Patients cancers gene rearrangement. Medical search. Frequent questions

however, RAS mutations are rare in breast cancer, despite frequent hyperactivation of Ras and ERK. (harvard.edu)
Subsequently, genetic testing for EGFR (epidermal growth factor receptor) mutations and ALK (anaplastic lymphoma kinase) gene rearrangements - which are targeted by the newer treatments - increased substantially. (nih.gov)
There are a host of treatments available for non-small cell lung cancer (NSCLC) these days, and for patients, perhaps the most crucial step in choosing one is to make sure a pathologist genetically sequences the tumor, so that doctors will know which mutations are driving the cancer. (curetoday.com)
This is vital because there is a growing array of targeted drugs, both approved by the Food and Drug Administration (FDA) and experimental, that are capable of honing in on specific gene mutations to stop their detrimental activity. (curetoday.com)
There are targeted drugs designed to stop the dangerous activity of a number of rare, cancer-causing mutations, including rearrangements of the ROS1, ALK, RET and TRK genes and mutations of the MET or EGFR genes. (curetoday.com)
What should people know about non-small lung cancers that are driven by MET mutations? (curetoday.com)
Additionally, Dr. Costa served as a co-Investigator in the NIH Clinical Genome Resource (ClinGen) Consortium, and led the engineering and product management teams developing FDA-recognized medical software applications used by healthcare providers, researchers, and biotechnology companies to define the clinical relevance of genes and pathogenicity of mutations identified in patients. (stanford.edu)
Identification of individuals with mutations that make them more likely to develop certain cancers can allow them to take steps to prevent cancer or find it early if it develops, leading to improved health outcomes. (cdc.gov)
ALK fusion and its association with other driver gene mutations in Finnish non-small cell lung cancer patients. (genomeweb.com)
Gene changes are also called gene variants or mutations . (medlineplus.gov)
Such leukemias are cancers of white blood cells, in which genetic mutations trigger overproduction of immature cells, called lymphoblasts. (news-medical.net)
To identify point mutations, the researchers also performed DNA re-sequencing of 25 genes that are commonly mutated in adult AML. (scienceblog.com)
Cancer results from a combination of spontaneous mutations that arise with age-just call it "bad luck"-and environmental exposures to carcinogens such as tobacco, ultraviolet light or viruses. (scientificamerican.com)
But if a cancer is mostly the result of random mutations, then little can be done to prevent it, and efforts might instead focus on early detection and treatment. (scientificamerican.com)
In the study, appearing in Molecular Biology and Evolution on April 26, the researchers used this method to investigate the causes of point mutations in 24 major cancer types . (scientificamerican.com)
For each type, they were able to estimate how many cancer-driving mutations were linked to "bad luck. (scientificamerican.com)
Confirming epidemiological studies, they found that melanomas and lung, bladder and cervical cancers are largely attributable to exposure to carcinogens such as UV light, tobacco or human papillomavirus, whereas brain and spinal cord tumors called gliomas and prostate tumors called adenocarcinomas are mostly the result of intrinsic mutations that accumulate with age. (scientificamerican.com)
The study "is a step forward because it's allowing a better assessment of the particular contribution of the agent- smoking, UV, et cetera-toward the actual driving mutations," says James DeGregori , a cancer researcher at the University of Colorado School of Medicine, who was not involved with the study. (scientificamerican.com)
Let's say you have a lung cancer with five driver mutations-you can say, 'These three clearly have the smoking signature, so they were directly caused by the smoking. (scientificamerican.com)
There have been a lot of sidetracks taken over the years," says cancer researcher and oncologist Rameen Beroukhim of the Dana-Farber Cancer Institute, who was not involved with the new study, because people assumed that frequently mutated genes in a given cancer type must be contributing to the development of the cancer-only to find out that those mutations were just passengers. (scientificamerican.com)
It has been important to understand the signatures of different mutational processes, but therapeutically, what Beroukhim and his colleagues are interested in is the small subset of mutations that are causing the cancer to grow. (scientificamerican.com)
Townsend says his team's new approach can be used to pin down the proximate causes of the driving mutations in a given patient's tumor and thus provides a more precise answer to one of the most difficult questions that patients and doctors struggle with after a cancer diagnosis: "Why me? (scientificamerican.com)
One caveat of the study is that the researchers focused only on mutations in single letters, or nucleotides, of DNA, not large rearrangements of chromosomes or increases in copies of a gene that frequently occur in cells as they become cancerous. (scientificamerican.com)
Durrett, R. Population genetics of neutral mutations in exponentially growing cancer cell populations. (nature.com)
TERT promoter mutations, TERT gene amplifications and rearrangements) and epigenetic (e.g. (mdanderson.org)
However, despite the progress in developing new targeted agents and increased knowledge of cancer genomics, the majority of cancers do not harbour mutations that can readily be linked to currently approved or investigational oncology drugs. (ddw-online.com)
A team that included St. Jude Computational Biology Chair Jinghui Zhang, PhD, discovered that mutations in a single gene drive this type of melanoma. (stjude.org)
An offshoot of German contract research and analytics firm Blackfield, New Oncology currently offers a targeted sequencing assay called NeoPlus, which profiles more than 70 cancer-associated genes for point mutations, gene amplifications, gene fusions, and other rearrangements using a target amplification and sequencing strategy. (genomeweb.com)
According to the company, the test will allow detection not only of point mutations, but also of therapeutically relevant gene fusions, for example, those affecting ALK, ROS, or RET kinases. (genomeweb.com)
Cancer biology is complex, so an alternative would be to perform multiple gene assays that could establish the somatic mutational profile of a tumour, and subsequently check if any of the mutations could be addressed therapeutically with agents targeting those specifically defined mutations (for example, BRAF, EGFR, KRAS etc. (hospitalhealthcare.com)
Numerous NGS-based tests are being developed by both companies and academic labs and these can test for point mutations, short insertions and deletions, copy number alterations and also genomic rearrangements in a wide range of genes known to be somatically mutated in cancer, using paraffin-embedded tissues and in clinically relevant turnaround times in a scalable manner depending on the specific needs. (hospitalhealthcare.com)
Somatic mutations of TP53 are among the most common in cancer and germline mutations of TP53 (usually missense) can cause Li-Fraumeni syndrome (LFS). (oncotarget.com)
Despite these advances, additional mutations seem to develop in the lung cancer cells that allow them to develop resistance to these newer chemotherapy agents. (medpagetoday.com)
These agents show great promise in patients who harbor epidermal growth factor receptor (EGFR) activating mutations or EML4-ALK, said Antonio Passaro, MD , from the European Institute of Oncology in Milan, and colleagues, writing in a recent article in OncoTargets and Therapy . (medpagetoday.com)
Patients who meet the clinical criteria for a syndrome as well as those with identified pathogenic germline mutations should receive appropriate surveillance measures in order to minimize their overall risk of developing syndrome-specific cancers. (medscape.com)
IHC is especially indicative for MMR mutations that result in truncation of the protein, such as frame shift, splice site mutations, large genomic rearrangements, and mismatch, although IHC is not always diagnostic for mismatch. (medscape.com)
Frequency of Rearrangements Versus Small Indels Mutations in BRCA1 and BRCA2 Genes in Turkish Patients with High Risk Breast and Ovarian Cancer. (cdc.gov)
Genetic analyses have provided a wealth of information on the genectic constitution of STT, and clearly nonrandom patterns of genetic changes, ranging from point mutations and gene fusions to massive genomic imbalalnces, have been identified in each histological entity studied in sufficient detail. (lu.se)
Characterization of novel Bruton's tyrosine kinase gene mutations in Central European patients with agammaglobulinemia. (lu.se)
Identification of Bruton tyrosine kinase mutations in 12 Chinese patients with X-linked agammaglobulinaemia by long PCR-direct sequencing. (lu.se)
Four novel and three recurrent mutations of the BTK gene and pathogenic effects of putative splice mutations. (lu.se)

In patients with medially inoperable or unresectable tumors, primary radiotherapy, with or without chemotherapy, has provided a survival advantage and significant palliation over stent placement or bypass surgery alone. (medscape.com)
Cancer is a primary focus of the PMI, with the launch of the MATCH trial (Molecular Analysis for Therapy CHoice), a precision medicine cancer treatment clinical trial in which treatment is based in genetic changes found in patients' tumors. (cdc.gov)
We used genome engineering to perform experimental modeling of AR gene rearrangements and long-read RNA sequencing to analyze effects on expression ofARandtruncatedARvariants (AR-V). Results: AR was among the most frequently rearranged genes in CRPC tumors. (wustl.edu)
Genomic assays have had a powerful influence on the management of early-stage breast cancer, particularly estrogen receptor-positive tumors. (ascopost.com)
Changes in six genes called ALK , RET , NTRK1/3 , MET , ROS1 and BRAF are known to play a role in about half of spitzoid tumors, but for the other half, any other driver mutation has been unknown - until now. (stjude.org)
To learn how common it was, the St. Jude researchers expanded their search to screen tumors from 49 patients in the database. (stjude.org)
The firm hopes a ctDNA test will expand access for individuals with difficult to biopsy tumors, or for those who might benefit from blood-based cancer testing after acquired therapy resistance or metastasis, Heuckmann said. (genomeweb.com)
Recently, recurrent genomic rearrangements in intron 1 of TP53 have been described in osteosarcoma (OS), a highly malignant neoplasm of bone belonging to the spectrum of LFS tumors. (oncotarget.com)
Screening of 288 OS and 1,090 tumors of other types revealed evidence for TP53 rearrangements in 46 (16%) OS, while none were detected in other tumor types, indicating this rearrangement to be highly specific to OS. (oncotarget.com)
Evaluation of NKX2-2 expression in round cell sarcomas and other tumors with EWSR1 rearrangement: imperfect specificity for Ewing sarcoma. (nih.gov)
Lack of NKX2.2 expression in bronchopulmonary typical carcinoid tumors: implications for patients with neuroendocrine tumor metastases and unknown primary site. (nih.gov)
Chronic inflammation is connected to neoplastic transformation, and it is known that patients with autoimmune diseases have increased risks for some types of tumors [ 3 , 4 ], with neoplastic transformation often occurring [ 5 - 8 ]. (medsci.org)
Heterogeneous Tumor-Immune Microenvironments between Primary and Metastatic Tumors in a Patient with ALK Rearrangement-Positive Large Cell Neuroendocrine Carcinoma. (go.jp)
Mertens F, Antonescu CR, Mitelman F: Gene fusions in soft tissue tumors: recurrent and overlapping pathogenetic themes. (lu.se)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)

Currently, crizotinib is the only drug that has been approved for treatment of ALK-rearranged non-small-cell lung cancer (NSCLC). (nih.gov)
In this multicentre, single-arm, open-label, phase 1-2 study of CH5424802, we recruited ALK inhibitor-naive patients with ALK-rearranged advanced NSCLC from 13 hospitals in Japan. (nih.gov)
CH5424802 is well tolerated and highly active in patients with advanced ALK-rearranged NSCLC. (nih.gov)
According to a new study, mortality rates from the most common lung cancer, non-small cell lung cancer (NSCLC), have fallen sharply in the United States in recent years, due primarily to recent advances in treatment. (nih.gov)
In this study, researchers looked at data for both NSCLC, which accounts for 76% of lung cancer in the U.S., and small-cell lung cancer (SCLC), which accounts for 13% (other subtypes of lung cancer that constitute the remaining share of cases were not covered in this study). (nih.gov)
Although death records do not distinguish between lung cancer deaths attributable to NSCLC versus SCLC, the cancer diagnosis records compiled by NCI's Surveillance, Epidemiology, and End Results (SEER) cancer registry program do distinguish between these two subtypes of lung cancer. (nih.gov)
Two-year survival for men with NSCLC improved over this time, from 26% for patients diagnosed in 2001 to 35% for those diagnosed in 2014. (nih.gov)
The researchers had originally considered the possibility that lung cancer screening might help explain the decreases in NSCLC mortality, but their findings suggest that lung cancer screening rates, which remained low and stable, do not explain the mortality declines. (nih.gov)
The researchers note that the accelerating decline in NSCLC mortality that began in 2013 corresponds with the time when clinicians began routinely testing patients for genetic alterations targeted by newly approved drugs. (nih.gov)
In 2012, the National Comprehensive Cancer Network recommended that all patients with nonsquamous NSCLC undergo genetic testing. (nih.gov)
In phase 1 and 2 clinical trials in patients with ROS1-positive NSCLC,) the overall response rate with entrectinib was about 75 percent, with a comparable response rate in the central nervous system and a progression-free survival (PFS) of 19 months. (curetoday.com)
Currently, selpercatinib has FDA-approved indications for the treatment of metastatic RET fusion-positive non-small cell lung cancer (NSCLC) and thyroid cancers, as well as RET- mutant medullary thyroid cancer (MTC) requiring systemic treatment. (jnccn.org)
There are two main types of lung cancer, small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). (medlineplus.gov)
Most people with lung cancer have NSCLC. (medlineplus.gov)
The most common lung cancer genetic tests are done for NSCLC. (medlineplus.gov)
There are many types of gene changes that can be involved in NSCLC. (medlineplus.gov)
It is the standard first-line treatment for patients with advanced NSCLC with ALK gene rearrangement. (mycancergenome.org)
Neoadjuvant immunotherapy with the programmed cell death protein 1 (PD-1) inhibitor nivolumab (Opdivo) is safe and feasible in early-stage non-small cell lung cancer (NSCLC). (ascopost.com)
For patients with advanced non-small cell lung cancer (NSCLC) harboring the ALK gene rearrangement, ceritinib (Zykadia) provided longer progression-free survival than chemotherapy in patients previously treated with chemotherapy and crizotinib (Xalkori), but gastrointestinal toxicity was. (ascopost.com)
About 4 years later, crizotinib (Xalkori), an epithelial-mesenchymal transition (EMT) inhibitor, was granted accelerated approval by the Food and Drug Administration for ALK-positive non-small cell lung cancer (NSCLC), and in 2013, the oral agent won an FDA green light for use in this patient population. (medpagetoday.com)
The discovery of ALK gene rearrangements and the development of tyrosine kinase inhibitors (TKIs) that target them have achieved unprecedented success in the management of patients with ALK-positive NSCLC. (medpagetoday.com)
In 2016, the FDA approved crizotinib for patients with ROS1-positive NSCLC. (medpagetoday.com)
On the basis of the findings, the researchers advocated for use of crizotinib as a first-line therapy for patients with ALK-positive NSCLC. (medpagetoday.com)
The PROFILE 1014 study put this assertion to the test in an open-label, Phase III trial comparing crizotinib with chemotherapy in 343 patients with advanced ALK-positive nonsquamous NSCLC who had received no previous systemic treatment for advanced disease. (medpagetoday.com)

Here, we report that the RasGAP gene, RASAL2, functions as a tumor and metastasis suppressor in the MMTV mouse model of breast cancer. (harvard.edu)
Stents usually are used if the tumor is unresectable or if the patient is not a surgical candidate. (medscape.com)
Cell lines with experimentally derived AR gene rearrangements displayed high expression of tumor-specific AR-Vs andwere resistant to endocrine therapies, including the AR antagonist enzalutamide. (wustl.edu)
Aventa™ Genomics, LLC, a clinical laboratory established as a joint venture between Arima Genomics, Inc. and Protean BioDiagnostics Inc., today announced the launch of Aventa FusionPlus, a next-generation sequencing (NGS) test for the detection of gene fusions, translocations, and rearrangements across 361 genes from formalin-fixed, paraffin embedded (FFPE) tumor tissue. (news-medical.net)
The best sample for lung cancer genetic tests is tissue from a tumor in your lung. (medlineplus.gov)
4. Tumor Requirements: All Patients must have at least one measurable target lesion according to RECIST v1.1. (mycancergenome.org)
Further lab testing confirmed that the MEK gene was indeed activated in the boy's tumor. (stjude.org)
Nowell, a tumor biologist in the pathology department at the University of Pennsylvania School of Medicine, was interested in the relationship between cancer and alterations in genes (although he had no proof there was one). (laskerfoundation.org)
Having witnessed how NeoPlus has improved the care of cancer patients in some of these early partnerships, New Oncology is now working toward a launch of a second offering, a blood-based sequencing assay called NeoLiquid, which will analyze patients circulating cell-free tumor DNA, by the end of this year. (genomeweb.com)
Clinical Implications and Molecular Characterization of Drebrin-Positive, Tumor-Infiltrating Exhausted T Cells in Lung Cancer. (go.jp)
2,3 Within this 20%, approximately 10-16% of patients have FGFR2 gene rearrangements, including fusions, which promote tumor proliferation. (biospace.com)
This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. (cancerindex.org)
Samples of tumor tissue are tested using IHC to assess for the MLH1, MSH2, MSH6, and PMS2 proteins associated with colorectal cancer. (medscape.com)
The Database of Chromosome Aberrations and Gene Fusions in Cancer, established in 1980, is an attempt to register systematically all published cytogenetic aberrations reported in cancer, including patient and tumor characteristics, gene fusions identified by cytogenetics or massively parallel sequencing, and studies pertaining to the clinical relevance of cytogenetic aberrations and/or gene rearrangements. (lu.se)
The aims of these studies are to identify genetic changes that are instrumental for tumor development and progression, to clarify the causes and consequences of increased genetic instability, which is a characteristic feature of several types of STT, and to establish objective and robust genetic assays that could improve the clinical management of patients with STT by adding diagnostic and prognostic precision. (lu.se)

A research team led by St. Jude Children's Research Hospital scientists has discovered details of how the abnormal breakage and rearrangement of chromosomes in white blood cells triggers a particularly aggressive form of acute lymphoblastic leukemia (ALL). (news-medical.net)
At just 10 weeks old, Harper was diagnosed with a high-risk form of blood cancer, infantile Acute Lymphoblastic Leukemia with the MLL gene rearrangement. (lls.org)
I. To evaluate the tolerability of azacitidine in addition to Interfant-06 standard chemotherapy in infants with newly diagnosed acute lymphoblastic leukemia (ALL) with KMT2A gene rearrangement (KMT2A-R). (iu.edu)

S100 calcium-binding protein A2 (S100A2) is a protein that in humans is encoded by the S100A2 gene and it is located on chromosome 1q21 with other S100 proteins. (wikipedia.org)
Imatinib has a 95% response rate in patients with chronic myeloid leukemia (caused by a chromosomal rearrangement called the Philadelphia chromosome) and extends quality-adjusted life . (cdc.gov)
Although the investigators had previously identified an abnormal chromosome rearrangement in Ph-like ALL, little was known about the biological effects of that rearrangement. (news-medical.net)
Compare clinical response, in terms of 1-year progression-free survival and rate of molecular complete remission, in patients with Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML) in chronic phase who have achieved a complete cytogenetic remission to single-agent tyrosine kinase inhibitor treated with interferon alfa and sargramostim (GM-CSF) vs tyrosine kinase inhibitor and GM-K562 cell vaccine. (knowcancer.com)
3- 16 However, these probes only reveal chromosome rearrangements located in the subtelomeric region. (bmj.com)
Routine chromosome analysis (450-500 bands) had failed to detect the rearrangements in all cases. (bmj.com)
Despite the large chromosome fragments involved in the unbalanced translocation in this case, repeated standard G-band analysis could not reveal this rearrangement due to the similarity in the banding pattern of the chromosome fragments involved. (bmj.com)
At a time when the idea that cancer had a genetic basis was widely disbelieved, Nowell's results provided the first clear evidence that a particular genetic defect in a single chromosome can lead to a population or clone of identical cells that accumulate in numbers to form a deadly malignancy. (laskerfoundation.org)
The tiny Philadelphia chromosome became a clear and consistent marker of CML, a cancer of the myeloid or bone marrow cells, with broad implications for diagnosis and prognosis of disease. (laskerfoundation.org)
She got a grant to study chromosomes and, when she returned to Chicago, even though she had "no special interest in chromosome abnormalities in hematological diseases," the course of her research was set by her ready response to clinical colleagues who frequently asked her to study their patients. (laskerfoundation.org)
I came to realize that there were many questions about chromosome changes in patients that would be rewarding to study," noted Rowley, and for the next decade she labored over the microscope looking at chromosomes in leukemic cells. (laskerfoundation.org)
In fact, she showed that in patients with CML, a crucial segment of chromosome 22 broke off and moved to chromosome 9, where it did not belong. (laskerfoundation.org)
Rowley had identified the first "translocation" in cancer, providing clear evidence that the cause of CML could be related to the fact that by moving from one chromosome to another, the aberrant segment of chromosome 22 was no longer sitting next to genes that controlled its behavior. (laskerfoundation.org)
This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. (nih.gov)
The continuously updated material also makes it possible to address scientific questions related to the mechanisms through which chromosomal/genomic changes participate in the carcinogenic process by elucidating why, how and when chromosome abnormalities are formed, the chromosomal anatomy of cytogenetic changes and genes involved in fusions, the role chromosome aberrations play in the formation of fusion genes, and the mechanisms by which gene fusions exert their effects. (lu.se)
Mitelman F, Johansson B, Mertens F, Schyman T, Mandahl N. Cancer chromosome breakpoints cluster in gene-rich genomic regions. (lu.se)

Using yet newer techniques for detecting abnormal chromosomes (called spectral karyotyping), Rowley found a chromosomal rearrangement that characterizes one of the childhood leukemias, and her work continues. (laskerfoundation.org)

In 2016, we documented that the clinical and public health translational action in genomics was clearly ahead for cancer compared with other common diseases, as evidenced by the greater number of epidemiological and clinical studies, evidence-based guidelines and implementation programs. (cdc.gov)
Cancer genomics can inform both prevention and treatment and could serve as a model for other health conditions. (cdc.gov)
Next-generation sequencing has provided a snapshot of the genetic landscape of most cancer types, and cancer genomics approaches are driving new insights into cancer evolutionary patterns in time and space. (nature.com)
The information is freely available ( https://mitelmandatabase.isb-cgc.org) as an integrated component of the Cancer Genomics Cloud (CGC) - a flexible and powerful platform for cancer genomics research initiated and sponsored by the US National Cancer Institute (NCI). (lu.se)

many patients present with unresectable or metastatic disease. (medscape.com)
Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer. (genomeweb.com)
PRINCETON, N.J., Sept. 30, 2022 /PRNewswire/ -- Taiho Oncology, Inc. and Taiho Pharmaceutical Co., Ltd. announced today that the U.S. Food and Drug Administration (FDA) has approved LYTGOBI ® tablets for the treatment of adult patients with previously treated, unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma (iCCA) harboring fibroblast growth factor receptor 2 (FGFR2) gene fusions or other rearrangements. (biospace.com)
The approval of LYTGOBI is based on the results of the primary analysis of the FOENIX*-CCA2 trial, a global Phase 2 open-label trial evaluating 103 patients with unresectable, locally advanced or metastatic iCCA harboring FGFR2 gene rearrangements including fusions. (biospace.com)
LYTGOBI is indicated for the treatment of adult patients with previously treated, unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma harboring fibroblast growth factor receptor 2 (FGFR2) gene fusions or other rearrangements. (biospace.com)
The management of locally advanced or metastatic lung cancer is challenging. (medpagetoday.com)
The Phase III PROFILE 1007 trial compared crizotinib with chemotherapy in 347 patients with locally advanced or metastatic ALK-positive lung cancer who had received one prior platinum-based regimen. (medpagetoday.com)

However, repurposing the use of approved therapies in patients with potentially targetable genomic alterations continues to be an emerging area of interest. (jnccn.org)
Given the rare incidence of RET alterations in GBM, findings from this report can help guide and support optimal treatment strategies for patients with RET -altered GBM. (jnccn.org)
2 , 3 Additionally, repurposing the use of approved targeted therapies in patients with specific genomic alterations or those with various genomic or metabolic abnormalities continues to be an emerging area of interest. (jnccn.org)
Our data raise the possibility that the development of AML may require fewer genetic alterations than other cancers and that a very limited number of biological processes may need to be altered in hematopoietic stem cells, multi-potential progenitors or committed myeloid progenitors to convert them from a normal cell to AML," the authors noted, referring to several types of immature and maturing cells that give rise to this cancer. (scienceblog.com)
Most cancers have lots of alterations," he explained. (scienceblog.com)
Gene dose alterations can cause mental retardation (MR), congenital malformations and miscarriages. (bmj.com)
Screening for chromosomal imbalances by array CGH, whether using cDNA 23 or BAC clones, 24 has mainly been performed on cancer samples, 25- 30 which usually contain large gene dose alterations. (bmj.com)
Although array CGH has provided a higher resolution compared to conventional CGH, it has not yet become a widely applied method for the analysis of gene dose alterations in individuals with idiopathic mental retardation. (bmj.com)
For incisive studies in patient-oriented research that paved the way for identifying genetic alterations that cause cancer in humans and that allow for cancer diagnosis in patients at the molecular level. (laskerfoundation.org)
Heuckmann said that New Oncology has not yet finalized NEOLiquid's panel of targets, but explained that the test will likely cover a smaller number of genes and alterations than NeoPlus - focused more on direct therapeutic targets and perhaps less on those that provide more peripheral information about a patient's disease. (genomeweb.com)

Healthcare utilization by long coronavirus disease (COVID) or LC patients between January 2020 and 2023. (news-medical.net)
AGAVE-201, a global pivotal Phase 2 trial of axatilimab in patients with cGVHD is ongoing and results are on track for mid-2023. (businesswire.com)

In addition, its decline is associated with poor prognosis, disease progression, increased occurrence of metastasis and increased patient mortality. (wikipedia.org)
Due to poor prognosis, the patient was assigned palliative care. (sfu.ca)
Patients diagnosed with this disease have a poor prognosis, with survival rates of 14 to 15 months after diagnosis. (jnccn.org)
To relate the occurrence of gene fusions to Gleason Grading Groups and disease prognosis, we performed survival analyses using the Kaplan-Meier estimator, log-rank test, and Cox regression. (biomedcentral.com)
We found evidence that the number of gene fusions was associated with the prognosis of PCa. (biomedcentral.com)
In the past, PCa prognosis has benefitted from a detailed understanding of the relationship between the clinical course of the disease and patient-specific molecular profiles. (biomedcentral.com)

Genes Chromosomes Cancer. (genomeweb.com)
Genes Chromosomes Cancer 58:149-154, 2019. (lu.se)
Genes Chromosomes Cancer 55:291-310, 2016. (lu.se)

Since 2017, LLS has helped advance 85% of the blood cancer treatment options approved by the FDA. (lls.org)
In June 2017 the US Multi-Society Task Force on Colorectal Cancer issued updated screening recommendations that divide screening tests into three tiers, based upon their effectiveness. (medscape.com)

The development of accurate and sensitive genome wide screening methods would facilitate the clinical diagnosis of patients with very small or subtle rearrangements. (bmj.com)
In certain circumstances, when a lymph node is not easily accessible for excisional or incisional biopsy, a combination of core biopsy and FNA biopsies in conjunction with appropriate ancillary techniques for the differential diagnosis (immunohistochemistry, flow cytometry, PCR for IGHV and TCR gene rearrangements, karyotype, and fluorescence in situ hybridization [FISH] for major translocations) may be sufficient for diagnosis. (medscape.com)
In September 2007, he had received a diagnosis of laryngeal cancer, which required 2 chemotherapy treatments through a central venous catheter (CVC), the second of which he had received 6 days before his November visit. (cdc.gov)
For patients with a family history of colorectal cancer or advanced adenoma that was diagnosed before age 60 years in one first-degree relative or at any age in two first-degree relatives, testing should begain with colonoscopy at an age10 years younger than the youngest age at diagnosis of a first-degree relative, or age 40, to be repeated every 5 years. (medscape.com)
WHO Classification of Tumours fifth edition: evolving issues in the classification, diagnosis, and prognostication of prostate cancer. (who.int)
Identification of a Btk mutation in a dysgammaglobulinemic patient with reduced B cells: XLA diagnosis or not? (lu.se)
What are the barriers patients with interstitial lung diseases may face in obtaining a timely and accurate diagnosis? (medscape.com)

Incorporating molecular biomarkers, such as transcriptome-wide expression signatures, improves patient stratification but so far excludes chromosomal rearrangements. (biomedcentral.com)
We describe here how coupling of genomic and molecular profiling of cancer with functional testing of drugs in patient-derived cell samples will make it possible to customise patient treatments as well as to identify biomarker patterns and genetic aberrations that explain the drug responses. (ddw-online.com)
In oncology, personalised medicine entails optimisation of the entire treatment strategy for an individual patient with the help of genetic information as well as molecular and cellular analysis. (ddw-online.com)
The European Organisation for Research and Treatment of Cancer (EORTC), for example, has already launched a novel collaborative molecular screening programme, SPECTA, Screening Patients for Efficient Clinical Trial Access for patients with cancer, an initiative which implements NGS technology to help provide patients with personalised treatment. (hospitalhealthcare.com)
Molecular profiling is becoming an increasingly common part of the diagnostic work-up of lung cancer patients and in the not too distant future will likely become routine. (medpagetoday.com)
Benjamin Solomon, MBBS, PhD , head of the Molecular Therapeutics and Biomarkers Laboratory at Peter MacCallum Cancer Centre in Melbourne, Australia, and colleagues found that crizotinib was superior to standard first-line pemetrexed-plus-platinum chemotherapy. (medpagetoday.com)
Clinical, immunological and molecular characteristics of 37 Iranian patients with X-linked agammaglobulinemia. (lu.se)

It has been reported that S100A2 is downregulated in lung, kidney, prostate cancer and melanoma. (wikipedia.org)
15 Lung Cancer Network NOWEL, Oldenburg, Germany. (aacrjournals.org)
Reduced tobacco consumption in the U.S. has been associated with a progressive decrease in lung cancer deaths that started around 1990 in men and around 2000 in women. (nih.gov)
This analysis shows for the first time that nationwide mortality rates for the most common category of lung cancer, non-small cell lung cancer, are declining faster than its incidence, an advance that correlates with the U.S. Food and Drug Administration approval of several targeted therapies for this cancer in recent years. (nih.gov)
Therefore, the researchers were able to estimate lung cancer mortality trends for these specific lung cancer subtypes by linking the lung cancer death records for each patient back to the incidence data for these patients in the SEER cancer database. (nih.gov)
In a recent interview, OncLive, one of CURE 's online sister publications, discussed the state of this field with Alexander Drilon, M.D., a medical oncologist who specializes in treating lung cancer at Memorial Sloan Kettering Cancer Center, in New York. (curetoday.com)
OncLive met with Drilon at the 18th World Conference on Lung Cancer, held by the International Association for the Study of Lung Cancer Oct. 15-18 in Yokohama, Japan. (curetoday.com)
For the treatment of patients with advanced ROS1-rearranged lung cancer, we're trying to move the needle forward by looking at better therapies that target ROS1. (curetoday.com)
The second is highly MET-amplified lung cancers. (curetoday.com)
If you have lung cancer , your health care provider may order genetic tests . (medlineplus.gov)
There are many types of gene changes that are found in lung cancer. (medlineplus.gov)
So, lung cancer genetic tests are important to check if your cancer has a gene change that can be treated with targeted therapy. (medlineplus.gov)
That's because this type of lung cancer is more likely to have gene changes that respond to targeted therapies. (medlineplus.gov)
The gene changes found in lung cancer affect genes that control how fast your cells grow and divide to make new cells. (medlineplus.gov)
The gene changes in lung cancer usually aren't inherited. (medlineplus.gov)
Lung cancer genetic testing is most often used to look for gene changes that are often involved in non-small cell lung cancer. (medlineplus.gov)
Lung cancer genetic tests may check a single gene or several genes may be checked in one test. (medlineplus.gov)
Why do I need a lung cancer genetic test? (medlineplus.gov)
You may need a lung cancer genetic testing if you have been diagnosed with lung cancer. (medlineplus.gov)
What happens during a lung cancer genetic test? (medlineplus.gov)
Lung cancer cells dividing (colored scanning electron micrograph). (scientificamerican.com)
TGF-β signaling activated by cancer-associated fibroblasts determines the histological signature of lung adenocarcinoma. (go.jp)
PD-1/PD-L1 inhibitor activity in patients with gene-rearrangement positive non-small cell lung cancer-an IMMUNOTARGET case series. (unibe.ch)
Translational lung cancer research, 11(12), pp. 2412-2417. (unibe.ch)
MicroRNA-106a targets autophagy and enhances sensitivity of lung cancer cells to Src inhibitors. (unibe.ch)
Lung cancer, 107, pp. 73-83. (unibe.ch)
Crizotinib inhibits migration and expression of ID1 in MET-positive lung cancer cells: implications for MET targeting in oncology. (unibe.ch)
Early detection of lung cancer: a statement from an expert panel of the Swiss university hospitals on lung cancer screening. (unibe.ch)
The stem cell gene "inhibitor of differentiation 1" (ID1) is frequently expressed in non-small cell lung cancer. (unibe.ch)
Lung cancer, 71(3), pp. 306-11. (unibe.ch)
Src inhibitors in lung cancer: current status and future directions. (unibe.ch)
Clinical lung cancer, 11(4), pp. 238-42. (unibe.ch)
Clinical lung cancer, 11(2), pp. 80-1. (unibe.ch)
Several of these new targeted therapies in ALK-positive lung cancer are reviewed in this article. (medpagetoday.com)
Researchers are continuing to work to develop new, molecularly targeted agents that will hopefully improve the progression-free and overall survival of lung cancer patients. (medpagetoday.com)
Ultimately, treatment decisions should be made by a multidisciplinary lung oncology team to provide the best care for each patient. (medpagetoday.com)
A decade ago, the echinoderm microtubule-associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene was identified from the DNA of a 62-year-old man with lung adenocarcinoma. (medpagetoday.com)
Hepatocellular Carcinomas from Iran: Evidence study of lung cancer among European asphalt carcinoma among postmenopausal women in the for Lack of Association between HBV Genotype workers. (who.int)
Lung and extrathoracic cancer incidence among underground uranium miners exposed to radon progeny in the Pribram region of the Czech Republic: a case-cohort study. (who.int)
Elevated α-defensin levels in plasma and bronchoalveolar lavage fluid from patients with myositis-associated interstitial lung disease. (medscape.com)

Chromosomal rearrangements and altered expression of this gene have also been implicated in breast cancer. (wikipedia.org)
In addition, the use of gene expression profiling in breast cancer management has matured in the past few years propelled by the results of a prospective clinical trial . (cdc.gov)
The mainstay of adjuvant treatment for early-stage, hormone receptor-positive breast cancer has been endocrine therapy, either with tamoxifen and. (ascopost.com)
The targeted smart drug revolution can be considered to have started in the late 1990s and early 2000s with the approval of trastuzumab (Herceptin®) for breast cancer patients with HER2 amplifications and shortly thereafter imatinib (Gleevec®) for patients with BCR-ABL1-driven chronic myeloid leukaemia (CML). (ddw-online.com)
2010). Polycyclic aromatic hydrocarbon exposure standard mammogram form and the interactive kinase in response to estradiol in breast cancer in oesophageal tissue and risk of oesophageal threshold measurement methods. (who.int)

Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer. (genomeweb.com)
Immunohistochemistry (IHC) testing for hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome uses monoclonal antibodies to show which mismatch repair (MMR) proteins are present in a tissue sample. (medscape.com)
While all the guidelines recommend routine screening for colorectal cancer and adenomatous polyps in asymptomatic adults starting at age 50, they differ with regard to frequency of screening and age at which to discontinue screening, as well as the preferred screening method. (medscape.com)
A joint guideline developed by the American Cancer Society, US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology recommends that screening for colorectal cancer and adenomatous polyps start at age 50 years in asymptomatic men and women. (medscape.com)
In patients with one first-degree relative with colorectal cancer, advanced adenoma, or an advanced serrated lesion diagnosed at age 60 or older, screening should begin with a tier 1 test at age 40 and continue at the same intervals as inaverage-risk patients. (medscape.com)
The USPSTF recommends that screening for colorectal cancer start at age 50 years and continue until age 75 years (A recommendation). (medscape.com)

The technique can cause big deletions or rearrangements of DNA, says Allan Bradley of the Wellcome Sanger Institute in the UK, meaning some therapies based on CRISPR may not be quite as safe as we thought. (newscientist.com)
Overall, this adds more safety challenges to CRISPR-based gene therapies but it doesn't compromise its use," says Burgio of the new findings. (newscientist.com)
p class=\'abstract\'>Successful implementation of precision oncology requires both the deployment of nucleic acid sequencing panels to identify clinically actionable biomarkers, and the efficient screening of patient biomarker eligibility to on-going clinical trials and therapies. (stanford.edu)
Castration-resistant prostate cancer (CRPC) is a lethal stage of the disease that emerges when endocrine therapies are no longer effective at suppressing activity of the androgen receptor (AR) transcription factor. (wustl.edu)
Conclusions: AR gene rearrangements are an important mechanism of resistance to endocrine therapies in CRPC. (wustl.edu)
Of the potential for aiding clinical trials, co-author Stephen Hunger, M.D., of Children's Hospital of Philadelphia, said: 'These findings expand the number of ALL patients who should be amenable to precision medicine therapies that add targeted inhibitors to chemotherapy for ALL patents with specific genetic changes in the leukemia cells. (news-medical.net)
In expanding now into ctDNA analysis, New Oncology is joining a rapidly crowding field in which a variety of technologies - from broad sequencing to simpler single-gene assays - are being pursued for clinical blood-based testing of cancer patients, both as companion diagnostics to individual-targeted cancer therapies and as broad tools to identify both therapeutic targets and prognostic indicators. (genomeweb.com)
NGS-based platforms can help clinicians and pharmaceutical companies screen patients for targeted, biomarker driven therapies that are already on the market or in the development phase and they would also prove extremely valuable in terms of biomarker discovery or identification of resistance markers. (hospitalhealthcare.com)

Cetuximab in combination with chemoradiotherapy before surgery in patients with resectable, locally advanced esophageal carcinoma: a prospective, multicenter phase IB/II Trial (SAKK 75/06). (unibe.ch)
Liver cancer is the third leading cause of cancer-associated mortality, of which hepatocellular carcinoma (HCC) represents 90% of all primary liver cancers. (wjgnet.com)
Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)
99:209 -215.doi:10.1007/s11060 - 010 - 0129 -5 cell carcinoma-a population-based study in with and without cervical cancer in Tbilisi, Georgia. (who.int)

As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)

Mixed-lineage leukemia gene rearrangement is the best-known hallmark of infantile leukemia and is a poor prognostic indicator. (sfu.ca)
In this study, we investigated gene fusions in PCa, characterized potential novel candidates, and explored their role as prognostic markers for PCa progression. (biomedcentral.com)
However, none of the prognostic models incorporates parameters reflecting the status of chromosomal rearrangements and transcriptional disorganization in a patient sample, even though gene fusions are known to drive PCa development and progression [ 8 ]. (biomedcentral.com)
Through my work, I aspire to contribute significantly to the field of Dermatopathology and ultimately improve patient outcomes by facilitating accurate diagnoses and prognostic assessments for cutaneous neoplasms. (mdanderson.org)
The database represents a unique international resource that enables clinicians to quickly find relevant information on cytogenetic aberrations and gene fusions in cancer and relate the findings to clinical data, in particular the diagnostic and prognostic significance of specific cytogenetic/genomic changes. (lu.se)

Clinical activity of FOLFIRI plus cetuximab according to extended gene mutation status by next generation sequencing: findings from the CAPRI-GOIM trial. (genomeweb.com)
Mutation analysis of pre-mRNA splicing genes in Chinese families with retinitis pigmentosa. (genomeweb.com)
The researchers found slightly more than two CNAs per AML patient, and less than one point mutation per patient in the genes sequenced. (scienceblog.com)
Thanks to St. Jude research, the discovery of a new gene mutation in spitzoid melanoma is helping kids like Addison receive the best treatment approach. (stjude.org)
Several months later, another MAP3K8 mutation turned up in a second patient with spitzoid melanoma. (stjude.org)
NEW YORK (GenomeWeb) - German MDx firm New Oncology is planning to launch a liquid biopsy cancer mutation test this year supported by an undisclosed amount raised in a funding round this week. (genomeweb.com)
In practice, there would only be a small number of patients who might actually carry the mutation and therefore benefit from the targeted therapy. (hospitalhealthcare.com)
The absence of a protein suggests a mutation in the gene that produces it. (medscape.com)
Endometrial cancer has also been associated with MSH6 mutation. (medscape.com)
Mutation of the BTK gene and clinical feature of X-linked agammaglobulinemia in mainland China. (lu.se)
De novo mutation in the BTK gene of atypical X-linked agammaglobulinemia in a patient with recurrent pyoderma. (lu.se)

While multi-agent high dose chemotherapy remains the first line of treatment for pediatric T-ALL, there are numerous side effects of these regimens, and most patients undergo relapse. (sfu.ca)
In a study of 1636 patients with unresectable localized intrahepatic cholangiocarcinoma, the addition of radiation to chemotherapy was associated with an improvement in overall survival. (medscape.com)
That patient had not responded significantly to other chemotherapy drugs, but when given ruxolitinib, showed a major drop in leukemia cells. (news-medical.net)
Only patients with KMT2A-R continue to post-induction chemotherapy. (iu.edu)
Traditional chemotherapy agents have had limited success for these patients over the last several decades. (medpagetoday.com)
Alice Tsang Shaw, MD, PhD , from Massachusetts General Hospital and Dana-Farber Cancer Institute in Boston, and colleagues found crizotinib superior to chemotherapy. (medpagetoday.com)
Treatment with granulocyte colony-stimulating factor is used to stimulate neutrophil production and prevent bacterial infections after cancer chemotherapy and with severe chronic neutropenia. (msdmanuals.com)
Patients with prolonged neutropenia after hematopoietic stem cell transplantation or chemotherapy and patients receiving broad-spectrum antibiotics and high doses of corticosteroids are predisposed to fungal infections. (msdmanuals.com)

Since fusion genes are associated with several cancers, Newman reviewed published studies to understand what this fusion gene might be doing. (stjude.org)

This work was supported in part by the National Cancer Institute, the Leukemia and Lymphoma Society, the National Health and Medical Research Council of Australia, and ALSAC. (scienceblog.com)
Immunotherapy with an anti-programmed cell death protein 1 (PD-1) inhibitor-pembrolizumab (Keytruda)-showed encouraging responses in patients with advanced cutaneous T-cell lymphoma (either mycosis fungoides or Sézary syndrome). (ascopost.com)
The Leukemia & Lymphoma Society® (LLS) is a global leader in the fight against cancer. (lls.org)
The LLS mission: Cure leukemia, lymphoma, Hodgkin's disease and myeloma, and improve the quality of life of patients and their families. (lls.org)

He learned that it could activate a gene called MEK , known for fueling melanoma growth in adults. (stjude.org)

Excel Diagnostics and Nuclear Oncology Center in Houston, Texas, is the first center in the United States to start recruiting patients in a multicenter randomized clinical trial of Lu-177 Octreotate in patients with progressive midgut carcinoid . (carcinoid.org)
Precision oncology has had some major successes… And yet, the overall effect of precision medicine on care for patients with cancer has been modest. (cdc.gov)
The funding comes amid a string of deals for New Oncology over the last six months, including partnerships with cancer centers and university hospitals in Oslo , Singapore , and France for the clinical sequencing of cancer patients. (genomeweb.com)
LYTGOBI is an effective, well-tolerated therapy for patients with intrahepatic CCA that can be taken orally," said Tim Whitten, President and CEO of Taiho Oncology, Inc. "This approval is an important milestone for patients and may provide hope for improved outcomes. (biospace.com)

Further research and clinical trials in this area of study are paramount to improving clinical outcomes for these young patients. (sfu.ca)
Q: There are targeted agents available that can treat ROS1 gene rearrangements, and more are being studied in clinical trials. (curetoday.com)
We present the development of a feature matching algorithmic pipeline that identifies patients who meet eligibility criteria of precision medicine clinical trials via genetic biomarkers and apply it to patients undergoing treatment at the Stanford Cancer Center. (stanford.edu)
This study demonstrates, through our patient eligibility screening algorithm that leverages clinical sequencing derived biomarkers with precision medicine clinical trials, the successful use of an automated algorithmic pipeline as a feasible, accurate and effective alternative to the traditional manual clinical trial curation. (stanford.edu)
This serves merely as an information platform about cancer clinical trials operated by different institutions in Hong Kong. (hkacs.org.hk)
Patients usually need to satisfy a complex and stringent set of selection criteria before being selected/ included in certain clinical trials. (hkacs.org.hk)
Retinal Pigment Epithelial Detachment (RPED) , which may cause symptoms such as blurred vision, occurred in 9% of 318 patients who received LYTGOBI across clinical trials. (biospace.com)
The World Health Organization, through its International Clinical Trials Registry Platform, has developed the ICTRP database to provide patients, family members and members of the public current information about clinical research studies. (who.int)

The IARC Perspective on Cervical Cancer Screening. (who.int)

During this period, tremendous success has been achieved in the fields of decoding of human genome, technological advancement of new era of human genome applications, toward personalized genomes and discovery of rare variants, leveraging genome sequencing to impact on cancer researches and mammalian evolution and population structure. (springer.com)
Experimental Design: We used whole-genome and targeted DNA-sequencing approaches to identify mechanisms underlying CRPC in an aggregate cohort of 272 prostate cancer patients. (wustl.edu)
We analyzed structural rearrangements at the genome-wide level and carried out a detailed structural rearrangement analysis of the AR locus. (wustl.edu)
The most comprehensive analysis yet of the genome of childhood acute myeloid leukemia (AML) found only a few mistakes in the genetic blueprint, suggesting the cancer arises from just a handful of missteps, according to new findings from St. Jude Children's Research Hospital. (scienceblog.com)
The characterisation of the genome and epigenome of many tumour types has been one of the focus areas of cancer research in recent years. (ddw-online.com)
Over the past 10 years, following the disclosure of the Human Genome Project's results, advances in sequencing technologies have reached a point where NGS-based diagnostics can be considered for cancer clinical research. (hospitalhealthcare.com)
Large-scale whole-genome or whole-exome sequencing might not appear to be the first choice for this type of screening strategy, but today high throughput, low cost, targeted genome sequencing is much further developed in the field of cancer research and diagnostics. (hospitalhealthcare.com)
Using whole-genome sequencing of OS, we found features of TP53 intron 1 rearrangements suggesting a unique mechanism correlated with transcription. (oncotarget.com)
International Cancer Genome Consortium. (cancerindex.org)

Its expression is reduced in many types of cancer, thereby distinguishing the cancerous expression profile of the other proteins of the S100 group. (wikipedia.org)
The drugs work by quieting proteins, or kinases, made by these defective genes, which sit on the outsides of cancer cells. (curetoday.com)
Transcriptome sequencing pinpoints how genes are read to make proteins. (stjude.org)
NTRK (neurotrophic tyrosine receptor kinase) gene fusions that encode chimeric proteins exhibiting constitutive activity of tropomyosin receptor kinases (TRK), are oncogenic drivers in multiple cancer types. (bvsalud.org)
In a recent study, Wang and colleagues reported that a significant fraction of cancer-associated fusion proteins display a common structural topology, including an N-terminal phase separation-prone region (PS) from one parent protein and a C-terminal DNA-binding domain (DBD) from the other. (bvsalud.org)

Net product revenues grew 7% compared with the first quarter of 2022, driven by strong underlying patient demand growth (+7% Y/Y) including an 8% growth in new patients. (businesswire.com)
Higher gross-to-net deductions, compared to fourth quarter of 2022, as a result of the Medicare coverage gap and higher commercial patient deductibles at the beginning of the plan year, as well as an increase in 340B orders. (businesswire.com)
Net product revenues grew 343% compared with the first quarter of 2022, driven by growth in patient demand and expansion in payer coverage as the launch in atopic dermatitis (AD) and vitiligo continues. (businesswire.com)
Acceleration of refills in December 2022 driven by patient demand in advance of annual deductible reset or health plan changes that negatively impacted refills during the months of January and February this year. (businesswire.com)

Fusion of the TMPRSS2 prostate-specific gene with the ERG transcription factor is a putatively oncogenic gene rearrangement that is commonly found in prostate cancer tissue from men undergoing prostatectomy. (nih.gov)

Mitelman F. Cancer gene fusions detected by massive parallel sequencing. (lu.se)

A landmark study showed that the investigational PARP (poly ADP-ribose polymerase) 1/2 inhibitor niraparib, when used as maintenance therapy, significantly improves the outcome of platinum-sensitive recurrent ovarian cancer. (ascopost.com)
Recurrent EWSR1-CREB3L1 Gene Fusions in Sclerosing Epithelioid Fibrosarcoma. (lu.se)
Recurrent PRDM10 Gene Fusions in Undifferentiated Pleomorphic Sarcoma. (lu.se)

Association between osteoporosis and polymorphisms of the IL-10 and TGF-beta genes in Turkish postmenopausal women. (cdc.gov)

Inevitably, there are fundamental and applied questions, such as those relating to transcriptional control of stem cell differentiation, intrinsic noise in gene expression, and the origins of disease, that may only be addressed at the single cell level. (justia.com)

Liu C, Pan Y, Li Q, Zhang Y. Bioinformatics analysis identified shared differentially expressed genes as potential biomarkers for Hashimoto's thyroiditis-related papillary thyroid cancer. (medsci.org)
Additionally, HT patients have a high risk of papillary thyroid cancer (PTC), which is probably related to the chronic inflammation and autoimmune pathologic process occurring in HT, as it is thought to be associated with neoplastic transformation. (medsci.org)
For example, there is evidence that HT patients have a high risk of thyroid cancer, the most common endocrine malignancy, than the general population [ 9 - 15 ]. (medsci.org)
According to the literature, the pathogenesis of HT-related thyroid cancer may be due to the diffuse lymphocyte infiltration, apoptosis of thyroid epithelial cells, fibrous replacement, and follicular destruction in HT. (medsci.org)
However, controversy exists regarding whether HT is related to papillary thyroid cancer (PTC), which accounts for 95% of all thyroid cancer cases and has increasing prevalence worldwide. (medsci.org)
Thyroid cancer patients with HT have higher TSH levels than those with benign nodules. (medsci.org)
Higher TSH levels have been found to be related to terminal cancer in Caucasian patients with well-differentiated thyroid cancer [ 16 - 20 ]. (medsci.org)

Association between HLA gene polymorphisms and mortality of COVID-19: An in silico analysis. (go.jp)
A new study examines the mortality risk factors among COPD patients hospitalized with community acquired pneumonia. (medscape.com)
Find out which factors may be associated with an increase in mortality among patients hospitalized for COPD exacerbations in the previous year. (medscape.com)

If at any time after stopping study therapy blood tests show disease recurrence, patients restart tyrosine kinase inhibitor and are eligible to cross over to arm II. (knowcancer.com)
If at any time after stopping study therapy blood tests show disease recurrence, patients restart tyrosine kinase inhibitor and are eligible to cross over to arm I. Patients are also eligible to cross over to arm I in the presence of unacceptable toxicity. (knowcancer.com)

4 The selective RET inhibitor selpercatinib is poised to alter the treatment landscape for patients with RET -altered malignancies. (jnccn.org)
Photodynamic therapy (PDT) is an experimental local cancer therapy already in use for other gastrointestinal malignancies. (medscape.com)
Furthermore, the mutational load is typically lacking in childhood malignancies of adult cancers, and they still exhibit high cellular heterogeneity levels largely mediated by epigenetic mechanisms. (bvsalud.org)

SPECTA links the effective development of biomarkers in clinical research to secure the safety of patients, stimulate innovative research and new technologies, and ensure high quality, streamlined study operation. (hospitalhealthcare.com)
3. Translational research - to identify predictive biomarkers for treatment decision - by immunohistochemistry, gene expression or sequencing. (lu.se)

Chromosomal rearrangements involving ETS transcription factors, such as ERG and ETV1, occur frequently in prostate cancer. (harvard.edu)
Purpose: Prostate cancer is the second leading cause of male cancer deaths. (wustl.edu)
Prostate cancer (PCa) is one of the most prevalent cancers worldwide. (biomedcentral.com)
Prevalence of TMPRSS2-ERG fusion prostate cancer among men undergoing prostate biopsy in the United States. (nih.gov)
However, the prevalence of the fusion was less common in samples of transurethral resection of the prostate from a Swedish cohort of patients with incidental prostate cancer followed by watchful waiting, raising the question as to whether the high prevalence in prostatectomy specimens reflects selection bias. (nih.gov)
We sought to determine the prevalence of TMPRSS2-ERG gene fusion among prostate-specific antigen-screened men undergoing prostate biopsy in the United States. (nih.gov)
We studied 140 prostate biopsies from the same number of patients for TMPRSS2-ERG fusion status with a fluorescent in situ hybridization assay. (nih.gov)
This is the first prospective North American multicenter study to characterize TMPRSS2-ERG prostate cancer prevalence in a cohort of patients undergoing needle biopsy irrespective of whether or not they subsequently undergo prostatectomy. (nih.gov)
Our results show that this gene rearrangement is common among North American men who have prostate cancer on biopsy, is absent in benign prostate biopsy, and is associated with specific morphologic features. (nih.gov)
These findings indicate a need for prospective studies to evaluate the relationship of TMPRSS2-ERG rearrangement with clinical course of screening-detected prostate cancer in North American men, and a need for the development of noninvasive screening tests to detect TMPRSS2-ERG rearrangement. (nih.gov)

In addition, improvements in two-year survival were seen for all races/ethnicities, despite concerns that the newer cancer treatments, many of which are expensive, might increase disparities. (nih.gov)
For some patients, these drugs can be more effective than treatments that affect both sick and healthy cells, such as chemotherapies, and can have less bothersome side effects. (curetoday.com)
Despite the effectiveness of these new treatments, all patients will virtually experience a relapse. (mycancergenome.org)
The discoveries of the malfunction underlying the type called 'Ph-like ALL' will aid in designing treatments for the leukemia, researchers said, and also offer useful lessons for investigators studying similar leukemias and other types of cancer. (news-medical.net)
Thus, the challenge is to systematically develop all these drugs to optimal indications across all cancer types and subtypes as well as to tailor treatments of individual patients based on the underlying mechanisms of disease and driver signals. (ddw-online.com)
Given that cancers are extremely heterogeneous between individual patients and within the tumour itself, optimised, personalised and combinatorial treatments are often required to achieve significant responses. (ddw-online.com)
The idea of personalised medicine, tailoring treatments to individual unique disease characteristics so as to administer the right treatment for the right patient, at the right dose, and at the right time, has been around for some time. (hospitalhealthcare.com)
Recently, we have received a number of concerned enquiries regarding organisations called "Cancer Association" and "Renyao Dehui", which providing health talk, promoting the sale of cancer-related health screenings, and/or purchasing cancer treatments. (hkacs.org.hk)
Funds raised through Light The Night allow LLS to fund treatments for patients who are suffering from all forms of blood cancers. (lls.org)

C ancer therapy increasingly involves the use of smart drugs with high specificity and low toxicity in selected patients based on a precision or personalised medicine paradigm. (ddw-online.com)

Here we show that in mice with ERG or ETV1 targeted to the endogenous Tmprss2 locus, either factor cooperated with loss of a single copy of Pten, leading to localized cancer, but only ETV1 appeared to support development of invasive adenocarcinoma under the background of full Pten loss. (harvard.edu)

In 2015, the United States launched the Precision Medicine Initiative (PMI) "to bring us closer to curing diseases like cancer and diabetes - and to give all of us access to the personalized information we need to keep ourselves and our families healthier. (cdc.gov)
Where is Cancer Precision Medicine Today? (cdc.gov)
Most of the early successes of precision medicine have been in cancer. (cdc.gov)
Nevertheless, the overall effect of precision medicine on cancer has been modest so far. (cdc.gov)
A recent study estimated that about 8% of patients with cancer are eligible for precision medications and 5% would actually benefit from them. (cdc.gov)
Prime editors (PEs) are precision gene editing agents that can perform virtually any substitution, small deletion and small insertion at target DNA sites in living cells 2 . (nature.com)
Patient stratification by clinical or pathological risk categories still lacks sufficient precision. (biomedcentral.com)
LYTGOBI is a key example of the potential of precision medicine in iCCA and represents another advance in the treatment of this rare and challenging disease," said medical oncologist Lipika Goyal, MD, MPhil, of the Massachusetts General Hospital Cancer Center and lead investigator of the pivotal study that led to the approval of LYTGOBI. (biospace.com)

November is National Pancreatic Cancer Awareness Month, the impetus for this article. (ascopost.com)
Pancreatic cancer is a huge health challenge. (ascopost.com)

Association analysis of the functional MAOA gene promoter and MAOB gene intron 13 polymorphisms in tension type headache patients. (cdc.gov)

E7 from human papil omavirus type 16 cooperate to cancer: the European prospective investigation into doi:10.1093/carcin/bgp321 PMID:20047954 target the PDZ protein Na/H exchange regulatory cancer and nutrition study. (who.int)

Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1. (genomeweb.com)
Variants in blood pressure genes and the risk of Accardi R, Rubino R, Scalise M et col . (2011). (who.int)

A study of 66 patients with unresectable intrahepatic cholangiocarcinoma treated with hypofractionated radiation therapy reported 2-year outcomes of 84% local control and 58% overall survival. (medscape.com)
Among patients who respond, many drugs only improve survival by a matter of months. (cdc.gov)
In western countries, leukaemia incidence and survival of childhood cancer was the first obstacle has been well established by many collaborative studies faced. (who.int)
The area of research for our group is malignant lymphomas - all possible aspects, aiming for the improvement of the quality of life and survival of these patients. (lu.se)
N-acetylcysteine exposure is associated with improved survival in anti-nuclear antibody seropositive patients with usual interstitial pneumonia. (medscape.com)

The researchers also cited the case of an adult patient at MD Anderson Cancer Research Center, Houston, whose genetic analysis revealed EPOR-rearranged ALL. (news-medical.net)

For both of these, we have data now with several agents, including crizotinib, (the experimental) capmatinib and other TKIs, showing that patients with either alteration can respond very well to targeted therapy. (curetoday.com)
Targeted therapy uses drugs or other substances that mainly attack specific cancer cells and cause less harm to normal cells. (medlineplus.gov)

McGranahan, N. & Swanton, C. Biological and therapeutic impact of intratumor heterogeneity in cancer evolution. (nature.com)
Even when drugs that inhibit the desired target exist, meaningful responses in patients may be limited due to cell plasticity, tumour heterogeneity and compensatory signals. (ddw-online.com)
For example, single cell analysis allows for the direct measurement of gene expression kinetics, or for the unambiguous identification of co-regulated genes, even in the presence of de-synchronization and heterogeneity that could obscure population-averaged measurements. (justia.com)

2 Consequently, screening for subtelomeric abnormalities has become a diagnostic test that is offered by diagnostic laboratories, and a number of studies reporting new subtelomeric rearrangements have been published. (bmj.com)
The Lyda Hill Cancer Prevention Center provides cancer risk assessment, screening and diagnostic services. (mdanderson.org)
For high-risk patients, the recommendations differ regarding the age at which to begin screening, as well as the frequency and method of screening. (medscape.com)
Screening options for average-risk adults consist of tests that detect adenomatous polyps and cancer, and tests that primarily detect cancer. (medscape.com)
Colonoscopy screening should be discontinued in patients aged 75 or older with prior negative screening tests or whose life expectancy is less than 10 years, or in those 85 years or older without prior screening. (medscape.com)

His research group developed DNA and RNA cancer diagnostic tests currently in use at Stanford Health Care as well as developing clinical algorithms using large-scale clinical laboratory datasets and patient electronic medical records to predict patient outcomes and aid in therapeutic clinical decision support. (stanford.edu)
The datasets included transcriptome-wide expression and matched clinical follow-up data to detect and characterize gene fusions in PCa. (biomedcentral.com)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)

Anatomy16

Organisms8

Diseases52

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes95

Disciplines and Occupations3

Information Science6

Health Care10

Mutations41

Tumors15

NSCLC24

Tumor15

Acute Lymphobl3

Chromosome16

Chromosomal rearrangement1

Genomics4

Metastatic7

Alterations10

20232

Prognosis6

Chromosomes3

20172

Diagnosis7

Molecular7

Lung40

Breast cancer5

Colorectal cancer6

Therapies8

Carcinoma4

Rare Cancers1

Prognostic5

Mutation11

Chemotherapy8

Fusion gene1

Lymphoma4

Melanoma1

Oncology4

Clinical trials8

Cervical1

Genome9

Proteins5

20224

Oncogenic1

Fusions detected1

Recurrent3

Postmenopausal women1

Transcriptional1

Thyroid Cancer7

Mortality3

Tyrosine2

Malignancies3

Biomarkers2

Prostate10

Treatments9

Specificity1

Locus1

Precision8

Pancreatic2

Polymorphisms1

PMID1

Variants2

Survival5

Adult1

Targeted therapy2

Heterogeneity3

Screening5

Datasets3