• Several articles in this month's issue focus on the core mission of Clinical Genetics: finding disease causing genes to help patients. (nature.com)
  • Studies in A. thaliana and maize identified microRNA MIR156 genes as master regulators of phase change, through their regulation of SQUAMOSA-PROMOTER-BINDING-LIKE (SBP/SPL) transcription factors. (wikipedia.org)
  • As a result of the rapid advances in genetics technology and the Human Genome Project, most of the estimated 100,000 genes in humans will be identified by the year 2005 (1). (cdc.gov)
  • Array studies provide candidate genes to identify common mechanistic pathways in the effector phase, as well as mechanistic pathways unique to individual allergens. (cdc.gov)
  • Seattle Genetics, Inc. and Millennium: The Takeda Oncology Company, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited (TSE:4502), today announced the initiation of a global phase III clinical trial evaluating ADCETRIS (brentuximab vedotin) in combination with chemotherapy for the treatment of newly diagnosed CD30-positive mature T-cell lymphoma (MTCL) patients, including patients with systemic anaplastic large cell lymphoma (sALCL) and other types of peripheral T-cell lymphomas. (news-medical.net)
  • Will Seattle Genetics' Deal With Immunomedics Get Scuttled? (foxbusiness.com)
  • The deal could be a big win for Seattle Genetics, but it doesn't have the full support of all of Immunomedics investors. (foxbusiness.com)
  • If the deal closes, Seattle Genetics will take over development of IMMU-132, an anti-TROP-2 antibody that can target multiple tumor types. (foxbusiness.com)
  • Seattle Genetics will pay Immunomedics $250 million in cash up front, plus an additional $50 million payment related to ex-U.S., Canada, and EU rights. (foxbusiness.com)
  • Otherwise,Seattle Genetics will pay Immunomedics a tiered double-digit royalty that's based on sales. (foxbusiness.com)
  • Seattle Genetics also agreed to pay Immunomedics up to $1.7 billion in regulatory and sales milestone payments on IMMU-132, and Seattle Genetics agreed to let Immunomedics continue negotiating with other companies on rights to IMMU-132 until Feb. 19. (foxbusiness.com)
  • If a competing offer is made, Seattle Genetics can match it. (foxbusiness.com)
  • If Immunomedics selects a competing offer, then it will pay Seattle Genetics a breakup fee. (foxbusiness.com)
  • Separately, Seattle Genetics acquired 3 million shares of Immunomedics at $4.90 per share that aren't tied to the closing of this deal. (foxbusiness.com)
  • Seattle Genetics also secured three-year warrants that allow it to acquirean additional 8,655,804 shares at $4.90 each. (foxbusiness.com)
  • Seattle Genetics already markets the lymphoma drug Adcetris, which is FDA approved for treating Hodgkin lymphoma patientswhose disease has progressed after autologous stem-cell transplant or after two prior chemotherapy treatments, if ineligible for transplant.Adcetris is also used to treat patients with systemic anaplastic large-cell lymphomawhose disease has progressed after one prior chemotherapy treatment. (foxbusiness.com)
  • That's a big opportunity, but there's no guarantee that IMMU-132 will get an early OK from the FDA, and if it doesn't, then Seattle Genetics will have to conduct a confirmatory phase 3 study. (foxbusiness.com)
  • Of course, for Seattle Genetics to benefit from IMMU-132 at all, this deal has to close, and based on venBio's comments, that might not be a given. (foxbusiness.com)
  • BOTHELL, Wash. & SEATTLE--( BUSINESS WIRE )-- Seattle Genetics, Inc. (Nasdaq:SGEN) and Cascadian Therapeutics, Inc. (Nasdaq:CASC) today announced the signing of a definitive merger agreement under which Seattle Genetics has agreed to acquire Cascadian Therapeutics. (businesswire.com)
  • Under the terms of the agreement, Seattle Genetics will pay $10.00 per share in cash, or approximately $614 million. (businesswire.com)
  • This acquisition would enhance our late-stage clinical pipeline with a potentially best-in-class, orally available and highly selective TKI for patients with HER2-positive metastatic breast cancer," said Clay Siegall, Ph.D., President and Chief Executive Officer of Seattle Genetics. (businesswire.com)
  • Seattle Genetics has the development and commercial capabilities and the resources needed to more fully realize the potential of tucatinib as a new best-in-class treatment option for metastatic breast cancer, colorectal cancer and potentially for other indications. (businesswire.com)
  • Under the terms of the definitive merger agreement, Seattle Genetics will commence a tender offer on or about February 8, 2018 to acquire all of the outstanding shares of common stock of Cascadian Therapeutics for $10 per share in cash. (businesswire.com)
  • Following the closing of the tender offer, a wholly-owned subsidiary of Seattle Genetics will merge with and into Cascadian Therapeutics, with each share of Cascadian Therapeutics common stock that has not been tendered being converted into the right to receive the same $10 per share in cash offered in the tender offer. (businesswire.com)
  • In connection with the transaction, Seattle Genetics has secured a financing commitment in the amount of $400 million from Barclays and JPMorgan-Chase Bank. (businesswire.com)
  • Leerink Partners LLC is acting as lead financial advisor to Seattle Genetics. (businesswire.com)
  • Genomic resources , including genetic maps and genotyping datasets, were developed during GCP's first phase (2004-2008) and were then used in molecular-breeding projects during the second five years of the Programme (2009-2014). (generationcp.org)
  • This project is set to tackle these challenges by testing different methods and approaches for imputing and phasing genomic datasets in endangered bird species. (lu.se)
  • In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). (yeastgenome.org)
  • The Forsburg lab uses a mixture of classical genetics, molecular biology, and state-of-the-art microscopy to investigate how defects in replication contribute to genome instability during normal cell growth and during the differentiation process of meiosis. (usc.edu)
  • Hedrick, PW & Ritland, K 2012, ' Population genetics of the white-phased "spirit" black bear of British Columbia ', Evolution , vol. 66, no. 2, pp. 305-313. (elsevierpure.com)
  • Profile: We seek a student with a strong foundation in bioinformatics, complemented by a keen interest and understanding of population genetics and evolutionary genomics. (lu.se)
  • It looks at the usefulness of the genome-wide association studies (GWAS) that have become ubiquitous in genetics in the last few years. (technologyreview.com)
  • This is the first major publication describing how PacBio long reads could be used for human genetics, showing that over 20,000 SVs are present in a typical human genome. (nature.com)
  • We performed whole genome sequencing and whole exome sequencing of 31 lung adenocarcinoma (LUAD) samples from the Environment And Genetics in Lung cancer Etiology (EAGLE) study. (opendata.aws)
  • The Swiss medical data firm Sophia Genetics has launched the latest iteration of its "genome browser" software, which uses artificial intelligence (AI) to help researchers assess whether errors in the DNA code are leading to diseases such as cancer. (pharmaphorum.com)
  • AndrĂ© Blavier, scientific director at Sophia Genetics, said: "The combined use of SOPHiA and Alamut Genova provides clinical researchers with a unique and complete solution, supporting them all the way from precise genomic variant detection to proper interpretation. (pharmaphorum.com)
  • deCODE genetics (Nasdaq:DCGN) today announced positive top-line results from its Phase I multiple dose clinical trial of DG051, which the company is developing for the prevention of heart attack. (decode.com)
  • About deCODE deCODE genetics (Nasdaq:DCGN) is a global leader in applying human genetics to develop drugs and diagnostics for common diseases. (decode.com)
  • NASDAQ: IMMU) IMMU-132, a cancer drug that's already completed midstage phase 2 trials. (foxbusiness.com)
  • Wonil Chung, Omer Weissbrod and Margaux Hujoel were awarded as semifinalists for the Charles J. Epstein Trainee Award for Excellence in Human Genetic Research for the 2018 American Society of Human Genetics Conference in San Diego, California this October. (harvard.edu)
  • Zhaozhong Zhu was selected to present a poster presentation with top 10% reviewers' score at the 2018 American Society of Human Genetics Conference in San Diego, California this October. (harvard.edu)
  • Nature Genetics, 50(6):857-864, 2018. (harvard.edu)
  • This was followed by birth defects and developmental disabilities, cardiovascular disease, genetic testing, and cancer, which all showed relatively high proportions of later phase translational studies. (cdc.gov)
  • SARS-CoV-2 encoded proteome and human genetics: from interaction-based to ribosomal biology impact on disease and risk processes. (cdc.gov)
  • Design, Setting, and Participants: This prospective quality improvement study was performed in 2 phases over 6 months between August 1, 2020, and January 31, 2021, at a community network hospital. (bvsalud.org)
  • Based on this concept, Phase III clinical trials comparing gefitinib monotherapy with standard platinum-based chemotherapy are currently ongoing for patients with EGFR mutations and lung cancer. (nih.gov)
  • In phase 2 trials of IMMU-132 in triple negative breast cancer, there was a 29% overall objective response rate in heavily pretreated patients. (foxbusiness.com)
  • The study has been published in the journal Cancer Genetics and Cytogenetics . (sciencedaily.com)
  • Requests for reprints: Sofia K. Gruvberger-Saal, Institute for Cancer Genetics, tumors in the adjuvant or metastatic setting. (lu.se)
  • Phase 2 incorporated peer coaching from cancer genetics experts for medical oncologists at the community network hospital. (bvsalud.org)
  • Of the 634 patients with cancer, 29 of 415 (7.0%) received genetic testing in phase 1, and 25 of 219 (11.4%) received genetic testing in phase 2. (bvsalud.org)
  • Conclusions and Relevance: This study suggests that peer coaching from cancer genetics experts was associated with an increase in ordering of genetic testing by medical oncologists. (bvsalud.org)
  • It is one of the few books where the issues of genetics, cancer, and work are brought together. (cdc.gov)
  • The beta [phase] is intended to see where things are working well and where we can make it work better, as we continue to develop new things," said Josh Denny, professor of biomedical informatics at Vanderbilt University, in a recent interview. (genomeweb.com)
  • Yet, the application of genetics research in the promotion of health and the prevention of disease and disability has been explored only minimally. (cdc.gov)
  • Theoretically, precise phasing and variant calling in the founder genomes should facilitate confident imputation in contemporary genomes. (lu.se)
  • The results of our Phase I trials show DG051 to be well tolerated and to provide a potent means of reining in the activity of the pathway our research has shown to modulate risk of heart attack. (decode.com)
  • This latest study also provides us with pharmacodynamic data suggesting that we may be able to achieve a high steady-state reduction in LTB4 production with a dose in the middle of the range we have tested, and we look forward to entering DG051 into Phase II trials later this year," said Kari Stefansson, CEO of deCODE. (decode.com)
  • Each of these vaccines is being studied in small phase I trials that enroll HIV-infected persons who are being treated with highly effective antiretroviral therapy and who have a stable clinical course and no detectable plasma viremia. (cdc.gov)
  • While midstage trial results were solid, investors should remember that, historically, 30% to 40% of drugs that advance into phase 3 trials fail. (foxbusiness.com)
  • Results from phase 1b trials showed that the combination of tucatinib, capecitabine and trastuzumab was generally well-tolerated and demonstrated clinical activity in patients with and without brain metastases. (businesswire.com)
  • The ChAd3-ZEBOV, developed by GlaxoSmithKline (GSK), in collaboration with the US National Institute of Allergy and Infectious Diseases (NIAID) is in phase III clinical trial in Liberia and rVSV-ZEBOV, developed by NewLink Genetics and Merck Vaccines USA, in collaboration with the Public Health Agency of Canada and WHO entered Phase III trials in Guinea. (who.int)
  • What was it like to be a major leader of clinical trials and genetics for cardiovascular research around the world? (medscape.com)
  • If you want to read the latest about current controversial issues read the letters in this issue of the European Journal of Human Genetics by Tellier et al. (nature.com)
  • Familial advanced sleep phase syndrome (FASPS) is a human behavioural phenotype characterized by early sleep times and early-morning awakening. (nih.gov)
  • The Molecular Genetics of Human Colour Vision - From Nucleotides to Nanometers. (routledge.com)
  • 156 (9.9%) were identified as human genomics/genetics publications. (cdc.gov)
  • All human genomics/genetics articles were coded according to topic and phase of translational research . (cdc.gov)
  • Newborn Screening is perhaps the most classic example of established public health applications of human genomics in practice, and accordingly, this topic had the highest proportion (86%) of late-phase studies (T2-T4). (cdc.gov)
  • We defined early phase research as basic or discovery research (T0-T1) and late phase research as applied and implementation research, surveillance, and development of evidence-based guidelines (T2-T4). (cdc.gov)
  • 103 papers (66%) represented primary research studies, while 53 (34%) were reviews, commentaries, guidelines, cost analyses, modeling studies, etc. 79 (51%) articles reported on early phase research (T0-T1) and 77 (49%) reported on late phase research and programs (T2-T4). (cdc.gov)
  • For most (6 of 9) of the topics coded, there was a higher proportion of papers reflecting late vs. early phase research. (cdc.gov)
  • In contrast, infectious diseases and environmental/occupational exposures reflected much higher proportions of early phase research. (cdc.gov)
  • Additionally, papers that could apply to multiple topic areas, and did not have a primary focus in any single topic above, were placed in the "other" category.Early phase translation (T0-T1) studies correspond to basic and discovery studies, while Late phase translation (T2-T4) studies report on surveillance, applied and implementation research and the development of evidence-based guidelines. (cdc.gov)
  • This meeting provided a forum for a thorough discussion on all scientific and ethical aspects of the proposed phase III clinical trial. (who.int)
  • Evaluation of the vaccine regimen commenced with Phase I clinical trial at the Oxford Vaccine Group in December 2014 and this has been followed by Phase 1 studies in the United States (US) and Africa (Kenya, Uganda, Tanzania). (who.int)
  • We describe a long-range phasing algorithm that makes use of this property to phase whole chromosomes and simultaneously impute a large number of missing markers. (usda.gov)
  • This study evaluated video footage of calf roping (also known as rope-and-tie) from two rodeos and assessed calves' behaviour to identify any signs of distress during five different phases of roping. (mdpi.com)
  • The study found that among the men - about half the overall group - the insurgency-phase veterans were more than twice as likely to have a diagnosis of PTSD, compared with those who served in either of the other two phases. (health.am)
  • This is a prospective, multicenter, open-label, randomized, controlled, parallel Phase 3 study with an open-label single-arm extension period to evaluate pharmacokinetics (PK), safety and efficacy of. (childrenshospital.org)
  • This will be a non-randomized, open-label, Phase 1/2 study of the safety and efficacy of AGTC-402, administered to one eye by subretinal injection in individuals with achromatopsia caused by mutations. (childrenshospital.org)
  • This is a phase II, open label, multi-center, intra-patient dose escalation study to characterize the pharmacokinetics (PK) after oral administration of eltrombopag in combination with. (childrenshospital.org)
  • So says Pooran Gaur, Principal Scientist for chickpea genetics and breeding at the International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) , and Product Delivery Coordinator for chickpeas for the CGIAR Generation Challenge Programme (GCP) . (generationcp.org)
  • This Small Business Innovation Research Phase I project addresses the critical need for long-life neutron generator s for use in nondestructive evaluation and in situ testing. (nsf.gov)
  • This Small Business Innovation Research Phase I project involves research on development and application of an optical data acquisition system, I/O devices, and optical data analysis and recognition. (nsf.gov)
  • This Small Business Innovation Research Phase I project will demonstrate a new class of optical devices that will form the heart of a low-cost, versatile, field-usable environmental monitoring system to be developed in Phase II. (nsf.gov)
  • The complex and controversial issues concerning genetics research that have emerged (e.g., the quality of laboratory testing, the rapid commercialization of genetic tests, and the potential for discrimination and stigmatization) require public health leadership. (cdc.gov)
  • Reverse genetics has supplied a magnificent tool for deriving the appropriate level of attenuation. (cdc.gov)
  • Instead, neuroimaging genetics studies have more commonly used the reverse approach, aiming to understand how risk variants for psychiatric disorders might alter brain function in non-psychiatric subjects. (bmj.com)
  • The recruiting facilities - 10 regional medical centers, six federally qualified health centers, and the US Department of Veterans Affairs Medical Centers - will also use the beta testing phase to refine their enrollment process. (genomeweb.com)
  • There's a big need for new treatments, and that hasSeattle Genetics thinking IMMU-132 could qualify for an accelerated FDA approval. (foxbusiness.com)
  • Is the Subject Area "Genetics" applicable to this article? (plos.org)
  • While there are around 4,000 registered participants, around 3,000 are currently fully enrolled in the beta testing phase after providing primary consent agreeing to join the project and agreeing to be contacted in the future, authorizing the use of their electronic health records, and filling out three surveys on demographics, lifestyle, and overall health status. (genomeweb.com)
  • The overall objective of the proposed project (Phases I and II) is to demonstrate the feasibility of the DNG concept. (nsf.gov)
  • In this randomised, double-blind, phase 3 trial, we recruited patients aged 18 years and older with glioblastoma from 165 hospitals in 22 countries. (nih.gov)
  • The concept will be rapidly prototyped for a proof-of-concept experiment, for feasibility evaluation, and for providing a preliminary design and demonstration plan for Phase II, which will involve development, building, and testing of a brass-board model of the optical security system. (nsf.gov)
  • abstract = "The Spirit (or Kermode) bear is a white-phased black bear found on the northwest coast of British Columbia, and is one of the most striking color polymorphisms found in mammals. (elsevierpure.com)
  • We hypothesized that mechanistic pathways leading to asthma symptoms in the effector phase of the disorder differ with the inciting allergen. (cdc.gov)
  • Both genetics and environmental factors influence the expression of asthma, and not all asthma is the result of a specific immune response to allergen. (cdc.gov)
  • Both host factors (genetics) and low molecular weight allergens. (cdc.gov)
  • Developments in plant genetics over the past 10-15 years have provided breeders with powerful tools to detect beneficial traits of plants much more quickly than ever before. (generationcp.org)
  • At the Department of Molecular Genetics and Microbiology (MGM), we are committed to delivering the best education for medical students, graduate students and postdoctoral fellows. (unm.edu)
  • These include genetics, the age it begins, your medical history or medications (such as chemotherapy drugs), and lifestyle habits (such as smoking). (medlineplus.gov)