Patients sirolimus. Medical search. Frequent questions

Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumor (PEComa). (wikipedia.org)
2. Inhibition of the mammalian target of rapamycin (mTOR) with sirolimus was linked to a decreased recurrence of APLS nephropathy and improved graft survival in post-renal transplant patients. (2minutemedicine.com)
Se realiz una b squeda sistem tica bajo los t rminos: sirolimus , rapamycin , kidney transplantation , mTOR y M xico de 2005 a 2016. (medigraphic.com)
Sirolimus is a lipophilic lactone isolated from Streptomyces hygroscopicus (soil bacteria), found to have anti-T-cell properties and classifies as an anticancer drug from the mammalian target of rapamycin (mTOR) inhibitors. (ijord.com)
Sirolimus (rapamycin): From thesoil of Easter Island to a bright future. (ijord.com)
Birca A, Mercier C, Major P. Rapamycin as an alternative to surgical treatment of subependymal giant cell astrocytomas in a patient with tuberous sclerosis complex. (ijord.com)
The mTOR inhibitor rapamycin significantly improves facial angiofibroma lesions in a patient with tuberous sclerosis. (ijord.com)
Sirolimus , also called rapamycin, is a drug that was never intended for Castleman's and had never been used before for Castleman's. (medscape.com)
Unilateral lymphoedema of the breast has been reported in a few patients with no history of breast cancer but treated with mammalian target of rapamycin (mTor) inhibitors (2). (medicaljournals.se)
We report a new case of unilateral inflammatory lymphoedema of the breast which had appeared after beginning treatment with sirolimus (also called rapamycin), and which disappeared after switching from sirolimus to cyclosporine. (medicaljournals.se)
LAM-001 is a proprietary, investigational, inhaled formulation of sirolimus, also known as rapamycin. (itbusinessnet.com)
Sirolimus is an oral mammalian target of rapamycin (mTOR) inhibitor that is approved by the US Food and Drug Administration (FDA) for rejection prophylaxis in renal transplant patients. (cancertherapyadvisor.com)
Although the use of rapamycin is favored, some patients with chylous effusions or ascites may try an MCT diet (see Medical Care). (medscape.com)
Sirolimus, also known as rapamycin (SRL, Rapamune®), was approved in 1999 by the US Food and Drug Administration to prevent graft rejection in renal transplantation. (medscape.com)
With the recent discovery that mTOR inhibitors extend the lifespan of mice, sirolimus and other rapamycin analogs (rapalogs) are emerging as therapeutic targets for the treatment and prevention of age-related diseases. (medscape.com)

In the EU, sirolimus, as Rapamune, is indicated for the prophylaxis of organ rejection in adults at low to moderate immunological risk receiving a renal transplant and, as Hyftor, is indicated for the treatment of facial angiofibroma associated with tuberous sclerosis complex. (wikipedia.org)
Serious side effects including hypersensitivity and swelling (edema) have been observed in renal transplant patients. (wikipedia.org)
For this reason, mTOR inhibitors have been hypothesized to prevent APLS-mediated activation (which would lead to vascular stenosis and subsequent graft failure) in post-renal transplant APLS patients. (2minutemedicine.com)
As observed in-vitro, post-renal transplant patients with APLS who were on sirolimus also had decreased phosphorylation of S6RP and AKT on renal biopsies taken at 3 and 12 months post-op. (2minutemedicine.com)
Only physicians experienced in immunosuppressive therapy and management of renal transplant patients should use sirolimus. (drreddys.com)
Sirolimus-based therapy with or without cyclosporine: long-term follow-up in renal transplant patients. (medigraphic.com)

A 2019 cohort study of nearly 10,000 lung transplant recipients in the US demonstrated significantly improved long-term survival using sirolimus + tacrolimus instead of mycophenolate mofetil + tacrolimus for immunosuppressive therapy starting at one year after transplant. (wikipedia.org)
Sirolimus can also be used alone, or in conjunction with a calcineurin inhibitor (such as tacrolimus), and/or mycophenolate mofetil, to provide steroid-free immunosuppression regimens. (wikipedia.org)
The aim of this study was the evaluation of the first commercially available in-vitro diagnostic (IVD)- mass spectrometric immunosuppressant assay from Chromsystems (MassTox Immunosuppressants ONEMINUTE Test) and the comparison to a routinely used online solid phase extraction liquid chromatography-tandem mass spectrometric assay method for the measurement of cyclosporine A, everolimus, sirolimus, and tacrolimus in patient whole blood samples. (nih.gov)
The limit of quantification for the commercial assay was 0.5 ng/mL for everolimus, sirolimus, and tacrolimus and 5 ng/mL for cyclosporine A. The coefficient of variation for all immunosuppressants was lower than 7% (within day) and 12% (between days) for all 5 concentration levels. (nih.gov)
The use of sirolimus in combination with tacrolimus was associated with excess mortality and graft loss in a study in de novo liver transplant patients. (drreddys.com)

Do not use FYARRO if you have had a severe allergic reaction to sirolimus or other medications that work similarly to sirolimus (eg, everolimus, temsirolimus), or human albumin. (fyarro.com)
Outcomes After Revascularization with Everolimus- and Sirolimus Eluting Stents In Patients with Small and Large Coronary Arteries. (sdu.dk)
Four patients were treated with everolimus, and one with sirolimus, that begun 2-14 months before the occurrence of lymphoedema. (medicaljournals.se)
Assessment of the adverse effects of sirolimus versus everolimus in pediatric heart transplant recipients. (bvsalud.org)
Literature is limited comparing adverse effects (AEs) of the proliferation signal inhibitors (PSIs) sirolimus (SRL) and everolimus (EVL) in pediatric heart transplant (HTx) recipients. (bvsalud.org)

Johnson RW, Kreis H, Oberbauer R, Brattstr m C, Claesson K, Eris J. Sirolimus allows early cyclosporine withdrawal in renal transplantation resulting in improved renal function and lower blood pressure. (medigraphic.com)
Sirolimus-based therapy following early cyclosporine withdrawal provides significantly improved renal histology and function at 3 years. (medigraphic.com)
A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts. (medigraphic.com)
Immunosuppressive therapy with cyclosporine and mycophenolate mofetil had been changed to sirolimus and mycophenolate mofetil in July 2011, after the occurrence of in situ cervical carcinoma and in situ squamous cell carcinoma of the skin. (medicaljournals.se)
Sirolimus was then replaced with cyclosporine and the dose of mycophenolate mofetil was unchanged. (medicaljournals.se)

Dr. Reddy s Laboratories (NYSE: RDY) announced today that it has launched Sirolimus Tablets 1 mg and 2 mg, a therapeutic equivalent generic version of RAPAMUNE (Sirolimus) tablets in the US market on October 27, 2014, following the approval by the United States Food & Drug Administration (USFDA). (drreddys.com)
Rapamune), a medicine used in transplant patients. (mydr.com.au)
Rapamune is also used for treating patients with sporadic lymphangioleiomyomatosis (S-LAM) with moderate lung disease or worsening lung function. (europa.eu)
Rapamune contains the active substance sirolimus. (europa.eu)
To treat patients with S-LAM, the dose of Rapamune is 2 mg daily and after 10 to 20 days the doctor will adjust the dose to achieve appropriate levels of sirolimus in the patient's blood. (europa.eu)
The active substance in Rapamune, sirolimus, is an immunosuppressant (a medicine that reduces the activity of the immune system). (europa.eu)
Rapamune was more effective than placebo (a dummy treatment) or azathioprine (another immunosuppressive medicine) in two main studies involving a total of 1,295 patients who were having a kidney transplant. (europa.eu)
In the first study, treatment failed in 19% (53 out of 284) of the patients adding Rapamune after 6 months, compared with 32% (52 out of 161) of those adding azathioprine. (europa.eu)
In the second study, treatment failed in 30% (68 out of 277) of the patients adding Rapamune, compared with 48% (62 out of 130) of those adding placebo. (europa.eu)
Two additional studies looked at Rapamune as continuing treatment for up to 5 years in 765 patients who were able to stop ciclosporin after 2 to 3 months. (europa.eu)
Rapamune was more effective than placebo in improving lung function in a study involving 81 patients with S-LAM. (europa.eu)
FEV 1 improved by an average of 1 ml per month in patients treated with Rapamune compared with a worsening by 12 ml per month in patients receiving placebo. (europa.eu)
Patients allergic to peanut or soya must not take Rapamune oral solution because the solution contains soya oil. (europa.eu)
In May 2015, sirolimus (Rapamune) was the first drug approved by the US FDA for LAM. (medscape.com)
A clinical trial of 89 patients over 12 months showed patients taking Rapamune had a slower decline in lung function than those taking a placebo. (medscape.com)

The safety and efficacy of sirolimus treatment of LAM were investigated in clinical trials that compared sirolimus treatment with a placebo group in 89 patients for 12 months. (wikipedia.org)
Purpose of this registry is to evaluate the safety and efficacy of Sirolimus Coated Balloon in the patients with Coronary Artery Disease. (conceptmedical.com)
The safety and efficacy of sirolimus as immunosuppressive therapy have not been established in liver or lung transplant patients, and therefore, such use is not recommended [see Warnings and Precautions. (drreddys.com)

We report here a new case of isolated, unilateral breast lymphoedema that had appeared 10 months after starting sirolimus. (medicaljournals.se)

The OUS SELUTION DeNovo study has more than 800 patients of the 3,326 enrolled in this ground-breaking coronary randomized study comparing treatment strategy with SELUTION SLR (DEB) vs. Limus drug eluting stent (DES) strategy. (interhospi.com)
As you probably know, there's been tremendous variation worldwide in how long patients are treated with aspirin plus a medication like clopidogrel or other thienopyridines after coronary stents are placed because we don't really know what the appropriate duration should be, in terms of preventing late stent thrombosis or other cardiovascular events. (acc.org)
Within the DAPT Study, we will get a chance to have a much stronger comparison of bare-metal and drug-eluting stents, as well as how long patients should be treated depending on the stent type. (acc.org)
In combination with aspirin, thienopyridine therapy (primarily clopidogrel [Plavix] in the United States) may reduce the incidence of early major adverse cardiac events in patients who have undergone placement of a bare-metal stent compared with aspirin therapy alone or in combination with warfarin (Coumadin). (aafp.org)
To help eliminate premature cessation of therapy, physicians should discuss the need for dual antiplatelet therapy with their patients before implanting a stent. (aafp.org)
Physicians should also strongly consider whether to avoid a drug-eluting stent in patients who are not expected to comply with 12 months of thienopyridine therapy. (aafp.org)
Implanting a bare-metal stent or performing balloon angioplasty with provisional stent implantation instead of using a drug-eluting stent should also be considered for patients undergoing preparation for percutaneous coronary intervention who are likely to require invasive or surgical procedures in the next year. (aafp.org)
For patients treated with a drug-eluting stent who are undergoing procedures for which thienopyridine therapy must be discontinued, aspirin therapy should be continued if possible. (aafp.org)
However, patients should restart thienopyridine therapy as soon as possible after the procedure because of the risk of late-stent thrombosis. (aafp.org)
Objectives: This study sought to assess stent strut coverage, malapposition, protrusion, and coronary evaginations as markers of healing 5 years after implantation of sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES), by optical coherence tomography (OCT). Background: Early-generation drug-eluting stents have been shown to delay vascular healing. (eur.nl)
Methods: A total of 88 event-free patients with 1 randomly selected lesion were suitable for final OCT analysis 5 years after drug-eluting stent implantation. (eur.nl)
During extended clinical follow-up, 2 patients suffered from very late stent thrombosis showing a high degree of malapposition, protrusion, and coronary evaginations at the time of OCT investigation. (eur.nl)

The doctor will adjust the dose to achieve appropriate levels of sirolimus in the patient's blood. (europa.eu)
Further assessments will include change in quality of life as measured by SGRQ-C over 48 weeks, change in 6-minute walk distance (6MWD) from baseline at 48 weeks, blood and BAL levels of sirolimus and various exploratory measures. (itbusinessnet.com)

Topical preparation produced by crushing tablets of sirolimus 1 mcg and mixing in an aqueous base emollient or the solution form of sirolimus has been used with beneficial effects in the treatment of angiofibroma, especially in younger patients. (ijord.com)
GUILFORD, Conn., Aug. 18, 2023 (GLOBE NEWSWIRE) - AI Therapeutics, Inc. , a clinical-stage biopharmaceutical company developing novel therapeutics for rare diseases, announced today the commencement of an investigator initiated Phase 2 study at UC San Francisco (UCSF) for its novel inhaled form of sirolimus, LAM-001, for the treatment of bronchiolitis obliterans syndrome (BOS) in patients post-lung transplant. (itbusinessnet.com)

Because neonates do not have prior sensitization to the major blood group antigens, they can successfully accept ABO‐incompatible allografts without increased risk for patient or graft survival, biliary complications, vascular complications, or rejection. (medscape.com)
Your physician may prescribe sirolimus to treat symptoms or complications of LAM. (thelamfoundation.org)
There are complications of serial transfusions of either of these cell types, and a patient needs intense prophylactic treatments to protect from infections if his or her white counts are low. (drugdiscoverynews.com)
Premature death has been reported in 20% of Proteus syndrome patients, most often related to deep venous thrombosis leading to pulmonary embolus, postoperative complications, or pneumonia. (medscape.com)
Pulmonary complications are a frequent cause of morbidity and mortality in Proteus syndrome patients. (medscape.com)
Factors to consider when assessing the level of immune competence in a patient include underlying disease severity, duration, clinical stability, complications, comorbidities, and any potentially immune-suppressing treatment. (cdc.gov)
Se ha concluido el complications is essential for these patients. (bvsalud.org)

The chief advantage sirolimus has over calcineurin inhibitors is its low toxicity toward kidneys. (wikipedia.org)
Moreover, unilateral lymphoedema of the breast has been reported with lymphoedema located on homolateral or both limbs in 6 other patients treated with mTor inhibitors (3). (medicaljournals.se)
Peripheral bilateral oedema is frequent, occurring in up to half of the patients treated with mTor inhibitors (5). (medicaljournals.se)

Sirolimus is indicated for the prevention of organ transplant rejection and for the treatment of lymphangioleiomyomatosis (LAM). (wikipedia.org)
In May 2015, the FDA approved sirolimus to treat lymphangioleiomyomatosis (LAM), a rare, progressive lung disease that primarily affects women of childbearing age. (wikipedia.org)
Consider patient referral to a center with expertise in lymphangioleiomyomatosis (LAM). (medscape.com)
Despite the theoretical risk of pneumothorax in patients with lymphangioleiomyomatosis (LAM), studies show no increased risk, even in patients with a prior history. (medscape.com)

study expected to start before the end of 2023BackBeat CNT™ global pivotal study in hypertensive pacemaker patients (in collaboration with Medtronic) on track for initiation in the second half of 2023 NEW HOPE, Pa. (yahoo.com)

In 2009, the FDA notified healthcare professionals that a clinical trial conducted by Wyeth showed an increased mortality in stable liver transplant patients after switching from a calcineurin inhibitor-based immunosuppressive regimen to sirolimus. (wikipedia.org)

Has been used as diagnostic (visualizing) dye † [off-label] in a variety of procedures, including sentinel lymph node biopsy in cancer patients (e.g., breast cancer patients), endoscopic evaluation of lesions in patients with GERD or Barrett's esophagus, urologic evaluation in patients with ureteral or renal pelvis injury, and thoroscopic procedures in patients with pulmonary nodules. (drugs.com)
A total of 105 consecutive patients with 110 calcified lesions underwent IVL. (frontiersin.org)
Up to 30% of patients undergoing percutaneous coronary intervention (PCI) have calcified lesions ( 1 ). (frontiersin.org)
This retrospective, observational study included consecutive patients with calcified coronary lesions treated with IVL from December 31, 2018 to December 31, 2020 at the Centro Cardiologico Monzino, University of Milan, Italy. (frontiersin.org)
Despite an overall low degree of uncovered and malapposed struts in event-free patients, some lesions show a clustering of these characteristics, indicating a heterogeneous healing response, which may be the source for very late adverse events. (eur.nl)

Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study. (medigraphic.com)
Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: a randomized clinical trial. (medigraphic.com)
Reserve use of ciprofloxacin for patients with no alternative treatment options for an acute exacerbation of chronic bronchitis or acute sinusitis. (drugs.com)
Liver transplantation is a treatment, used in appropriately selected patients, for acute and chronic liver failure due to any cause. (medscape.com)
We really had very broad inclusion criteria, so there are patients who are quite complex in the trial lots of patients with acute coronary syndromes and diabetes. (acc.org)
The guidelines would recommend, after placement of drug-eluting stents, 1 year of dual antiplatelet therapy for any patient with an acute coronary syndrome. (acc.org)

Los estudios de centros mexicanos a su vez agrupados en: uso de novo de SRL, conversiones (tempranas y/o tard as) y efectos adversos. (medigraphic.com)
En los estudios de investigadores mexicanos en uso de SRL de novo se hallaron dos reportes que utilizaron esta estrategia. (medigraphic.com)

Sirolimus is in a class of medications called immunosuppressants. (medlineplus.gov)
0.91) in patient samples over the whole concentration range for all immunosuppressants. (nih.gov)

Sirolimus is used in combination with other medications to prevent rejection of kidney transplants. (medlineplus.gov)
It is particularly advantageous in patients with kidney transplants for hemolytic-uremic syndrome, as this disease is likely to recur in the transplanted kidney if a calcineurin-inhibitor is used. (wikipedia.org)
However, elderly patients are more likely to have age-related heart or kidney problems, or develop severe tendon problems (including tendon rupture), which may require caution in patients receiving ciprofloxacin injection. (drugs.com)
In another paper, the cumulative survival in 150 adults was followed from 2003 to 2016 and patients were screened for heart, lung, and kidney disease. (nih.gov)
The patient had received a kidney transplant in 2004 after end-stage renal failure related to polycystic kidney disease. (medicaljournals.se)
The lymphoedema disappeared within 6 months of ceasing treatment with sirolimus in this kidney-grafted patient. (medicaljournals.se)
As health care practitioners gained more experience with sirolimus, it began to be used "off-label" to prevent rejection in multiple transplant recipients outside of the kidney including liver, heart, and lung. (cancertherapyadvisor.com)

In addition, patients with APLS also develop vascular cellular infiltrates which is thought to also contribute to the increased incidence of stroke, myocardial infarction, mesenteric ischemia and nephropathy. (2minutemedicine.com)
This study is the first to examine the role of mTOR in APLS and whether blockade of this pathway, as achieved by sirolimus, can be linked to clinically significant vascular stenosis. (2minutemedicine.com)
this demonstrated that renal vascular endothelial cells from APLS patients had higher levels of a phosphorylated proteins downstream of the mTOR pathway (i.e. (2minutemedicine.com)
Post-transplant patients for APLS nephropathy were specifically examined in this study, therefore the effects of mTOR inhibition cannot be generalized to preventing all types of vascular stenosis. (2minutemedicine.com)
The initial part of this study focused on in-vivo studies using renal vascular cells from patients (both with and without APLS) to confirm the association between APLS and mTOR pathway activation (ie. (2minutemedicine.com)

All patients were also treated with ciclosporin and corticosteroids and were at low to moderate risk of rejection. (europa.eu)
As more experience with sirolimus has been gained, it began to be used "off-label" to prevent rejection in multiple transplant recipients and is now being studied in the treatment of GVHD. (cancertherapyadvisor.com)

At a mean follow up of 82 months, transplant recipients with antiphospholipid syndrome receiving sirolimus have a graft survival of 70% (7/10) versus 11% (3/27) in those not receiving sirolimus. (2minutemedicine.com)
In a publication on 225 patients, primarily with Hb SS disease, data shows that even though 60% of patients were taking hydroxyurea, the median survival age was only 48 years. (nih.gov)
While retrospective analyses have shown that oral sirolimus can improve survival in BOS patients, systemic toxicities have limited its widespread adoption. (itbusinessnet.com)
Limited retrospective data in humans administered oral sirolimus post lung transplant has demonstrated improved survival in both the prevention and treatment settings of BOS. (itbusinessnet.com)
Compare clinical response, in terms of 1-year progression-free survival and rate of molecular complete remission, in patients with Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML) in chronic phase who have achieved a complete cytogenetic remission to single-agent tyrosine kinase inhibitor treated with interferon alfa and sargramostim (GM-CSF) vs tyrosine kinase inhibitor and GM-K562 cell vaccine. (knowcancer.com)

tell your doctor and pharmacist if you are allergic to sirolimus, any other medications, or any of the ingredients in sirolimus tablets or solution. (medlineplus.gov)
Dr. Reddy s Sirolimus tablets in 1 mg and 2 mg are available in bottle counts of 100. (drreddys.com)
For patients who cannot reliably swallow tablets, liquid efavirenz formulations are available. (who.int)

The antiproliferative effect of sirolimus has also been used in conjunction with coronary stents to prevent restenosis in coronary arteries following balloon angioplasty. (wikipedia.org)
Yes, they are interested in one specific drug, ticagrelor, and a population of patients who have had a myocardial infarction not necessarily just patients who were treated with coronary stents, but any patient with a myocardial infarction over the past year. (acc.org)
The AHA, ACC, the Society for Cardiovascular Angiography and Interventions, the American College of Physicians, the American College of Surgeons, and the American Dental Association have released a science advisory on the importance of antiplatelet therapy in patients with coronary artery stents. (aafp.org)

We conducted a historical cohort study of adult patients with neurofibromatosis type 1 with spinal involvement. (ajnr.org)

Treatment is with sirolimus or lung transplantation. (msdmanuals.com)
Consider lung transplantation for patients with end-stage pulmonary disease. (medscape.com)

Sirolimus (Fyarro), as protein-bound particles, is indicated for the treatment of adults with locally advanced unresectable or metastatic malignant perivascular epithelioid cell tumor (PEComa). (wikipedia.org)
FYARRO ® (sirolimus protein-bound particles for injectable suspension) (albumin-bound) is a prescription medicine used to treat adults with malignant perivascular epithelioid cell tumors (PEComa) that have spread to other parts of the body (metastatic) or cannot be removed by surgery (locally advanced, unresectable). (fyarro.com)

Pharmacists can assist patients with medication therapy management for some symptoms of TSC and SWS. (uspharmacist.com)
Sirolimus is one such medication that can be considered an off-label second line treatment option (as well as for prophylaxis) when a patient's symptoms are refractory to steroids. (cancertherapyadvisor.com)

Your doctor will probably adjust your dose of sirolimus during your treatment, usually not more than once every 7 to 14 days. (medlineplus.gov)
The patients were observed for 12 months after the treatment had ended. (wikipedia.org)
While sirolimus was considered for treatment of LAM, it received orphan drug designation status because LAM is a rare condition. (wikipedia.org)
The safety of LAM treatment by sirolimus in people younger than 18 years old has not been tested. (wikipedia.org)
Nobelpharma America, LLC (NPA) is focused on the commercialization of pharmaceuticals and medical devices for patients with limited treatment options. (prnewswire.com)
HYFTOR™ (sirolimus topical gel) 0.2% is indicated for the treatment of facial angiofibroma associated with tuberous sclerosis in adults and children 6 years of age and older. (prnewswire.com)
However, antiplatelet therapy is sometimes prematurely discontinued in the first year of treatment either by the patient or a health care professional. (aafp.org)
Thus, there is an unmet need for additional treatment options for these patients. (drugdiscoverynews.com)
Based on its success in the solid organ transplant world, sirolimus has also been evaluated in prevention and treatment of graft versus host disease (GVHD). (cancertherapyadvisor.com)
Determine the toxicity of these treatment regimens in these patients. (knowcancer.com)
Patients are randomized to 1 of 2 treatment arms. (knowcancer.com)
Lisinopril tablet USP is indicated for the treatment of hypertension in adult patients and pediatric patients 6 years of age and older to lower blood pressure. (nih.gov)
The discussed cases reflect the panels' real-world clinical experience with crisaborole for the treatment of patients with AD and the off-label treatment of irritant dermatitis. (skintherapyletter.com)
Patients should be made aware of all of the options available geared at repigmentation and depigmentation prior to formulating a treatment plan. (skintherapyletter.com)
An endocrinologist can assist with prophylaxis and treatment of osteoporosis in patients in whom exogenous estrogen is contraindicated. (medscape.com)

Sequelae in patients with Proteus syndrome include ambulatory difficulty due to toe macrodactyly, scoliosis, and joint instability, with frequent hip dislocations. (medscape.com)

Recipients in both groups were randomized (based on physician preference) to immunosuppression with either a calcineurin inhibitor or sirolimus. (2minutemedicine.com)

Retrospective review of patient outcomes after pediatric cochlear implantation and analysis of temporal bone thickness. (lu.se)

Sirolimus blocks this pathway. (wikipedia.org)
Based on work I did in the lab, and based on the data in front of me that my mTOR signaling pathway was turned into overdrive, I became the first patient with my disease to be treated with this drug. (medscape.com)

HYFTOR is produced in a current good manufacturing practices (cGMP) environment and is available through a limited network of specialty pharmacies equipped to handle cold storage requirements and meet the unique needs of the small population of TSC patients with facial angiofibroma and their providers. (prnewswire.com)
Here we reported a case of a 34-year-old male, a known case of TSC with facial angiofibroma in which the topical 0.1% sirolimus had been used with beneficial effects and clinical outcomes. (ijord.com)
Sustained clinical effectiveness and favorable safety profile of topical sirolimus for tuberous sclerosis - Associated facial angiofibroma. (ijord.com)

HYFTOR is contraindicated in patients with a history of hypersensitivity to sirolimus or any other component of the gel. (prnewswire.com)

Sirolimus coated balloon demonstrated safety and efficacy in real world patients. (conceptmedical.com)
This is another significant milestone for MedAlliance: we were the first sustained limus release balloon to receive FDA IDE approval, the first to treat a US peripheral patient and now the first to treat a US coronary patient. (interhospi.com)
MedAlliance's unique DEB technology involves MicroReservoirs which contain a mixture of biodegradable polymer intermixed with the anti-restenotic drug 'sirolimus' applied as a coating on the surface of an angioplasty balloon. (interhospi.com)

When a pediatric patient is likely to require a liver transplant, the medical management is generally divided into pretransplant and posttransplant periods, with the posttransplant period further separated into early and late time frames. (medscape.com)

BETHESDA, Md. , Aug. 30, 2022 /PRNewswire/ -- Nobelpharma America, LLC, a pharmaceutical and medical device company headquartered in Bethesda, Maryland , and a subsidiary of Nobelpharma Co., Ltd. in Tokyo , has initiated distribution of HYFTOR™ (sirolimus topical gel) 0.2% into the United States healthcare marketplace. (prnewswire.com)
Additional information is available in the full Prescribing Information for HYFTOR (sirolimus topical gel) 0.2% at www.HYFTORPI.com . (prnewswire.com)
HYFTOR™ (sirolimus topical gel) 0.2% is not indicated for children younger than 6 years of age. (prnewswire.com)

Discontinue ciprofloxacin and avoid use of fluoroquinolones in patients with these serious adverse reactions. (drugs.com)
Patients should be monitored carefully for dose-related adverse reactions, particularly nervous system symptoms (see sections 4.3 and 4.4). (who.int)
Please do not use this form to submit personal or patient medical information or to report adverse drug events. (medscape.com)

The clinical outcomes in complex patient cohorts are very encouraging warrants the use of SCB in complex patients too. (conceptmedical.com)
Long-term use of azithromycin in patients with chronic inflammatory lung diseases, such as cystic fibrosis (CF), results in improved outcomes. (nih.gov)
Something may look the same under the microscope, but molecularly, it behaves very differently and, therefore, patients have completely different outcomes. (medscape.com)

However, this benefit with sirolimus was not observed for transplant recipients without antiphospholipid antibody. (2minutemedicine.com)
1 Sirolimus works through mTOR to produce a blockade of B- and T-cell activation and antibody product. (cancertherapyadvisor.com)

Clinical and para clinical manifestations of tuberous sclerosis: a cross sectional study on 81 pediatric patients. (ijord.com)

Sirolimus is a potent inhibitor of mTOR. (medscape.com)
If at any time after stopping study therapy blood tests show disease recurrence, patients restart tyrosine kinase inhibitor and are eligible to cross over to arm II. (knowcancer.com)
If at any time after stopping study therapy blood tests show disease recurrence, patients restart tyrosine kinase inhibitor and are eligible to cross over to arm I. Patients are also eligible to cross over to arm I in the presence of unacceptable toxicity. (knowcancer.com)

Sirolimus also reduces the size of angiomyolipomas, lymphangioleiomyomas, and chylous effusions. (medscape.com)

An inhaled version of sirolimus has the promise of delivering drug directly to the lung tissue where it is needed while potentially reducing systemic exposures and concomitant toxicities. (itbusinessnet.com)

This made sirolimus the first drug approved to treat this disease. (wikipedia.org)
Our findings emphasize the essential role for autophagy in the host response to infection with NTM, reveal why chronic use of azithromycin may predispose to mycobacterial disease, and highlight the dangers of inadvertent pharmacological blockade of autophagy in patients at risk of infection with drug-resistant pathogens. (nih.gov)
Patients receiving the drug should be managed in facilities equipped and staffed with adequate laboratory and supportive medical resources. (drreddys.com)
Factors that may contribute to premature cessation of thienopyridine therapy include drug costs, instructions from a physician or dentist to discontinue therapy before a procedure, and inadequate patient education about the importance of continuing therapy. (aafp.org)
It is well known that patient compli- the consumption of medicine reached 4 could be a very important factor in drug ance can be attained when substitution billion UAE dirhams in 2010 [2]. (who.int)
The is predicted to rise from US$ 14 billion scribing between a branded drug and objective of this survey was, therefore, in 2008 to US$ 60 billion in the coun- its generic counterpart for a new patient to evaluate current awareness, knowl- tries of the Gulf [2]. (who.int)
However, drug substitution can be edge and understanding about generic countries may be encouraged to reduce considered more critical than drug pre- substitution among renal patients' in their healthcare expenditures. (who.int)

Organ damage and, among female patients, infertility are more difficult to address but can be managed in some cases. (drugdiscoverynews.com)

Thus patients with SCD continue to experience early mortality (DeBaun M et al. (nih.gov)

Based on the three patients losing their grafts, stopping rules were met and the study moved to the 2nd cohort where 1 dose of Cy was given at 50mg/kg on day 3 post-transplant. (nih.gov)
The first-step of decreasing the dose of sirolimus was associated with a decrease in plasma level of sirolimus from 14.7 to 6 ng /ml but there had been no reduction of oedema after 3 months. (medicaljournals.se)

Anatomy3

Organisms2

Diseases15

Chemicals and Drugs26

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes6

Technology, Industry, Agriculture1

Named Groups2

Health Care7

Rapamycin15

Renal transplant6

Tacrolimus5

Everolimus5

Cyclosporine5

Rapamune15

Safety and efficacy of sirolimus3

Months after starting1

Stent12

Levels of sirolimus2

Form of sirolimus2

Complications7

Inhibitors3

Lymphangioleiomyomatosis4

20231

Immunosuppressive regimen1

Lesions5

Acute6

Novo2

Immunosuppressants2

Kidney7

Vascular5

Rejection2

Survival5

Tablets3

Stents3

Cohort study1

Lung transplantation2

Fyarro2

Medication2

Treatment15

Sequelae1

Calcineurin1

Implantation1

Pathway2

Facial angiofibroma3

Hypersensitivity1

Balloon3

Liver transplant1

Topical3

Adverse3

Outcomes3

Antibody2

Pediatric patients1

Inhibitor3

Reduces1

Systemic1

Drug7

Organ1

Mortality1

Dose2