• The CD4+ T-lymphocyte is the primary target for HIV infection because of the affinity of the virus for the CD4 surface marker (3). (cdc.gov)
  • Safety of autologous stem cell transplantation in patients with known Human T-cell Lymphotropic Viruses Type 1 and 2 infection: A case series of four patients. (bu.edu)
  • White blood cells function by producing antibodies to fight off infection from our body. Leukemia patients are more prone to infections as their abnormal white blood cells cannot produce antibodies. (intelligentdental.com)
  • Special Tests Acute swelling and redness at a bursal web site requires aspiraпїЅ tion to rule out infection particularly if the patient is either febrile (temperature greater than 37 [url=https://modestedu.com/technology/order-cheap-aygestin-no-rx/] breast cancer ribbon cost of aygestin[/url]. (ehd.org)
  • The ability of a pathogenic virus to lie dormant within a cell (latent infection). (lookformedical.com)
  • Adult T cell leukemia- lymphoma is a rare aggressive malignancy of the peripheral T lymphocytes, caused by human T cell lymphotropic virus -1 (HTLV-1) infection. (openarchives.gr)
  • Acute human immunodeficiency virus type 1 infection. (ocu-radiology.jp)
  • HTLV-1 prevalence in Portugal is low and mainly affects immigrants from endemic areas where HIV infection represents a public health problem. (htlv.net)
  • Epstein-Barr virus (EBV), vitamin D, and smoking are among the most well-established environmental risk factors in MS. Infectious mononucleosis, which is caused by delayed primary EBV infection, increases the risk of developing MS. (vitamindwiki.com)
  • Human immunodeficiency virus type 2 infection and cerebral toxoplasmosis. (ocu-radiology.jp)
  • Strongyloidiasis with human T-lymphotropic virus type 1 infection. (ocu-radiology.jp)
  • White blood cells (WBC) (consisting mainly of neutrophils, lymphocytes and monocytes) are our "front-line soldiers" and defend the body against infection from bacteria, viruses and other organisms. (sjmccancerradiosurgerycentre.com)
  • Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain infections and cancers. (msdmanuals.com)
  • Human Immunodeficiency Virus (HIV) Infection in Infants and Children Human immunodeficiency virus (HIV) infection is caused by the retrovirus HIV-1 (and less commonly by the related retrovirus HIV-2). (msdmanuals.com)
  • Buehring G, Shen HM, Jensen H, Block G. Bovine leukemia virus infection is significantly associated with risk of breast cancer. (ac.ir)
  • Planning and management to control and eliminate HTLV-1 infection in Iran. (ac.ir)
  • Clinical features of breast cancer patients with human T-cell lymphotropic virus type-1 infection. (ac.ir)
  • Imaging of lung damage caused by the HTLV-1 hyperinflammatory cascade can be similar to sequelae from TB infection. (uchile.cl)
  • Human T lymphotropic virus type I (HTLV-I) infection in neurological patients in Salvador, Bahia, Brazil. (fiocruz.br)
  • The earliest known case of infection with HIV-1 in a human was detected in a blood sample collected in 1959 from a man in Kinshasa, Democratic Republic of the Congo. (dc.gov)
  • Sensitivity of two ELISA tests in relation to Western blot in detecting HTLV-I and HTLV-II infection among HIV-1-infected patients from São Paulo, Brazil. (sp.gov.br)
  • The human papillomavirus (HPV) is a common sexually transmitted infection that can cause various diseases, including genital warts and malignant diseases, such as cervical, head and neck, and anal cancer. (koreamed.org)
  • This review assesses the complement system and its activation, with the pathological features of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human immunodeficiency virus (HIV) infection and preeclampsia (PE). (koreamed.org)
  • In contrast, infection fector cells or from blockage of intra- of action associated with oncogenic with certain pathogens, such as hu- cel ular pathways essential for anti- viruses, may escape immune sur- man immunodeficiency virus type 1 gen recognition or of other elements veillance in immunosuppressed indi- (HIV-1) or malaria parasites, is per- of the immune response. (who.int)
  • who are latently infected with an on- Certain pharmaceutical drugs, Immunosuppression as a medi- cogenic virus are at greatly increased ionizing and ultraviolet radiation, cal therapy is used to treat autoim- risk for developing virus-related or infection with certain viruses mune diseases such as lupus ery- cancers when they become immu- and parasites can cause immu- thematosus or rheumatoid arthritis. (who.int)
  • An uncommon but potential y lized to act as an alkylating agent, Infection with HIV-1 is the cause of dangerous side effect of immuno- causes acute myeloid leukaemia and the acquired immune deficiency syn- suppression to support organ trans- carcinoma of the urinary bladder in drome (AIDS). (who.int)
  • Les résultats sérologiques de 10 560 patients ayant une infection par EBV suspecte ont été évalués. (who.int)
  • 1 ). of VCA IgG and EBNA IgG in the infections according VCA IgM and EBV is a globally prevalent virus and absence of VCA IgM is typical of past VCA IgG positivity, and the presence or over 90% of the world's population is infection. (who.int)
  • Patients who survive the initial infection often require prolonged artificial respiratory support (mechanical ventilation or extra corporeal membrane oxygenation), so even a few cases impact significantly on higher-level clinical services. (who.int)
  • The human immunodeficiency virus type 1 (HIV-1) is a worldwide distributed pathogen and the occurrence of coinfections with other human retroviruses like the human T-cell lymphotropic virus type I and II (HTLV-I and HTLV-II) has been shown to be a fairly common event in Brazil (Schechter et al. (scielo.br)
  • In (Figure 3) open reading frames (ORF) are shown which can if translated can predict which genes will be present and this can help to better understand human retroviruses. (wikipedia.org)
  • Identification of human T-cell lymphotropic virus type 1 (HTLV-1), herpesviruses 6, 7, and 8, and human endogenous retroviruses within LyP has been reported, but no clear relationship has been found. (logicalimages.com)
  • Retroviruses are enveloped RNA viruses defined by their mechanism of replication via reverse transcription to produce DNA copies that integrate into the host cell's genome. (msdmanuals.com)
  • The human T-lymphotropic viruses represent a group of retroviruses that possess tropism for T lymphocytes and are transmitted parenterally, vertically and sexually. (bvsalud.org)
  • Similar to other retroviruses, HTLV-1 evolves either through accumulation of point mutations or recombination. (biomedcentral.com)
  • Research has been done in many parts of the world to investigate the presence of bovine leukemia virus (BLV) and its correlation with breast cancer on breast paraffin tissue and human blood samples. (ac.ir)
  • Can bovine leukemia virus be related to human breast cancer? (ac.ir)
  • Schwartz I, Levy D. Pathobiology of bovine leukemia virus. (ac.ir)
  • Bovine leukemia virus gene segment detected in human breast tissue. (ac.ir)
  • HTLV-1 is a type C retrovirus, related to other human and primate lymphotropic viruses and the bovine leukemia virus. (medscape.com)
  • HTLV-1 is a member of the Retroviridae family, the Orthoretrovirinae subfamily and the Deltaretrovirus genus, which includes bovine leukemia virus (BLV) and T-lymphotropic viruses infecting primates (PTLV). (biomedcentral.com)
  • The etiologic agent of acquired immunodeficiency syndrome (AIDS) is a retrovirus designated human immunodeficiency virus (HIV). (cdc.gov)
  • EBV may also contribute to MS pathogenesis indirectly by activating silent human endogenous retrovirus-W. The emerging B-cell depleting therapies, particularly anti-CD20 agents such as rituximab, ocrelizumab, as well as the fully human ofatumumab, have shown promising clinical and magnetic resonance imaging benefit. (vitamindwiki.com)
  • Human immunodeficiency virus (HIV) is a retrovirus. (msdmanuals.com)
  • Early Juvenile Human T-cell Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: Study of 25 Patients. (bvsalud.org)
  • Human T-cell lymphotropic virus type-1 ( HTLV-1 ) may cause severe diseases such as HTLV-1-associated myelopathy / tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH). (bvsalud.org)
  • Human T- leukemia, type 2 (HTLV-2) generally causes no signs or symptoms. (wikipedia.org)
  • Human T- leukemia, type 2 (HTLV-2) is usually diagnosed based on blood tests that detect to the virus. (wikipedia.org)
  • Serologic testing using the enzyme-linked immunosorbent assay (1) and the Western blot technique (2) for antibody to the human T-lymphotropic virus type III (HTLV-III) has been done, with specific informed consent, on 40 HCWs enrolled in the surveillance system. (cdc.gov)
  • Six months before, the patient was diagnosed with stage IV human T-lymphotropic virus type 1 (HTLV-1)-associated adult T cell lymphoma (ATLL). (the-rheumatologist.org)
  • The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE , infecting B-cells in humans. (lookformedical.com)
  • The type species is HERPESVIRUS 1, HUMAN . (lookformedical.com)
  • The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS , but whose true origin is unknown. (lookformedical.com)
  • Vasculopathy and myocardial infarction associated with Neurofibromatosis type 1. (ocu-radiology.jp)
  • Type 1 has been most frequently associated with disease in infected individuals. (bvsalud.org)
  • It is estimated that 15 to 20 million people are affected by human T-lymphotropic virus type 1. (bvsalud.org)
  • The main diseases associated with human T-lymphotropic virus type 1 are adult T-cell leukemia/lymphoma and tropical spastic paraparesis. (bvsalud.org)
  • Kaveh F, Amini K, Sadeh M. Prevalence of Herpes Simplex Virus type 1 and 2 (HSV-1 and HSV-2) in the women with breast cancer by Multiplex-PCR method. (ac.ir)
  • Mutations in TET2 , encoding one of the TET members responsible for the conversion of DNA cytosine methylation to hydroxymethylation (5-hmc), have been recently described in Human T-lymphotropic virus type 1-associated adult T-cell leukemia/lymphoma (ATLL). (oncotarget.com)
  • RATIONALE: Human T-cell lymphotropic virus type 1 can cause cancer. (druglib.com)
  • Zidovudine is an antiviral drug that acts against the human T-cell lymphotropic virus type 1. (druglib.com)
  • complete response or partial response) to zidovudine, recombinant interferon alfa-2b, and PEG-interferon alfa-2b therapy in patients with human T-cell lymphotropic virus type 1-associated adult T-cell leukemia/lymphoma (ATLL). (druglib.com)
  • asked whether human T lymphotropic virus type 1 (HTLV‐1) antibody status is associated with the risk of developing gastric cancer. (diseases-illness.com)
  • The virus was at first named HTLV-III/LAV (human T-cell lymphotropic virus-type III/lymphadenopathy-associated virus) by an international scientific committee. (dc.gov)
  • Adult T-cell leukemia/lymphoma (ATLL) is a rare and aggressive disease caused by human T-cell lymphotropic virus type 1 that predominantly affects Japanese and Caribbean populations. (oncotarget.com)
  • The causative agent of ATLL has been identified as the human T cell lymphotropic virus type 1 (HTLV-1) [ 2 - 4 ], which is endemic to Japan, the Caribbean islands, Central and South America, and parts of sub-Saharan Africa [ 5 ]. (oncotarget.com)
  • A new international consensus for diagnosis requires objective signs and symptoms of dryness including a characteristic appearance of a biopsy sample from a minor salivary gland or autoantibody such as anti-SS-A. Exclusions to the diagnosis include infections with HIV, human T-lymphotropic virus type I, or hepatitis C virus. (nih.gov)
  • PTLVs consist of simian T-lymphotropic viruses (STLVs) type 1 to 4, which infect non-human primates and human T-lymphotropic viruses type 1-4. (biomedcentral.com)
  • Human T lymphotropic virus type 1-assoicated (HTLV-1-associated) myelopathy/tropical spastic paraparesis (HAM/TSP) is a neuroinflammatory disease caused by the persistent proliferation of HTLV-1-infected T cells. (jci.org)
  • Although HIV has been isolated from a variety of body fluids, including blood, semen, vaginal secretions, breast milk, urine, saliva, and tears, the risk of transmission is a consequence of the amount of virus present and the type of exposure to infected bodily fluids. (health.am)
  • Adult T cell leukemia/lymphoma(ATL) is an aggressive, fatal malignancy associated with human T-lymphotropic virus type I(HTLV-I). The median survival time of acute- and lymphoma-type ATL is 6 and 10 months, respectively. (elsevierpure.com)
  • Detection and isolation of type C retrovírus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. (sp.gov.br)
  • 5. Moriuchi H, Moriuchi M, Fauci A. Factors secreted by human T lymphotropic virus type I (HTLV-I)-infected cells can enhance or inhibit replication of HIV-1 in HTLV-I-uninfected cells: implications for in vivo coinfection with HTLV-I and HIV-1. (sp.gov.br)
  • 6. Moriuchi H, Moriuchi M. In vitro induction of HIV-1 replication in resting CD4+ T cells derived from individuals with undetectable plasma viremia upon stimulation with human T-cell leukemia virus type I. Virology. (sp.gov.br)
  • The epidemiology and disease outcomes of human T-lymphotropic virus type II. (sp.gov.br)
  • Interest is increasing in human T-cell lymphotropic virus type-1 (HTLV-1) transmission. (koreamed.org)
  • Des mesures de protection contre cet type d'iinfection devraient être mises en place. (who.int)
  • Hypercalcemia occurs in about 70% of patients with acute adult T cell leukemia. (openarchives.gr)
  • The only oral manifestation associated with human T-lymphotropic virus is adult T-cell lymphoma. (bvsalud.org)
  • No specific sequence differences have been found between HTLV-1 recovered from patients with HAM, those with adult T-cell leukemia/lymphoma also caused by HTLV-1 (ATLL), and HTLV-1 carriers. (medscape.com)
  • Adult T-cell leukemia/lymphoma (ATLL) is a rare mature T-cell malignancy first described in Japan in 1977 [ 1 ]. (oncotarget.com)
  • HTLV-2 Encoded Antisense Protein APH-2 Suppresses HIV-1 Replication Abstract Antisense protein of Human T-cell. (htlv.net)
  • Nuclear antigens encoded by VIRAL GENES found in HUMAN HERPESVIRUS 4. (lookformedical.com)
  • B-lymphotropic human herpesvirus IgG, VCA IgM and EBNA IgG) can database. (who.int)
  • A group of 149 patients attending the AIDS Reference Unit of the State Department of Health was tested for the presence of antibodies to HTLV-I/II using an enzyme immunoassay and the positive reactions were confirmed with a Western blot that discriminates between HTLV-I and HTLV-II infections. (scielo.br)
  • Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
  • Safety and Efficacy of Propylene Glycol-Free Melphalan in Patients with AL Amyloidosis Undergoing Autologous Stem Cell Transplantation: Results of a Phase II Study. (bu.edu)
  • Modified High-Dose versus High-Dose Melphalan Conditioning in Older Patients Undergoing Autologous Stem Cell Transplantation for Immunoglobulin Light Chain Amyloidosis. (bu.edu)
  • Following-up 37 IDH patients with neurological examinations , 54% developed HAM/TSP. (bvsalud.org)
  • The patients were HTLV-1 + and were submitted to dermatological and neurological examinations . (bvsalud.org)
  • Twenty-one patients were classified as definite HAM/TSP by both criteria, 3 as probable HAM/TSP by Osame et al, and another as probable HAM/TSP according to Castro-Costa et al Median age at onset of neurological manifestations was 9 years for the IDH/HAM/TSP group and 16 years for the HAM/TSP group (P = .045). (bvsalud.org)
  • In 12 patients , the onset of neurological manifestations occurred when they were less than 10 years of age. (bvsalud.org)
  • To the best of our knowledge, these are the first cases of a proven association between HTLV-I and TSP/HAM in Belem, Para, and emphasize the need to actively look for cases of neurological disease associated to the virus. (scielo.br)
  • The following cases demonstrate the usefulness of ultrasound in providing clues to the underlying diagnosis and highlight a case in which this imaging modality was helpful in assessing disease activity in an established RA patient, which altered the patient management. (the-rheumatologist.org)
  • Diagnosis of MS relies primarily on clinical evaluation and imaging studies such as magnetic resonance imaging (MRI), particularly in patients who present with typical disease progression. (arupconsult.com)
  • Which diseases should be considered in the differential diagnosis when evaluating patients with possible multiple sclerosis? (arupconsult.com)
  • The majority of patients with CC are older than 65 years of age and although cases of long-term survival have been reported after resection, most patients with unresectable disease die between 6 months and 1 year following diagnosis [ 3 ]. (biomedcentral.com)
  • However, overall prognosis was poor and the patient died due to progressive disease within 3 months of diagnosis. (biomedcentral.com)
  • The most difficult challenge in diagnosis and therapy is patients with symptoms of fibromyalgia (arthralgia, myalgia, fatigue) and oral and ocular dryness in the presence of circulating antinuclear antibodies. (nih.gov)
  • 10. Caterino-de-Araujo A. Best screening assays for the diagnosis of human T-cell lymphotropic virus types 1 and 2 in South America. (sp.gov.br)
  • Read below how to identify any viruses present in a clinical sample through metagenomics and how precision medicine can help clinicians to release an accurate and personalized diagnosis. (varsomics.com)
  • The mission of the International Retrovirology Association (IRVA) is to encourage research in retrovirology, especially the study of human T-lymphotropic virus (HTLV) infections and the associated diseases, to foster collaborations between research groups, provide a platform for critical analysis of new data, and contribute to the dissemination of knowledge about these infections. (htlv.net)
  • We have clearly documented certain enterovirus infections triggering autoimmune responses in some patients…Can you imagine how we would feel if there are viruses surviving in our muscles, brains, hearts and gastrointestinal tracts triggering ongoing immune responses? (investinme.org)
  • HIV-1 causes most HIV infections worldwide, but HIV-2 causes a substantial proportion of infections in parts of West Africa. (msdmanuals.com)
  • Only 0.1%-3% of HTLV‐1 infections result in T cell leukemia. (diseases-illness.com)
  • Most primary infections occur between 1 and 5 years while most reactivation infections occur after the age of 25 years. (who.int)
  • Cell-to-cell transmission is essential for virus replication and occurs through the formation of a virological synapse. (wikipedia.org)
  • This previously unknown and unsuspected aspect of enterovirus replication provides an explanation for reports of enteroviral RNA detected in diseased tissue in the apparent absence of virus particles" (Journal of IiME 2009:3:1). (investinme.org)
  • treatment can restore immune function in most patients if suppression of replication is sustained. (msdmanuals.com)
  • Meanwhile, the virus was spreading around the world, without researchers and health officials being able to do anything significant to control its replication and dispersal. (varsomics.com)
  • As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. (oncotarget.com)
  • Some authors believe it is possible for some patients with tropical spastic paraparesis to also present virus-related Sjögren's syndrome. (bvsalud.org)
  • Keikha M, Babaki MK, Fonseca LA, Casseb J. The Relevance of HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis in Iran: A Review Study. (ac.ir)
  • Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil. (fiocruz.br)
  • One of the worst treatment disasters in modern history took place in the 1980s with the widespread transmission of HIV and hepatitis viruses through infected blood products. (who.int)
  • In this study, we analyzed these two parameters as well as the mutational status of TET2 in ATLL patients. (oncotarget.com)
  • ATLL develops in approximately 5% of HTLV-1 infected individuals who acquire the virus via vertical transmission [ 5 ]. (oncotarget.com)
  • The pathogenesis of ATLL in HTLV-1-infected individuals may differ from one population to another. (oncotarget.com)
  • The occurrence of HTLV-I/II and HIV-1 coinfections have been shown to be frequent, probably in consequence of their similar modes of transmission. (scielo.br)
  • 1997). The similar modes of transmission of the same organic fluids in which HIV and HTLV are present, favours their joint transmission, sharing the same human host when the viruses occur in the same epidemiological setting (Galvão-Castro 1994). (scielo.br)
  • Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL). (lookformedical.com)
  • In this manner, an early diagnostic and a molecular surveillance of HTLV-1 transmission remains necessary in Portugal. (htlv.net)
  • Blood samples tested by an enzyme immune assay and a discriminatory Western blot were positive for HTLV-I. The familial analysis of one patient showed a possible pattern of sexual and vertical transmission of the virus. (scielo.br)
  • Several studies indicate that HTLV-1 transmission occurs through sexual or other intimate contact-intrauterine, perinatal, breastfeeding, sharing of needles by drug users, or blood transfusion from infected persons. (medscape.com)
  • it derives from interspecies zoonotic transmission from non-human primates to humans (ancient or recent). (biomedcentral.com)
  • HTLV-1 transmission occurs through sexual intercourse, prolonged breast-feeding, or blood transfusion. (biomedcentral.com)
  • Les études qui doivent être menées, en particulier dans les pays où la transmission est active, sont répertoriées dans le présent article. (who.int)
  • The system is based on three ranges of CD4+ T- lymphocyte counts and three clinical categories and is represented by a matrix of nine mutually exclusive categories (Table 1). (cdc.gov)
  • This system replaces the classification system published in 1986, which included only clinical disease criteria and which was developed before the widespread use of CD4+ T-cell testing (1). (cdc.gov)
  • This study aimed to analyse epidemiological and clinical data, and to assess the diversity of HTLV-1 strains circulating in infected-residents diagnosed in the Portuguese national reference laboratory between 2010 and 2021. (htlv.net)
  • Clinical studies show that depletion of B cells reduces disease burden in both relapsing-remitting and progressive multiple sclerosis (MS) patients. (vitamindwiki.com)
  • [ 1 ] Whereas only a small proportion of HTLV-1-infected individuals develop HAM/TSP (1-4%), the mechanisms responsible for the progression of a HTLV-1 carrier state to clinical disease are not clear. (medscape.com)
  • Testing for these autoantibodies is recommended in patients who present with acute central nervous system (CNS) demyelination and clinical, imaging, or laboratory features that are atypical for MS. Research to identify MS-specific autoantibodies is ongoing. (arupconsult.com)
  • HHM has been rarely documented in patients with CC. In this report, we present a case of advanced CC associated with clinical and laboratory findings consistent with HHM. (biomedcentral.com)
  • This pilot clinical trial studies the side effects of irradiated donor cells following stem cell transplant in controlling cancer in patients with hematologic malignancies. (bioseek.eu)
  • Initial management consisted of en una paciente con topical corticosteroids and oral antihistamines with little clinical response. (bvsalud.org)
  • Therefore, a reduced-intensity allogeneic stem cell transplantation(RIST) is applied to ATL patients and a multi-center phase I clinical trial is now underway. (elsevierpure.com)
  • Virus diseases caused by the HERPESVIRIDAE. (lookformedical.com)
  • A general term for diseases produced by viruses. (lookformedical.com)
  • Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. (mdpi.com)
  • six patients (30%, mean age 40.3 years) showed HTLV-1 related diseases and six (30%, mean age 45.2 years) were coinfected with HIV/AIDS. (htlv.net)
  • A high proportion of HTLV-1 related diseases and HIV/AIDS coinfection was observed. (htlv.net)
  • Risk behaviour practices and the absence of specific control measures, including diagnostic and treatment, may contribute to a silent dissemination of a broad diversity of HTLV-1 strains and, therefore, the increased rate of progression to debilitating diseases. (htlv.net)
  • Ninety to ninety-five percent of people with MS have proteins in their spinal fluid that are typically found in the spinal fluid of people with nervous system diseases that are known to be reactions to viruses. (vitamindwiki.com)
  • Other patients experience a more gradual increase in symptom severity, with peak deficits occurring days (acute form of transverse myelitis) to weeks (subacute form of transverse myelitis) after the initial symptoms first presented. (encyclopedia.com)
  • Moreover, recent research has shown that even viruses which were hitherto believed not to persist after an acute infectious episode are capable of long-term viral persistence. (investinme.org)
  • Furthermore, this 5-hmc defect was more pronounced in tumor T cells from acute patients than from chronic ones and correlated with reduced expression of TET2 protein. (oncotarget.com)
  • Patients are young and seek care because of acute tender, cervical lymphadenopathy and low-grade fever. (medscape.com)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • In the 1980s, HTLV-2 was identified in a patient with an unidentified T cell lymphoproliferative disease that was described as having characteristics similar to the B cell disorder, hairy cell leukemia. (wikipedia.org)
  • Prognosis of such coinfections is a controversial matter and it is suggested that in the course of disease patients can be significantly deprived (Schechter et al. (scielo.br)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • It is estimated that 15%-50% of patients with LyP will develop another lymphoproliferative disorder, such as ALCL, Hodgkin disease , or mycosis fungoides (MF). (logicalimages.com)
  • B cells are now known to play a major role in disease, demonstrated by the highly impactful effect of a B cell-depleting antibody on controlling MS. The idea that a virus may play a role in the development of MS has a long history and is supported mostly by studies demonstrating a link between B cell-tropic Epstein-Barr virus (EBV) and disease onset. (vitamindwiki.com)
  • Spondyloarthritis in patients with inflammatory bowel disease (Crohn's disease). (ocu-radiology.jp)
  • One patient who referred disease duration of more than 16 years, showed diminished deep reflexes, bilateral Babinski's sign, diminished sensation of vibration, abnormal bladder function and back pain. (scielo.br)
  • The other two patients (with one and six years of disease duration) complained of weakness in one leg, increased deep reflexes and back pain. (scielo.br)
  • Babinski's sign and bladder disturbance were also present in the patient with six years of disease. (scielo.br)
  • Patients become ill within weeks and, if left untreated, will usually succumb to the disease within weeks or months. (sjmccancerradiosurgerycentre.com)
  • Viruses cause disease at the most basic level, by damaging the cells of living things. (investinme.org)
  • one of the less-explored is HTLV-1-associated pulmonary disease. (uchile.cl)
  • We found that nine out of fourteen patients with no known TB disease history presented bronchiectasis, mainly found bilaterally while five presented pulmonary fibrosis. (uchile.cl)
  • Treatment of hypercalcemia with saline infusion, loop diuretics, biphosphonate and calcitonin was effective in normalizing calcium levels and consciousness state within 48 hours, but a relapse occurred 4 weeks later and the patient succumbed to his disease. (biomedcentral.com)
  • Hypercalcemia occurs in around 30% of patients with malignant disease. (biomedcentral.com)
  • Computer tomography (CT) revealed a large multinodular mass in the right lobe of the liver consistent with neoplastic disease (Figure 1 ) and smaller nodules in the right lung. (biomedcentral.com)
  • Patients that do not have evidence of relapse or progressive disease may be treated every 8-12 weeks for up to 3 doses. (bioseek.eu)
  • COHORT II: Patients with high-risk disease receive initial treatment with IHC within 70 days after hematopoietic engraftment (both neutrophils and platelets) after allogeneic HSCT. (bioseek.eu)
  • Patients being treated for relapsed disease may receive initial treatment with IHC any time after relapse is documented. (bioseek.eu)
  • Allogeneic transplantation was performed in five patients, two of whom achieved complete remission despite residual or refractory disease. (oncotarget.com)
  • It is crucial that we continue to develop new therapies for use in uveitis that aim to suppress disease activity, prevent accumulation of damage, and preserve visual function for patients with the minimum possible side effects. (dovepress.com)
  • Until now, no viral genotype or subgroup is associated with a specific HTLV-1-associated disease. (biomedcentral.com)
  • Viral load is a strong predictor of disease progression in untreated patients. (health.am)
  • A 44 year old female patient, with no preexisting underlying disease, with a history of approximately ten months of presenting pruritic erythematous-desquamative lesions initially localized in the lower extremities and Insuficiencia respiratoria later generalized throughout the body, associated with weight loss of 15 kg. (bvsalud.org)
  • According to recent reports, nearly half of the ATL patients who received allogeneic hematopoietic stem cell transplantation could survive without disease for over 3 years. (elsevierpure.com)
  • This retrospective on the history of HIV shows us the time that passed between the first reports of the disease and the identification of the virus: more than 20 years. (varsomics.com)
  • For both, PPMS patients according to revised McDonald 2010 criteria and RMS patients meeting criteria for PMS disease course as per Lublin et al. (who.int)
  • Concerns have been raised globally by the appearance in 2012 of a novel coronavirus (nCoV) causing severe respiratory disease within some countries in the Middle East and in patients transferred for medical care in Europe [1-3]. (who.int)
  • The most compelling data supporting an etiologic role for viral involvement in MS have emerged for Epstein-Barr virus (EBV). (vitamindwiki.com)
  • In relation to "CFS", the most-studied viruses have been the Epstein-Barr Virus (EBV) and the Human Herpes Virus-6 (HHV-6). (investinme.org)
  • Identification of joint gene players implicated in the pathogenesis of HTLV-1 and BLV through a comprehensive system biology analysis. (ac.ir)
  • On August 15, 1983, CDC initiated prospective surveillance of health-care workers (HCWs) with documented parenteral or mucous-membrane exposure to potentially infectious body fluids from patients with definite or suspected acquired immunodeficiency syndrome (AIDS). (cdc.gov)
  • Two hundred nine (92%) were AIDS patients meeting the CDC surveillance definition, and 17 (8%) were suspected AIDS cases. (cdc.gov)
  • Two hundred three (97%) of the 209 AIDS patients were in an identified risk group for acquiring AIDS. (cdc.gov)
  • This paper presents the prevalence of coinfection of HTLV among HIV-1 infected and AIDS patients in Belém, State of Pará, Brazil. (scielo.br)
  • it is to be used by all states for AIDS case reporting effective January 1, 1993. (cdc.gov)
  • It is the virus that can lead to acquired immune deficiency syndrome, or AIDS. (dc.gov)
  • In 1983, scientists discovered the virus that causes AIDS. (dc.gov)
  • This incomplete understanding has led some persons to make statements that AIDS is not caused by an infectious agent or is caused by a virus that is not HIV. (dc.gov)
  • The incidence of Kaposi's sarcoma in patients with AIDS has declined in the era of effective antiretroviral therapy (ART), and cases of disseminated Kaposi's sarcomas have rarely been reported in Korea. (sch.ac.kr)
  • We report a successfully treated case of gastrointestinal and cervical lymph nodal Kaposi's sarcoma in a patient with AIDS who had combined treatment with ART, interferon-α, and paclitaxel. (sch.ac.kr)
  • 4. Brites C, Sampaio J, Oliveira A. HIV-1/Human T-cell lymphotropic virus coinfection revisited: impact on AIDS progression. (sp.gov.br)
  • Perhaps the oldest documented case of what would be Acquired Immunodeficiency Syndrome (AIDS) is that of a patient in Congo, dated from 1959 [1]. (varsomics.com)
  • The severe immune plants is that suppression of the patients in whom it has been used deficiency that is characteristic of immune response can allow occult as an antineoplastic agent ( IARC, AIDS results from a deficiency in tumours or metastatic tumour cel s 2012b ). (who.int)
  • HTLV-1 and HTLV-2 are both involved in actively spreading epidemics, affecting 15-20 million people worldwide. (wikipedia.org)
  • Three patients (males, black, ages 37, 40 and 57) attended a university clinic with a progressive paraparesis of obscure origin. (scielo.br)
  • An increase mortality rate and faster progression to death is often related to HTLV-1/HIV coinfection. (htlv.net)
  • Further evidence that HTLV protects against HIV-1 progression. (sp.gov.br)
  • [ 1 ] This may result in prolonged remission, but relapse is to be expected. (medscape.com)
  • To Analyze Clones From Patients Who Relapse to Determine Whether Antiviral Escape is Associated With Expression of IRF-4, c-Rel or Other Molecular Events (p53, p16 Mutations) Including Expansion of Novel Clones. (druglib.com)
  • The relationship between viral and immunologic factors in patients with viral relapse on antiretroviral therapy is complex and incompletely understood. (diseases-illness.com)
  • In this study, we compared patients who maintained virus suppression with patients experiencing viral relapse yet maintaining stable CD4+ lymphocytes while receiving antiretroviral therapy. (diseases-illness.com)
  • Combination antiretroviral therapies potently suppress plasma human immunodeficiency virus (HIV) RNA levels, although many patients who initially achieve suppression below the limits of detection experience viral relapse to detectable levels. (diseases-illness.com)
  • Despite virologic relapse, many HIV‐infected patients continue to benefit clinically and can maintain CD4+ lymphocyte counts above pretreatment baseline values for prolonged periods. (diseases-illness.com)
  • The mechanism by which latent viruses, such as genetically transmitted tumor viruses ( PROVIRUSES ) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. (lookformedical.com)
  • Molecular studies point to a fairly low evolution rate of HTLV-1 (between 5.6E−7 and 1.5E−6 substitutions/site/year), supposedly because the virus persists within the host via clonal expansion (instead of new infectious cycles that use reverse transcriptase). (biomedcentral.com)
  • HTLV-1 and HTLV-2 share broad similarities in their overall genetic organization and expression pattern, but they differ substantially in their pathogenic properties. (wikipedia.org)
  • Although gaps remain in our understanding of the etiology of MS, the role, if any, of viruses in propagating pathogenic immune responses deserves attention. (vitamindwiki.com)
  • Our results indicate that exploring TCR repertoires of HTLV-1-infected cells can elucidate individual clonal dynamics and identify potential pathogenic clones expanded in the CNS. (jci.org)
  • Under normal conditions, the immune system reacts to the presence of a viral or bacterial illness by producing a variety of immune cells designed to attack the invading viruses or bacteria. (encyclopedia.com)
  • For many years scientists theorized as to the origins of HIV and how it appeared in the human population, most believing that HIV originated in other primates. (dc.gov)
  • There is increasing awareness that the dysregulated immune system that is a hall-mark of ME/CFS allows multiple latent viruses and microbial agents to become reactivated (Co-Cure NOT:12th November 2009). (investinme.org)
  • In relation to "pure" ME, the most studied viruses (and for which there is extensive evidence) have been the enteroviruses, usually Coxsackie B (CBV). (investinme.org)
  • Patients with evidence of maternal engraftment or an elevated response to phytohemagglutinin (PHA) should receive RETHYMIC with immunosuppressive medications (Table 2). (rxlist.com)
  • 1. Evidence for Dissemination in space (DIS) in the brain based on =1 T2 lesions in at least one area characteristic for MS (periventricular, juxtacortical, or infratentorial). (who.int)
  • 3. Positive findings in a cerebrospinal fluid (CSF) specimen (isoelectric focusing evidence of oligoclonal bands and/or elevated immunoglobulin (Ig) G index) [If a recent CSF sample or results from a previous CSF test from each patient is not available, this data will be considered missing information]. (who.int)
  • Detection of mammary tumor virus env gene-like sequences in human breast cancer. (ac.ir)
  • Following stimulation by HTLV-1 antigens on the surface of infected T cells in the CNS compartment, expansion of immunocompetent T cells directed against viral proteins may result in CNS tissue damage, which may be mediated by cytokines such as tumor necrosis factor (TNF) alpha. (medscape.com)
  • It is caused either by tumor production of humoral factors [humoral hypercalcemia of malignancy (HHM)] or by locally enhanced bone resorption associated with metastatic lesions of solid cancers [ 1 ]. (biomedcentral.com)
  • The present results show for the first time in Belém not only the occurrence of HTLV-II/HIV-1 coinfections but also a higher prevalence of HTLV-II in relation to HTLV-I. Furthermore, it also enlarges the geographical limits of the endemic area for HTLV-II in the Amazon region of Brazil. (scielo.br)
  • In Brazil, the virus is endemic, presenting the greatest absolute number of cases in the world and included in blood bank screening tests. (bvsalud.org)
  • What is the role of autoantibody testing in patients with multiple sclerosis? (arupconsult.com)
  • Which lab tests should be considered for patients beginning or undergoing treatment for multiple sclerosis? (arupconsult.com)
  • One study showed that transfusion of HTLV-1 antibody-positive blood causes seroconversion in 60% of recipients. (medscape.com)
  • In one study involving cultured lymphocytes from patients with mycosis fungoides (Figure 1), PCR amplification showed gene sequences of HTLV-II. (wikipedia.org)
  • Resistance assays fall into two classes: genotyping examines the virus for mutations known to confer drug resistance, whereas phenotyping tests the susceptibility of the patient's virus to specific medications. (health.am)
  • Methods: in this observational, cross-sectional and quantitative study carried out with 49 patients diagnosed with HAM/TSP from the Neuroscience sector of the Professor Francisco Magalhães Neto Ambulatory, in the city of Salvador, Bahia, Brazil, quality of life was assessed using the Short Form Health Questionnaire Form - 36 (SF-36), from February/19 to July/20 and from February/22 to April/22. (bvsalud.org)
  • Cluster analysis showed similarity in TCRβ sequences in HTLV-1-infected cells, suggesting that they proliferate after common antigen stimulation. (jci.org)
  • Patients with LyP should be monitored closely for these additional malignancies. (logicalimages.com)
  • A cohort study comprised of 504 LyP patients found that there was an increased risk of developing nonhematologic malignancies such as squamous cell carcinoma (SCC), melanoma , bladder cancer , and lung cancer . (logicalimages.com)
  • I. To determine the toxicity associated with the administration of irradiated haploidentical cells (IHC) to patients with high-risk hematologic malignancies. (bioseek.eu)
  • A strain of PRIMATE T-LYMPHOTROPIC VIRUS 1 isolated from mature T4 cells in patients with T-lymphoproliferation malignancies. (nih.gov)
  • Deoxyribonucleic acid that makes up the genetic material of viruses. (lookformedical.com)
  • Viruses whose genetic material is RNA. (lookformedical.com)
  • Genetic analysis of this blood sample suggested that HIV-1 may have stemmed from a single virus in the late 1940s or early 1950s. (dc.gov)
  • HTLV-1 exhibits a remarkable genetic stability, however, viral strains have been classified in several genotypes and subgroups, which often mirror the geographic origin of the viral strain. (biomedcentral.com)
  • In this review, we describe the genetic diversity of HTLV-1, and analyze the molecular mechanisms that are at play in HTLV-1 evolution. (biomedcentral.com)
  • The most commonly used HIV test-enzyme-linked immunosorbent assay (ELISA) followed, if positive, by Western blot-detects the presence of antibodies produced by the host as an immune response to certain genetic components of the virus, but not the presence of the virus itself. (health.am)
  • A Novel Coronavirus from Patients with Pneumonia in China, 2019. (ocu-radiology.jp)
  • The patient had been diagnosed with RA four years earlier, with manifestations of bilateral hand symptoms along with high titer rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibodies. (the-rheumatologist.org)
  • Nevertheless, studies showed that some antiretrovirals used in HIV treatment lead to a positive immune response against HTLV-1. (htlv.net)
  • B cell-tropic viruses may trigger aberrant immune responses in MS in genetically susceptible individuals owing, in part, to a failure in viral surveillance and clearance. (vitamindwiki.com)
  • Transfusion of irradiated donor cells (immune cells) from relatives may cause the patient's cancer to decrease in size and may help control cancer in patients receiving a stem cell transplant. (bioseek.eu)
  • Rethymic ( allogeneic processed thymus tissue-agdc) is processed thymus tissue indicated for immune reconstitution in pediatric patients with congenital athymia. (rxlist.com)
  • The LEukemia Artificial Intelligence Program (LEAP) in Chronic Myeloid Leukemia in Chronic Phase: A Model to Improve Patient Outcomes. (cdc.gov)
  • Our annual international Conferences and research Colloquiums are designed to bring together researchers, clinicians, patient groups and patients/carers in order to make progress in research into ME. (investinme.org)
  • [ 1 ] Clinicians and pathologists are unfamiliar with this entity. (medscape.com)
  • Visual impairment is common, affecting between 2.8% and 10% of patients, 1 - 3 and may result directly from damage to uveal tract structures, or may occur due to secondary effects on neighboring tissues: for example, accelerated cataract formation, glaucoma, and macular edema. (dovepress.com)
  • 4] In the United States, the overall prevalence is 22 per 100,000 population, with HTLV-2 more common than HTLV-1. (wikipedia.org)
  • Symptoms of transverse myelitis may reach their peak within 24 hours of onset for some patients (considered the hyperacute form of the condition). (encyclopedia.com)
  • Patients with the quicker onset form and who experience more severe initial symptoms tend to have more complications and a greater likelihood of permanent disability. (encyclopedia.com)
  • Patients may have symptoms for months, and prolonged survival (years) is possible, sometimes even with no treatment. (sjmccancerradiosurgerycentre.com)
  • As a consequence, patients develop symptoms of anaemia (low haemoglobin due to low red cell production) and complain of feeling tired, short of breath on exertion, or palpitations (conscious feeling of their heartbeat). (sjmccancerradiosurgerycentre.com)
  • Respondent Abbott is infected with the human immunodeficiency virus (HIV), but had not manifested its most serious symptoms when the incidents in question occurred. (justia.com)
  • Nora Chapman et al from the Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Centre, have shown that human enteroviruses Coxsackie B can naturally delete sequence from the 5' end of the RNA genome and that this deletional mechanism results in long-term viral persistence, which has substantially altered the previously held view (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440640/?tool=pubmed). (investinme.org)
  • INTRODUÇÃO: A Paraparesia Espástica Tropical / Mielopatia Associada ao HTLV-1 (HAM/TSP) apresenta alterações crônico-degenerativas que comprometem os indivíduos nas atividades diárias, principalmente aquelas ligadas à locomoção. (bvsalud.org)
  • According to one theory, supply of HTLV-1-infected CD4 cells via the blood to the CNS is essential for development of CNS lesions. (medscape.com)
  • Our study aims to describe the pulmonary lesions of HTLV-1-positive patients without past or current active TB and evaluate pulmonary function. (uchile.cl)
  • The first HTLV-1 complete sequence (ATK prototype) was obtained in 1983 [ 12 ]. (biomedcentral.com)
  • Transfusion of plasma alone in humans did not result in seroconversion. (medscape.com)
  • All case-patients were male. (cdc.gov)
  • Case 1-2021: A 76-Year-Old Woman with Lethargy and Altered Mental Status. (ocu-radiology.jp)
  • In our institute, 5 patients, who received RIST, are all alive, with 1 case relapsed after 6 months. (elsevierpure.com)
  • Most patients with LyP have chronic, self-limited eruptions. (logicalimages.com)
  • Comparing machine learning algorithms to predict 5-year survival in patients with chronic myeloid leukemia. (cdc.gov)
  • The youngest seropositive patient was 11 months old. (who.int)
  • A virus closely related to HTLV-I, human T-lymphotropic virus 2 (HTLV-II) shares approximately 70% genomic homology (structural similarity) with HTLV-I. It was discovered by Robert Gallo and colleagues. (wikipedia.org)
  • HIV-1 originated in Central Africa in the first half of the 20th century, when a closely related chimpanzee virus first infected humans. (msdmanuals.com)
  • Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? (mdpi.com)
  • Purpose: Human milk oligosaccharides (HMOs) may be genetically determined based on the secretor and Lewis status of the mother. (koreamed.org)
  • this patient later developed hairy cell leukemia, but HTLV-2 was not found in the hairy cell clones. (wikipedia.org)
  • Human T cell leukemia virus (HTLV-1) is an oncoretrovirus that infects at least 10 million people worldwide. (biomedcentral.com)
  • A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia. (sp.gov.br)
  • Respiratory viruses can also exacerbate asthma and lead to various types of respiratory distress syndromes. (mdpi.com)
  • Respiratory failure in a patient plus respiratory distress associated with bilateral basal rales, presented respiratory failure, and during induction of mechanical with Sézary syndrome. (bvsalud.org)
  • Expanded HTLV-1-infected clones revealed different distributions between cerebrospinal fluid (CSF) and peripheral blood and were enriched in the CSF of patients with HAM/TSP. (jci.org)