AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
Kidney TransplantationGlomerulonephritisGlomerulonephritis, MembranoproliferativeKidneyGraft SurvivalLiver TransplantationGraft RejectionTransplantation, HomologousKidney Failure, ChronicKidney GlomerulusTissue DonorsImmunosuppressive AgentsLiving DonorsGlomerulonephritis, MembranousPancreas TransplantationKidney DiseasesDelayed Graft FunctionGlomerulonephritis, IGABone Marrow TransplantationTissue and Organ ProcurementCadaverBlood Group IncompatibilityProteinuriaHeart TransplantationHematopoietic Stem Cell TransplantationImmune Complex DiseasesAnti-Glomerular Basement Membrane DiseaseTime FactorsWaiting ListsLung TransplantationTreatment OutcomeTransplantation, AutologousRetrospective StudiesTacrolimusMycophenolic AcidBiopsyOrgan TransplantationTransplantation ImmunologyTransplantation ConditioningImmunosuppressionKidney Function TestsStem Cell TransplantationHistocompatibility TestingKidney TubulesCreatinineCyclosporinePostoperative ComplicationsIsoantibodiesTransplantationFollow-Up StudiesDonor SelectionIslets of Langerhans TransplantationRenal DialysisABO Blood-Group SystemNephrotic SyndromePlasmapheresisAntibodies, Antineutrophil CytoplasmicGlomerular Filtration RateLupus NephritisRisk FactorsAcute Kidney InjuryDisease Models, AnimalGlomerular MesangiumTransplantation, IsogeneicGlomerulosclerosis, Focal SegmentalCell TransplantationSurvival RateRenal InsufficiencyOrgan PreservationAzathioprineTransplantation ChimeraTransplantation ToleranceBasement MembraneAntilymphocyte SerumSurvival AnalysisComplement C3Immunoglobulin GAntigen-Antibody ComplexTransplantsHistocompatibilityRecurrenceAutoantibodiesGraft vs Host DiseaseAcute DiseaseHLA AntigensRats, Inbred LewDirected Tissue DonationIncidenceNephritisVasculitisTransplantation, HeterotopicPrognosisLiver FailureBiological MarkersPrednisoneProspective StudiesKidney CortexCord Blood Stem Cell TransplantationMice, Inbred C57BLCold Ischemia
DiseasesEtiologyHematopoietic Stem Cell TransChronic kidneyMembranoproliferativeSystemicMPGNDisordersNephriticDiseaseRenal replaceGlomerulusGlomerularHSCTHypertensionClinicalDepositionRecurInflammatory2018OrganBiopsyNephritisUrine output2017ThrombosisSyndromeInflammationOrgansTreatmentBackgroundConditionsPatients
Diseases7
  • Glomerulonephritis is a collection of glomerular diseases mediated by different immunologic pathogenic mechanisms, resulting in varied clinical presentation and therapeutic outcomes. (basicmedicalkey.com)
  • Glomerulopathies can further be classified as primary or secondary, with primary diseases directly affecting the kidneys and secondary diseases caused by another disease or process. (shiken.ai)
  • This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. (lookformedical.com)
  • The immunosuppressant Cyclosporin A (CsA) represents a standard of care in organ transplantation, as well as an important treatment option in a variety of autoimmune diseases. (charite.de)
  • So as a new therapeutic approach, stem cells are under research with a focus on reducing the burden of several kidney diseases. (biomedcentral.com)
  • Chronic Granulomatous Disease , autoimmune diseases Autoimmune diseases Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. (lecturio.com)
  • Undifferentiated connective tissue diseases (UCTDs) are clinical entities characterised by signs and symptoms suggestive of a systemic autoimmune disease, which do not fulfil the diagnostic criteria for a defined connective tissue disease. (lookformedical.com)
Etiology2
  • Systemic lupus erythematosus is a chronic, multisystem, inflammatory disorder of autoimmune etiology, occurring predominantly in young women. (merckmanuals.com)
  • This chapter provides an overview of the primary causes of glomerulonephritis with a focus on their etiology, the pathophysiologic mechanisms responsible for glomerular injury, and the clinical presentation of the eight predominant types of glomerulonephritis. (basicmedicalkey.com)
Hematopoietic Stem Cell Trans2
  • Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
  • Another form of lipodystrophy that fits the classification of "acquired partial" not involving the complement pathway is associated with hematopoietic stem cell transplantation (HSCT) to treat leukemia or neuroblastoma. (medscape.com)
Chronic kidney2
  • acute and chronic kidney disease-their statistical data, and the conventional drugs used for treatment. (biomedcentral.com)
  • The paper further underestimates chronic kidney disease because their endpoint was restricted to the absence of chronic dialysis or need for renal transplantation. (abdominalkey.com)
Membranoproliferative5
Systemic4
  • Lupus nephritis is an inflammation of the kidneys caused by systemic lupus erythematosus (SLE), an autoimmune disease. (wikipedia.org)
  • Rheumatoid Arthritis (RA) Rheumatoid arthritis is a chronic systemic autoimmune disease that primarily involves the joints. (merckmanuals.com)
  • Primary Sjogren syndrome (pSS) is a systemic autoimmune disease characterised by lymphocytic infiltration of exocrine glands and by a number of systemic manifestations, including those regarding the lung. (ersjournals.com)
  • SS can occur as a primary disease (primary SS (pSS)) or be associated with another autoimmune disease, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), dermatomyositis, or systemic sclerosis (SSc) [ 1 ]. (ersjournals.com)
MPGN1
  • Clinical presentations are similar for the three types of MPGN, but they manifest somewhat different mechanisms of complement activation and predisposition to recur in kidney transplants. (medscape.com)
Disorders2
  • The GFR examination and albuminuria, a marker of kidney damage, are both used by nephrologists to categorise kidney conditions into two categories: acute and chronic kidney disorders. (biomedcentral.com)
  • Given the proposed wider application of these medicines and their potentially important advantages in treatment of inflammatory and autoimmune disorders, more studies are needed with special focus on the molecular targets of statins included in regulating the immune response. (archivesofmedicalscience.com)
Nephritic2
Disease12
  • The proliferative forms of lupus nephritis are associated with a higher risk of progression to end stage kidney disease. (wikipedia.org)
  • Black and Hispanic people with lupus nephritis are more likely to present with severe disease at initial presentation (with more proteinuria and more extensive histopathologic changes) and progress to end stage kidney disease. (wikipedia.org)
  • Men with SLE tend to have more aggressive forms of lupus nephritis as well with a higher risk of progression to end stage kidney disease and higher risk of concurrent cardiovascular disease. (wikipedia.org)
  • In the absence of specific and effective therapy for many types of glomerulonephritis, supportive treatments for edema, hypertension, hyperlipidemia, and intravascular thrombosis play important roles in reducing the complications associated with the disease. (basicmedicalkey.com)
  • Epidemic proportions have been reached in Kidney disease due to an increase in diabetes , hypertensive disease, and obesity. (insightconferences.com)
  • Genetic factors such as APOL-L1 mutations are associated with an increased risk of FSGS and progression to end-stage kidney disease. (shiken.ai)
  • Anti-GBM disease is defined as the triad of glomerulonephritis (usually rapidly progressive or crescentic), pulmonary hemorrhage, and anti-GBM antibody formation. (medscape.com)
  • On the basis of this clinical report, Goodpasture's name is often linked to the pulmonary renal syndrome of alveolar hemorrhage and necrotizing and proliferative glomerulonephritis, although vasculitis and not anti-GBM disease is believed to be the cause of the pulmonary renal syndrome in Goodpasture's original patient. (medscape.com)
  • The pathogenesis of anti-glomerular basement membrane (anti-GBM) disease (Goodpasture disease) is linked to the presence of autoantibodies that react with the alveolus in the lung and the basement membrane of the glomerulus in the kidney. (medscape.com)
  • Some of these triggers include pregnancy or postpartum experiences, autoimmune disease, malignant hypertension, and organ transplantation. (ahussource.com)
  • From the pathology standpoint, it is important to determine whether the membranous glomerulopathy may be due to a secondary cause such as an autoimmune disease, neoplasia, infection, or drugs. (abdominalkey.com)
  • whilst both may present with similar clinical features, they are best considered as distinct disease entities since the underlying pathophysiology and treatment strategies are very different. (dovepress.com)
Renal replace1
Glomerulus1
Glomerular3
  • Diabetes mellitus is an important secondary cause of glomerular injury, and a thorough discussion of the pathophysiology and management of this condition can be found in Chapter 57 . (basicmedicalkey.com)
  • Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. (lookformedical.com)
  • Glomerular filtration rate (GFR) is the most accessible guide for normal kidney function, which rises to the aggregate sum of fluid filtered through the entirety of the working nephrons per unit of time [ 4 ]. (biomedcentral.com)
HSCT1
  • This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (medscape.com)
Hypertension1
  • Dr. Mak's research interests include the contrasts between the cardiovascular physiology of men and women, the pathophysiology of pulmonary arterial hypertension and heart failure, and the quality of care for patients with acute and chronic heart failure. (utoronto.ca)
Clinical2
  • Goodpasture syndrome (GS) is the clinical entity of acute glomerulonephritis and pulmonary alveolar hemorrhage, and the term Goodpasture syndrome is used interchangeably with pulmonary renal syndrome. (medscape.com)
  • We concluded that chronic CsA administration (in clinical settings twice daily) translates into large daily fluctuations of pO2 in various kidney regions. (charite.de)
Deposition1
  • Its pathophysiology includes immune complex deposition and a wide range of skin lesions. (lookformedical.com)
Recur1
Inflammatory1
  • Most uveitis seen in Western countries is noninfectious and appears to be autoimmune or autoinflammatory in nature, requiring treatment with immunosuppressive and/or anti-inflammatory drugs. (dovepress.com)
20183
  • Kidney Int . 2018;94:408-418. (ahussource.com)
  • According to the 2018 survey of the National Kidney Foundation, around 37 million people in the USA are affected by kidney failure, while almost 750,000 patients endure kidney failure annually, making it the leading cause of death among the US population [ 2 ]. (biomedcentral.com)
  • In India, as per the report of 2018, the average capital spent by a kidney patient on each haemodialysis session is around USD64. (biomedcentral.com)
Organ1
  • Kidneys are an overly sensitive organ with restricted regenerative efficiency with respect to other vital organs. (biomedcentral.com)
Biopsy2
Nephritis1
Urine output1
  • An unexpected decrease in urine output followed by a rise in serum creatinine concentration, including an inability to excrete waste, keep-up electrolytes, and maintain water balance, is termed acute kidney injury (AKI) or acute renal failure. (biomedcentral.com)
20171
Thrombosis1
  • Thrombotic microangiopathy is not a rare complication of kidney transplantation and is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury with extensive thrombosis of the arterioles and capillaries. (ekjt.org)
Syndrome2
  • Common manifestations may include arthralgias and arthritis, Raynaud syndrome, malar and other rashes, pleuritis or pericarditis, renal or central nervous system involvement, and autoimmune cytopenias. (merckmanuals.com)
  • Oedema is thought to be related to either hypoalbuminemia or excess salt and water retention in the kidney triggered by nephrotic syndrome, presenting with peripheral oedema. (shiken.ai)
Inflammation1
Organs1
Treatment2
Background1
  • BACKGROUND: B cell activating factor (BAFF), a crucial factor for B cell survival and differentiation, has been linked to several autoimmune conditions. (bvsalud.org)
Conditions1
  • We show that in the nephron BPGM is constitutively expressed, and up-regulated under conditions like acute kidney injury, clear cell renal carcinoma, or knock-out of the tumor suppressor von Hippel Lindau protein (VHL). (charite.de)
Patients1
  • However, taking into consideration that the mean age at presentation was 51 years and the mean follow-up was 69 months (making these patients ~56 years at follow-up), the recalculated eGFR should be ~30 ml/min if males and ~22 ml/min if females, indicating that a significant loss of kidney function occurred. (abdominalkey.com)