Patients clinical trials as topic. Medical search. Frequent questions

RALEIGH, N.C., March 14, 2023 (Newswire.com) - Carebox Healthcare Solutions today announced the launch of the Carebox Connect™ application ( https://connect.careboxhealth.com ), which enables patients and their caregivers to find and get connected to the latest treatment options for hundreds of conditions. (rocklandreviewnews.com)
Chair of Physical Medicine and Rehabilitation Craig McDonald was honored with a 2023 Top Ten Clinical Research Achievement Award, in recognition of his remarkable work on Duchenne muscular dystrophy. (ucdavis.edu)

Co-design clinical trials with participants who will validate the recruitment content, protocol design and trial design. (accenture.com)
Target real participants' needs, uncovered by research and targeted analytics, and engage patients where they are in their health journeys, with their specific medical conditions in mind. (accenture.com)
We also have a trial ongoing at Cedar Sinai in Los Angeles and participants are experiencing almost miraculous results. (blogspot.com)
There was relatively good correlation between the estimated burden of disease at year 2000 and the number of trials performed ( r =0.53, P=0.024) and the number of participants randomised ( r =0.68, P=0.002). (bmj.com)
Medable's software-as-a-service (SaaS) platform has been used in more than 300 decentralized and hybrid clinical trials, serving over one million patients and research participants in 60 countries. (outsourcing-pharma.com)
Virtual clinical trials represent a relatively new method of collecting safety and efficacy data from clinical trial participants, from study start-up through execution to follow-up. (appliedclinicaltrialsonline.com)
The nine trials covered 7267 participants, 4744 of whom used varenicline. (who.int)
The one cytisine trial included in this review found that more participants taking cytisine stopped smoking compared with placebo at two-year follow up, with an RR of 1.61 (95% CI 1.24 to 2.08). (who.int)
To help identify these potential risk factors, the Registry's Research Notification Mechanism connects individuals with ALS with scientists who are recruiting participants for their ALS studies and clinical trials. (cdc.gov)
Infusion of autologous OTQ923 into three participants with severe sickle cell disease resulted in sustained induction of red-cell fetal hemoglobin and clinical improvement in disease severity. (cdc.gov)

In fact, 90% of patients surveyed would like to participate in medical research, but only around 3% of patients ever do, while one in five investigators fails to enroll a single patient into their trials. (accenture.com)
Leverage technology to ease the transfer of research data and make clinical trial data accessible to patients. (accenture.com)
By challenging assumptions, embracing experience-based knowledge and matching the needs of patients and researchers-in the set-up and design of research priorities, study design, information sharing and clinical trials overall-we can positively impact the success of ongoing and upcoming clinical offerings. (accenture.com)
Clinical trials are research studies that test how well new medical approaches work in people. (medlineplus.gov)
The clinical trial complements a commitment by Novartis, through Sandoz, to donate up to 130 million tablets of hydroxychloroquine to supply global clinical research efforts in the event the medicine is proven beneficial for treatment of COVID-19. (novartis.com)
As part of its research and development commitment, Novartis has formed a clinical investigation team to provide rapid access for approved clinical requests and support of clinical evaluation of its medicines to be repurposed and address the needs of patients with COVID-19 infections. (novartis.com)
Patients in Europe with MSI-H/dMMR colorectal cancer have had only chemotherapy-containing regimens available to them in the first-line treatment setting and have historically faced poor outcomes," said Dr. Vicki Goodman, vice president, clinical research, Merck Research Laboratories. (merck.com)
This positive EU CHMP opinion reinforces the potential of KEYTRUDA as a new option for patients with MSI-H/dMMR colorectal cancer and illustrates our ongoing commitment to pursuing biomarker research to help address the needs of patients who have few effective options. (merck.com)
Merck has the industry's largest immuno-oncology clinical research program. (merck.com)
In the 1960s, the USPHS TB control and clinical research programs were transferred to CDC from the National Institutes of Health in Maryland. (cdc.gov)
At this time, CDC began a series of clinical trials of rifampin that, in follow-up to key trials conducted by the British Medical Research Council, the British Thoracic Association, and others, helped to establish the efficacy and safety of rifampin-based, 6-month, short-course outpatient therapy for TB. (cdc.gov)
Carebox Connect is the platform used by tens of leading pharma trial sponsors, hospital research centers, and patient advocacy groups for their patient-facing clinical trial websites and services. (rocklandreviewnews.com)
Clinical trials are a cornerstone of research at the OHSU Brain Institute. (ohsu.edu)
Clinical trials follow many steps of lab research. (ohsu.edu)
Read about research breakthroughs, patient care and many other topics on the OHSU News site . (ohsu.edu)
The vision of the conference has been to unite researchers, scientists, physicians and other healthcare professionals, patient advocates, and students from across the world to discuss research advancements, identify gaps, and develop actionable goals to translate basic research findings into clinical best practices, effective community interventions, and professional training programs to decrease cancer risks and eliminate cancer disparities for Latinos. (springer.com)
Frequently, when your group or our group leads a clinical trial, it's already being replicated by multiple parties: a sponsor (government or private), an academic research organization, and perhaps a second one. (medscape.com)
LLS funds lifesaving blood cancer research around the world, provides free information and support services, and is the voice for all blood cancer patients seeking access to quality, affordable, coordinated care. (lls.org)
The Pancreatitis Center conducts research to improve understanding of pancreatitis and develop treatments that will improve patients' lives. (hopkinsmedicine.org)
The market for clinical trial management system software is expected to be worth nearly $1.8 billion by 2019 with much of the double-digit growth taking place in developing countries, according to Persistence Market Research. (fdanews.com)
Amid the push among House and Senate Republicans to pass a sweeping tax reform bill, clinical researchers called on the federal government to modernize the research and development tax credit. (fdanews.com)
The FDA will issue grants of $1 million each to Duke University and the Institute for Advanced Clinical Trials for Children to promote pediatric clinical trials and trial-related research. (fdanews.com)
Clinical trial sponsors are doing a better job of representing women in drug trials but still lag in representing racial minorities, according to FDA research. (fdanews.com)
An Alzheimer's research group offers positive news on clinical trials for Alzheimer's drugs as well as suggestions for the way forward, in a new report. (fdanews.com)
To evaluate whether the amount of randomised clinical research on various medical conditions is related to the burden of disease and health needs of the local populations in sub-Saharan Africa. (bmj.com)
Clinical research in this part of the world should focus more evenly on the major contributors to burden of disease. (bmj.com)
An evaluation of randomised controlled trials could therefore be used to determine the amount of clinical research on different health conditions. (bmj.com)
Since its inception, the Annals of Family Medicine has sought research on clinical topics: new knowledge that fills a gap in our understanding of how health and illness are gained and lost, how patients present and progress in primary care, and how diagnosis and treatment of patients in primary care can be improved. (annfammed.org)
Accepted manuscripts will be included in a clinical research theme in the July/August 2010 issue of the Annals . (annfammed.org)
The cover letter should state that the manuscript is for consideration in the clinical research theme. (annfammed.org)
Manuscripts received before October 15, 2009, will have the best chance of being included in the theme, but since clinical research is an ongoing interest of the Annals , we encourage authors to submit manuscripts at any time to be considered for publication in other issues. (annfammed.org)
AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. (ingentaconnect.com)
Published material includes peer-reviewed original research, clinical trials and review articles. (ingentaconnect.com)
At age 27, Tenaerts accepted the job, where she "fell in love" with clinical research, explaining "I love that you can set up an experiment and establish a methodology to determine if a new treatment works or not. (outsourcing-pharma.com)
The danger lies not just in the particular circumstances that led to Dan's death, but in a system of clinical research that has been thoroughly co-opted by market forces, so that many studies have become little more than covert instruments for promoting drugs. (narpa.org)
Given the research and evidence available about decentralized trials, this highly customized trial model should be attractive to sponsors. (clinicalleader.com)
These electronic processes offer new opportunities for a patient-centric approach to clinical research. (appliedclinicaltrialsonline.com)
Participating in a clinical trial does not require travel to a clinical research facility or doctor's office. (appliedclinicaltrialsonline.com)
Your mobile device (maybe a phone, watch, or even your glasses) is your link to the clinical research study and how you report general information and adverse events. (appliedclinicaltrialsonline.com)
1 Unlike site-based clinical trials, which require frequent visits to a designated research facility, remote clinical trials are based from the patient's home so those with mobility issues--such as the elderly or patients who live in rural areas--are also able to participate in the trial. (appliedclinicaltrialsonline.com)
In 2011, Pfizer pioneered the virtual clinical trial model with its Research On Electronic Monitoring of Overactive Bladder Treatment Experience (REMOTE) trial. (appliedclinicaltrialsonline.com)
Designed to promote productivity and efficiency, Velos eResearch simplifies the management of the entire clinical research portfolio by linking study status, patient enrollment, calendars, budgets, electronic data capture and more. (umc.edu)
All UMMC clinical research studies must be housed in Velos. (umc.edu)
The Office of Clinical Trials (OCT) will create records for new clinical research studies in Velos at the outset of the activation process. (umc.edu)
Velos records for all prospective clinical research studies that start the activation process on or after March 1, 2021 will include a study calendar and budget. (umc.edu)
Once the study is activated, the relevant clinical research coordinator (CRC) will conduct patient management in Velos, which will then feed into the Epic electronic health record system. (umc.edu)
The relevant OCT Project Manager will then invoice the sponsor/clinical research organization based on the CRCs' Velos input, as well as track collections in the system. (umc.edu)
Investigators, business administrators, and division and department chairs will be able to run reports on particular studies and their clinical research study portfolios. (umc.edu)
Learn about how to participate in clinical trials or research studies here at Columbia Psychiatry. (columbiapsychiatry.org)
Read about the world of psychiatric research, education, and patient care-and see what's happening here at Columbia Pyschiatry. (columbiapsychiatry.org)
COVID-19 has further amplified the need to work collaboratively as we continue to drive rare disease clinical research forward. (prweb.com)
The aim of our research is to provide evidence of clinical and cost-effectiveness for commonly used interventions in the National Health Service (NHS) for the management of frozen shoulder in secondary care. (springer.com)
They also can choose to be alerted about research studies and clinical trials and have the option to contact the researchers to find out more. (cdc.gov)
Join CDC for this session of Public Health Grand Rounds as experts discuss the challenges for research, drug development, patient care, and the past, present and future of the national registry. (cdc.gov)
To date, ATSDR has helped over 70 studies, both domestically and abroad, recruit thousands of patients for research. (cdc.gov)
Information gleaned from the research will help ATSDR prioritize topics for future surveys. (cdc.gov)

The challenge is that if you try to answer too many questions from a clinical trial dataset, spurious findings arise. (medscape.com)
The most notable changes in these guidelines reflect both the findings of clinical trials that evaluated new drug regimens for treating and preventing TB among HIV-infected persons and recent advances in the use of antiretroviral therapy. (cdc.gov)
Findings should directly help primary care clinicians better care for the patients they see. (annfammed.org)
The combination of benmelstobart, anlotinib, and chemotherapy may be effective at improving median progression-free survival and overall survival in patients with extensive-stage small cell lung cancer compared with placebo and chemotherapy, according to findings presented by Cheng et al at the. (ascopost.com)
The stigma that patients face when diagnosed with lung cancer may be associated with poorer psychosocial outcomes, including distress and isolation, delayed help-seeking, and concerns about the quality of care, according to findings presented by Harrison et al at the International Association for. (ascopost.com)
The oral KRAS G12C inhibitor adagrasib may offer durable clinical activity, with a median overall survival of 14.1 months and a 2-year survival rate of about 33%, in patients with KRAS G12C-mutated non-small cell lung cancer (NSCLC), according to findings presented by Gadgeel et al at the. (ascopost.com)
Researchers have discovered that therapy with first-line nivolumab in combination with ipilimumab may improve the 6-year survival and quality of life of patients with metastatic non-small cell lung cancer (NSCLC) compared with standard chemotherapy, according to findings presented by Peters et al. (ascopost.com)
Findings from the phase 3 INTERCEPT trial demonstrated that an orally administered, novel nonsteroidal anti-inflammatory drug (NSAID)/triptan medication is effective in treating migraine pain. (medscape.com)
The new findings suggest that the combination resulted in a 4-day reduction, compared with a 2-day benefit found in a separate study of treatment with just erenumab, the most commonly used anti-CGRP antibody, in patients who did not respond to at least two oral preventives. (medscape.com)
Rather than make a case that there is a right or wrong answer regarding decompressive craniectomy for MCI, we put our findings into a clinical decision algorithm to help frame the question for treating physicians and families, based on the likelihood of attaining a 'good" or "poor" quality of life as it relates to the individual family and patient's perception of those outcomes. (medscape.com)

Researchers at the company compressed months of work into a few weeks to design the large clinical trial in order to rapidly respond to the need for COVID-19 disease treatments. (novartis.com)
We are donating hydroxychloroquine tablets for COVID-19 patients including for use in this and other clinical trials with the hope that researchers and healthcare workers can quickly and scientifically determine whether hydroxychloroquine can help patients around the world combat this disease," said Richard Saynor, CEO of Sandoz. (novartis.com)
Planning together, the researchers and CDC decided to conduct first a randomized, clinical trial comparing a once-weekly, rifapentine-based, continuation-phase regimen to the then-standard, twice-weekly, rifampin-based "Denver" regimen, both given for the last 4 months of the 6-month treatment for TB. (cdc.gov)
Clinical researchers can use mobile technologies to improve the trial process if they focus on patient-centric measures and engagement with regulators, according to the Clinical Trials Transformation Initiative (CTTI). (fdanews.com)
Researchers have begun a new stem cell clinical trial to treat patients with swallowing problems. (ucdavis.edu)

Trials are marked by critical issues such as low patient retention, low recruitment, countless inefficiencies and rising costs in drug development. (accenture.com)
Traditionally, clinical trial experiences and recruitment processes have been designed around the investigators and the pharmaceutical teams behind them. (accenture.com)
submitted robust plans for recruitment, management, and follow-up of patients. (cdc.gov)
For pharma companies, clinical trial recruitment is the primary bottleneck in the $100B+ drug development market now being reshaped by precision medicine treatment specificity, new trial models, diversity requirements, and digital health consumer expectations. (rocklandreviewnews.com)
With clinical trials, most early adopters will add some decentralized solutions to the traditional study design to support their patients, but widespread adoption across portfolios to drive recruitment and retention as part of a patient-centric model appears to be far off. (clinicalleader.com)
These trials take full advantage of technologies (apps, monitoring devices, etc.) and online social engagement platforms to conduct each stage of the clinical trial from the comfort of the patients home--including recruitment, informed consent, patient counseling, through to measuring clinical endpoints and adverse reactions. (appliedclinicaltrialsonline.com)
Patient recruitment and enrollment is often the longest stage of a clinical trial with almost 80% of trials failing to meet initial targets. (appliedclinicaltrialsonline.com)
The featured speakers will discuss the safety of staff and patients, ensuring studies are convenient for site staff to implement and simplifying recruitment communication to reduce site burden, among other topics. (prweb.com)
In many rare disease trials, recruitment relies heavily on their existing patient population. (prweb.com)

When they do attempt to participate, they're often confused and frustrated by unclear eligibility criteria and trial procedures. (accenture.com)
Randomized controlled trials can benefit from proactive assessment of how well their participant selection strategies during the design of eligibility criteria can influence the study generalizability. (nih.gov)
In this paper, we present a quantitative metric called generalizability index for study traits 2.0 (GIST 2.0) to assess the a priori generalizability (based on population representativeness) of a clinical trial by accounting for the dependencies among multiple eligibility criteria. (nih.gov)
This study exemplifies the promising use of Big Data in electronic health records and ClinicalTrials.gov for optimizing eligibility criteria design for clinical studies. (nih.gov)
Applying human-supervised AI, Carebox converts the unstructured text in ClinicalTrials.gov that describes eligibility criteria for enrollment, into a searchable index of clinical criteria for matching with patient characteristics. (rocklandreviewnews.com)
The Carebox Connect clinical trial database and matching technology make eligibility criteria for participation in the trial as searchable as those trial characteristics. (rocklandreviewnews.com)
Completing a condition questionnaire is typically the best way for patients to take advantage of the indexed eligibility criteria in the Carebox Connect trial database. (rocklandreviewnews.com)
For more sophisticated users, as an alternative to questionnaire completion, the Carebox Connect application pioneers "eligibility filters" that make it as easy to filter trials based on eligibility criteria - such as genomic marker, type and staging of disease, or treatment history - as it is to filter on the trial properties searchable on other clinical trial finders. (rocklandreviewnews.com)

C linical trials are the foundation of advancements in medical treatment but remain one of the pharmaceutical sector's most challenging and costly processes. (accenture.com)
While engaging stakeholders has been and continues to be the biggest barrier to optimizing clinical trials, a novel approach can be informed by similar successes in patient care and hospital treatment, as well as trends in consumer experiences beyond the healthcare realm. (accenture.com)
Clinical trials may also compare a new treatment to a treatment that is already available. (medlineplus.gov)
Will I Always Get the Experimental Treatment in a Clinical Trial? (medlineplus.gov)
Basel, April 20, 2020 - Novartis has reached an agreement with the US Food and Drug Administration (FDA) to proceed with a Phase III clinical trial with approximately 440 patients to evaluate the use of hydroxychloroquine for the treatment of hospitalized patients with COVID-19 disease. (novartis.com)
As the new virus continues to spread and claim lives around the globe, doctors and patients are eager for treatment options. (novartis.com)
Patients in all treatment groups are receiving standard of care for COVID-19. (novartis.com)
Blinding patients in clinical trials is a key methodological procedure, but the expected degree of bias due to nonblinded patients on estimated treatment effects is unknown. (nih.gov)
WOODCLIFF LAKE, N.J. , April 27, 2017 /PRNewswire/ -- Eisai Inc. announced today the presentation of results from a new meta-analysis of published clinical trials showing that the effect of adjunctive antiepileptic drug (AED) treatment versus placebo on primary generalized tonic-clonic (PGTC) seizures appears similar between adults and children (greater than or equal to four years old) living with epilepsy. (prnewswire.com)
The results support the extrapolation of AED efficacy data from adult to pediatric patients (greater than or equal to four years old) with PGTC seizures to predict treatment response. (prnewswire.com)
FYCOMPA (perampanel) is indicated as adjunctive therapy for the treatment of partial-onset seizures with or without secondarily generalized seizures and primary generalized tonic-clonic seizures in patients with epilepsy 12 years of age and older. (prnewswire.com)
The trial is a pivotal Phase 2/3 clinical study evaluating teplizumab, an investigational compound under development for the treatment of individuals with recent-onset type 1 diabetes. (science20.com)
There are currently more than 1,300 trials studying KEYTRUDA across a wide variety of cancers and treatment settings. (merck.com)
The KEYTRUDA clinical program seeks to understand the role of KEYTRUDA across cancers and the factors that may predict a patient's likelihood of benefitting from treatment with KEYTRUDA, including exploring several different biomarkers. (merck.com)
KEYTRUDA is indicated for the treatment of patients with unresectable or metastatic melanoma. (merck.com)
KEYTRUDA, Merck's anti-PD-1 therapy, plus best supportive care, for the treatment of patients with advanced hepatocellular carcinoma (HCC) who were previously treated with systemic therapy, did not meet its co-primary endpoints of overall survival (OS) and progression-free survival (PFS) compared with placebo plus best supportive care. (merck.com)
The study enrolled 413 patients who were randomized to receive either KEYTRUDA (200 mg fixed dose every three weeks for up to 35 cycles of treatment [up to approximately two years]) plus best supportive care (including pain management and management of other potential complications including ascites per local standards of care) or placebo plus best supportive care. (merck.com)
Carebox Connect™ empowers patients, families, and their physicians to find treatment options only available in clinical trials. (rocklandreviewnews.com)
Carebox connects patients, families, and their physicians\nwith treatment options only available in clinical trials. (rocklandreviewnews.com)
Carebox connects patients and physicians seeking treatment options with clinical trials. (rocklandreviewnews.com)
For patients and families, access to information about the newest and most advanced treatment options is obscured and frustrating to find. (rocklandreviewnews.com)
Our clinical trials, combined with our many services and treatments, combine to offer you more treatment options than anywhere else in Oregon. (ohsu.edu)
Our multispecialty team offers each patient a personalized treatment plan that addresses all symptoms and effects of the disease. (hopkinsmedicine.org)
Early diagnosis and effective treatment of TB among HIV-infected patients are critical for curing TB, minimizing the negative effects of TB on the course of HIV, and interrupting the transmission of Mycobacterium tuberculosis to other persons in the community. (cdc.gov)
All HIV-infected patients undergoing treatment for TB should be evaluated for antiretroviral therapy, because most patients with HIV-related TB are candidates for concurrent administration of antituberculosis and antiretroviral drug therapies. (cdc.gov)
Ideally, the management of TB among HIV-infected patients taking antiretroviral drugs requires a) directly observed therapy, b) availability of experienced and coordinated TB/HIV care givers, and in most situations, c) use of a TB treatment regimen that includes rifabutin instead of rifampin. (cdc.gov)
Because alternatives to the use of rifampin for antituberculosis treatment are now available, the previously recommended practice of stopping protease inhibitor therapy to allow the use of rifampin for TB treatment is no longer recommended for patients with HIV-related TB. (cdc.gov)
Physicians and patients also should be aware that paradoxical reactions might occur during the course of TB treatment when antiretroviral therapy restores immune function. (cdc.gov)
In the fight against pancreatic cancer, clinical trials often provide the best treatment options. (pancan.org)
He urges all patients to investigate their treatment options. (pancan.org)
UK FROST is a rigorously designed and adequately powered study to inform clinical decisions for the treatment of this common condition in adults. (springer.com)
Normal cervical biopsy, a normal Pap smear, and a negative human papillomavirus (HPV) test were seen in 14 of the 28 patients in the treatment group at 6-month follow-up, compared with 6 of the 17 patients in the observation group. (medscape.com)
After treatment, these patients require lifelong surveillance. (medscape.com)
SELECTION CRITERIA: We included randomized controlled trials which compared the treatment drug with placebo. (who.int)
We excluded trials which did not report a minimum follow-up period of six months from start of treatment. (who.int)
Thirty minutes after treatment, more than one third of the patients who received eptinezumab were also free of nausea, compared with about one quarter of those who received placebo. (medscape.com)
In nonmedication treatment news, results of a randomized, sham-controlled trial found that a noninvasive, self-administered neurostimulation device recently approved by the US Food and Drug Administration is safe, tolerable, and offers "highly effective" pain relief in acute migraine. (medscape.com)
The study found that 46% of patients with acute migraine achieved complete freedom from pain 2 hours after treatment with combined occipital and trigeminal nerve stimulation (COT-NS) vs 11.8% of those assigned to sham stimulation. (medscape.com)
And describe antiviral testing and treatment recommendations for patients with suspected and confirmed influenza. (cdc.gov)
Her projects focus on studies of influenza and antiviral treatment, and antiviral effectiveness, vaccine effectiveness, pandemic preparedness, and development of CDC clinical guidance related to treatment and prevention of seasonal and novel influenza viruses. (cdc.gov)
You recently published a meta-analysis of decompressive craniectomy treatment for MCI in the journal Neurology Clinical Practice . (medscape.com)
With the caveat that the expected outcomes after decompressive craniectomy are in line with the treatment goals of the patient and family, the indications for decompressive craniectomy are typically major middle cerebral artery stroke with subsequent cerebral edema, leading to decreased level of consciousness and the expectation of further progression of edema and neurologic deterioration. (medscape.com)
To that end, the National ALS Registry had developed a Continuing Education course to teach healthcare providers how to recognize ALS symptoms, how to better communicate the next steps in treatment and care with the patient, and how to talk about the importance of the Registry and enrollment. (cdc.gov)
Treatment with topic and systemic antimycotic drugs (fluconazole or itraconazole) results in temporary recovery, but is unable to reach complete remission. (lu.se)
In recent years, clinical trials have established targeted therapy as the first-line treatment in patients with metastatic disease. (medscape.com)
These agents have largely replaced cytokines (immunotherapy) in treatment-naive patients. (medscape.com)
Clinical trials are currently exploring possible future directions in treatment. (medscape.com)

After a stint as executive director of CTTI (Clinical Trials Transformation Initiative), a partnership between Duke University and the FDA, Tenaerts joined Medable in 2021. (outsourcing-pharma.com)
TORONTO , April 15, 2021 /PRNewswire-PRWeb/ -- Although a well-recognized diagnostic endpoint in clinical care and drug development, blood pressure assessment continues to be an important topic of discussion in drug development. (prweb.com)
They were presented on May 28 during the American Association of Clinical Endocrinology (AACE) Virtual Annual Meeting 2021 and simultaneously published in Endocrine Practice . (medscape.com)
TORONTO, Ontario , Feb. 10, 2021 /PRNewswire-PRWeb/ -- Investigative sites are fundamental to the success of clinical trials. (prweb.com)
Trending Clinical Topic: Migraine - Medscape - Jul 02, 2021. (medscape.com)

Is it to: (a) replicate the top-line analyses from randomized clinical trials of novel therapeutics? (medscape.com)
We are covering topics on tissue 3D bioprinting, clinical trials in silica, quantum computing in product development, blockchain-powered patient management portals, nanotechnologies, and digital therapeutics. (tunein.com)

Data from KEYNOTE-177 were presented at the virtual scientific program of the 2020 American Society of Clinical Oncology Annual Meeting and were published in The New England Journal of Medicine . (merck.com)
During 2010-2020, TBTC's international presence expanded from a few clinical study sites located outside of North America, to sites in Peru, Spain, South Africa (two sites), Uganda, Kenya, Vietnam, and China (Hong Kong). (cdc.gov)

The average difference in effect size for patient-reported outcomes was -0.56 (95% confidence interval -0.71 to -0.41), (I(2)=60%, P=0.004), i.e. nonblinded patients exaggerated the effect size by an average of 0.56 standard deviation, but with considerable variation. (nih.gov)
Two of the 12 trials also used observer-reported outcomes, showing no indication of exaggerated effects due lack of patient blinding. (nih.gov)
This study provides empirical evidence of pronounced bias due to lack of patient blinding in complementary/alternative randomized clinical trials with patient-reported outcomes. (nih.gov)
As confirmed by previous studies, the brief multifamily program (consisting of six sessions over a period of 1.5 months) was found to be effective in improving outcomes for caregivers (e.g., burden, depression, knowledge) and patients (e.g., preventing relapse) in the context of routine care. (frontiersin.org)
For patients, family psychoeducation has been effective in improving outcomes in schizophrenia with a better level of global functioning, medication adherence, and a reduction in the use of healthcare resources and the frequency of relapse ( 6 - 8 ). (frontiersin.org)
UNMC continuing education is raising the skill level and knowledge among Nebraska's health care professionals, improving patient outcomes and community health. (unmc.edu)
The technology can collect a diverse range of study data - including patient reported outcomes, smartphone sensor data, contextual data sets (UV index, urban air pollution, location), and medical and wearable device data. (outsourcing-pharma.com)
Each of the six trials showed that decompressive craniectomy improves survival and functional outcomes. (medscape.com)
Our first question was: Does decompressive craniectomy for patients with MCI improve the likelihood of attaining functional outcomes with a consensus that the quality of life is worth living? (medscape.com)

It's time to redesign the clinical trial experience by embracing a more patient-centered philosophy, one where patients are as informed, actively involved and invested in the process as investigators, sponsors and healthcare professionals (HCPs) are. (accenture.com)
If you are a patient, please refer your questions to your healthcare provider. (cdc.gov)

Because of delays in implementing the EU regulation, the UK's compliance with future EU clinical trials rules will likely be subject to negotiation, as the country plans to only immediately implement EU regulations that were in place ahead of the planned March 2019 exit from the EU, according to a UK government official. (fdanews.com)

In addition, there are several ongoing trials investigating KEYTRUDA in combination with other treatments, including therapies through our collaborations. (merck.com)
They offer patients a chance to try promising new treatments or approaches. (ohsu.edu)
The FDA invited comments from stakeholders on a new draft guidance for clinical trial designs and drug development programs to support indications for uncomplicated urinary tract infection (uUTI) treatments. (fdanews.com)
It is no secret that clinical trials play a crucial role in determining the safety and effectiveness of new medical treatments, Tenaerts tells Outsourcing-Pharma. (outsourcing-pharma.com)
Spark the scientific breakthroughs that innovate treatments to improve the lives of patients. (pancan.org)
We will explore the acceptability of the different treatments to patients and health care professionals using qualitative methods. (springer.com)

We conduct trials of new therapies and diagnostic methods. (hopkinsmedicine.org)
The focus of this webinar is on the Lessons Learned from IND/Phase I trials including overcoming the challenges, and addressing the regulatory issues, as stem cell based therapies move towards the clinic. (ca.gov)
This will increase patient access to therapies. (ucdavis.edu)
CIRM awarded UC Davis' Alpha Stem Cell Clinic an $8 million grant renewal to expand its successful clinical trials operation and advance toward onsite manufacturing of therapies. (ucdavis.edu)

We appreciate the dedication of the patients, their caregivers and clinical investigators who helped advance this important late-stage clinical trial. (science20.com)
Schizophrenia is recognized for its severe impact on both patients and caregivers. (frontiersin.org)
A total of 25 days of patients with schizophrenia (DSM-IV-TR) and family primary caregivers were recruited in a single regional psychiatric outpatient facility located in Bordeaux. (frontiersin.org)
Schizophrenia is a chronic and severe mental disorder which has serious consequences for both the patient and caregivers. (frontiersin.org)
Therefore, family intervention should be developed to reduce the burden of caregivers and enhance patients' prognosis. (frontiersin.org)
They have a deep understanding of the disease area and the challenges it presents to the patient and their caregivers. (prweb.com)

The systematic meta-analysis was performed to evaluate the feasibility of extrapolating AED efficacy data from published clinical trials conducted in adults to pediatric patients with PGTC seizures. (prnewswire.com)
The PROTEGE trial is a randomized, double-blind, multi-center, multi-national, 4-arm, controlled study designed to evaluate the safety and efficacy of teplizumab in individuals with recent-onset type 1 diabetes, aged 8 to 35, who are within 12 weeks of their diagnosis. (science20.com)
Longer term safety and efficacy data from patients who complete the PROTEGE trial are being collected in a separate Phase 3 study called the PROTEGE Extension trial. (science20.com)
The companies also announced today that they have initiated the PROTEGE ENCORE trial, another Phase 3 global study of teplizumab in individuals with recent-onset type 1 diabetes, designed to capture patient-reported outcome measures in addition to safety and efficacy data. (science20.com)
In a 12-month follow-up randomized clinical trial, we aimed to measure the efficacy of a brief family psychoeducation program in terms of reducing relapse risk and improving medication adherence in patients, as well as reducing caregiver burden, depression and increasing knowledge of the illness. (frontiersin.org)
The clinical trial will let us know the efficacy of this molecule on COVID-19 patients. (livemint.com)
Such was the lack of support for CDC's clinical trials program that a key CDC trial (USPHS Study 21, which confirmed for U.S. TB programs the efficacy of 6-month short-course therapy) was nearly terminated for lack of adequate funding. (cdc.gov)
Effective interventions are needed to improve health, and efficacy is best assessed by randomised controlled trials. (bmj.com)

Because no matter how challenging this feat may be, there may be benefits-for all parties-to changing up traditional means of conducting clinical trials. (patheon.com)

When patients enroll in clinical trials, to date, we have specified in the consent forms that the data would be shared only with a very small group of individuals. (medscape.com)
The convenience of a virtual methodology alone will increase numbers of patients willing and able to enroll. (appliedclinicaltrialsonline.com)

Whether you're a large or small biopharma company, if there is one trend that should have you rethinking how you approach clinical trials, it is the shift to patient-centricity. (patheon.com)
The trend of patient-centricity isn't just a shift for clinical trials either-it's a fundamental change to the entire life science industry. (patheon.com)
Patient-centricity is a total mindset change, and can mean different things to different people, making it sometimes important to outline and define what patient-centricity is not . (patheon.com)
According to an article by Deloitte- Striving to become more patient-centric in life sciences -there isn't "one standard definition of patient-centricity. (patheon.com)
And while companies may even call "patient-centricity" other things-such as: patient engagement, patient-focused, etc.-most industry leaders tend to agree what isn't patient-centric. (patheon.com)
Patient-centricity is a mindset and behavioral change-it should drive your processes and systems in such a way that improving the patient experience is at the center of everything you do. (patheon.com)
How Do We Conduct Clinical Trials and Maintain Patient-Centricity? (patheon.com)
The reality checks this pandemic has presented us, leaves biopharma and life science companies no choice but to reevaluate how they conduct clinical trials and maintain patient-centricity. (patheon.com)

MacroGenics, Inc. and Eli Lilly and Company (NYSE: LLY) today announced that the PROTEGE trial achieved its targeted patient enrollment. (science20.com)
Yes, the subject/administer relationship does help make clinical trials more patient-friendly, can quicken enrollment, and get drugs to market faster, but this doesn't make your clinical trials necessarily patient-centric. (patheon.com)
The most obvious advantage is that the virtual trial design maximizes patient availability and enrollment in the study. (appliedclinicaltrialsonline.com)
Establishing the site as your partner early in the trial process, seeking opportunities to reduce site staff/patient burden, and providing appropriate support tools and personnel will aid enrollment. (prweb.com)

Are Clinical Studies for You? (medlineplus.gov)
Requests for investigator-initiated trials have been granted for COVID-19-related clinical studies of ruxolitinib, canakinumab, imatinib mesylate, secukinumab, hydroxychloroquine and valsartan. (novartis.com)
The drug hydroxychloroquine has garnered interest in the medical community after showing preliminary promise in small clinical studies, including one with co-administration with the antibiotic azithromycin. (novartis.com)
Within each trial, we compared the difference in effect sizes (i.e. standardized mean differences) between the sub-studies. (nih.gov)
A recent systematic review including 11 studies demonstrates consistent improvement in many outcome measures of patients, such as relapse rates and medication adherence, but heterogeneity in symptoms reliefs ( 9 ). (frontiersin.org)
Its effectiveness has also been demonstrated for individuals at clinical high risk for psychosis although rigorous further studies are required ( 10 ). (frontiersin.org)
The safety profile of KEYTRUDA in this trial was consistent with that observed in previously reported studies. (merck.com)
Clinical trials are studies involving human subjects that test a new way to prevent, detect, treat or manage an illness or injury. (ohsu.edu)
What I want to get, Michelle, is your perspective coming from a clinical trials organization that leads a lot of these studies. (medscape.com)
Most retrospective studies have shown equivalent survival rates for trachelectomy and hysterectomy, though such studies usually are flawed because of patient selection bias and other compounding factors. (medscape.com)
Reference lists of identified studies, clinicaltrials.gov and the WHO International Clinical Trials Registry were also searched. (lu.se)
RESULTS: Ten randomized trials were identified among 150 studies screened. (lu.se)
Studies presented at the recent American Headache Society (AHS) Annual Meeting resulted in this week's top trending clinical topic. (medscape.com)

We will conduct a randomised controlled trial (RCT) of 500 adult patients with a clinical diagnosis of frozen shoulder, and who have radiographs that exclude other pathology. (springer.com)

So, every aspect of how we interact with patients should be challenged and it's important for biopharma companies to be agile and reassess how they conduct clinical trials, in various iterations. (patheon.com)
Mumbai-based Glenmark Pharmaceuticals today said has received approval from the Drug Controller General of India to conduct clinical trials of antiviral drug favipiravir on coronavirus patients. (livemint.com)

Another Indian pharmaceutical company, Strides Pharma Science Ltd , said on Wednesday it had developed and commercialized favipiravir antiviral tablets, and had applied to the authorities to start trials. (livemint.com)
Medable has partnered with several pharma industry giants, with GlaxoSmithKline (GSK) recently selecting its DCT platform to use across its portfolio, indicating a wider industry shift towards hybrid and decentralized trial models. (outsourcing-pharma.com)
Making a Killing: Clinical trials have become marketing exercises for Big Pharma - and cash-strapped universities are helping make the sale. (narpa.org)
We are also covering topics on leadership in the new pharma paradigm post-COVID-19 and what it will mean to function in the new virtual world we find ourselves in. (tunein.com)

We have seen that technology has the potential to make clinical trials much better and more productive," Tenaerts says. (outsourcing-pharma.com)

Moving toward a participant-centric clinical development process could begin by surveying, investigating and understanding the needs and values of patients, investigators, sponsors and other stakeholders. (accenture.com)
We sincerely thank the patients and investigators for their participation in this study and are committed to helping patients diagnosed with this common and difficult-to-treat type of liver cancer. (merck.com)
Data from remote monitoring devices could be accessed by trial investigators in real time, opening up possible efficiencies in data cleaning, which could move to an on-going process rather than cyclical. (appliedclinicaltrialsonline.com)

Even though clinical trial patients and patient advocacy groups have expressed their desire for decentralized options, these solutions can be seen as back-up options or "nice to haves" in case other tried and tested approaches fail to deliver or in other exceptional circumstances, such as a worldwide pandemic stopping the clinical trial industry in its tracks, it is the exception, not the norm. (clinicalleader.com)
Finally, the virtual trial design may allow groups who have a vested interest in the success of the trial (including investors, physicians, government agencies, patient advocacy groups and even the patients themselves) to have more opportunities to play an active role in the study, potentially leading to better data quality and shorter timelines. (appliedclinicaltrialsonline.com)

Ethical variability -- Arts of drug development -- The global clinical trial -- Pharmaceuticals and the right to health. (who.int)

Comments on Medscape are moderated and should be professional in tone and on topic. (medscape.com)

Clinical trial search tools are not all created equal," explains Carebox VP of Medical Affairs Rob Rutigliano, Ph.D. "Most only allow users to search based on condition, location, and basic trial characteristics like the phase of the trial. (rocklandreviewnews.com)
Search for topics. (lls.org)
SEARCH STRATEGY: We searched the Cochrane Tobacco Addiction Group's specialised register for trials, using the terms ('varenicline' or 'cytisine' or 'Tabex' or 'nicotine receptor partial agonist') and 'smoking' in the title or abstract, or as keywords. (who.int)
When experiments travel : clinical trials and the global search for human subjects / Adriana Petryna. (who.int)

Then, patient participation and retention would rise while dropout rates and costs would decrease. (accenture.com)
The company's technology enables remote participation, so patients can take part in trials without needing to travel to a clinic every time they need to be tested. (outsourcing-pharma.com)

We believe that a fundamental contributor to the challenges of patient engagement and retention faced by the sector is a faulty perspective. (accenture.com)
However, she says they have long been plagued by inefficiency, high costs, poor patient retention and lack of diversity, among other issues. (outsourcing-pharma.com)
Virtual clinical trials could remove the need for frequent travel to study sites and automate data collection, increasing patient engagement and retention. (appliedclinicaltrialsonline.com)

It is estimated approximately 5-15% of colorectal cancer patients have tumors that score as either MSI-H or dMMR when testing is performed. (merck.com)
DNA fragments circulating in patients' blood can reveal the presence of tumors long before CT scans and lead to more agile use of cancer drugs. (ucdavis.edu)

The meta-analysis examined median percent reduction in seizure frequency and the percentage of people whose seizures were reduced by 50 percent or more in seven trials involving adult, adolescent and pediatric patients with PGTC seizures. (prnewswire.com)

Included in the meta-analysis are the results from a global Phase 3 clinical trial of perampanel (marketed as FYCOMPA® CIII) administered as an adjunctive therapy in patients with epilepsy 12 years of age and older with PGTC seizures. (prnewswire.com)
By using data from a 2015 clinical trial on Ebola convalescent-phase plasma in Guinea, we assessed the prevalence of electrolyte and metabolic abnormalities at admission and their predictive value to stratify patients into risk groups. (cdc.gov)
As monotherapy in second-line HCC, in addition to KEYNOTE-240 and KEYNOTE-224, KEYTRUDA is being investigated in the ongoing Phase 3, KEYNOTE-394 trial, a randomized, double-blind trial evaluating KEYTRUDA in combination with best supportive care, compared to placebo in combination with best supportive care, in Asian patients with advanced HCC who were previously treated with systemic therapy. (merck.com)
As many as 40% of Phase III trial subjects become disengaged and drop out of the study. (appliedclinicaltrialsonline.com)
As reported in the Journal of Clinical Oncology by Goto et al, primary results of the phase II DESTINY-Lung02 trial have shown activity of fam-trastuzumab deruxtecan-nxki (T-DXd) in patients with HER2-mutant metastatic non-small cell lung cancer (NSCLC) previously treated with platinum-containing. (ascopost.com)
In a 5-year analysis of the Japanese phase III JIPANG trial reported in the Journal of Clinical Oncology, Kenmotsu et al found no significant differences in overall or recurrence-free survival with adjuvant pemetrexed/cisplatin vs vinorelbine/cisplatin in patients with stage II-IIIA nonsquamous. (ascopost.com)
In the phase II HERTHENA-Lung01 trial reported in the Journal of Clinical Oncology, Helena Yu, MD, and colleagues found that patritumab deruxtecan (HER3-DXd), a new anti-HER3 antibody-drug conjugate, showed activity in patients with EGFR-mutated advanced non-small cell lung cancer (NSCLC). (ascopost.com)

Now, the newly launched Carebox Connect application brings the power of the platform and over two decades of experience in navigating patients searching for clinical trials globally directly to patients. (rocklandreviewnews.com)

In addition to hydroxychloroquine, Novartis plans to sponsor or co-sponsor clinical trials to study ruxolitinib and canakinumab for hospitalized patients with COVID-19 infections. (novartis.com)
Systematic review of randomized clinical trials with one sub-study (i.e. experimental vs control) involving blinded patients and another, otherwise identical, sub-study involving nonblinded patients. (nih.gov)
Just about being better engaged with patients as study subjects. (patheon.com)
According to a Patient Engagement Leader from the Deloitte article, engaging with "patients about clinical trials is not patient-centric if you are just doing the study you want, looking at what you think is important. (patheon.com)
Decentralized trials allow patients to engage with their trials at home for most-if not all-of the study, so it's no surprise that decentralized trials are one of the hottest topics in the biopharma industry. (patheon.com)
As per the clinical trial protocol approved, 150 subjects with mild to moderate COVID-19 will be randomized in the study in a 1:1 ratio to Favipiravir with standard supportive care or standalone standard supportive care. (livemint.com)
This trial, called USPHS Study 22, began in 1995, enrolled 1,075 TB patients from the United States and Canada, and reported final results in 2002. (cdc.gov)
Meeting topics cover rapid publication or how many study authors are representative of the study group. (medscape.com)
The presentation will highlight the identification of design and analysis considerations for a study to define the potential BP signal, and also provide case study experience in implementing BP monitoring in clinical trials across different trial phases. (prweb.com)
Register for this session to hear a review of trial design considerations and technology/BP methodology selection using a case study approach. (prweb.com)
There are a number of advantages that virtual trials have over the traditional model, which uses multiple study sites and requires multiple patient visits to the site in order to conduct the study protocol. (appliedclinicaltrialsonline.com)
While virtual trials still require the study site to house support staff and invest in data collection and analysis platforms, they are potentially significantly more cost effective because they don't require the traditional brick-and-mortar set-up of multiple study sites. (appliedclinicaltrialsonline.com)
Another advantage to virtual trials is their potential to keep subjects engaged with the study. (appliedclinicaltrialsonline.com)
2 Some of the causes of this attrition are related to convenience--due to issues like the inconvenience of traveling to study sites, or the complexity of the trial design and data collection. (appliedclinicaltrialsonline.com)
The primary aim of this study is to assess colon and rectal surgery patient perceptions of physical fitness, willingness to participate in a prehabilitation program, access to cardiovascular and strength training equipment, and impact of the COVID19 pandemic on fitness and health. (mayo.edu)
As the epicenter of clinical trial execution, providing sites with complementary support enables them to execute the study at the highest level. (prweb.com)
The study included patients aged 18-65 years, 85% of whom were women. (medscape.com)
Genomic alteration using adenine base editors demonstrated the most potency in restarting fetal hemoglobin expression in cells of patients with sickle cell disease, study results showed. (cdc.gov)

Lack of patient blinding also increased attrition and use of co-interventions: ratio of control group attrition risk 1.79 (1.18 to 2.70), and ratio of control group co-intervention risk 1.55 (0.99 to 2.43). (nih.gov)
The use of placebos in controlled trials of surgical interventions: a brief history. (jameslindlibrary.org)
Our aim is to evaluate the clinical and cost-effectiveness of two invasive and costly surgical interventions that are commonly used in secondary care in the National Health Service (NHS) compared with a non-surgical comparator of Early Structured Physiotherapy. (springer.com)
From searching the Health Technology Assessment (HTA) website and the ISRCTN register, there was no large-scale, multi-centre, randomised controlled trial (RCT) of interventions for primary frozen shoulder being undertaken. (springer.com)

Xtalks has created an eBook for Top Trending Life Science Topics for 2022 which offers a strong overview of the current year and a much needed future outlook of the sector. (xtalks.com)
With ~10% of clinical trials started between 2014 and 2022 incorporating DCT elements, why is the adoption of something that appears so beneficial not more widely adopted? (clinicalleader.com)

Lung cancer patient who was told seven years ago nothing more could be done, celebrates his 100th dose on clinical trial. (ucdavis.edu)
In patients with advanced non-small cell lung cancer (NSCLC) harboring EGFR mutations, the role of immune checkpoint inhibitors following disease progression with tyrosine kinase inhibitors has been unclear. (ascopost.com)
The biomarker-driven Lung Cancer Master Protocol (Lung-MAP) may have enrolled a higher percentage of patients who are older, are from rural or socioeconomically deprived areas, and have Medicaid or no insurance compared with conventional, standalone clinical trials in advanced non-small cell lung. (ascopost.com)

Sclerotherapy for male alcoholic cirrhotic patients who have bled from esophageal varices: Results of a randomized, multicenter clinical trial. (jameslindlibrary.org)

1179 eligible randomised controlled trials were identified. (bmj.com)

Patients underwent testing with a point-of-care device. (cdc.gov)
ClinicalTrials.gov, NCT02702401 ) evaluating KEYTRUDA plus best supportive care compared to placebo plus best supportive care in patients with advanced HCC who were previously treated with systemic therapy. (merck.com)
Pursuing discoveries to improve scientific understanding and patient care is one of our core missions. (ohsu.edu)
Talk with your care team about whether a clinical trial is right for you. (ohsu.edu)
Cancer Care Delivery Among Breast Cancer Patients: Is it the Same for All? (springer.com)
Disparities continue to impact this population in critical areas: access to preventive and clinical care, changeable risk behaviors, quality of life, and mortality. (springer.com)
The Johns Hopkins Pancreatitis Center is dedicated to providing the best care to patients with acute and chronic pancreatitis and related problems. (hopkinsmedicine.org)
To help stimulate new knowledge relevant to primary care practice, the Annals is issuing a call for manuscripts on clinical topics. (annfammed.org)
Topics should relate to care of patients in the primary care setting. (annfammed.org)
and clinical trials conducted in primary care settings. (annfammed.org)
The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. (ingentaconnect.com)
So we really think it's critical for clinical care. (medscape.com)
Learn about our patient and family-centred care model. (sickkids.ca)
Our care extends across a wide range of clinical specialties. (sickkids.ca)
The only health care provider many patients have access to is their primary care provider and many are not well equipped to address ALS diagnoses and the help with care and recommendations afterwards. (cdc.gov)
Targeted therapy and immunomodulatory agents are considered standard of care in patients with metastatic disease. (medscape.com)

This statistic depicts the main reasons patients do not participate in clinical trials after reviewing informed consent forms as of 2017. (statista.com)

That's because when patients are linearly advanced through trials as experimental subjects, it's easy to lose the human element that is so critical to success. (accenture.com)
Also, electronic health records can help identify increasingly targeted trial subjects and online patient support networks which could be used more to raise awareness of trials and directly recruit subjects. (appliedclinicaltrialsonline.com)

The new guidance has taken DCT's to another level of validation, by having the backing of such an important body in the US and around the world saying that we support DCT's as an effective mechanism to conduct trials," Tenaerts says. (outsourcing-pharma.com)
The development of the draft FDA pressor effect guidance evolved out of industry and regulatory discussions with the goal of enhancing patient safety. (prweb.com)
Previous AACE guidance on the clinical use of insulin pumps and CGM over the past decade has been published in the form of consensus or position statements rather than official evidence-based guidelines, task force cochair George Grunberger, MD, of the Grunberger Diabetes Institute, Bloomfield Hills, Michigan, explained. (medscape.com)

Should I Participate in a Clinical Trial? (medlineplus.gov)
Patients have opportunities to participate in clinical trials in many health disciplines at RUSH. (rush.edu)
Learn about clinical trials, and how you can participate, through the University of Nebraska Medical Center. (unmc.edu)
There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. (mayo.edu)

The metric was evaluated on 16 sepsis trials identified from ClinicalTrials.gov, with their adverse event reports extracted from the trial results sections. (nih.gov)
In another development, preliminary results from a US government trial showing that patients given Gilead Sciences Inc's experimental antiviral drug remdesivir recovered faster than those given a placebo. (livemint.com)

As a baseline, the Carebox Connect trial database is synchronized daily with the ClinicalTrials.gov clinical trial data maintained by the National Library of Medicine (NLM) at the National Institutes of Health (NIH). (rocklandreviewnews.com)
RUSH offers classes and events across a wide range of health topics. (rush.edu)
RUSH offers a library of videos on a variety of health topics in our Digital Patient Education Center. (rush.edu)
Randomised controlled trials conducted in Africa have not been comprehensively assessed, and it is not known whether the trials cover the local health needs. (bmj.com)
We considered all randomised controlled trials conducted in sub-Saharan Africa that investigated one or more health problems. (bmj.com)
In fact, the National Institute of Health estimates that 85% of all clinical trials experience significant operational delays, with 94% being delayed by over a month. (outsourcing-pharma.com)
Gil feels lucky to be here, and his good health is due, in part, to a clinical trial. (pancan.org)
As Canada's largest and most respected paediatric academic health sciences centre, we deliver comprehensive services across a wide range of clinical specialties. (sickkids.ca)
So flu surveillance on the national level is really a collaborative effort between those of us at CDC, and also our public health partners at the state and local level and territories, and also numerous other data providers, many of whom are at the clinical level. (cdc.gov)
Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. (cdc.gov)

Those in the trial who did not receive stem cells did not see any scaring improvements at all. (blogspot.com)
After suffering a serious heart attack two years ago, Ken Miles volunteered to be patient No. 1 in a risky clinical trial involving stem cells. (blogspot.com)

The use of risk-based monitoring in clinical trials is expected to climb - with many sponsors planning to implement policies for the first time over the next two years - driven by the need to reduce oversight costs and mitigate risks. (fdanews.com)

The following numbers show that patient engagement is clearly a challenge. (accenture.com)
Virtual Clinical Trials: The Future of Patient Engagement? (appliedclinicaltrialsonline.com)
Virtual clinical trials use tech devices and social engagement platforms to conduct trials from a patient's home. (appliedclinicaltrialsonline.com)

He was treated by Dr. Stephen C. Olson, an associate professor in the university's psychiatry department, who prescribed Dan Risperdal (risperidone), an antipsychotic drug often prescribed for patients with schizophrenia or bipolar disorder. (narpa.org)
Child and youth counsellors support patients and families in the psychiatry and eating disorder units. (sickkids.ca)

We found one relapse prevention trial, comparing varenicline with placebo. (who.int)
AXS-07 also significantly reduced functional disability, with 74% of patients who received the drug reporting no disability at 24 hours, compared with 47% of patients who received placebo. (medscape.com)
RELIEF, a randomized controlled trial , showed that those who received the drug were more likely to be free of pain (9.7%) and their most bothersome symptom (33.2%) at 1 hour, compared with those who received placebo (4.1% and 22.1%, respectively). (medscape.com)

The seven trials reviewed included one trial in adolescents and children, two in adults and children, two in adolescents and adults, and two in adults-only. (prnewswire.com)

This presentation will focus on the implementation of BP monitoring in clinical trials with specific attention to the considerations to monitoring blood pressure as a safety "Off-target" endpoint. (prweb.com)
Included in the webinar will be a review of the BP monitoring options that have been implemented in clinical trials including: Ambulatory Blood Pressure Monitoring (ABPM), Automated Office Blood Pressure Monitoring (AOBPM) and remote telemonitored home blood pressure (BP). (prweb.com)
Remote monitoring capabilities could thus facilitate an adaptive clinical trial approach, allowing improvements in trial design based on the accumulating data. (appliedclinicaltrialsonline.com)

it's about understanding a patient's illness as well as their everyday life and empathetically viewing the effects of clinical trial interactions at every level. (accenture.com)
Patients showing signs of systemic illness should be excluded, as well as patients being treated with other antibacterial drugs effective in treating uUTI. (fdanews.com)

Decentralized" trials (also known as hybrid, remote, or virtual trials) is an umbrella term - covering a broad range of services and solutions that can be mixed and matched depending on the circumstances, preferences and requirements of the patients, clinical sites and sponsors. (clinicalleader.com)
Virtual trials also offer the ability to reduce risk in the drug development process. (appliedclinicaltrialsonline.com)

As one of the members of what I would call North America's leading clinical trials units, you have a lot of interest in this subject of data sharing, open data, and transparency. (medscape.com)
Rather than restate known data, our meta-analysis attempted to ask and answer questions in a way that could provide clinical clarity. (medscape.com)

Diseases23

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment100

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