Loading...
  • clinically
  • No family history of epilepsy No birth trauma No significant head trauma No meningitis or encephalitis No subarachnoid hemorrhage No episodes of unconsciousness, including syncope No prostatic hypertrophy No narrow-angle glaucoma, i.e., intraocular pressure greater than 22 mm Hg No uncontrolled hyperthyroidism No other clinically significant abnormality, e.g. (clinicaltrials.gov)
  • Arthritis that is clinically similar to that of patients with PMC has been described in the arthritides of inflammatory bowel disease, post-intestinal bypass, and hepatitis B infection, as well as in Reiter's syndrome and the reactive arthritis seen with infectious diarrhea that is secondary to Shigella jlexneri, Yersinia entercolitica, Salmonella, and Campylobacter jejuni. (docme.ru)
  • Neutropenia itself is a rare entity, but can be clinically common in oncology and immunocompromised patients as a result of chemotherapy (drug-induced neutropenia). (wikipedia.org)
  • prolongation
  • Unexpected marked prolongation of the QT interval after initiation of drug therapy associated with risk of a morphologically distinct pattern of polymorphic ventricular tachycardia (torsades de pointes) has been recognized since the 1960s. (ahajournals.org)
  • 12 , 14 In addition, 1 study reported that the extent of QT prolongation among first-degree relatives of subjects with diLQTS was greater than that seen in first-degree relatives of subjects who tolerated QT-prolonging drugs without relevant QT prolongation. (ahajournals.org)
  • Moxifloxacin is also considered to be contraindicated within the pediatric population, pregnancy, nursing mothers, patients with a history of tendon disorder, patients with documented QT prolongation, and patients with epilepsy or other seizure disorders. (wikipedia.org)
  • apoptosis
  • The common final pathway in the tumor cell death is believed to be apoptosis or programmed cell death and chemotherapeutic drugs like other DNA-damaging agents act on rapidly multiplying cells including both the tumor and the normal cells by following the same common final pathway. (biomedcentral.com)
  • A large number of anti-cancer agents with widely differing modes of action have been demonstrated to induce apoptosis in vitro, suggesting this as a significant final common pathway for exerting their clinical effects. (biomedcentral.com)
  • anticonvulsant drugs
  • The results of deoxyuridine suppression tests on the bone marrow cells of 14 patients on anticonvulsant drugs, 11 of whom had evidence of megaloblastic erythropoiesis, indicated that the megaloblastic changes and macrocytosis encountered in treated epileptics are often not caused either by folate deficiency or by drug-induced impairment of the 5, 10-methylenetetrahydrofolate-dependent methylation of deoxyuridylate to thymidylate. (bmj.com)
  • pulmonary
  • Under-nutrition is the stark reality of 90% of pulmonary TB cases in India, or more than 1 million patients," said Bhargava, based on his 2013 study of 1,700 patients from rural India. (hindustantimes.com)
  • Patients with extensive pulmonary TB have approximately 1012 bacteria in their body, and therefore will probably be harboring approximately 105 EMB-resistant bacteria, 104 STM-resistant bacteria, 104 INH-resistant bacteria and 10² RMP-resistant bacteria. (wikipedia.org)
  • symptoms
  • Off-time describes a period when the patient experiences increased parkinsonian symptoms (e.g. immobility or inability to move with ease). (clinicaltrials.gov)
  • On-time describes a period when the patient has no symptoms of off-time and is not asleep. (clinicaltrials.gov)
  • Under the traditional medical model, treatment usually emphasizes the management of psychotic symptoms through medication, even though anti-psychotic drugs are associated with severe side effects, which can diminish patients' physical and psychological well-being. (biomedcentral.com)
  • Levin and Gimino [ 6 ] showed that aerobic exercise reduces depression, anxiety and obsessive-compulsive symptoms in hospitalized patients with schizophrenia, relative to non-exercise-based treatment regimes. (biomedcentral.com)
  • Family physicians frequently encounter patients with symptoms that could be related to cardiac arrhythmias, most commonly atrial fibrillation or supraventricular tachycardias. (aafp.org)
  • Since pseudomembranous colitis and arthritis may occur without prior use of antibiotics, as seen in our patient, we recommend flexible sigmoidoscopy and fecal evaluation for C dificile toxin in all patients with persistent gastrointestinal symptoms and arthritis, to exclude a diagnosis of pseudomembranous colitis. (docme.ru)
  • Similarly, symptoms and signs resulting from drug-induced hyperthyroidism are indistinguishable from causes of spontaneous hyperthyroidism. (renalandurologynews.com)
  • Patients should try to schedule the exam at a time when they will be having symptoms and will not need to drive for 2 to 3 days. (wikipedia.org)
  • Symptoms tend to worsen with muscle exercise, and often continue after a patient is removed from statin therapy. (wikipedia.org)
  • Patients who start taking colchicine, and who have compromised renal function, develop a myopathy that shows symptoms in proximal muscle weakness, distal sensory loss and areflexia. (wikipedia.org)
  • Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) is caused by exposure to certain medications that may result in a rash, fever, inflammation of internal organs, lymphadenopathy, and characteristic hematologic abnormalities such as eosinophilia, thrombocytopenia, and atypical lymphocytosis. (wikipedia.org)
  • The symptoms of DRESS syndrome usually begin several weeks after exposure to the offending drug. (wikipedia.org)
  • 2007). "Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? (wikipedia.org)
  • In these cases, a diagnostic assessment or pre-assessment should watch for other signs and symptoms that the patient may present with. (wikipedia.org)
  • Symptoms include a blueish or greenish discoloration of the blood, skin, and mucous membranes, even though a blood count test may not show any abnormalities in the blood. (wikipedia.org)
  • Severity (usually a pain rating) Modifying factors (what aggravates/reduces the symptoms - activities, postures, drugs, etc. (wikipedia.org)
  • Additional symptoms (un/related or significant symptoms to the chief complaint) Treatment (has the patient seen another provider for this symptom? (wikipedia.org)
  • A medical diagnosis for the purpose of the medical visit on the given date of the note written is a quick summary of the patient with main symptoms/diagnosis including a differential diagnosis, a list of other possible diagnoses usually in order of most likely to least likely. (wikipedia.org)
  • systemic
  • DRESS syndrome is one of several terms that have been used to describe a severe idiosyncratic reaction to a drug that is characterized by a long latency of onset after exposure to the offending medication, a rash, involvement of internal organs, hematologic abnormalities, and systemic illness. (wikipedia.org)
  • severity
  • Undernutrition increases the severity of TB, reduces patients' speed of recovery, and increases their chances of suffering side effects from the medicine, and the likelihood of their becoming one of the 480,000 Indian lives that TB, an infectious airborne disease, claims every year. (hindustantimes.com)
  • The variation in cortisol levels according to disease type and severity, as well as variation within the same patient, hampers the establishment of a clear threshold below which CIRCI occurs. (wikipedia.org)
  • commonly
  • Patients with acquired non-inflammatory myopathy typically experience weakness, cramping, stiffness, and tetany, most commonly in skeletal muscle surrounding the limbs and upper shoulder girdle. (wikipedia.org)
  • HMG-CoA) reductase inhibitors are commonly used in the clinic to reduce lipid levels in patients. (wikipedia.org)
  • diLQTS
  • Methods and Results- In a case-control setting, we included 176 patients of European descent from North America and Europe with diLQTS, defined as documented torsades de pointes during treatment with a QT-prolonging drug. (ahajournals.org)
  • 1 - 3 However, diLQTS can occur, albeit more rarely, during treatment with various drugs, including many that are not prescribed for cardiovascular indications. (ahajournals.org)
  • 1 - 3 diLQTS has been a major cause for drug relabeling and withdrawal, creating obstacles for drug development and uncertainties during drug approval and regulatory processes. (ahajournals.org)
  • The 176 diLQTS patients who constituted the case cohort, defined as documented torsades de pointes during treatment with a drug having known QT-prolonging potential, were from North America or Europe, and all were of self-identified European descent. (ahajournals.org)
  • This study suggests that patient-specific iPSC can be used to model the functional abnormalities observed in acquired diLQTS. (ahajournals.org)
  • adrenal
  • Critical illness-related corticosteroid insufficiency (CIRCI) is a form of adrenal insufficiency in critically ill patients who have blood corticosteroid levels which are inadequate for the severe stress response they experience. (wikipedia.org)
  • Combined with decreased glucocorticoid receptor sensitivity and tissue response to corticosteroids, this adrenal insufficiency constitutes a negative prognostic factor for intensive care patients. (wikipedia.org)
  • Moreover, in patients whose adrenal glands are already maximally stimulated, a stimulation test would not be informative. (wikipedia.org)
  • Other stimulation tests for adrenal insufficiency which are used in non-critical patients, such as the test using metyrapone or a test which employs insulin to induce hypoglycemia, are not preferred for CIRCI. (wikipedia.org)
  • arrhythmia
  • The median age of patients with atrial fibrillation is 75 years, and the prevalence of the arrhythmia doubles every 10 years after the age of 55. (aafp.org)
  • If the arrhythmia is long-standing and the patient is not a suitable candidate for rate cardioversion, initial treatment should focus on ventricular rate control, with consideration given to long-term stroke prophylaxis. (aafp.org)
  • Last, the electrophysiologist may administer various drugs (proarrhythmic agents) to induce arrhythmia. (wikipedia.org)
  • If the arrhythmia is reproduced by the drugs, the electrophysiologist will search out the source of the abnormal electrical activity. (wikipedia.org)
  • nonsteroidal
  • Only two listed contraindications are found within the 2008 package insert: "Nonsteroidal anti-inflammatory drugs (NSAIDs): Although not observed with moxifloxacin in preclinical and clinical trials, the concomitant administration of a nonsteroidal anti-inflammatory drug with a fluoroquinolone may increase the risks of CNS stimulation and convulsions. (wikipedia.org)
  • GGT elevation has also been occasionally reported following nonsteroidal anti-inflammatory drugs (including aspirin), St. John's wort and kava. (wikipedia.org)
  • inflammatory
  • In general, non-inflammatory myopathies are a grouping of muscular diseases not induced by an autoimmune-mediated inflammatory pathway. (wikipedia.org)
  • characteristic
  • With these potential benefits, a randomized controlled trial (RCT) is planned to investigate the effects of Tai-chi intervention on the cognitive and motor deficits characteristic of patients with schizophrenia. (biomedcentral.com)
  • clinical
  • The clinical response, immunohistochemical response and the drug-induced toxicity were correlated and compared. (biomedcentral.com)
  • There was a statistically significant correlation observed between clinical, immunohistochemical response (bcl-2/bax ratio) and the drug-induced toxicity. (biomedcentral.com)
  • In clinical trials, ALT elevations above 5 times the upper limit of normal (5 X ULN) were reported in 2% of patients, about 50% had at least 1 elevated ALT, and 8% had at least one elevated ALT level above 3 x ULN. (drugs.com)
  • Laitinen 0, Leirisalo M, Skylv G: Relation between HLA-B27 and clinical features in patients with Yersinia arthritis. (docme.ru)
  • The clinical presentation of drug-induced hypothyroidism is indistinguishable from other causes of hypothyroidism. (renalandurologynews.com)
  • The drugs are listed using their single letter abbreviations (in the order given above, which is roughly the order of introduction into clinical practice). (wikipedia.org)
  • hypothesis
  • Because the congenital LQTS may have variable penetrance 8 and some mutation carriers may display normal QT intervals, this finding has lead to the hypothesis that the drug-induced "acquired" LQT syndromes are conditions predisposed by heritable variants in QT-controlling genes. (ahajournals.org)
  • 1 This is consistent with the Braak hypothesis suggesting that PD patients have Lewy body pathology in autonomic centres and nerves that include the dorsal motor nucleus of the glossopharyngeal and vagal nerves, gastrointestinal submucosal plexus and postganglionic sympathetic nervous system, which is present in the pre-motor stage before nigral involvement. (bmj.com)
  • cardiac
  • In patients with severely depressed cardiac output and recent-onset atrial fibrillation, immediate electrical cardioversion is the treatment of choice. (aafp.org)
  • Findings from physical examinations, including basic systems of cardiac and respiratory, the affected systems, possible involvement of other systems, pertinent normal findings and abnormalities. (wikipedia.org)
  • Among other things, an ECG can be used to measure the rate and rhythm of heartbeats, the size and position of the heart chambers, the presence of any damage to the heart's muscle cells or conduction system, the effects of cardiac drugs, and the function of implanted pacemakers. (wikipedia.org)
  • Mutations
  • The rate of spontaneous mutations that confer resistance to an individual drug are well known: 1 mutation for every 107 cell divisions for EMB, 1 for every 108 divisions for STM and INH, and 1 for every 1010 divisions for RMP. (wikipedia.org)
  • Resistance mutations appear spontaneously and independently, so the chances of them harbouring a bacterium that is spontaneously resistant to both INH and RMP is 1 in 108 x 1 in 1010 = 1 in 1018, and the chances of them harbouring a bacterium that is spontaneously resistant to all four drugs is 1 in 1033. (wikipedia.org)
  • toxic
  • This drug is known to have toxic effects on myofibrils, resulting in muscle pain and tenderness. (wikipedia.org)
  • chronic
  • That 52% of the patients had stunting-low height-for-age-showed that their undernutrition status was chronic, said Bhargava, co-author of the study. (hindustantimes.com)
  • More often, patients have chronic arrhythmias, such as atrial fibrillation, that may require treatment to reduce the risk of future complications. (aafp.org)
  • Latent elevations in GGT are typically seen in patients with chronic viral hepatitis infections often taking 12 months or more to present. (wikipedia.org)
  • ventricular
  • Part II discusses ventricular arrhythmias and the management of rhythm abnormalities in special populations, including pregnant women, athletes, and children. (aafp.org)
  • orally
  • A Double-blind, Double-dummy, Placebo-controlled, Randomized, Three Parallel Groups Study Comparing the Efficacy, Safety and Tolerability of Pramipexole Extended Release (ER) Versus Placebo and Versus Pramipexole Immediate Release (IR) Administered Orally Over a 26-week Maintenance Phase in L-Dopa+ Treated Patients With Advanced Parkinsons Disease (PD). (clinicaltrials.gov)
  • usually
  • The exact definition of this condition, the best ways to test for corticoid insufficiency in critically ill patients, and the therapeutic use of (usually low doses) of corticosteroids remains a subject of debate. (wikipedia.org)
  • citation needed] Chest radiography is usually the first test to detect interstitial lung diseases, but the chest radiograph can be normal in up to 10% of patients, especially early on the disease process. (wikipedia.org)
  • Sulfhemoglobinemia is usually drug induced. (wikipedia.org)
  • susceptible
  • Patients with neutropenia are more susceptible to bacterial infections and, without prompt medical attention, the condition may become life-threatening (neutropenic sepsis). (wikipedia.org)
  • mortality
  • 4 The mortality rate for stroke in patients with atrial fibrillation is approximately twice as high as the rate in patients without this rhythm abnormality. (aafp.org)
  • Major VTE plus VTE-related mortality occurred in 2.7 % (46/1,714) and 4.0 % (69/1,711) (RD: -1.4 %, 95 % CI -2.6 to -0.2) of patients receiving dabigatran 220 mg and enoxaparin, respectively. (springer.com)
  • The prespecified pooled analysis of these two studies was planned to compare the effect of dabigatran 220 mg and enoxaparin 40 mg once daily on the primary efficacy endpoint of total VTE and all-cause mortality in patients undergoing total hip arthroplasty. (springer.com)
  • high
  • PV had high abnormality rates of TP and ALB, however, the abnormality rate of ALB of PV was clearly lower than that of EP and GPP. (alliedacademies.org)
  • Patients with schizophrenia are characterized by high prevalence rates and chronicity that often leads to long-term institutionalization. (biomedcentral.com)
  • The first step in managing a patient with atrial fibrillation is to decide whether there is a high likelihood of safe conversion to sinus rhythm or whether the patient should be allowed to remain in atrial fibrillation. (aafp.org)
  • Both very high and very low levels of cortisol have been linked to a poor outcome in intensive care patients. (wikipedia.org)
  • In the US only, streptomycin is no longer considered a first line drug by ATS/IDSA/CDC because of high rates of resistance. (wikipedia.org)
  • either
  • LQTS can be either inherited or induced notably after drugs intake. (ahajournals.org)
  • Certain drugs or agents can cause either or both of these abnormalities and understanding their potential thyroidal effects will help the clinician to appropriately manage the patient. (renalandurologynews.com)
  • The two large magnets are brought in on either side of the patient. (wikipedia.org)
  • Chemical imbalances brought on by abnormal diets may either affect the muscle directly or induce abnormal functionality in upstream pathways. (wikipedia.org)
  • These drugs are listed here either because they are not very effective (e.g., clarithromycin) or because their efficacy has not been proven (e.g., linezolid, R207910). (wikipedia.org)
  • doses
  • Use of certain drugs may result in altered thyroid hormone metabolism and require higher doses of replacement LT4 to achieve a normal TSH. (renalandurologynews.com)
  • In this case, sulfhemoglobinaemia was possibly caused by the patient taking higher-than-prescribed doses of sumatriptan. (wikipedia.org)
  • pathway
  • GGT plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione and drug and xenobiotic detoxification. (wikipedia.org)
  • cause
  • Corticosteroids often cause muscle weakness to some degree in patients. (wikipedia.org)
  • The first drugs reported to cause fetal masculinization were the androgens methandriol and methyltestosterone in the mid 1950s. (wikipedia.org)
  • Cancer
  • On the other hand, arginine depletion has lower toxicity profile and can effectively reduce the level of pro-cancer biochemicals in patients as shown by ours and others' data. (biomedcentral.com)
  • efficacy
  • Efficacy analysis was based on the modified intention-to-treat (ITT) population and safety analysis was based on all treated patients. (springer.com)
  • significant
  • A significant number of drugs found within this class, including moxifloxacin, are not licensed by the FDA for use in children due to the risk of permanent injury to the musculoskeletal system. (wikipedia.org)
  • function
  • The annual risk of stroke in patients with atrial fibrillation and normal valve function has been reported to be 4.5 percent per year. (aafp.org)
  • Particular families of drugs are known to induce myopathies on the molecular level, thus altering organelle function such as the mitochondria. (wikipedia.org)