• It was first synthesized in the late 1990s by a team including David E. Nichols at Purdue University while investigating derivatives of 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxy-N-methylamphetamine (MDMA). (wikipedia.org)
  • Thus, while several-fold less potent than its analogues 2-methyl-MDA and 5-methyl-MDA, and approximately half as potent as MDA, 6-methyl-MDA is still significantly active, and appropriate doses may be similar to or somewhat higher than those of MDMA. (wikipedia.org)
  • Hernández, A. MDMA (3,4-Methylenedioxymethamphetamine) Analogues as Tools to Characterize MDMA-Like Effects: An Approach to Understand Entactogen Pharmacology . (isomerdesign.com)
  • This multi-site, double-blind, placebo-controlled, randomized Phase 3 study will assess the efficacy and safety of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy compared to psychotherapy with placebo in participants diagnosed with at least moderate PTSD. (clinicaltrials.gov)
  • 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy may be a potential treatment option for PTSD. (clinicaltrials.gov)
  • This multi-site, double-blind, placebo-controlled, randomized Phase 3 study will assess the efficacy and safety of MDMA-assisted psychotherapy versus psychotherapy with placebo control in participants diagnosed with at least moderate PTSD. (clinicaltrials.gov)
  • The primary objective of this study is to evaluate the efficacy of MDMA-assisted psychotherapy for PTSD compared to identical psychotherapy with inactive placebo, as measured by change in Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) Total Severity Score from Visit 3 (Baseline) to Visit 19 (18 weeks post Baseline) (Blake et al. (clinicaltrials.gov)
  • Although most of these compounds are only of historical interest, amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), and 3,4-methylenedioxymethamphetamine (MDMA) continue to be used recreationally. (erowid.org)
  • 3,4-Methylenedioxymethamphetamine (MDMA) modulates cortical and limbic brain activity as measured by [H215O]-PET in healthy humans. (researchgate.net)
  • Recent work with noninvasive human brain imaging has started to investigate the effects of 3, 4-methylenedioxymethamphetamine (MDMA) on large-scale patterns of brain activity. (researchgate.net)
  • A phase 3 clinical trial of MDMA-assisted therapy demonstrated statistically significant improvement in PTSD symptoms after three sessions, and FDA approval by late 2023 is possible. (medscape.com)
  • In 1985, published reports stated that MDMA and its demethylated metabolite 3,4-methylenedioxyamphetamine (MDA) had long-term neurotoxic effects in laboratory animals. (medscape.com)
  • "Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA)" J Med Chem . (erowid.org)
  • 6-Methyl-3,4-methylenedioxyamphetamine (6-Methyl-MDA) is an entactogen and psychedelic drug of the amphetamine class. (wikipedia.org)
  • The three isomeric ring-methylated derivatives of the well-known hallucinogen and entactogen MDA (1a) were synthesized and evaluated for pharmacological activity as monoamine-releasing agents and as serotonin agonists. (erowid.org)
  • In animal studies it substitutes for MBDB, MMAI, LSD, and 2,5-dimethoxy-4-iodoamphetamine (DOI), though not amphetamine, but only partially and at high doses. (wikipedia.org)
  • [3] However it is more commonly known as a metabolite of the N-alkylated analogues MBDB and EBDB which have appeared in street "Ecstasy" pills. (bionity.com)
  • [4] [5] While BDB itself has not been reported as being sold as "Ecstasy", urine analysis of "Ecstasy" users suggest that this drug may have appeared as a street drug, although it is unclear whether the positive urine test for BDB resulted from consumption of BDB itself or merely as a metabolite of MBDB. (bionity.com)
  • Kronstrand R. Identification of N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB) in urine from drug users. (bionity.com)
  • The erroneous association is due to MDA, 3,4-methylenedioxyamphetamine, a close analogue studied for its antidepressive and appetite suppressant effects developed in 1949-1957 by Smith, Kline, and French. (medscape.com)
  • 3a) 'Commission' means the Commission for Mental Health, Developmental Disabilities, and Substance Abuse Services established under Part 4 of Article 3 of Chapter 143B of the General Statutes. (ncleg.net)
  • 4) 'Control' means to add, remove, or change the placement of a drug, substance, or immediate precursor included in Schedules I through VI of this Article. (ncleg.net)
  • 3. The physical appearance of the tablets, capsules or other finished product containing the substance is substantially identical to a specified controlled substance. (ncleg.net)
  • Any pharmacological substance which is not addressed by any of the subsequent sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g. drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited at all times. (wada-ama.org)
  • Synthetic opioid derivatives, which represent the second major class of 'designer drugs', are derivatives of fentanyl (e.g. alpha-methylfentanyl, 3-methylfentanyl) or pethidine (meperidine) and are extremely potent compounds responsible for numerous overdose deaths. (erowid.org)
  • The 2-methyl derivative 2a and the 5-methyl derivative 2b were found to be more potent and more selective than the parent compound in inhibiting [3H]-serotonin accumulation in rat brain synaptosomal preparations. (erowid.org)
  • This particular compound is what I call a pharmacological tofu. (erowid.org)
  • Attempts to synthesise pethidine have resulted in the accidental production of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), a compound which is metabolised in the brain by the monoamine oxidase system to a toxic intermediate (MPP+) which selectively destroys the sustantia nigra, resulting in the rapid onset of severe Parkinsonian symptoms. (erowid.org)
  • Both the synthetic and the pharmacological details for this compound are sparse. (drugwiki.net)
  • 6-Methyl-MDA has IC50 values of 783 nM, 28,300 nM, and 4,602 nM for inhibiting the reuptake of serotonin, dopamine, and norepinephrine in rat synaptosomes. (wikipedia.org)
  • J , BDB , or 3,4-methylenedioxy-alpha-ethyl- phenethylamine , is a psychedelic drug with a limited history of use in humans. (bionity.com)
  • Very little data exists about the pharmacological properties, metabolism, and toxicity of BDB. (bionity.com)
  • The 2C is because its had a 2-carbon chain sticking off of the phenyl ring (which is why its a phenethylamine instead of an amphetamine), and I *assume* the B is because of the Br atom in the 4 position. (erowid.org)
  • This turns the phenethylamine into an alpha-methyl-phenethylamine (because the addition of a carbon means attatching a methyl group to the alpha carbon of the phenethylamine) also called a phenylisopropylamine or simply an amphetamine. (erowid.org)
  • Subtle alterations of the phenylethylamine molecule give rise to a spectrum of pharmacological properties ranging from pure sympathomimetic stimulation to primarily psychoactive effects. (erowid.org)
  • Moreover, the compounds are effective in a wide panel of cancer cell lines and possess adequate pharmacological properties rendering them promising drug candidates for the treatment of AML and other neoplasias. (bvsalud.org)
  • Doses are 12-24 mg, Duration is 4-8 hours. (erowid.org)
  • Trenbolone (17β-hydroxyestr-4,9,11-trien-3- one) and other substances with a similar chemical structure or similar biological effect(s). (wada-ama.org)
  • This unique class of psychoactive agents exhibits broad and complex pharmacological effects. (erowid.org)
  • Pharmacological Research. (edu.pe)
  • Garofano L, Santoro M, Patri P, Guidugli F, Bollani T, Favretto D, Traldi P. Ion trap mass spectrometry for the characterization of N-methyl-1- (3,4-methylene-dioxyphenyl)-2-butanamine and N-ethyl-3,4- methylenedioxyamphetamine, two widely distributed street drugs. (bionity.com)
  • 3) 'Bureau' means the Bureau of Narcotics and Dangerous Drugs, United States Department of Justice or its successor agency. (ncleg.net)
  • 2C-D has a potency of 20-60 mg and a duration of 4-6 hours. (erowid.org)
  • DOM has a potency of about 3-10 mg and a duration of 14-20 hours. (erowid.org)
  • And the replacement of the Br atom in DOB with a methyl group would give you DOM also. (erowid.org)
  • This unique class of psychoactive agents exhibits broad and complex pharmacological effects. (erowid.org)
  • The pronounced effects of the methylenedioxy-substituted compounds on [3H]serotonin and [3H]norepinephrine uptake implicate these neurotransmitters in the pharmacological effects of these drugs. (erowid.org)
  • Molecules of the amphetamine class contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα. (psychedelicsdaily.com)
  • Subtle alterations of the phenylethylamine molecule give rise to a spectrum of pharmacological properties ranging from pure sympathomimetic stimulation to primarily psychoactive effects. (erowid.org)
  • 3,4-methylenedioxymethamphetamine ('ecstasy'): its long-term emotional and cognitive effects, and serotonin depletion]. (nih.gov)
  • The erroneous association is due to MDA, 3,4-methylenedioxyamphetamine, a close analogue studied for its antidepressive and appetite suppressant effects developed in 1949-1957 by Smith, Kline, and French. (medscape.com)
  • Here, we investigated the pharmacological effects of enantiomers of pyrovalerone, α-pyrrolidinovalerophenone, and 3,4-methylenedioxypyrovalerone as compared to the traditional psychostimulants cocaine and methylphenidate, using a variety of in vitro, computational, and in vivo approaches. (nih.gov)
  • 6-Methyl-3,4-methylenedioxyamphetamine (6-Methyl-MDA) is an entactogen and psychedelic drug of the amphetamine class. (wikipedia.org)
  • 6-Methyl-MDA has IC50 values of 783 nM, 28,300 nM, and 4,602 nM for inhibiting the reuptake of serotonin, dopamine, and norepinephrine in rat synaptosomes. (wikipedia.org)
  • 4) "Office" means the office of Drug Control Policy. (legiscan.com)