Chemicals and DrugsPhenomena and ProcessesInformation Science
Methionine Sulfoxide ReductasesOxidoreductasesMethioninePeptidesSequence Homology, Amino AcidMolecular Sequence DataAmino Acid SequencePeptide FragmentsMethionine AdenosyltransferasePeptide LibraryAntimicrobial Cationic Peptides5-Methyltetrahydrofolate-Homocysteine S-MethyltransferasePeptides, CyclicS-Adenosylmethionine
ProteinsLeucineSynthetic peptidesHistidineCollagen PeptidesPhenylalanineSulfoxideResidueSolid-phase pepProteinSynthaseAmount of the peptideSynthesisOxidationCysteineAmino acidFormylAlzheimer'sTRNAResiduesOpioidCodonFindingsHydroxylysineReceptorsFragmentsShiftsEnzymesInsulinBondsBody'sChainsBondTherapeuticVitaminBlendFormStudiesMolecularContentStudyPotential
Proteins5
  • We insert synthetic peptides into proteins of interest via tandem protein trans-splicing using two orthogonal split intein pairs and validate our approach by investigating different aspects of GFP, Na V 1.5 and P2X2 receptor function. (biorxiv.org)
  • We thus sought to complement these approaches with a method that could incorporate synthetic peptides carrying multiple post-translational modifications (PTMs) or ncAAs into both cytosolic and membrane proteins in live eukaryotic cells. (biorxiv.org)
  • Amino Acids are known as the monomers of peptides and proteins. (medchemexpress.com)
  • The standard experiment is to separate the proteins, e.g. by 2D gel electrophoresis, digest the proteins with a highly specific enzyme, measure the masses of the peptide fragments with a mass spectrometer (typically a MALDI-TOF mass spectrometer) and then compare the peptide monoisotopic masses with expected monoisotopic masses from a database (protein or DNA database). (lu.se)
  • Cyclophilins are intracellular proteins with the capacity to catalyse the cis/trans isomerization of the peptide bonds at the proline residues facilitating protein folding and conformational changes affecting the function of the targeted proteins. (lu.se)
Leucine1
  • Methionine-enkephalin (Met-Enk) and leucine-enkephalin (Leu-Enk) belong to family of opioid peptides. (nih.gov)
Synthetic peptides3
  • The use of synthetic peptides approved by the health authorities for vaccine, for cancer, and in drug delivery systems is increasing with these developments. (intechopen.com)
  • The aim of this chapter is to review some applications of synthetic peptides providing a brief knowledge about peptide synthesis. (intechopen.com)
  • 2006). The LLNA is based upon characterization of chemicals comprising allergens of different potencies and non- induced proliferative responses in draining lymph nodes allergenic chemicals were evaluated for their ability to react with following topical exposure of mice to chemicals (Gerberick reduced glutathione (GSH) or with two synthetic peptides et al. (cdc.gov)
Histidine1
  • Dopamine (DA) is the principal PIF, and thyrotropin-releasing hormone (TRH), vasoactive intestinal peptide, and peptide histidine methionine are the putative PRFs. (medscape.com)
Collagen Peptides6
  • Enhance your beauty routine with Swanson's Unflavored Collagen Peptides. (swansonvitamins.com)
  • Wondering why collagen peptides? (swansonvitamins.com)
  • Collagen peptides prove to be a more bioavailable option than traditional collagen supplements. (swansonvitamins.com)
  • Collagen peptides can do more than upgrade your skin care routine-from exercise recovery to overall wellness, this unflavored collagen powder is a versatile option to better your day-to-day. (swansonvitamins.com)
  • Ultimate Collagen Peptides contains a Vitamin, Mineral and Amino Acid Blend which are necessary for healthy collagen formation. (a1supplements.com)
  • Other Ingredients CollaPure proprietary enzymatically hydrolyzed collagen peptides bovine , filtered water, glycerin, malic acid, natural mango flavor, phosphoric acid, stevia stevia rebaudiana extract leaf and polylysine. (vitaminlife.com)
Phenylalanine3
  • A chemical bond forms between the methionine and phenylalanine (in a protein, this covalent bond is called a peptide bond ). (howstuffworks.com)
  • A peptide bond forms between the phenylalanine and the threonine. (howstuffworks.com)
  • The prototypical fMet-containing oligopeptide is N -formylmethionine-leucyl-phenylalanine (FMLP) which activates leukocytes and other cell types by binding with these cells' formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2) G protein coupled receptors (see also formyl peptide receptor 3 ). (wikipedia.org)
Sulfoxide3
  • Peptide methionine sulfoxide reductase may refer to: Protein-methionine-S-oxide reductase Peptide-methionine (S)-S-oxide reductase This set index page lists enzyme articles associated with the same name. (wikipedia.org)
  • Methionine is a sulfur-containing amino acid whose oxidation leads to methionine sulfoxide or methionine sulfone. (phys.org)
  • As the study published in the Journal of Agricultural and Food Chemistry shows, a methionine sulfoxide-containing class 4 cyclolinopeptide was mainly detectable in relevant amounts in the stored oil. (phys.org)
Residue7
  • In the interesting debate entitled "Challenging Views of Alzheimer's Disease II," we defended the position that factors such as oxygen, the single methionine residue of amyloid β-peptide(1-42) [Aβ(1-42)], and redox metal ions were important for the oxidative stress and neurotoxic properties of this peptide that is critically involved in the pathogenesis of Alzheimer's disease. (uky.edu)
  • This brief review summarizes some of our findings relevant to the role of the single methionine residue of Aβ(1-42) in the oxidative stress and neurotoxic properties of this peptide. (uky.edu)
  • Butterfield, DA & Bush, AI 2004, ' Alzheimer's amyloid β-peptide (1-42): Involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide ', Neurobiology of Aging , vol. 25, no. 5, pp. 563-568. (uky.edu)
  • You only have two carboxyls on this whole peptide - the D residue and the C-terminus. (bio.net)
  • First, peptide deformylase deformylates it, converting the residue back to a normal methionine. (wikipedia.org)
  • Then methionine aminopeptidase (MAP) removes the residue from the chain. (wikipedia.org)
  • Butterfield says this indicates the damage to neurons caused by the human peptide in an Alzheimer's disease patient is related to the peptide's methionine residue. (j-alz.com)
Solid-phase pep2
  • In the first part, information about the peptide synthesis was given in a very simple and readable format under the title of solid-phase peptide synthesis including a brief history, solid supports, linkers, protecting groups, and analysis method sections. (intechopen.com)
  • Review methods and reagents for avoiding aggregation in solid-phase peptide synthesis. (sigmaaldrich.com)
Protein4
  • Using patch-clamp electrophysiology in brain slices prepared from male rats, we reveal that opioid withdrawal abruptly reduces the ability of these peptides to inhibit neurotransmission, a direct consequence of a protein kinase A (PKA)-driven increase in the synaptic activity of peptidases. (jneurosci.org)
  • The latter facilitates the simultaneous use of two orthogonal split inteins within the same peptide or protein, an approach termed tandem protein trans-splicing (tPTS). (biorxiv.org)
  • The strategy therefore promises reliable automated user- independent protein identification using peptide mass fingerprints. (lu.se)
  • Casein glycomacropeptide (CGMP), a bioactive peptide, is an alternative protein source to traditional amino acids (L-AA). (bvsalud.org)
Synthase4
  • Cobalamin-independent methionine synthase (MetE) catalyzes the synthesis of methionine by a direct transfer of the methyl group of N5-methyltetrahydrofolate (CH3-H2PteGlun) to the sulfur atom of homocysteine (Hcy). (rcsb.org)
  • Indanomycin is biosynthesized by a hybrid nonribosomal peptide synthase/polyketide synthase (NRPS/PKS) followed by a number of `tailoring' steps to form the two ring systems that are present in the mature product. (iucr.org)
  • Homocystinuria is an inherited autosomal recessive defect in methionine metabolism that is caused by a deficiency in cystathionine synthase. (medscape.com)
  • Urine methionine and homocysteine levels are elevated because of deficient levels of cystathionine beta-synthase. (medscape.com)
Amount of the peptide1
  • Provided herein are anti-angiogenic comprising the N-terminal end of endostatin, nucleic acids encoding the same, pharmaceutical preparations comprising an effective amount of the peptide and nucleic acids and use of the pharmaceuticals in treating or preventing diseases or conditions associated with undesirable angiogenesis. (justia.com)
Synthesis3
  • The synthesis and applications of the peptides are gaining increasing popularity as a result of the developments in biotechnology and bioengineering areas and for a number of research purposes including cancer diagnosis and treatment, antibiotic drug development, epitope mapping, production of antibodies, and vaccine design. (intechopen.com)
  • The synthesis of the peptides may provide sufficient material to enable further studies and to determine the structure-activity relationships or may provide discovery of new analogues with improved properties [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. (intechopen.com)
  • The ease of assembly of a given peptide sequence is hard to predict, which makes peptide synthesis challenging. (sigmaaldrich.com)
Oxidation1
  • If you get oxidation of the peptide, you lose 2 A.U. on the C-C bond (minus two hydrogens). (bio.net)
Cysteine1
  • The transsulfuration pathway of methionine/homocysteine degradation produces the amino acids cysteine and taurine. (medscape.com)
Amino acid3
  • When the codon is used for initiation, fMet is used instead of methionine, thereby forming the first amino acid as the peptide chain is synthesized. (wikipedia.org)
  • Peptide bonds occur when the carboxyl group of one amino acid bonds with the amine group of another. (databasefootball.com)
  • For example, if the mRNA codon is 'AUG' then the corresponding tRNA base pairing is 'TAC', which specifies the amino acid methionine. (databasefootball.com)
Formyl3
  • Among the neutrophil activating factors, mitochondrial-derived N-formyl methionine (fMet) has been reported in several autoinflammatory conditions. (lu.se)
  • The addition of the formyl group to methionine is catalyzed by the enzyme methionyl-tRNA formyltransferase . (wikipedia.org)
  • However, transformylase will catalyze the addition of the formyl group to methionine only if methionine has been loaded onto tRNA fMet , not onto tRNA Met . (wikipedia.org)
Alzheimer's5
  • In Butterfield's study, which was funded by the National Institutes of Health, he focused on amyloid beta peptide, a compound known to contribute to the senile plaques seen in the brains of Alzheimer's patients. (j-alz.com)
  • The study compared amyloid beta peptide in an animal model to the same compound in humans and found both forms of the compound cause loss of connections between neurons and decreased cell viability as well as other damage associated with Alzheimer's. (j-alz.com)
  • Butterfield's study identified methionine in the human amyloid beta peptide as a key contributor to Alzheimer's disease. (j-alz.com)
  • A previous theory held that it was the copper binding sites in the human peptide that contributed to Alzheimer's. (j-alz.com)
  • These results provide new insights into the mechanisms of action of human amyloid beta peptide, which many researchers believe causes the damage seen in the brains of Alzheimer's disease patients. (j-alz.com)
TRNA4
Residues2
  • Here, we combine in-vitro structural measurements, which used EPR spectroscopy and UV-Vis measurements, with cell experiments to explore the role of the various methionine residues in CusB. (biorxiv.org)
  • We targeted two methionine residues (M227 and M241) that are essential for the proper function of CusB. (biorxiv.org)
Opioid1
  • These findings provide novel insights into how peptidases control synaptic activity within the amygdala and presents restoration of endogenous peptide activity during withdrawal as a viable option to mitigate withdrawal-induced disruptions in emotional learning circuits and rescue the relapse behaviors exhibited during opioid withdrawal and beyond into abstinence. (jneurosci.org)
Codon1
Findings1
  • Based on these findings, the disclosure features anti-angiogenic peptides comprising at least about 12 amino acids of SEQ ID Nos. (justia.com)
Hydroxylysine1
Receptors1
  • According to the scientists, almost all of the peptides that were able to activate the receptors contained one or two oxidized methionine building blocks in their ring structure . (phys.org)
Fragments1
Shifts1
  • Reduced peptide control of neurotransmission in the amygdala shifts the excitatory/inhibitory balance of inputs onto accumbens-projecting amygdala cells involved in relapse. (jneurosci.org)
Enzymes1
  • Natural products classed as polyketides, nonribosomal peptides and hybrids of both are often biosynthesized by giant, complex enzymes known as polyketide synthases (PKS) and nonribosomal peptide synthetases (NRPS). (iucr.org)
Insulin1
  • Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas. (drugbank.com)
Bonds1
  • Amino acids are linked to neighboring amino acids via covalent bonds called peptide bonds. (databasefootball.com)
Body's1
  • Methionine can then be used to produce SAM, the body's universal methyl donor, which participates in several other key metabolic pathways, including the methylation of DNA and myelin. (medscape.com)
Chains1
  • Peptides, short chains of amino acids, have diverse therapeutic applications. (chemblink.com)
Bond2
  • You can hydrolyze the Q and N amides but the rate of this would be close to the rate of spontaneous hydrolysis of peptide bond. (bio.net)
  • A peptide bond is a dehydration reaction that removes a molecule of water. (databasefootball.com)
Therapeutic1
  • The specific characters of peptides (high bioactivity, high specificity, and low toxicity) have made them attractive therapeutic agents. (intechopen.com)
Vitamin2
  • Butterfield also demonstrated that in the animal form of the peptide, the introduction of the antioxidant vitamin E slowed the destruction of brain cells as it appears to in the human form. (j-alz.com)
  • Folate and vitamin B-12 are required for the remethylation of homocysteine to methionine. (medscape.com)
Blend1
  • With 20 grams of collagen per scoop in an easy-to-mix powder, bettering your wellness routine can now be as simple as drinking a glass of water packed with perfect blend of beauty-supporting peptides. (swansonvitamins.com)
Form1
  • His study found the animal form of the peptide, which does not have the copper binding sites, still causes damage. (j-alz.com)
Studies1
  • Isothermal titration calorimetry (ITC) measurements were combined with structural data derived from X-ray crystallographic studies on 12 peptide-SH2 domain complexes. (rcsb.org)
Molecular3
  • In the last part, information about cell-penetrating peptides that can be used as molecular carries is mentioned with providing classification and cellular uptake mechanism of them. (intechopen.com)
  • Thermodynamic measurements, structural determinations, and molecular computations were applied to a series of peptide ligands of the pp60(c-src) SH2 domain in an attempt to understand the critical binding determinants for this class of molecules. (rcsb.org)
  • As assumed, the proportion of oxidized peptides increased significantly due to storage," reports food chemist Oliver Frank from the Chair of Food Chemistry and Molecular Sensory Science. (phys.org)
Content1
  • Consequently, it would be conceivable to optimize the flavor quality of stored linseed oil by removing or reducing the content of this peptide class in the oil through breeding or technical measures," he continues. (phys.org)
Study1
  • In this work, a computational study is described to identify novel potential peptides designed by employing a database of non-natural amino acids. (mdpi.com)
Potential3
  • Thus, inhibiting HOX-PBX interaction represents a potential strategy to prevent these malignancies, as demonstrated by the patented peptide HTL001 that is being studied in clinical trials. (mdpi.com)
  • Potential roles of flavin-containing monooxygenases in sulfoxidation reactions of l-methionine, N-acetyl-l-methionine and peptides containing l-methionine. (wikipathways.org)
  • The results of these investigations reveal that measurement of peptide reactivity has considerable potential the development of alternative methods for skin sensitization utility as a screening approach for skin sensitization testing, and testing. (cdc.gov)