• Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. (researchgate.net)
  • These correlations were not observed in group B. Conclusion: Injection of MSCs with marrow stimulation treatment was encouraging in patients older than 50 years compared with patients treated with marrow stimulation treatment alone, especially when the lesion size was larger than 109 mm(2) or a subchondral cyst existed. (researchgate.net)
  • Although still in the early stages of application, MSCs may have great potential in the treatment of OLTs in patients older than 50 years, and more evaluations of its effect should be performed. (researchgate.net)
  • Objective To evaluate the feasibility, safety, and immunological effects of intrathecal and intravenous administration of autologous mesenchymal stem cells (MSCs) (also called mesenchymal stromal cells ) in patients with multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). (thestemcellfoundation.com)
  • Magnetic resonance imaging visualized the MSCs in the occipital horns of the ventricles, indicating the possible migration of ferumoxides-labeled cells in the meninges, subarachnoid space, and spinal cord. (thestemcellfoundation.com)
  • Conclusion Transplantation of MSCs in patients with MS and ALS is a clinically feasible and relatively safe procedure and induces immediate immunomodulatory effects. (thestemcellfoundation.com)
  • We propose a novel, scaffold-less technique of cartilage repair in the human knee that combines arthroscopic microfracture and outpatient intra-articular injections of autologous bone marrow-derived mesenchymal stem cells (MSCs) and hyaluronic acid (HA). (nih.gov)
  • Human orofacial bone-derived mesenchymal stem cells (OMSCs) showed distinct differentiation traits from mesenchymal stem cells (MSCs) derived from long bones, mouse OMSCs have not been isolated due to technical difficulties, which in turn precludes using mouse models to study orofacial diseases. (ca.gov)
  • Their ongoing Phase 2 study is evaluating whether infusion of mesenchymal stem cells (MSCs) can treat steroid-resistant acute graft-versus-host disease (GVHD) or poor graft function after HSCT. (drugdiscoverynews.com)
  • One trial is testing whether MSCs with or without peripheral blood stem cells could treat poor graft function and delayed platelet engraftment. (drugdiscoverynews.com)
  • In another trial, this group is evaluating whether peripheral blood stem cells combined with MSCs can treat poor graft function. (drugdiscoverynews.com)
  • Here, a team of experts led by Bing Liang from Baoshan People's Hospital published the details of the case of a critically ill 65-year-old Chinese woman infected with Sars-CoV-2, whose conditions significantly improved after the infusion of mesenchymal stem cells ( MSCs ). (bioinst.com)
  • Not only, as reported once again in chinaXiv.org, 7 Covid-19 pneumonia patients (1 critically severe, 4 severe and 2 common) were treated with MSCs at Beijing YouAn Hospital, and their functional outcomes significantly improved. (bioinst.com)
  • According to Beijing experts, MSCs would act by improving lung microenvironment, inhibiting immune system overactivation, promoting tissue repair, protecting lung alveoli epithelial cells, preventing pulmonary fibrosis, and improving lung function. (bioinst.com)
  • The Baoshan patient received 3 infusions of 50 million umbilical blood cord-derived MSCs, whereas each Beijing patients received 1 infusion of 1 million cells per kilogram of weight. (bioinst.com)
  • The HUCMSCs derived different donors have individual heterogeneity, which potentially lead to distinct therapeutic outcomes in mouse liver fibrosis, indicating we could make use of the donor-variation of MSCs to screen out guaranteed general indicators of MSCs for specific diseases in further stem cell therapy. (researchsquare.com)
  • Mesenchymal stem cells (MSCs) have been widely tested for treating a variety of refectory medical indications such as type 1 diabetes mellitus, systemic lupus erythematosus, rheumatoid arthritis and Crohn's disease due to their multiple differentiation potentials and immunomodulation capability [1-5]. (researchsquare.com)
  • Over the past few years, MSCs researches have achieved some inspiring results and some of which moved up to clinic period from preclinical phases, resulting in the marketing approval of a few cell-based therapy products (CTPs) by different national regulatory authorities [18]. (researchsquare.com)
  • MSCs, if considered as a CTP in therapeutic use, have a huge challenge to achieve stable and uniform biological characteristics for ensuring safety and effectiveness in patients received MSCs treatment. (researchsquare.com)
  • We established a Good Manufacturing Practice (GMP) grade cell facility to produce clinic-grade human umbilical cord derived MSCs (HUCMSCs) for treating premature ovarian failure (POF) and recurrent uterine adhesion [18, 20]. (researchsquare.com)
  • Mesenchymal stem cells (MSCs) have been shown to migrate to various tissues. (radioprotection.org)
  • The efficacy and safety profile of mesenchymal stem cells (MSCs) augmentation in chondral procedures are controversial. (springer.com)
  • This systematic review updated the current evidence on MSCs augmentation for chondral procedures in patients with symptomatic chondral defects of the knee. (springer.com)
  • 12 Bang and colleagues reported the safety and feasibility of intravenous infusion of autologous mesenchymal stem cells (MSCs) with no reported adverse effects in five patients treated with intravenous MSCs. (bmj.com)
  • We analyzed expanded mesenchymal stem cells (MSCs) isolated from sporadic ALS patients and compared them with MSCs isolated from healthy donors. (unito.it)
  • No morphological differences were observed in the MSCs isolated from donors or patients. (unito.it)
  • The cellular expansion potential of MSCs from donors and patients was slightly different. (unito.it)
  • After three passages, the MSCs isolated from donors reached a cumulative population doubling higher than from patients but the difference was not statistically significant. (unito.it)
  • These results suggest that extensive in vitro expansion of patient MSCs does not involve any functional modification of the cells, including chromosomal alterations or cellular senescence. (unito.it)
  • Hence, there is a good chance that MSCs might be used as a cell-based therapy for ALS patients. (unito.it)
  • Conducted by a multi-institutional team of researchers in Japan who had developed the new therapy, the study was designed to confirm that their treatment-which involves transplanting the patient's own mesenchymal stem cells (MSCs) into the affected knee-did not cause tumors. (medicalxpress.com)
  • The team behind the current study, which included researchers from Tokyo Medical and Dental University, Kyoto University and Kazusa DNA Research Institute, recently developed a therapy involving the transplantation of MSCs derived from the knee's soft tissue (the synovium) into the injured meniscus. (medicalxpress.com)
  • MSCs are multipotent adult stem cells present in the umbilical cord, bone marrow, fat, dental and other body tissues. (medicalxpress.com)
  • Dr. Sekiya added, "Keep in mind that these were autologous MSCs used in our study, which means that the transplanted MSCs came from the patients themselves. (medicalxpress.com)
  • Nevertheless, we believe that these data suggest that MSCs with trisomy 7 are safe for transplantation into human knees and show much promise in treating osteoarthritis. (medicalxpress.com)
  • Mesenchymal stem/stromal cells (MSCs)‐based therapy brings the reassuring capability to regenerative medicine through their self‐renewal and multilineage potency. (biomedcentral.com)
  • Accordingly, pre-conditioning of MSCs is strongly suggested to upgrade their performances in vivo, leading to more favored transplantation efficacy in regenerative medicine. (biomedcentral.com)
  • Although there is no particular quantitative assay to provide MSCs identification in mixed cells population [ 8 ], the International Society for Cellular Therapy (ISCT) has provided minimum principles to determine MSCs. (biomedcentral.com)
  • However, natural MSCs in vivo survival and their biological effects on tissue recovery decrease with long-term cultivation called aging and also injected cells demonstrate poor targeted migration [ 21 ]. (biomedcentral.com)
  • The aim of this study is to evaluate the therapeutic effect of mesenchymal stem cells (MSCs) in a severe case of brain and multiple organ involvement in a patient with COVID-19. (elis.sk)
  • MSCs were transplanted to the patient four times systematically and once intrathecally. (elis.sk)
  • As a result, the application of MSCs has been found to have a healing effect on organs in this patient with severe COVID-19 infection. (elis.sk)
  • In addition, transplantation of MSCs both systematically and intrathecally is considered to be effective in the treatment of the central nervous system (Tab. (elis.sk)
  • The patients were observed for 14 days after the introduction of the infused MSCs. (thebiotalkmagazine.com)
  • Mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) have been shown to counter rheumatoid arthritis, autoimmune hepatitis, and systemic sclerosis [ 8 ]. (biomedcentral.com)
  • Why should mesenchymal stem cells (MSCs) cure autoimmune diseases? (cellsurgicalnetwork.com)
  • They can then induce the release of bioactive agents and the formation of progenitor cells in response to these changes. (wikipedia.org)
  • The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
  • Although there is no definitive evidence, combinations of progenitor cells seem to be more benefical than specific stem cell type for cardiac repair (3). (escardio.org)
  • Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
  • Increasing evidence suggests that SDF-1 is involved in bone formation through regulation of recruitment, engraftment, proliferation, and differentiation of stem/progenitor cells. (omicsdi.org)
  • This process relies on the formation of a blastema, a pool of progenitor cells that is formed in response to amputation. (lu.se)
  • The blood clot formed inside the root canal would act as a matrix for the migration of the progenitor cells from the apical papilla to the canal lumen 1 . (bvsalud.org)
  • We isolated a new population of stem cells from human orofacial tissue gingiva, a tissue source easily accessible from the oral cavity, namely GMSC, which exhibited clonogenicity, self-renewal, and multipotent differentiation capacities. (ca.gov)
  • Moreover, it seems that paracrine action of skeletal myoblasts facilitate neighboring cardiomyocytes to maintain their replicative potential and/or stimulate differentiation of native cardiac stem cells (8,9). (escardio.org)
  • They also can inspire angiogenesis by direct differentiation, cell-to-cell interaction, or paracrine effects. (biomedcentral.com)
  • Ghasemi-Mobarakeh L, Prabhakaran MP, Tian L, Shamirzaei-Jeshvaghani E, Dehghani L, Ramakrishna S. Structural properties of scaffolds: Crucial parameters towards stem cells differentiation. (wjgnet.com)
  • Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
  • Neurogenic differentiation of murine and human adipose-derived stromal cells. (stemcellclinicsofamerica.net)
  • Mesenchymal Stem Cells for Multiple Sclerosis: Does Neural Differentiation Really Matter? (cellsurgicalnetwork.com)
  • works in concert with bone morphogenetic protein-2 (BMP-2) to potentiate osteogenic differentiation of bone marrow-derived mesenchymal stem/stromal cells (BMSCs). (omicsdi.org)
  • Sadan O, Melamed E, Offen D. Bone-marrow-derived mesenchymal stem cell therapy for neurodegenerative diseases. (jamanetwork.com)
  • Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: a potential therapy for Huntington's disease. (jamanetwork.com)
  • Sadan O, Shemesh N, Cohen Y, Melamed E, Offen D. Adult neurotrophic factor-secreting stem cells: a potential novel therapy for neurodegenerative diseases. (jamanetwork.com)
  • In mesenchymal stem cell therapy, most of the cells are extracted from the adult patient's bone marrow Mesenchymal stem cells can be obtained via a procedure called bone marrow aspiration. (wikipedia.org)
  • Human mesenchymal stem cell therapy is limited due to variation in individual response to treatment and the high number of cells needed for treatment. (wikipedia.org)
  • Bisphosphonate related osteonecrosis of the jaw (BRONJ) is a recently described adverse side effect of bisphosphonate therapy, with an estimated 94% of cases reported in the oncologic patients receiving intravenous nitrogen-containing bisphosphonates (BP). (ca.gov)
  • Cell-based therapy using systemic infusion of GMSC in experimental colitis significantly ameliorated both clinical and histopathological severity of the colonic inflammation, restored the injured gastrointestinal mucosal tissues, reversed diarrhea and weight loss, and suppressed the overall disease activity in mice. (ca.gov)
  • Here we report application of human umbilical cord mesenchymal stem cell (HUCMSC)-derived therapy for pulmonary arterial hypertension (PAH). (nature.com)
  • This therapy, limited by the number of donor organs and by the need to select patients who are able to tolerate the twin demands of surgery and immunosuppression, nevertheless offers the potential of years of disease-free living. (mayoclinic.org)
  • Cell therapy is a potential new treatment for post MI patients, but the main challenges are : the necessity to preserve immune competency and to gain adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
  • As such, stem cell therapy cannot be regarded as a valid therapeutic option for patients with cardiovascular disease in the present era of evidenced-based medicine, yet it holds great hope for the future. (escardio.org)
  • Preclinical and some small-scaled clinical trials have suggested feasibility and safety of cardiac stem cell therapy. (escardio.org)
  • However, there are still questions waiting for answers and results of large-scale randomized trials are needed for the appearance of myocardial cellular therapy as a clinical therapeutic option for patients with ischemic heart disease. (escardio.org)
  • Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
  • Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
  • Preclinical studies suggest that cell therapy may be safe and effective in improving functional outcomes. (bmj.com)
  • Several recent clinical trials have reported safety and some improvement in outcomes following cell therapy administration in ischaemic stroke, which are reviewed. (bmj.com)
  • Cell therapy may provide a promising new treatment for stroke reducing stroke-related disability. (bmj.com)
  • Further investigation is needed to determine specific effects of cell therapy and to optimise cell delivery methods, cell dosing, type of cells used, timing of delivery, infarct size and location of infarct that are likely to benefit from cell therapy. (bmj.com)
  • 8 For patients with residual deficits after stroke, we have no currently approved therapy for restoring function. (bmj.com)
  • Cell therapy is one approach to enhancing recovery after stroke. (bmj.com)
  • 9 Clinical trials of cell therapy completed in the 2000s mostly treating small cohorts of patients with chronic stroke demonstrated adequate safety and a suggestion of efficacy with the use of cell therapy. (bmj.com)
  • 13 These early clinical trials mostly focused on chronic subcortical strokes, but more recent trials are now investigating cell therapy for treatment of both cortical and subcortical infarcts. (bmj.com)
  • Cell replacement therapy has been suggested as a promising therapeutic approach for multiple neurodegenerative diseases, including motor neuron disease. (unito.it)
  • A study released in Stem Cells Translational Medicine has confirmed the safety of a novel type of cellular therapy for knee pain caused by osteoarthritis. (medicalxpress.com)
  • But some stem cell treatments have been known to cause tumors, which is why the team wanted to ensure that their therapy was free of any negative side effects. (medicalxpress.com)
  • Stem cell therapy has been the subject of many studies for its potential to cure many disorders. (biomedcentral.com)
  • high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
  • This presentation describes the current state of the stem cells marketplace as it relates to their utilization for pharmaceutical screening as well as their development for cellular therapy. (selectbiosciences.com)
  • Details are provided about the quantitative market opportunity for various stem cell classes as well as the current state of the clinical trials space wherein stem cell-based therapeutics are being evaluated for therapy in various disease classes. (selectbiosciences.com)
  • Stem cell therapy has emerged as a breakthrough treatment option for arthritis. (arthritistreatmentlab.com)
  • Recent scientific studies and clinical trials have demonstrated the effectiveness of stem cell therapy in relieving pain and improving joint function in individuals with arthritis. (arthritistreatmentlab.com)
  • While each approach to stem cell therapy has its advantages and limitations, all have shown promising results in improving pain relief, joint function, and overall quality of life in individuals with arthritis. (arthritistreatmentlab.com)
  • This broadly encompasses the use of cells, tissues, drugs, synthetic biomaterials and devices to help patients heal more effectively from trauma, cancer therapy, other disease processes and birth anomalies. (plasticsurgery.org)
  • stromal vascular fraction cell therapy for multiple sclerosis. (stemcellclinicsofamerica.net)
  • Stem cell therapy is an emerging therapeutic modality in the treatment of stroke. (stemcellclinicsofamerica.net)
  • Cell-replacement therapy with stem cells in neurodegenerative diseases. (stemcellclinicsofamerica.net)
  • Mesenchymal stem cells have been used in cell-based therapy. (thebiotalkmagazine.com)
  • However, additional studies and trials on patients on a larger scale to validate the therapy are still needed. (thebiotalkmagazine.com)
  • We explored whether stem cell therapy was effective for animal models and patients with Crohn's disease (CD). (biomedcentral.com)
  • Stem cell transplantation is a valuable supplementary therapy for CD. (biomedcentral.com)
  • Several studies have evaluated the safety and effectiveness of CD stem cell therapy, but the results remain controversial. (biomedcentral.com)
  • Mechanisms of oxidative damage in multiple sclerosis and a cell therapy approach to treatment. (cellsurgicalnetwork.com)
  • Clinicians must stress the need for patient compliance with therapy. (medscape.com)
  • The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
  • An experimental stem cell therapy for the treatment of mild to moderate amyotrophic lateral sclerosis (ALS) received a resounding rejection today from a US Food and Drug Administration (FDA) advisory panel that cited efficacy, safety, and product manufacturing concerns. (medscape.com)
  • Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. (lu.se)
  • In this article, we first provide a short history of cell therapy in Parkinson's disease and briefly describe the current state-of-art regarding human stem cell-derived dopamine neurons for use in any patient trial. (lu.se)
  • Added to the implications to the patients, the treatment of permanent necrotic immature teeth also represents a challenging to the clinicians due to several factors associated with the conventional therapy generally used, the so called apexification technique 21 . (bvsalud.org)
  • Systemic treatment with adipose-derived mesenchymal stem cells ameliorates clinical and pathological features in the amyotrophic lateral sclerosis murine model. (jamanetwork.com)
  • Intravenous mesenchymal stem cells improve survival and motor function in experimental amyotrophic lateral sclerosis. (jamanetwork.com)
  • Forostyak S, Jendelova P, Kapcalova M, Arboleda D, Sykova E. Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis. (jamanetwork.com)
  • Human mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in a mouse model of amyotrophic lateral sclerosis. (jamanetwork.com)
  • Bone marrow mesenchymal stem cells from healthy donors and sporadic amyotrophic lateral sclerosis patients. (unito.it)
  • Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis. (stemcellclinicsofamerica.net)
  • Stem cells: comprehensive treatments for amyotrophic lateral sclerosis in conjunction with growth factor delivery. (stemcellclinicsofamerica.net)
  • P = .45) or in improvements on the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R), which reflects motor impairment and functional deterioration in patients with ALS ( P = .69). (medscape.com)
  • Purpose: To compare the clinical outcomes of MSC injection and arthroscopic marrow stimulation treatment with those of arthroscopic marrow stimulation treatment alone for the treatment of OLTs in older patients. (researchgate.net)
  • Patients were divided into 2 groups: 35 patients (37 ankles) treated with arthroscopic marrow stimulation treatment alone (group A) and 30 patients (31 ankles) who underwent MSC injection along with arthroscopic marrow stimulation treatment (group B). Clinical outcomes were evaluated according to the visual analog scale (VAS) for pain, the American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale, and the Roles and Maudsley score. (researchgate.net)
  • The following patient reported outcomes measures (PROMs) were retrieved at baseline and last follow-up: Visual Analogic Scale (VAS), Tegner Activity Scale, Lysholm Knee Scoring System, International Knee Documentation Committee (IKDC). (springer.com)
  • In animal models, delivery of several different types of stem cells reduce infarct size and improve functional outcomes. (bmj.com)
  • This study demonstrated safety and feasibility of stereotactic cell implantation, although there was no significant improvement in functional outcomes. (bmj.com)
  • These outcomes suggest a potential approach that could change the overall physical health of patients who suffer from osteoarthritis and experience debilitating joint pain. (medicalxpress.com)
  • Advances in regenerative medicine and cell-based therapies, particularly the transplantation of mesenchymal stem cells and intervertebral disc chondrocytes, have led to the publication of numerous studies and clinical trials utilising these biological therapies to treat degenerative spinal conditions, often reporting favourable outcomes. (monash.edu)
  • Owing to its rarity, the clinical and radiological factors affecting outcomes in patients with PIVH have not been widely studied. (bvsalud.org)
  • A new study published in the journal Aging and Disease reported that the intravenous administration of clinical-grade human mesenchymal stem cells into patients with COVID-19 resulted in improved functional outcomes. (thebiotalkmagazine.com)
  • The beneficial outcomes included an increased number of peripheral lymphocytes and a decline in the C-reactive protein and the disappearance of overactivated cytokine-secreting immune cells by 3-6 days in the circulating blood. (thebiotalkmagazine.com)
  • Genetic cancer risk assessment in general practice: systematic review of tools available, clinician attitudes, and patient outcomes. (cdc.gov)
  • In the research process of expanding the therapeutic uses of mesenchymal stem cells, they are grown in laboratories or grown using medication to stimulate new cell growth within the human body. (wikipedia.org)
  • One of the most extensively studied stem cell types are embryonic stem cells, which possess many of the same therapeutic properties as mesenchymal stem cells, including the ability to self-regenerate and differentiate into a number of cell lineages. (wikipedia.org)
  • Also, the host's immune system may reject injected embryonic stem cells and thus eliminate their therapeutic effects. (wikipedia.org)
  • PLX-R18 cells, derived from mesenchymal-like cells collected from donated placentas, are designed to release a combination of therapeutic proteins to jumpstart the regeneration of a poorly functioning hematopoietic system. (drugdiscoverynews.com)
  • To compare the heterogeneities of human umbilical cord mesenchymal stem cells (HUCMSCs) derived from different donors and test their therapeutic variations in mouse liver fibrosis model. (researchsquare.com)
  • Novel culture and cryopreservation systems for human pluripotent stem cells and neural stem cells will be presented and their advantages and applicability in the production of high quality advanced therapeutic products or functional screening tools for preclinical research discussed. (selectbiosciences.com)
  • The opportunities and challenges of development of stem cell-based therapeutic interventions for joint surface repair for the treatment and prevention of osteoarthritis will be discussed. (selectbiosciences.com)
  • This presentation will describe the current status of strategies to generate induced pluripotent stem (iPS) cells from mouse and human somatic cells for patient-specific disease modeling and cell therapeutic applications. (selectbiosciences.com)
  • BMSCs, augments the cell-mediated therapeutic effects resulting in enhanced bone formation, as evidenced by ex vivo ?CT and bone histomorphometry. (omicsdi.org)
  • With this background information as a foundation, we then discuss each of the key questions in relation to the upcoming therapeutic trial and critically assess if the time is ripe for clinical translation of parthenogenetic stem cell technology in Parkinson's disease. (lu.se)
  • Adult mesenchymal stem cells are being used by researchers in the fields of regenerative medicine and tissue engineering to artificially reconstruct human tissue which has been previously damaged. (wikipedia.org)
  • Also, transplanted mesenchymal stem cells pose little risk for rejection as they are derived from the patients own tissue, so are genetically identical, however graft versus host disease is a possibility, where the cells change enough while outside the patient's body that the immune system recognizes them as foreign and can attempt to reject them. (wikipedia.org)
  • Genetic mutations in stem cells as well as conditions at target tissue may result in formation of a cancerous tumor. (wikipedia.org)
  • White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
  • The white blood cells present within the transplanted tissue then attack the recipient's body's cells, which leads to GvHD. (wikipedia.org)
  • Also, following transplantation and migration to target tissue, they encounter a harsh milieu accompanied by death signals because of the lack of proper tensegrity structure between the cells and matrix. (biomedcentral.com)
  • Embryonic stem cells are derived from embryos and have the ability to become any type of cell in the body, while adult stem cells are found in various tissues and can develop into different cell types within that tissue. (arthritistreatmentlab.com)
  • Additionally, stem cells have the ability to migrate to areas of injury or inflammation, where they can promote tissue repair and reduce inflammation. (arthritistreatmentlab.com)
  • Stem cells have shown immense potential in treating arthritis by reducing inflammation, promoting tissue repair, and stimulating cartilage regeneration. (arthritistreatmentlab.com)
  • Promote Tissue Repair: Stem cells can differentiate into chondrocytes, the cells that make up cartilage, promoting cartilage repair and regeneration. (arthritistreatmentlab.com)
  • Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. (wjgnet.com)
  • Importantly, fat tissue is an important source of adult mesenchymal stem cells. (plasticsurgery.org)
  • Discovered by plastic surgeons, adipose derived stem cells are easy to isolate from fat tissue and hold tremendous promise for treating many disorders across the body. (plasticsurgery.org)
  • Specifically, 9 patients received systemic infusion of mesenchymal stem cells derived from adipose tissue and followed up for a 12-month follow-up period. (sscb-stembiotech.com)
  • As reported by the researchers, allogeneic transplantation of mesenchymal stem cells from adipose tissue was shown to be safe and able to reduce proteinuria and disease activity. (sscb-stembiotech.com)
  • For this reason, multiple infusions of adipose tissue mesenchymal stem cells over time are necessary to maintain long-term remission of refractory lupus nephritis. (sscb-stembiotech.com)
  • Tissue engineering combining functional cells, biomaterials and osteoinductive cues may provide alternative treatment strategies. (omicsdi.org)
  • The mesenchymal tissue separating the 2 systems is known as the tracheoesophageal septum. (medscape.com)
  • Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
  • It has become clear, however, that the susceptibility of cells to infection with TSE agents cannot be reliably predicted either from their tissue of origin or level of expression of PrP C ( 11 , 12 ). (cdc.gov)
  • Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. (lu.se)
  • Conclusion: Most of the publications highlight that the disinfection of the root canal (and the stimulation of residual stem cells) would induce formation of new hard tissue on the dentin wall and continue root development in length, improving the tooth survival. (bvsalud.org)
  • We have recently demonstrated that stromal cell-derived factor-1? (omicsdi.org)
  • Mesenchymal stem cell expression of stromal cell-derived factor-1? (omicsdi.org)
  • Increasing evidence suggests that stromal cell-derived factor-1 (SDF-1) is involved in bone formation. (omicsdi.org)
  • Stromal cell-derived factor-1? (omicsdi.org)
  • In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
  • A needle is inserted into the back of the patients hip bone and cells are removed to be grown under controlled in vitro conditions in a lab. (wikipedia.org)
  • HADSCs were induced to confirm that they can express the characteristics of endothelial cells (ECs) in vitro. (molvis.org)
  • Therefore, in this study, we assessed the ability of human adipose mesenchymal stem cells (hADSCs) to express the characteristics of ECs after induction in vitro to evaluate the theoretical feasibility of maintaining or restoring the function of ECs after intraocular application. (molvis.org)
  • Kondziolka and colleagues used N-Tera 2 cells derived from a lung metastasis of a human testicular germ cell tumour that when treated with retinoic acid generate postmitotic neurons that maintain a fetal neuronal phenotype indefinitely in vitro (LBS neurons). (bmj.com)
  • We are working to generate red blood cells in vitro from pluripotent stem cells, however the extremely large cell numbers involved pose unique challenges to culture technology and scale-up. (selectbiosciences.com)
  • In vitro cell proliferation studies showed that supplementing BMP-2 to Tet-Off BMSCs significantly increased the cell number during the first 24 h. (omicsdi.org)
  • potentiates bone morphogenetic protein-2-stimulated osteoinduction of genetically engineered bone marrow-derived mesenchymal stem cells in vitro. (omicsdi.org)
  • This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)
  • Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
  • The mature cells are then harvested and injected back into the patient through local delivery or systemic infusion. (wikipedia.org)
  • But expanding them to the quantity needed for infusion, that corresponds to at least 1 million cells per kg of weight, takes 2 to 3 weeks. (bioinst.com)
  • A group of CD 14ᐩ CD11cᐩ CD11 bmid regulatory dendritic cell populations increased after MSC treatment The patients receiving MSC infusion displayed a decreased level of tumor necrosis factor-alpha, a major pro-inflammatory cytokine. (thebiotalkmagazine.com)
  • Intravenous infusion of MSC results in their accumulation in lungs, here they secrete multiple paracrine factors, these factors play a role in protecting or rejuvenating alveolar epithelial cells, counteracting fibrosis, and treating pneumonia. (thebiotalkmagazine.com)
  • Therefore, in conclusion, it has been proven by clinical tests that intravenous infusion of MSC is a safe and efficient method for treating patients with COVID-19 pneumonia, including elderly patients with severe pneumonia. (thebiotalkmagazine.com)
  • Innovative therapies, such as progenitor and mesenchymal stem cell transplantation, targeting the specific altered pathway rather than the symptoms, are in the process of development. (smw.ch)
  • Other groups are also working on cell therapies for the treatment of poor graft function after HSCT. (drugdiscoverynews.com)
  • This paper will systematically review the current status of basic science studies, preclinical and clinical trials utilising cell-based therapies to repair the degenerate intervertebral disc. (monash.edu)
  • Although there are various treatment options available, some patients may not respond to conventional therapies. (arthritistreatmentlab.com)
  • Cell-based therapies may provide a new strategy for bolstering regeneration and repair through neuro-axonal protection or remyelination. (drcalapai.com)
  • Numerous studies have revealed that bone marrow-derived mesenchymal stem/stromal cells (BMSCs) hold great potential for regenerative therapies. (omicsdi.org)
  • The project recognizes the limitations of EVLP in treating all damaged lungs and therefore aims to develop new therapies, particularly based on mesenchymal stem cells (MSC). (lu.se)
  • Overall, " The bridge - lungs for life " seeks to revolutionize lung transplantation in Scandinavia by combining centralized EVLP facilities, innovative therapies, and efforts to promote equality in access to transplant services. (lu.se)
  • Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016? (lu.se)
  • Stem cell-based therapies for Parkinson's dis- ogy company International Stem Cell Corporation ease (PD) are rapidly moving towards clinical trials. (lu.se)
  • To stimulate and facilitate further research, the NCI and NHLBI held the First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation on April 28 and 29, 2011. (medscape.com)
  • Sadan O, Melamed E, Offen D. Intrastriatal transplantation of neurotrophic factor-secreting human mesenchymal stem cells improves motor function and extends survival in R6/2 transgenic mouse model for Huntington's disease. (jamanetwork.com)
  • This study demonstrated clinical and experimental evidences supporting a potential efficacy and safety of utilizing autologous PDL cells in the treatment of human periodontitis. (ca.gov)
  • We designed a study to find theoretical evidence for the induction, movement, fusion, proliferation, and safety of human adipose mesenchymal stem cells (hADSCs) in intraocular application. (molvis.org)
  • A comparative analysis of single-cell RNA sequencing data collected from three HUCMSCs and two human umbilical vein endothelial cell (HUVEC) controls identified eight common cell clusters, all of which indicated regenerative potential specific for HUCMSCs. (nature.com)
  • Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells. (bioinst.com)
  • [10] It is less common in younger patients and in those with closer human leukocyte antigens (HLA) matches between donor and the patient. (wikipedia.org)
  • Mitsuru Mizuno et al, Transplantation of human autologous synovial mesenchymal stem cells with trisomy 7 into the knee joint and 5 years of follow‐up, STEM CELLS Translational Medicine (2021). (medicalxpress.com)
  • Clinical use of human embryonic stem (hES) cells is already being explored in a several phase1 safety trials. (selectbiosciences.com)
  • SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas, including insulin producing beta cells (4). (diabetesresearch.org)
  • Regenerative medicine is the science of using adipose-derived stem cells harvested from fat to regenerate cells and tissues in the human body. (plasticsurgery.org)
  • Regenerative medicine is the science of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal form and function. (plasticsurgery.org)
  • It is therefore reasonable to move mesenchymal stem cells transplantation into properly controlled human studies to explore their potential as a results for multiple sclerosis. (drcalapai.com)
  • Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice. (stemcellclinicsofamerica.net)
  • Inflammatory cytokine induced regulation of superoxide dismutase 3 expression by human mesenchymal stem cells. (cellsurgicalnetwork.com)
  • Without this, the patient cells lost in PD could be replaced by grafted community is left trying to interpret complex scien- immature human dopaminergic neurons [3, 5]. (lu.se)
  • Sozzi E, Nilsson F, Kajtez J, Parmar M, Fiorenzano A. Generation of Human Ventral Midbrain Organoids Derived from Pluripotent Stem Cells . (lu.se)
  • Follow-up (≤25 months) included adverse events evaluation, neurological disability assessment by means of the EDSS, magnetic resonance imaging to exclude unexpected pathologies and track the labeled stem cells, and immunological tests to assess the short-term immunomodulatory effects of MSC transplantation. (thestemcellfoundation.com)
  • GMSC can function as an immunomodulatory and anti-inflammatory component of the immune system in vivo and is a promising cell source for cell-based treatment in experimental inflammatory diseases. (ca.gov)
  • Immunomodulatory and antiinflammatory properties of these cells in the treatment of respiratory system degenerative processes were confirmed by 15 completed clinical trials, and more than 50 new trials will explore them. (bioinst.com)
  • To date, the immunomodulatory capacity of mesenchymal stem cells is well known. (sscb-stembiotech.com)
  • There are several different types of stem cells, including embryonic stem cells and adult stem cells. (arthritistreatmentlab.com)
  • Following into the adult striatum, but were shown to release the rapid spread via social media, many PD patients dopamine, make and receive connections from the worldwide, and their families, became engaged in dis- host brain and ameliorate numerous types of motor, cussions and have asked whether they should try to as well as other, behavioural deficits in rodent mod- sign up for such a study. (lu.se)
  • Immunological analysis revealed an increase in the proportion of CD4 + CD25 + regulatory T cells, a decrease in the proliferative responses of lymphocytes, and the expression of CD40 + , CD83 + , CD86 + , and HLA-DR on myeloid dendritic cells at 24 hours after MSC transplantation. (thestemcellfoundation.com)
  • Most of the identifiable cells are lymphocytes or plasma cells. (medscape.com)
  • Cells such as T and B lymphocytes, macrophages, bone marrow, lymph nodes tested negative for ACE2. (thebiotalkmagazine.com)
  • Pluristem Therapeutics, based in Haifa, Israel, is currently recruiting patients in the United States and Israel for its Phase 1 trial of PLX-R18 cells in this unmet need. (drugdiscoverynews.com)
  • Stem cells as therapeutics for neurodegenerative disorders? (cellsurgicalnetwork.com)
  • BrainStorm Cell Therapeutics), uses mesenchymal stem cells harvested from patients' own bone marrow that are engineered to secrete neurotrophic factors, proteins important for the survival and function of neurons. (medscape.com)
  • Several academic and industry efforts are well under owned subsidiary Cyto Therapeutics, it had received way to produce dopaminergic neurons from stem approval by the Australian government to conduct a cells under conditions compliant with use in patients. (lu.se)
  • MSC mediated bone formation involves in both donor and recipient cells, but only recipient cells contribute to marrow element formation. (ca.gov)
  • of these, 53 percent are autologous (taken from the patient) and 47 percent are allogenic (taken from a donor other than the patient). (drugdiscoverynews.com)
  • The results showed that five years after transplantation, osteoarthritis-related tears to the knee meniscus had healed and, just as importantly, none of the patients experienced any serious side effects from the treatment. (medicalxpress.com)
  • The images revealed that tears in the patients' knee meniscus were obscured three years after transplantation. (medicalxpress.com)
  • [ 7 ] of 798 patients who survived more than 5 years after transplantation, 328 were children. (medscape.com)
  • HP75 cells treated with overexpressed miR-543 exhibited increased cell proliferation, migration and invasion, while decreased cell apoptosis as well as expression of Cleaved caspase-3 and Cleaved caspase-8 were observed. (cancerindex.org)
  • To the best of our knowledge, this is the first report in which autogenous bone marrow transplantation, noninvasive to the iliac crest, was performed in an incomplete AFF patient. (hindawi.com)
  • In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
  • [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
  • These data reinforce the need for marked vigilance in ensuring proper screening and management of long-term survivors of bone marrow transplantation. (medscape.com)
  • The properties of HUCMSCs were validated by untargeted label-free quantitation of the cell and CM proteome, suggesting increased activity of regeneration, autophagy and anti-inflammation pathways and mitochondrial function. (nature.com)
  • The idea of myocardial regeneration with stem cell transplantation after myocardial infarction receives tremendous interest. (escardio.org)
  • Stem cell mediated disc regeneration may bridge the gap between the two current alternatives for patients with low back pain, often inadequate pain management at one end and invasive surgery at the other. (monash.edu)
  • Through cartilage formation and disc regeneration or via modification of pain pathways stem cells are well suited to enhance spinal surgery practice. (monash.edu)
  • Stem cells have the ability to differentiate into various types of cells, including those needed for cartilage repair and regeneration. (arthritistreatmentlab.com)
  • Background: The ideal treatment for osteochondral lesions of the talus (OLTs) is still controversial, especially in older patients. (researchgate.net)
  • Mesenchymal stem cells possess many properties that are ideal for the treatment of inflammatory and degenerative diseases. (wikipedia.org)
  • However, there have been some cases where there were both improvement and toxicity inflicted on the targeted organ, as well as cases where treatment of mesenchymal stem cells did not show improvement of function at all. (wikipedia.org)
  • The long-term goal of this proposal is to develop stem cell-based treatment for major defects in the orofacial regions. (ca.gov)
  • We examined the clinical outcome of three autologous PDLP-treated patients in an effort to provide primary knowledge on the effectiveness of this treatment approach and preliminary clinical evidence for randomized controlled trial in the future. (ca.gov)
  • Here we demonstrate safe and efficient HUCMSC-derived treatment of severe, progressive PAH by means of serial intravascular infusions of HUCMSC-CM in one young patient with heritable PAH and HHT type 2 caused by an ACVLR1 missense mutation. (nature.com)
  • The current treatment for incomplete hematopoietic recovery includes administration of factors stimulating white and red blood cell growth, such as granulocyte-colony stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin. (drugdiscoverynews.com)
  • Thus, there is an unmet need for additional treatment options for these patients. (drugdiscoverynews.com)
  • these studies confirm the efficacy and the safety of mesenchymal stem cells in the treatment of critical immunodeficiency associated with high systemic inflammation too. (bioinst.com)
  • March 15, 2019 - Biohaven announced that the company has initiated patient enrollment in a Phase 3 clinical trial of its third generation pro-drug troriluzole for the treatment of SCA. (ataxia.org)
  • The good news is that stem cells have emerged as a breakthrough treatment option for arthritis. (arthritistreatmentlab.com)
  • There is currently no cure for arthritis, so effective treatment options are crucial in managing symptoms and improving the overall well-being of patients. (arthritistreatmentlab.com)
  • As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein. (drcalapai.com)
  • An oral antipsychotic agent, penflurido (PFD), used for schizophrenia treatment, has shown an antitumor effect on various types of cancer cells. (bvsalud.org)
  • PFD treatment reduced cancer cell migration and invasion by reducing the Integrin α6 and uPAR levels and suppression of the expression of epithelial-to-mesenchymal transition (EMT) factors, vimentin and Zeb1. (bvsalud.org)
  • We evaluated the efficacy and safety of CIK cell immunotherapy with radiotherapy-temozolomide (TMZ) for the treatment of newly diagnosed glioblastomas. (bvsalud.org)
  • In this phase one clinical trial, the efficacy of these cells for the treatment of refractory lupus nephritis (LN) was verified. (sscb-stembiotech.com)
  • During the first three months after treatment, a complete and partial renal response was observed in 33.3% and 44.4% of patients, respectively. (sscb-stembiotech.com)
  • In the animal studies, the disease activity index dramatically decreased in the mesenchymal stem cell (MSC) treatment groups compared to the control group. (biomedcentral.com)
  • SCs have been found to inhibit intestinal inflammation, promote long-term intestinal mucosal healing, and significantly improve patient quality of life, making them a valuable alternative CD treatment. (biomedcentral.com)
  • Skeletal injuries are among the most prevalent clinical problems and bone marrow-derived mesenchymal stem/stromal cells (BMSCs) have successfully been used for the treatment thereof. (omicsdi.org)
  • Cell-free DNA in the supernatant of pleural effusion can be used to detect driver and resistance mutations, and can guide tyrosine kinase inhibitor treatment decisions. (cdc.gov)
  • Lung transplantation is the only treatment for patients with severe lung disease, but the organs are not enough, resulting in patients dying while waiting for organs. (lu.se)
  • Ultimately, the panel denied the company's BLA, ruling that evidence from phase 2 and 3 trials failed to demonstrate the therapy's efficacy and raised safety concerns after more patients in the treatment group died during the study. (medscape.com)
  • Conducted at six US sites, the trial included 189 patients with ALS who received at least one treatment of NurOwn or a placebo. (medscape.com)
  • In the cases where the treatment is not performed, the patient might spend a long time of his/her life with the necrotic tooth without a diagnosis. (bvsalud.org)
  • The care of patients with progressive lung disease has been transformed by orthotopic lung transplantation. (mayoclinic.org)
  • The decision concerning single- or double-lung transplantation is often of major concern to patients and is influenced by organ availability, age and functional status - single lung is generally a shorter, less complex operation - as well as past surgical history, but in general, carefully selected patients have good quality of life and often excellent lung function after single-lung transplantation. (mayoclinic.org)
  • The clinical course and pathological results of the patient are presented with a review of the related literature. (hindawi.com)
  • Mesenchymal stem cells modulate pathological responses in experimental autoimmune encephalitis, alleviating disease, but also stimulate repair of the central nervous system through the release of soluble factors. (drcalapai.com)
  • Animal tests suggested stem cells might be able to repair the severe organ damage caused by Sars-CoV-2. (bioinst.com)
  • If the GvHD is severe and requires intense immunosuppression involving steroids and additional agents to get under control, the patient may develop severe infections [12] as a result of the immunosuppression and may die of infection. (wikipedia.org)
  • Trisomy 7 occurs frequently in patients with severe knee disease such as osteoarthritis. (medicalxpress.com)
  • The use of specialized footwear is recommended for high-risk patients with diabetes including those with severe neuropathy, foot deformities or history of amputation. (medscape.com)
  • In patients with diabetes the increased levels of glucose in the blood, the increased level of inflammation, and the problems at the level of beta cells all facilitate the emergence of symptoms that are more severe. (diabetesresearch.org)
  • Mortality in patients that develop such severe disease is dramatically high: it was reported to be 52.4% (9). (diabetesresearch.org)
  • Treating COVID_19 patients, especially those afflicted with severe pneumonia is challenging as there is no specific drug available. (thebiotalkmagazine.com)
  • The patients were tested positive for SARS-CoV-2, with one displaying critically severe type, 4 exhibiting severe types, and the other 2showing common types of the syndrome. (thebiotalkmagazine.com)
  • Nos travaux ont permis de mettre en évidence la répartition spatiale et le taux de prise de greffe des CSM injectées par voie intraveineuse (IV) dans un organisme en fonction de la configuration pour une irradiation gamma. (radioprotection.org)
  • En revanche, le taux de CSMh implantées est plus important au niveau des zones irradiées à forte dose, suggérant que la colonisation des CSMh dans les tissus après irradiation est dépendante de la configuration d'irradiation. (radioprotection.org)
  • L'ensemble de nos résultats suggère que la thérapie cellulaire par les CSM pourrait être utilisée pour la régénération des tissus normaux lésés suite à une irradiation accidentelle ou chez les patients soumis à une radiothérapie. (radioprotection.org)
  • Common problems include poor cell engraftment, which can be addressed by irradiation prior to transplantation. (omicsdi.org)
  • augments bone formation in vivo in a model of local BMSC transplantation following irradiation. (omicsdi.org)
  • Chondrocytes have the longest cell cycle in the body (similar to central nervous system and muscle cells). (msdmanuals.com)
  • Inflammatory mediators trigger an inflammatory cycle that further stimulates the chondrocytes and synovial lining cells, eventually breaking down the cartilage. (msdmanuals.com)
  • Our study suggests that both OMSCs and host cells contribute to bone formation in vivo. (ca.gov)
  • PURPOSE: Adoptive cell immunotherapy involves an ex vivo expansion of autologous cytokine-induced killer (CIK) cells before their reinfusion into the host. (bvsalud.org)
  • Identification of an eight-gene signature for survival prediction for patients with hepatocellular carcinoma based on integrated bioinformatics analysis. (cdc.gov)
  • In the absence of any reliable treatments for established bronchiolitis obliterans, investigators from Mayo Clinic in Jacksonville, Florida, are conducting a clinical trial of mesenchymal stem cells in lung transplant recipients with chronic rejection. (mayoclinic.org)
  • Various cell types have been tested experimentally for cardiac repair so far, but only those of autologous origin have yet undergone clinical testing due to immune competency. (escardio.org)
  • In particular, these stem cells can secrete many cytokines (molecules that participate in inflammatory processes) and can directly interact with immune cells. (bioinst.com)
  • GvHD occurs when the donor's immune system's white blood cells reject the recipient. (wikipedia.org)
  • Use of targeted next generation sequencing to characterize tumor mutational burden and efficacy of immune checkpoint inhibition in small cell lung cancer. (cdc.gov)
  • We know that innate immune cells are required for blastema progenitor cell formation, but are lacking an understanding of the immune cell processes and functions that are required for inducing and maintaining these progenitors cells. (lu.se)
  • This will be coupled with next generation sequencing based approaches to understanding the consequences of perturbing immune cell function. (lu.se)
  • Most current cell-based cartilage repair techniques require some form of scaffolds and 2 separate surgical procedures. (nih.gov)
  • This study highlights the ability of a patient's own stem cells to potentially heal torn cartilage in the knee," said Anthony Atala, M.D., Editor-in-Chief of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine. (medicalxpress.com)
  • Mesenchymal stem cells are able to differentiate, or mature from a less specialized cell to a more specialized cell type, to replace damaged tissues in various organs. (wikipedia.org)
  • Stem cells have the potential to regenerate damaged tissues and organs. (arthritistreatmentlab.com)
  • Lung patients die for lack of organs healthy enough for donation. (lu.se)
  • Cells Tissues Organs. (cancercentrum.se)