of the Phase 3 clinical study to evaluate Bucillamine in the treatment of patients with mild-moderate COVID-19, our team and partners are working diligently to align our resources and expertise that will fast-track the Phase 3 study," said Michael Frank, Revive's Chief Executive Officer. (frontiersmallcaps.com)
  • Results At a minimum follow-up of 18 months, median progression-free survival was 8.4 months for patients who discontinued treatment because of AEs during the induction phase and 10.8 months for patients who did not discontinue because of AEs ( P = .97). (medscape.com)
  • Conclusion Efficacy outcomes seemed similar between patients who discontinued nivolumab plus ipilimumab treatment because of AEs during the induction phase and those who did not discontinue because of AEs. (medscape.com)
  • Antiviral medications are recommended in all with chronic hepatitis C, except those with conditions that limit their life expectancy. (wikipedia.org)
  • Hepatitis is inflammation of the liver tissue. (wikipedia.org)
  • hepatitis , inflammation of the liver that results from a variety of causes, both infectious and noninfectious. (britannica.com)
  • The second part of the ACIP statement, which will include updated recommendations and strategies to increase hepatitis B vaccination of adults, will be published separately. (cdc.gov)
  • Since they were first issued in 1982, recommendations for hepatitis B vaccination have evolved into a comprehensive strategy to eliminate HBV transmission in the United States ( 2 -- 6 ) ( Box 1 ). (cdc.gov)
  • INTRODUCTION: India is looking to achieve hepatitis elimination status by 2030 through vaccination, diagnostic tests, medicines, and education campaigns. (bvsalud.org)
  • For more than four decades, corticosteroids, either alone or in combination with azathioprine, have been the mainstays of drug therapy for patients with autoimmune hepatitis. (medscape.com)
  • [ 2 ] Budesonide (in combination with azathioprine) is now considered to be first-line therapy for autoimmune hepatitis. (medscape.com)
  • PALIZADE is a global, placebo-controlled, randomized, double-blind Phase 2b clinical trial evaluating the efficacy and safety of two dose-levels of zetomipzomib in patients with active LN. Target enrollment will be 279 patients, randomly assigned (1:1:1) to receive 30 mg of zetomipzomib, 60 mg of zetomipzomib or placebo subcutaneously once weekly for 52 weeks, in addition to standard background therapy. (businesswire.com)
  • PORTOLA is a placebo-controlled, randomized, double-blind Phase 2a clinical trial evaluating the efficacy and safety of zetomipzomib in patients with AIH that are insufficiently responding to standard of care or have relapsed. (businesswire.com)
  • The poster contains preliminary data from the Phase 2a clinical trial (AB-729-202) combining Arbutus' RNAi therapeutic, imdusiran (AB-729), with Barinthus Bio's T-cell stimulating immunotherapeutic, VTP-300, and standard-of-care nucleos(t)ide analogue (NA) therapy. (arbutusbio.com)
  • Revive Therapeutics Update Following U.S. FDA Approval of Phase 3 Clinical Trial for Bucillamine. (frontiersmallcaps.com)
  • Revive expects to engage up to 10 clinical trial sites in the U.S. and open the Phase 3 clinical trial for patient screening in Q3-2020. (frontiersmallcaps.com)
  • The Phase 3 confirmatory clinical trial titled, "A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study of Bucillamine in Patients with Mild-Moderate COVID-19", will enroll up to 1,000 patients that will be randomized 1:1:1 to receive Bucillamine 100 mg three times a day ("TID"), Bucillamine 200 mg TID or placebo TID for up to 14 days. (psychedelicfinance.com)
  • Marketing Authorisation is based on the pivotal phase III ATLAS (Antiretroviral Therapy as Long-Acting Suppression), FLAIR (First Long-Acting Injectable Regimen) and ATLAS-2M studies, which included more than 1,200 participants from 16 countries. (natap.org)
  • LONDON , April 11, 2014 /PRNewswire/ -- AbbVie (NYSE: ABBV) announced that detailed results from its phase III pivotal study, SAPPHIRE-I, will be presented today at the International Liver Congress ™ (ILC) 2014 and featured in the ILC press conference. (abbvie.com)
  • Results from the pivotal phase III study, SAPPHIRE-II, were also presented at the congress yesterday. (abbvie.com)
  • Hepatitis is acute if it resolves within six months, and chronic if it lasts longer than six months. (wikipedia.org)
  • Dr. Karen Sims, Chief Medical Officer of Arbutus Biopharma, commented, "Imdusiran consistently delivers compelling efficacy and safety data in multiple Phase 2a populations and combinations. (arbutusbio.com)
  • Evaluation of the autoimmune regulator (AIRE) gene mutations in a cohort of Italian patients with autoimmune-polyendocrinopathy-candidiasis-ectodermal-dystrophy (APECED) and in their relatives. (lu.se)
  • A novel missense mutation of AIRE gene in a patient with autoimmune polyendocrinopathy, candidiasis and ectodermal dystrophy (APECED), accompanied with progressive muscular atrophy: case report and review of the literature in Japan. (lu.se)
  • Hepatitis results in more than a million deaths a year, most of which occur indirectly from liver scarring or liver cancer. (wikipedia.org)
  • In the United States, hepatitis A is estimated to occur in about 2,500 people a year and results in about 75 deaths. (wikipedia.org)
  • The results from an on-going phase 4 trial add to the growing evidence that teriflunomide is effective for relapsing-remitting multiple sclerosis, according to Patricia K. Coyle, MD, of Stony Brook University in New York. (hcplive.com)
  • Seattle, WA, 13 February 2017 - Janssen Sciences Ireland UC (Janssen) announced positive results from the full data read out for two Phase III studies evaluating the safety and efficacy of switching virologically suppressed patients from a three- or four-drug antiretroviral regimen to the two-drug regimen of dolutegravir (ViiV Healthcare) and rilpivirine (Janssen). (jnj.com)
  • For comparison, the table below provides results from both the Phase 3 GENEr8-1 Study and the Phase 1/2 Study (201), by Study Year, for Factor VIII activity (by CS assay), ABR, and annualized Factor VIII utilization (infusions per year). (checkorphan.org)