• Hematopoietic cell transplantation improved survival among high-risk genetic subgroups of patients with myelodysplastic syndrome, a recent study found. (curetoday.com)
  • The following is a summary of "Busulfan Plus Fludarabine Compared With Busulfan Plus Cyclophosphamide for AML Undergoing HLA-Haploidentical Hematopoietic Cell Transplantation: A Multicenter Randomized Phase III Trial," published in the October 2023 issue of Oncology by Ling, et al. (physiciansweekly.com)
  • For a study, researchers sought to compare the outcomes of two conditioning regimens, busulfan plus fludarabine (BuFlu) and busulfan plus cyclophosphamide (BuCy), in HLA-haploidentical hematopoietic cell transplantation (haplo-HCT) for patients with acute myeloid leukemia (AML). (physiciansweekly.com)
  • Although allogeneic hematopoietic cell transplantation (alloHCT) is the treatment of choice, patient eligibility criteria and optimal conditioning regimen remain under study. (confex.com)
  • Outcomes of Allogeneic Hematopoietic Cell Transplantation (Allo-HCT) in Patients with CALR-Mutated Myelofibrosis compared to those patients with a JAK2-mutation. (ebmt.org)
  • For decades transplantation clinicians have used age in decisions about candidacy for hematopoietic cell transplantation (HCT) It has often been joked that as transplanters have aged the "acceptable" age for HCT has increased. (bloodline.net)
  • Treosulfan, fludarabine, and 2-Gy total body irradiation followed by allogeneic hematopoietic cell transplantation in patients with myelodysplastic syndrome and acute myeloid leukemia. (bvsalud.org)
  • Allogeneic hematopoietic cell transplantation (HCT) offers curative therapy for many patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). (bvsalud.org)
  • The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
  • Five patients received autologous HSCT: threemarrow and two peripheral blood stem cells. (cancernetwork.com)
  • Six patients relapsed, includingall five autologous and one allogeneic recipients. (cancernetwork.com)
  • We have treated 4 patients with either focal or generalized stable vitiligo using a graft of autologous melanocytes' culture on a denuded amniotic membrane (AM). (cun.es)
  • Our results demonstrate that transplantation of autologous melanocytes cultured on AM is a new, simple, and effective treatment for stable vitiligo. (cun.es)
  • 70 years, ECOG performance status≥3 at presentation, induction regimens≤2, and autologous or haploidentical HCT because these were performed in individual patients. (confex.com)
  • Transplanting their own (autologous) bone marrow-derived stem cells into 48 patients with end-stage liver disease resulted in therapeutic benefit to a high number of the patients, report researchers publishing in the current issue of Cell Transplantation (19:11). (medicaldaily.com)
  • Methods: The aim of this trial is to determine whether adoptive transfer of autologous Tregs into HLA sensitised patients can suppress memory T and B cell responses against specific HLA antigens. (kcl.ac.uk)
  • There are notable differences in patient and transplant outcomes for intestine transplants with and without liver. (medscape.com)
  • The body of literature related to liver transplantation for patients with HCC includes several comparison studies of sufficient sample size to clearly establish patient outcomes comparable to liver transplantation for non-malignant conditions. (cms.gov)
  • Patients with transformation to AML had similar outcomes to patients with less advanced stages. (nih.gov)
  • The Role of Patient-reported Outcomes and Medication Adheren. (lww.com)
  • Drug development of immunosuppressive therapies (ISTs) for use in transplantation has historically focused on morbidity and mortality as the primary clinical outcomes of interest, with patient experiences often being an afterthought. (lww.com)
  • Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o. (medscimonit.com)
  • In these studies, sofosbuvir clearly demonstrated the potential to improve patient outcomes by either preventing or effectively treating recurrent HCV infection following liver transplantation. (gilead.com)
  • Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St. (medscimonit.com)
  • Professional Education Resource Center (PERC) is designed for professionals committed to improving patient outcomes. (kidney.org)
  • All of these conditions lead to poor outcomes during or after transplantation. (msdmanuals.com)
  • The aim of this study was to assess the vision-related quality of life and satisfaction of patients who underwent corneal transplantation and to evaluate the effects of corneal transplantation on the health related quality of life of patient's. (amrita.edu)
  • The present report describes an incomplete atypical femoral fracture (AFF) patient who underwent simultaneous autogenous bone transplantation to the resected fracture region during intramedullary nail fixation. (hindawi.com)
  • Patients who underwent WMT experienced a 90.7% clinical cure rate, with no difference observed between patients with primary CDI and recurrent CDI but a slightly lower rate among those with severe and complicated CDI. (consultantlive.com)
  • In total, investigators enrolled 54 patients with CDI who underwent a total of 105 WMTs. (consultantlive.com)
  • Of the 37 patients who experienced primary CDI, 56.7% (n = 21) underwent WMT as the first-line treatment and had not received antibiotics prior to WMT. (consultantlive.com)
  • We performed a retrospective study including end stage heart failure patients not eligible for transplant listing secondary to morbid obesity that underwent laparoscopic sleeve gastrectomy (LSG) at a single institution from 2013 - present. (sages.org)
  • Five patients with advanced heart failure underwent LSG, four of whom had a left-ventricular assist device in place. (sages.org)
  • One patient underwent successful heart transplantation and 2 additional patients were reactivated on the transplant list. (sages.org)
  • Three LL patients underwent surgery for persistent air leak and required muscle flap repair. (nih.gov)
  • In December 2014, he underwent a successful lung transplantation. (cdc.gov)
  • As of February 2021, the Organ Procurement and Transplant Network (OPTN) listed 214 patients awaiting intestinal transplantation. (medscape.com)
  • There were no deaths, graft losses or episodes of organ rejection among post-liver transplantation patients in the study. (gilead.com)
  • This document is an updated guideline and details the recommendations for the front‐line management of adult patients with an established diagnosis of post‐transplant lymphoproliferative disorder (PTLD) following solid organ transplantation (SOT). (b-s-h.org.uk)
  • Introduction Orthotopic Liver Transplantation (OLT) is the potential curative treatment option for patients with end-stage liver disease (ESLD) or hepatocellular carcinoma (HCC) within organ procurement and transplantation network (OPTN) criteria. (medrxiv.org)
  • However, these groups of patients may require bridging interventions, including Transjugular Intrahepatic Portosystemic Shunt (TIPS) or Locoregional Therapies (LRTs), given the nationwide organ shortage and increasing waitlist time. (medrxiv.org)
  • Methods and analysis Three datasets from the United Network for Organ Sharing (UNOS) database will be included and linked to estimate the causal effect of 1) Transjugular Intrahepatic Portosystemic Shunts and 2) Locoregional therapies in patients undergoing OLT, the latter among patients with HCC. (medrxiv.org)
  • This investigation documents F. tularensis transmission by solid organ transplantation. (cdc.gov)
  • A safe, supportive, and anonymous place where patients and caregivers can share experiences, ask questions, and get answers related to kidney health, kidney disease, transplantation and living organ donation. (kidney.org)
  • Because injection drug or HBV DNA) in an organ recipient without evidence for HBV infection (anti-HBc, HBsAg, or HBV DNA) preceding transplantation. (cdc.gov)
  • In 2008, the charity Kidney Wales Foundation established Opt for Life Cymru, with People Like us Cymru, the Welsh Kidney Patients Association, the British Heart Foundation, the British Lung Foundation, Diabetes Cymru, Cystic Fibrosis and the British Medical Association, to campaign to change the law in Wales to a 'soft opt-out' system of organ donation. (wikipedia.org)
  • Matthew Kuehnert] First of all, I think it's important to say that organ transplantation is, for most people who get a transplant, a lifesaving procedure, and the biggest problem is that there aren't enough organs to go around. (cdc.gov)
  • Liver transplantation is the 2nd most common type of solid organ transplantation. (msdmanuals.com)
  • Researchers from Aarhus University and Aarhus University Hospital replace sick intestinal bacteria with intestinal bacteria from healthy donors in a treatment intended to help patients with cirrhosis of the liver. (news-medical.net)
  • The researchers are therefore now carrying out a treatment trial with faeces-microbiome transplantation, with the patients' sick bacteria being replaced by intestinal bacteria from healthy donors. (news-medical.net)
  • Obese potential donors who may be a size match to our patient cohort are more likely to have hearts that are not suitable for transplantation. (sages.org)
  • Transplantations with kidneys from marginal donors. (lu.se)
  • Patients received 14 g/m(2)/day treosulfan i.v. on days -6 to -4, 30 mg/m(2)/day fludarabine i.v. on days -6 to -2, and 2 Gy TBI on day 0, followed by infusion of hematopoietic cells from related (n = 27) or unrelated (n = 69) donors . (bvsalud.org)
  • Annually, more than 500 transplants in the US come from living donors, who can live without their right lobe (in adult-to-adult transplantation) or the lateral segment of their left lobe (in adult-to-child transplantation). (msdmanuals.com)
  • Dr. Appelbaum is the Executive Vice President and Clinical Research Professor at Fred Hutch Cancer Center (Seattle, WA) and author of " Living Medicine: Don Thomas, Marrow Transplantation, and the Cell Therapy Revolution " (2023). (iwmf.com)
  • To determine whether umbilical cord blood transplantation (UCBT) is an alternative cure for myelofibrosis (MF), we evaluated 35 UCBTs reported to Eurocord. (nih.gov)
  • Umbilical cord blood transplantation. (nih.gov)
  • The product is intended for use in adults and pediatric patients 12 years and older with blood cancers planned for umbilical cord blood transplantation following a myeloablative conditioning regimen (treatment such as radiation or chemotherapy). (fda.gov)
  • Eighty-seven percent of subjects who were randomized to receive Omisirge achieved neutrophil recovery with a median of 12 days following treatment with the product, compared to 83% of subjects who were randomized to receive umbilical cord blood transplantation and who achieved neutrophil recovery with a median of 22 days. (fda.gov)
  • Non-congenital short gut syndrome (SGS) was the most common reason for transplantation in 2019, accounting for 48.8% of intestine transplants and 30.0% of intestine-liver transplants. (medscape.com)
  • Between November 20, 2015, and September 30, 2019, 386 patients were randomly assigned, with 194 in the BuFlu group and 192 in the BuCy group. (physiciansweekly.com)
  • Allogeneic HCT confers superior survival in transplant-eligible patients with high-risk MDS and an available donor. (curetoday.com)
  • For an allogeneic stem cell transplant , after the bone marrow is destroyed, the patient receives blood-forming stem cells from another person - the donor," the American Cancer Society explained. (curetoday.com)
  • Among the 309 participants in the recent study there was a similar distribution of genetic mutations between the 229 patients who received HCT (the donor arm) and the 80 who did not (the non-donor arm): TP53 (28% vs. 29%), ASXL1 (23% vs. 29%) and SRSF2 (16% vs. 16%) were the most common genetic mutations. (curetoday.com)
  • Likewise, OS at three years was 68% among patients with very high risk IPSS (IPSS-M) without a TP53 mutation in the donor arm was 68%, but 0% for patients in the non-donor arm. (curetoday.com)
  • Each dose is patient-specific, containing healthy stem cells from an allogeneic pre-screened donor, meaning it comes from a different individual rather than using the patient's own cells. (fda.gov)
  • OUTLINE: All patients receive elutriated, CD34+ stem cell augmented donor bone marrow according to another protocol on day 0. (knowcancer.com)
  • Four patients were alive withno evidence of disease (three matched unrelated donor and one matched relateddonor). (cancernetwork.com)
  • The aim of these trials was to provide patients with the protection of T-cells after T-cell-depleted allo-HSCT in the matched or mismatched donor setting with an option to delete transduced T-cells, if severe aGvHD occurred within the trial period. (frontiersin.org)
  • Donor chimerism was stabilized after transfusion of the transduced cells in all patients treated. (frontiersin.org)
  • Fecal microbiota transplantation (FMT) offers a viable treatment option for patients who do not respond to antibiotic therapy and involves transferring a healthy microbiome from the feces of a donor to a recipient, which restores healthy bacteria in the lower intestine to help control CDI and keep it from coming back. (consultantlive.com)
  • In human patients who receive bone marrow transplants, GVHD can cause severe gut damage from donor cells attacking host cells. (oncologynurseadvisor.com)
  • Since 2013, we have introduced FluTreo for patients with a suitable donor that would have been previously eligible only for reduced intensity conditioning/RIC. (confex.com)
  • Only therapy naïve adult patients, without multivisceral transplants, and without living donor transplants will be included. (medrxiv.org)
  • Through the NKF Peers program, speak with someone who has been through the kidney transplantation or living donor process. (kidney.org)
  • Donor-recipient height mismatch was not significantly different between PSP and non-PSP patients (p = 0.53). (nih.gov)
  • Here, we report, for the first time, the cross-generational transmission of specific bacterial strains from an FMT donor to a pregnant patient with CDI and further to her child, born at term, 26 weeks after the FMT treatment. (biomedcentral.com)
  • The gut microbiota of the patient with CDI differed considerably from the healthy donor and was characterized as low in alpha diversity and enriched for several potential pathogens. (biomedcentral.com)
  • Importantly, our analysis revealed that some specific strains were transferred from the donor to the patient and then further to the infant, thus demonstrating cross-generational microbial transfer. (biomedcentral.com)
  • infections were detected a median of 38 from the same donor as the liver recipient were evaluated for (range = 5-116) weeks after transplantation. (cdc.gov)
  • Recipients of a the Advisory Committee on Immunization liver from a donor with isolated total anti-HBc positive results can develop reactivation of hepatitis B after transplantation. (cdc.gov)
  • Disadvantages to the donor include mortality risk of 1/600 to 700 (compared with 1/3300 in living-donor kidney transplantation) and complications (eg, bile leakage, bleeding) in up to one fourth. (msdmanuals.com)
  • In order to better understand the LPI kinetics and its determinants and implications, we undertook sequential LPI determinations before and after conditioning until engraftment in 25 auto-HSCT patients. (karger.com)
  • CONCLUSION: These data demonstrate the feasibility of allogeneic orautologous HSCT in heavily pretreated lymphoma patients who also receivedtositumomab/iodine-131 tositumomab. (cancernetwork.com)
  • Despite prophylactic treatment of the patients with immunosuppressive drugs after allo-HSCT, GvHD is still associated with non-relapse mortality (NRM) and contributes around 25% of NRM. (frontiersin.org)
  • EA and EDPc were increased in patients after HSCT. (medscimonit.com)
  • Thus, indeed with a critical rate of blended chimerism, HSCT gives considerable advantage to WAS patients, with amazing by and large survival [ 2 ]. (alliedacademies.org)
  • 4-year DFS was 32.3% in FluTreo, versus 29.3% in other transplants and 10.2% in chemotherapy only patients (p=0.001, Figure 1B). (confex.com)
  • Senior investigator Faming Zhang, MD, PhD, vice chief of the medical center of digestive diseases at Nanjing Medical University in China, and a team of investigators assessed clinical cure rate, total abdominal symptom score, and recurrence rate in patients with CDI treated with WMT at medical centers applying for rescue WMT through the China Microbiota Transplantation System from October 1, 2021, to September 30, 2022. (consultantlive.com)
  • This pivotal prospective study demonstrates that allogeneic HCT represents an important, potentially curative, therapeutic strategy in patients with high-risk genetic sub-groups of MDS, including patients with TP53 mutated MDS," Journal of Clinical Oncology associated editor Dr. Charles F. Craddock of Queen Elizabeth Hospital in Birmingham, England wrote in a contextual commentary published along with the study. (curetoday.com)
  • Attached is a request for a technology assessment that we need in order to develop a Medicare national coverage determination for liver transplantation for malignancies other than hepatocellular carcinoma. (cms.gov)
  • These criteria plus the absence of extrahepatic and major vessel involvement satisfy the Milan criteria, used to assess suitability of liver transplantation for patients who have cirrhosis and hepatocellular carcinoma. (msdmanuals.com)
  • maximum graft survival time was 79 days, and all patients died of technical complications, sepsis, or rejection. (medscape.com)
  • In 31 patients (25%) delayed discharge was due to complications: in 14 patients (11.4%) because of GIT problems, in 16 patients (13%) because of infectious complications and in one patient because of cardiotoxicity. (nature.com)
  • Suppression of HCV RNA prior to liver transplantation should reduce the risk of re-infection and its serious complications, but currently available treatment options are often ineffective and poorly tolerated. (gilead.com)
  • Within this observation period, no difference in the rate of these complications, including secondary neoplasms, was observed between patients treated with and without HD-ASCT. (lu.se)
  • Drug development programs that aim to include patients' experiences through various methodologies, including patient-reported outcome (PRO) measures, help ensuring novel therapies meet the most pressing needs felt by patients. (lww.com)
  • Outcome data are in line with previously reported studies, especially the data for salvage treatment and BEAM conditioning in DLBCL patients confirmed the outcome reported recently in a phase III study. (smw.ch)
  • A postoperative, both clinical and histological follow-up of more than 3 weeks was obtained in 22 patients, enabling us to look for indicators predictive of NL regeneration and outcome. (erowid.org)
  • The percentage and distribution of necrosis observed in tissue samples of the NL at the time of transplantation was not related to the final outcome. (erowid.org)
  • 2002 until 2007), two were included in TK007 (2005-2009) and six serves as a control group for outcome after haploidentical transplantation without HSV-TK-transduced DLI. (frontiersin.org)
  • We studied 19 FluTreo recipients compared to 46 recipients of other conditioning regimens (38 myeloablative and 8 RIC), and 52 patients treated only with chemotherapy. (confex.com)
  • Investigation included review of laboratory data and medical in liver recipients after transplantation that were reported to records. (cdc.gov)
  • recipients constituted 42% of those patients, while underlying malignancies were found in 26% (Table 1). (who.int)
  • One hundred patients (receiving 123 conditioning regimens) were included in the analysis. (nature.com)
  • METHODS: Patient charts and our prospective ASCT database were assessed for the impact of documented variables on event free survival (EFS) and overall survival (OS), including salvage and conditioning regimens used, and PET/CT results before and after ASCT. (smw.ch)
  • The advent of effective reduced-intensity conditioning regimens allows consideration of HCT for groups of patients once thought to be too fragile. (bloodline.net)
  • Twenty-four patients received a reduced-intensity conditioning (RIC) regimen, and 17 of 35 patients received total body irradiation (2 to 12 Gy)-fludarabine-cyclophosphamide (TCF) conditioning. (nih.gov)
  • On September 27-28, 2018, the US Food and Drug Administration (FDA) and the Critical Path Institute's Transplant Therapeutics Consortium convened a public workshop to address drug development in the field of transplantation, titled "Evidence-based Treatment Decisions in Transplantation: The Right Dose & Regimen for the Right Patient/Individualized Treatment. (lww.com)
  • All patients except two who received reduced intensity had severe mucositis.Reversible veno-occlusive disease of the liver also developed in two patients.There was one death from graft-vs-host disease and no regimen-related mortality.Engraftment was prompt, with a median recovery of absolute neutrophil count to ³ 500/µL of 12 days (range: 11-18 days). (cancernetwork.com)
  • WASHINGTON --(BUSINESS WIRE)--Nov. 2, 2013-- Gilead Sciences, Inc. (Nasdaq: GILD) today announced results from two Phase 2 studies evaluating an all-oral treatment regimen of the investigational once-daily nucleotide analogue sofosbuvir plus ribavirin (RBV) for both the prevention and treatment of recurrent chronic hepatitis C virus (HCV) infection among patients who undergo liver transplantation. (gilead.com)
  • The BuFlu regimen in haplo-HCT for AML patients demonstrated lower TRM and regimen-related toxicity, with similar relapse rates compared to the BuCy regimen, indicating its potential as a more favorable treatment option. (physiciansweekly.com)
  • However, the long-term effects of this regimen remain unknown, especially in comparison to patients not receiving alloHCT. (confex.com)
  • 2000 patients in the UK) no genetic defects have yet been discovered in most CVIDs. (ucl.ac.uk)
  • Physiotherapist Dawn Gleeson at Forth Valley NHS in Central Scotland provides advice on how to clear your chest with breathing exercises for patients with chronic obstructive lung disease. (ucl.ac.uk)
  • We report one of these cases that resulted in lung transplantation. (cdc.gov)
  • Patients received a median of 3(range: 2-6) prior chemotherapy regimens (exclusive of tositumomab/iodine-131tositumomab) before or after tositumomab/iodine-131 tositumomab. (cancernetwork.com)
  • A high index of suspicion is essential in susceptible patients presenting with pulmonary infiltrate, cerebral abscess or deep soft-tissue abscess and usually requires an active diagnostic workup and early administration of appropriate therapy. (who.int)
  • Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
  • Initial lymphoma stage and number of previous treatment lines were identified as independent risk factors for EFS in DLBCL and HL patients. (smw.ch)
  • Studies on late effects in patients with mantle cell lymphoma (MCL) are becoming increasingly important as survival is improving, and novel targeted drugs are being introduced. (lu.se)
  • Most of the patients died from their lymphoma and not from another cause or treatment complication. (lu.se)
  • We conclude that in spite of rapid engraftment, non-hematological toxicities and infections remain important limitations for further reduction of the length of patient hospitalization in a significant number of patients after PBSCT. (nature.com)
  • Shortly after conditioning, LPI levels were increased in 23 patients, with peak at day 0, returning to normal range upon engraftment in 21 patients. (karger.com)
  • The latest study findings were reached via genetic analysis of the Blood and Marrow Transplant Clinical Trials Network 1102 multicenter study of comparing different therapy options among 309 patients with MDS ages 50 to 75 with International Prognostic Scoring System (IPSS) intermediate-2 or high-risk MDS. (curetoday.com)
  • The safety and effectiveness of Omisirge was supported by a randomized, multicenter study comparing transplantation of Omisirge to transplantation of umbilical cord blood, in subjects between the ages of 12 and 65 years. (fda.gov)
  • HCV infection is the most common cause of liver transplantation in the United States and Europe . (gilead.com)
  • Sixty-one patients with HCV infection (Child-Pugh class A or B cirrhosis) and liver cancer, who were either treatment-naïve or treatment-experienced were enrolled. (gilead.com)
  • Study 0126 is an ongoing open-label Phase 2 study evaluating the efficacy and safety of 24 weeks of treatment with sofosbuvir 400 mg once-daily plus RBV (starting at 400 mg/day) among 40 treatment-naïve and treatment-experienced patients with recurrent HCV infection. (gilead.com)
  • In these investigations, a case of acute HBV infection was defined as seroconversion from hepatitis B surface antigen (HBsAg)-negative to HBsAg-positive in a hemodialysis patient during the exposure period defined in each investigation. (cdc.gov)
  • An immune patient was defined as a patient who was positive for anti-HBs as a result of vaccination or positive for anti-HBc and/or anti-HBs as a result of natural infection. (cdc.gov)
  • A patient with chronic HBV infection was defined as any patient who was positive for HBsAg for greater than 6 months or was positive for both HBsAg and anti-HBc (immunoglobulin M negative). (cdc.gov)
  • From April 1 through May 18, 1994, cases of acute HBV infection were identified through routine seroscreening in 14 (70%) of 20 patients at center A, which opened in January 1994. (cdc.gov)
  • In addition, a case of previously unrecognized chronic HBV infection was identified in a patient who had received hemodialysis nine times at center A from January 26 through February 9, but had not been isolated from other patients during these treatments. (cdc.gov)
  • The source-patient had been transferred from another center where he was known to have chronic infection, but his serologic status had not been reviewed on admission to center A. In addition, although all patients at center A were screened monthly for HBsAg, results were not reviewed routinely. (cdc.gov)
  • From April 1 through June 1, 1994, cases of acute HBV infection were identified in seven (5.3%) of 131 susceptible patients in center B. Of the two patients with chronic infections, one was identified as the source of the transmission through genetic sequencing of virus isolates from all infected patients. (cdc.gov)
  • Staff frequently were assigned to provide simultaneous care for the source-patient with chronic infection and for susceptible patients. (cdc.gov)
  • A total of 19 patients were identified as having culture-proven nocardial infection. (who.int)
  • Generally, before receiving this kind of transplant, the patient will undergo a course of treatments to remove their own stem cells and prepare the body for the new stem cells. (fda.gov)
  • In any case, of these 5 patients, 2 had normalization of the platelet tally in spite of the blended chimerism, 2 had full giver chimerism after getting a moment transplant with the same giver, and 1 remains transfusion subordinate anticipating a moment transplant. (alliedacademies.org)
  • Both transfusion and transplantation are very, very safe, in terms of transmission of infectious diseases. (cdc.gov)
  • these infections were spread through transfusion and transplantation. (cdc.gov)
  • A retrospective chart review study of a nosocomial origin for the pathogens as patients diagnosed as having nocardiosis all the patients came from the community. (who.int)
  • The majority of PID patients suffer from recurrent infections, but some typers are due to defects in genes that control inflammation. (ucl.ac.uk)
  • The efficacy of Omisirge was based on the amount of time needed for recovery of the subject's neutrophils (a type of white blood cell that helps protect the body from infections) and the incidence of infections following transplantation. (fda.gov)
  • Bacterial or fungal infections by 100 days following transplantation were seen in 39% of subjects receiving Omisirge versus 60% of subjects in the control group who received umbilical cord blood. (fda.gov)
  • Standard treatment for CDI involves antibiotics, but many patients continue to suffer from repeat infections. (consultantlive.com)
  • Indeed, antibiotic treatment of infections carries an intrinsic risk of acquiring CDI, especially in vulnerable patient groups. (biomedcentral.com)
  • Seven patients had secondary acute myeloid leukemia (AML) at UCBT, and median age at UCBT was 54 years. (nih.gov)
  • Eight patients from the first NGFR-HSV-TK-studies developed acute ( n = 6) or chronic GvHD ( n = 2), which resolved after treatment with GCV alone in seven of eight patients. (frontiersin.org)
  • Twenty-three patients experienced acute GVHD and 17 developed chronic GVHD. (medscimonit.com)
  • A trend toward an overall survival advantage for cyclophosphamide-thalidomide-dexamethasone over cyclophosphamide-vincristine-doxorubicin-dexamethasone was also observed in a subgroup of patients with favorable interphase fluorescence in situ hybridization. (haematologica.org)
  • Patients with coordinated kin or parent benefactors (MSD) and coordinated irrelevant benefactors (URD) display the most noteworthy survival rates up to 80%, particularly in case transplantation happens at an early age with a URD. (alliedacademies.org)
  • We hypothesized that patients transplanted with FluTreo would have a long-term survival advantage over other treatment alternatives. (confex.com)
  • PET was performed in 22 liver-transplanted patients (3 CNI free, 9 with low-dose CNI, 10 with standard-dose CNI immunosuppression) and 9 healthy controls. (springer.com)
  • Mean V T corrected for TSPO genotype was significantly lower in patients compared to controls, especially in patients in whom CNI dose had been reduced because of nephrotoxic side effect. (springer.com)
  • Part 2 is an adaptive, open labelled trial based on Simon's two-stage design, with 21 patients receiving Good Manufacturing Practice (GMP)-grade polyclonally expanded Tregs to a dose of 5-10 × 106 cells/kg body weight. (kcl.ac.uk)
  • In conclusion, treosulfan, fludarabine, and low- dose TBI provided effective conditioning for allogeneic HCT in patients with MDS or AML and resulted in low relapse incidence , regardless of cytogenetic risk . (bvsalud.org)
  • Because one heparin vial probably had been shared among these patients, contamination of a shared multiple-dose vial was considered the most likely route of HBV transmission among patients in this outbreak. (cdc.gov)
  • Advantages of living donation for the recipient include shorter waiting times and shorter cold ischemic times for explanted organs, largely because transplantation can be scheduled to optimize the patient's condition. (msdmanuals.com)
  • Patients and comparators were followed up via the National Patient Register and Cause of Death Register, from 12 months after diagnosis or matching to December 2017. (lu.se)
  • Three percent and five percent of patients discontinued treatment due to adverse events in the pre- and post-transplant studies, respectively. (gilead.com)
  • More than 90% of patients with CDI treated with WMT achieved clinical cure, while only 3.8% of WMTs resulted in adverse events. (consultantlive.com)
  • At least one type of grade 3-5 adverse event was reported in 68.1% of patients in the BuFlu group and 77.4% in the BuCy group ( P = 0.041). (physiciansweekly.com)
  • However, post-HCT relapse remains a major problem, particularly in patients with high- risk cytogenetics . (bvsalud.org)
  • n = 10) at the time of HCT predicted higher relapse incidence (70% versus 18%) and lower OS (41% versus 79%) at 2 years, when compared with patients without MRD. (bvsalud.org)
  • In patients with AML, MRD at the time of HCT remained a risk factor for post-HCT relapse . (bvsalud.org)
  • Method A descriptive study conducted to determine the vision-related quality of life among corneal transplanted patients. (amrita.edu)
  • PROJECTED ACCRUAL: A total of 45 patients will be accrued for this study within 3-4 years. (knowcancer.com)
  • A single-center eight-year study of 155 patients. (smw.ch)
  • This study used positron emission tomography (PET) imaging with the translocator protein (TSPO) ligand 18 F-GE-180 to evaluate microglial activation in liver-transplanted patients under different regimens of immunosuppression. (springer.com)
  • This study is a sub-study of a collaborative research project on the impact of long-term CNI therapy on brain function in patients after liver transplantation funded by the German Federal Ministry of Education and Research (reference number: 01EO1302). (springer.com)
  • A subsample of 22 patients and three controls agreed to take part in the PET sub-study. (springer.com)
  • In a study conducted among pre-transplant HCV patients (Study 2025), up to 48 weeks of sofosbuvir/RBV therapy was administered. (gilead.com)
  • Study 2025 is an on-going open-label Phase 2 study evaluating the efficacy and safety of sofosbuvir (SOF) 400 mg once daily plus weight-based ribavirin (RBV) for up to 48 weeks or until liver transplantation. (gilead.com)
  • Patients in the study had received a transplant a median of four years prior to the study, and 40 percent were cirrhotic. (gilead.com)
  • To be included in the study, patients were required to have ≥ 3 liquid stools (Bristol 6-7) per day or present with confirmed intestinal obstruction and notable abdominal distention correlated with CDI, a diagnosis of CDI confirmed through laboratory tests, or colonoscopy-confirmed pseudomembranous colitis. (consultantlive.com)
  • The current study demonstrates the attractive efficacy and safety of WMT in patients with CDI. (consultantlive.com)
  • The broad inclusion of CDI patients with varying clinical characteristics enhances the representativeness of our real-world study, thereby providing valuable insights into clinical practice," investigators concluded. (consultantlive.com)
  • Discussion: This is a prospective study aiming to identify patients with unregulated cellular memory responses to Pure HLA Proteins and determine baseline variation in these patterns of response. (kcl.ac.uk)
  • Our results provide evidence of chronic suppression of microglial activity in liver-transplanted patients under CNI therapy especially in patients with high sensitivity to CNI toxicity. (springer.com)
  • Medicare conducted an analysis of the scientific evidence related to liver transplantation for patients with malignancies. (cms.gov)
  • Currently, Medicare national coverage policy for liver transplantation excludes coverage for all malignancies. (cms.gov)
  • HCFA has determined that it does not possess sufficient internal expertise to fully and fairly review liver transplantation for these other malignancies, and that additional resources are required to facilitate this process. (cms.gov)
  • In the final two presentations, Drs. Stephen Forman and Marcos de Lima discuss specific types of malignancies prevalent in the older patient and the role of nonmyeloablative transplantation. (bloodline.net)